公开(公告)号：USD440599S1

公开(公告)日：2001-04-17

申请号：US29116674

申请日：2000-01-10

申请人： Yasuo Kotaki ,  Masashi Ogawa ,  Tsutomu Abe ,  Hitomi Ito

设计人： Yasuo Kotaki ,  Masashi Ogawa ,  Tsutomu Abe ,  Hitomi Ito

公开(公告)号：USD436990S1

公开(公告)日：2001-01-30

申请号：US29119151

申请日：2000-02-25

申请人： Yasuo Kotaki ,  Masashi Ogawa ,  Shigeyuki Nakayama ,  Tsutomu Abe

设计人： Yasuo Kotaki ,  Masashi Ogawa ,  Shigeyuki Nakayama ,  Tsutomu Abe

公开(公告)号：USD436619S1

公开(公告)日：2001-01-23

申请号：US29119152

申请日：2000-02-25

申请人： Yasuo Kotaki ,  Masashi Ogawa ,  Shigeyuki Nakayama ,  Tsutomu Abe

设计人： Yasuo Kotaki ,  Masashi Ogawa ,  Shigeyuki Nakayama ,  Tsutomu Abe

公开(公告)号：US5811439A

公开(公告)日：1998-09-22

申请号：US768937

申请日：1996-12-18

申请人： Masashi Ogawa ,  Tadashi Morita ,  Norihiro Iibuchi ,  Hideyuki Tsutsui

发明人： Masashi Ogawa ,  Tadashi Morita ,  Norihiro Iibuchi ,  Hideyuki Tsutsui

IPC分类号： A61K31/425 ,  A61K31/44 ,  A61K31/475 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  C07D417/06 ,  C07D417/14

CPC分类号： C07D417/06 ,  C07D417/14

摘要： A thiazolidinedione derivative represented by the following general formula (I): ##STR1## �wherein the dotted line represents a single bond or a double bond, the thiazolidinedione ring residue is linked to either of 2-, 3-, 4-, 5- and 6-positions on the indole ring and R represents a group selected from the group consisting of hydrogen atom and alkyl, alkenyl, alkynyl, phenyl, aralkyl, heterocycloalkyl, arylsulfonyl and arylaminocarbonyl groups! or a pharmaceutically acceptable salt thereof exhibits excellent effects of reducing the blood sugar level and of reducing the lipid concentration in blood and is accordingly useful as a therapeutic agent for treating diabates mellitus. These derivatives and pharmaceutically acceptable salt thereof are almost free of any side effect.

摘要翻译： 由下列通式（I）表示的噻唑烷二酮衍生物：其中虚线代表单键或双键，噻唑烷二酮环残基与2-，3-，4- 在吲哚环上的5-和6-位，R表示选自氢原子和烷基，烯基，炔基，苯基，芳烷基，杂环烷基，芳基磺酰基和芳基氨基羰基的基团]或其药学上可接受的盐显示出优异的 降低血糖水平和降低血液中的脂质浓度的效果，因此可用作治疗二倍体的治疗剂。 这些衍生物及其药学上可接受的盐几乎没有副作用。

公开(公告)号：US5447846A

公开(公告)日：1995-09-05

申请号：US91661

申请日：1993-07-14

申请人： Hiroshi Shinoki ,  Masashi Ogawa

发明人： Hiroshi Shinoki ,  Masashi Ogawa

IPC分类号： G01N33/542 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  G01N33/53

CPC分类号： G01N33/581 ,  G01N33/542 ,  G01N33/54386 ,  G01N33/6857 ,  Y10S435/964 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/972 ,  Y10S530/866

摘要： An enzyme-labelled antibody adapted for use in a homogeneous immunoassay is provided. The enzyme-labelled antibody is a conjugate of an enzyme with two or more different monoclonal antibodies, each of the monoclonal antibodies being capable of specifically recognizing and binding to a different epitope of the same antigen. By using the enzyme-labelled antibody in the homogeneous enzyme immunoassay process, an analyte can be quantitatively analyzed at a higher sensitivity through a simple operation. Also provided is a dry immunoassay element comprising an immunological reaction layer containing the enzyme-labelled antibody. By the provision of such an immunoassay element, a further simplified quick analysis of an analyte is realized to give an accurate result.

摘要翻译： 提供适用于均相免疫测定法的酶标记抗体。 酶标记的抗体是酶与两种或更多种不同单克隆抗体的缀合物，每种单克隆抗体能够特异性识别并结合相同抗原的不同表位。 通过在均相酶免疫测定法中使用酶标记的抗体，可以通过简单的操作以更高的灵敏度对分析物进行定量分析。 还提供了包含含有酶标记抗体的免疫反应层的干免疫测定元件。 通过提供这样的免疫测定元件，实现了分析物的进一步简化的快速分析以给出准确的结果。

公开(公告)号：US4963243A

公开(公告)日：1990-10-16

申请号：US483317

申请日：1990-02-21

申请人： Masashi Ogawa ,  Hisashi Shiraishi ,  Teppei Ikeda

发明人： Masashi Ogawa ,  Hisashi Shiraishi ,  Teppei Ikeda

IPC分类号： G01N27/26 ,  G01N27/447

CPC分类号： G01N27/44747

摘要： In a medium for electrophoresis comprising a polyacrylamide gel formed by crosslinking polymerization of an acrylamide compound and a crosslinking agent in the presence of water, and a modifier, the improvement in which the medium contains a water-soluble polymer and agarose.

摘要翻译： 在包含通过丙烯酰胺化合物和交联剂在水存在下交联聚合形成的聚丙烯酰胺凝胶和改性剂的电泳介质中，介质含有水溶性聚合物和琼脂糖的改进。

公开(公告)号：US4844786A

公开(公告)日：1989-07-04

申请号：US160161

申请日：1988-02-25

申请人： Mitsuru Sugihara ,  Masashi Ogawa

发明人： Mitsuru Sugihara ,  Masashi Ogawa

IPC分类号： G01N27/447

CPC分类号： G01N27/44704 ,  G01N27/44747

摘要： A means for electrophoresis suitably employable for analysis of biopolymers such as proteins, as well as for determination of base sequence of DNA, RNA, their fragments, and their derivatives is disclosed. The means comprises a membrane of an aqueous polyacrylamide gel for electrophoresis which is sandwiched between a plane support and a plane covering sheet. The membrane has a thickness gradient in its electrophoresis direction.

公开(公告)号：US4722777A

公开(公告)日：1988-02-02

申请号：US903884

申请日：1986-09-03

申请人： Masashi Ogawa ,  Hideo Matsunaga ,  Yukio Shinagawa

发明人： Masashi Ogawa ,  Hideo Matsunaga ,  Yukio Shinagawa

IPC分类号： G01N27/447 ,  C25D13/02 ,  C25D13/08

CPC分类号： G01N27/44747

摘要： An element for electrophoresis suitably employable for analysis of biopolymers such as proteins, as well as for determination of base sequence of DNA, RNA, their fragments, and their derivatives, which comprises a plastic material support, an adhesive layer containing an inorganic oxide and a binder, a medium layer for electrophoresis comprising an aqueous polyacrylamide gel formed by crosslinking polymerization of an acrylamide compound and a crosslinking agent in the presence of water, and a plastic material covering film. The electrophoresis medium layer may contain a water-soluble polymer and agarose. The medium layer may contain a modifier such as an anionic surfactant, formamide or urea.

摘要翻译： 适用于分析生物聚合物如蛋白质的电泳元件，以及用于测定DNA，RNA，其片段及其衍生物的碱基序列，其包含塑料材料载体，含有无机氧化物的粘合剂层和 粘合剂，用于电泳的中间层，其包含通过在水存在下交联聚合丙烯酰胺化合物和交联剂而形成的聚丙烯酰胺凝胶水溶液和塑料材料覆盖膜。 电泳介质层可含有水溶性聚合物和琼脂糖。 中间层可以含有改性剂，例如阴离子表面活性剂，甲酰胺或脲。

公开(公告)号：US4650556A

公开(公告)日：1987-03-17

申请号：US710131

申请日：1985-03-11

申请人： Masakazu Hashiue ,  Masashi Ogawa ,  Daijiro Nishio

发明人： Masakazu Hashiue ,  Masashi Ogawa ,  Daijiro Nishio

IPC分类号： G01N27/447 ,  G01N27/26 ,  G01N27/28

CPC分类号： G01N27/44747

摘要： A medium for electrophoresis which is substantially free from smiling effect or is reduced in the smiling effect, in which both side portions along the direction of electrophoresis are made thicker than the center portion. A support preferably employed for the preparation of the medium is also disclosed.

摘要翻译： 基本上没有微笑效果的电泳介质或微笑效果的降低，其中沿着电泳方向的两侧部分比中心部分厚。 还公开了优选用于制备介质的载体。

公开(公告)号：US4640759A

公开(公告)日：1987-02-03

申请号：US710130

申请日：1985-03-11

申请人： Masakazu Hashiue ,  Masashi Ogawa

发明人： Masakazu Hashiue ,  Masashi Ogawa

IPC分类号： G01N27/447 ,  G01N27/28

CPC分类号： G01N27/44747

摘要： A process for electrophoresis employing a medium wherein the potential gradient along the direction of electrophoresis is made larger at both side portions of the medium than at the center portion thereof. A medium for employable for said process in that the length of the both side portions along the direction of electrophoresis is made shorter than that of the center portion is disclosed. Also disclosed is a support for the medium.

摘要翻译： 使用介质的电泳方法，其中沿着电泳方向的电位梯度在介质的两侧部比在其中心部分更大。 用于所述方法的介质是沿着电泳方向的两侧部分的长度比中心部分的长度被公开。 还公开了对该介质的支持。