公开(公告)号：US08017638B2

公开(公告)日：2011-09-13

申请号：US12293246

申请日：2007-03-28

申请人： Tomoyuki Ogawa ,  Nobuo Chomei ,  Koji Masuda ,  Satoru Tanaka

发明人： Tomoyuki Ogawa ,  Nobuo Chomei ,  Koji Masuda ,  Satoru Tanaka

IPC分类号： A61K31/42 ,  C07D261/06

CPC分类号： C07D261/18 ,  C07D275/02 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

摘要： Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.

摘要翻译： 公开了一种可用作11型β-羟基类固醇脱氢酶抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是下式的基团：-C（= O）NR 4 R 5，（ 其中R 4和R 5各自独立地为氢，任选取代的烷基等）或下式的基团：-NR 6 C（= O）R 7，（其中R 6和R 7各自独立地为氢，任选取代的烷基等） X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的烷基，任选取代的烯基等。

公开(公告)号：US20100185852A1

公开(公告)日：2010-07-22

申请号：US12095402

申请日：2007-07-05

申请人： Tomoyuki Ogawa ,  Takashi Nishide

发明人： Tomoyuki Ogawa ,  Takashi Nishide

IPC分类号： G06F21/24 ,  H04L9/08 ,  G09C1/00

CPC分类号： G06F21/602 ,  H04L9/083

摘要： Encryption and decryption is achieved without the requirement for updating of the encryption key or re-encryption of an encrypted file when a shared encrypted file is generated, renamed or deleted.In response to a request to read or store a shared encrypted file, a filter driver in a client computer receives client authentication from a key management server and acquires a key list having pairs of UNC path names and encryption keys corresponding to shared encrypted folders allowed to be accessed from the key management server. The filter driver accesses a shared encrypted folder as a destination of the read or store request and performs decryption or encryption of the shared encrypted file by using an encryption key of the key list corresponding to a UNC path name concerned with the UNC path name to be accessed when the UNC path name concerned is present in the key list.

摘要翻译： 实现加密和解密，而不需要在生成，重命名或删除共享加密文件时更新加密密钥或加密文件的重新加密。 响应于读取或存储共享加密文件的请求，客户端计算机中的过滤器驱动程序从密钥管理服务器接收客户端认证，并获取具有对应于允许共享加密文件夹的UNC路径名和加密密钥对的密钥列表 从密钥管理服务器访问。 过滤器驱动程序访问作为读取或存储请求的目的地的共享加密文件夹，并通过使用与UNC路径名相关的UNC路径名称相对应的密钥列表的加密密钥来执行共享加密文件的解密或加密 当有关的UNC路径名存在于密钥列表中时被访问。

公开(公告)号：US20100168446A1

公开(公告)日：2010-07-01

申请号：US12449669

申请日：2008-01-28

申请人： Kazuyuki Yamane ,  Tomohiro Hoshi ,  Tomoyuki Ogawa

发明人： Kazuyuki Yamane ,  Tomohiro Hoshi ,  Tomoyuki Ogawa

IPC分类号： C07D319/12

CPC分类号： C07D319/12

摘要： A method of purifying a cyclic ester, comprising: mixing a co-distillated liquid comprising a cyclic ester produced by heating depolymerization of a hydroxycarboxylic acid oligomer in the presence of a depolymerization solvent and the depolymerization solvent with an organic solvent for washing which is mutually soluble with the depolymerization solvent and has a lower boiling point than the cyclic ester; subjecting the resultant mixture liquid to liquid-liquid separation into an organic solvent phase containing the depolymerization solvent and a cyclic ester phase containing the organic solvent; and then evaporating the organic solvent from the cyclic ester phase containing the organic solvent to recover the cyclic ester containing a reduced amount of the depolymerization solvent. As a result, purified cyclic ester is recovered at high heat efficiency, purification efficiency and operation efficiency, from the co-distillate liquid containing the depolymerization solvent and the cyclic ester from the depolymerization system for thermal decomposition of the hydroxycarboxylic acid oligomer in the presence of the depolymerization solvent.

摘要翻译： 一种环状酯的提纯方法，其特征在于，包括：在解聚溶剂和解聚溶剂的存在下，通过将羟基羧酸低聚物的解聚反应与溶解有机溶剂进行溶解而得到的包含环状酯的共蒸馏液， 具有解聚溶剂并且具有比环酯低的沸点; 将所得混合液进行液 - 液分离成含有解聚溶剂的有机溶剂相和含有有机溶剂的环状酯相; 然后从含有机溶剂的环状酯相中蒸发有机溶剂，回收含有减少量的解聚溶剂的环状酯。 结果，从含有解聚溶剂的共馏出液和来自用于羟基羧酸低聚物的热分解的解聚体系的环状酯在高热效率，净化效率和操作效率下，在存在 解聚溶剂。

公开(公告)号：US20090318716A1

公开(公告)日：2009-12-24

申请号：US12309872

申请日：2007-07-10

申请人： Tomoyuki Ogawa ,  Michio Kikuchi

发明人： Tomoyuki Ogawa ,  Michio Kikuchi

IPC分类号： C07D305/12 ,  C07C51/42

CPC分类号： C07D319/12 ,  C07C51/44 ,  C08G63/08 ,  C07C59/06

摘要： A process for purification of a hydroxycarboxylic acid by distillation, comprising: distilling a hydroxycarboxylic acid solution containing a high-boiling point hydroxy compound comprising at least one species selected from the group consisting of alcohols and phenols having a higher boiling point than the hydroxycarboxylic acid. As a result, a hydroxycarboxylic acid suitable as a starting material for production of a polyhydroxycarboxylic acid can be obtained. The purified hydroxycarboxylic acid is further polycondensed to provide a hydroxycarboxylic acid oligomer, which is de-polymerized to provide a cyclic ester comprising a dimer of the hydroxycarboxylic acid, and the cyclic ester is converted into a polyhydroxycarboxylic acid by ring-opening polymerization thereof.

摘要翻译： 一种通过蒸馏纯化羟基羧酸的方法，包括：蒸馏含有高沸点羟基化合物的羟基羧酸溶液，所述高沸点羟基化合物包含选自醇和酚的沸点高于羟基羧酸的酚类中的至少一种。 结果，可以得到适合作为多羟基羧酸的制造原料的羟基羧酸。 将纯化的羟基羧酸进一步缩聚以提供羟基羧酸低聚物，其被脱聚以提供包含羟基羧酸的二聚体的环状酯，并且环酯通过其开环聚合转化为聚羟基羧酸。

公开(公告)号：US07541979B2

公开(公告)日：2009-06-02

申请号：US11252889

申请日：2005-10-19

申请人： Ken Takei ,  Tomoyuki Ogawa ,  Morihiko Ikegaya

发明人： Ken Takei ,  Tomoyuki Ogawa ,  Morihiko Ikegaya

IPC分类号： H01Q1/38

CPC分类号： H01Q1/243 ,  H01Q1/38

摘要： A small size thin type antenna using a thin type structure having a wavelength compaction effect without using a bulk conductive material and a high frequency module using the same are disclosed. The small size thin type antenna comprises an open stub 3 including at least one transmission line 13, 16, a connecting line 5 including at least one transmission line 15, and a short stub 4 including a transmission line 14. A characteristic impedance Zo of the open stub 3 is determined to be lower than a characteristic impedance Zb of the connecting line 5 and a characteristic impedance Zs of the short stub 4.

摘要翻译： 公开了一种使用不使用体导电材料的具有波长压实效应的薄型结构的小尺寸薄型天线，以及使用该天线的高频模块。 小尺寸薄型天线包括开口短截线3，其包括至少一个传输线13,16，包括至少一个传输线15的连接线5和包括传输线14的短短短截线4.特征阻抗Zo 开路短截线3被确定为低于连接线5的特性阻抗Zb和短截线4的特性阻抗Zs。

公开(公告)号：US07486238B2

公开(公告)日：2009-02-03

申请号：US11806664

申请日：2007-06-01

申请人： Tomoyuki Ogawa ,  Ken Takei

发明人： Tomoyuki Ogawa ,  Ken Takei

IPC分类号： H01Q1/38

CPC分类号： H01Q1/38 ,  H01Q1/243 ,  H01Q1/36 ,  H01Q5/25

摘要： A group of metallic conductors 1 are prepared and a power feed point 2 is formed at one of the metallic conductors to provide a circular polarized wave antenna. The circular polarized wave antenna is designed such that an absolute value of a sum of projections of an electric current induced on the metallic conductors in x-axis and an absolute value of a sum of projection of the electric current in y-axis that is spatially orthogonal to the x-axis are approximately equal to each other, and an absolute value of a difference between an argument of the sum of the projections in the x-axis and an argument of the sum of the projection in the y-axis is approximately 90°.

摘要翻译： 准备一组金属导体1，并且在一个金属导体上形成馈电点2以提供圆极化波天线。 圆极化波天线被设计成使得在x轴上在金属导体上感应的电流的投影的和的绝对值与在空间上的y轴中的电流的投影之和的绝对值 与x轴正交的方式大致相等，x轴上的投影之和的自变量和y轴上的投影之和的自变量的绝对值约为 90°。

公开(公告)号：US20080214842A1

公开(公告)日：2008-09-04

申请号：US11792234

申请日：2005-10-17

申请人： Tomoyuki Ogawa ,  Tomohiro Hoshi ,  Tsutomu Kushida ,  Kentaro Otawara

发明人： Tomoyuki Ogawa ,  Tomohiro Hoshi ,  Tsutomu Kushida ,  Kentaro Otawara

IPC分类号： C07D305/02 ,  C07C53/00

CPC分类号： C08G63/78 ,  C07C51/43 ,  C07D319/12 ,  C08G63/06 ,  C07C59/06

摘要： Disclosed is a process for purifying a hydroxycarboxylic acid, comprising: a crystallization step of subjecting a hydroxycarboxylic acid aqueous solution to crystallization for purification, a separation step of separating a hydroxycarboxylic acid crystal from a mother liquid, and a washing step of washing the hydroxycarboxylic acid crystal for further purification with a washing liquid, wherein the washing liquid is a hydroxycarboxylic acid aqueous solution. The purified or refined hydroxycarboxylic acid obtained through the above process is suitably used as a starting material for production of a polyhydroxycarboxylic acid. The above process is suitably included in a process for producing a cyclic ester and a process for producing a polyhydroxycarboxylic acid.

摘要翻译： 公开了一种纯化羟基羧酸的方法，包括：使羟基羧酸水溶液进行结晶纯化的结晶步骤，从母液中分离羟基羧酸晶体的分离步骤和洗涤羟基羧酸的洗涤步骤 晶体，用于用洗涤液进一步纯化，其中洗涤液是羟基羧酸水溶液。 通过上述方法获得的纯化或精制羟基羧酸适合用作制备聚羟基羧酸的起始原料。 上述方法适合地包括在环酯的制备方法和聚羟基羧酸的制造方法中。

公开(公告)号：US20070293653A1

公开(公告)日：2007-12-20

申请号：US11808854

申请日：2007-06-13

申请人： Tomoyuki Ogawa ,  Masaru Kagoshima

发明人： Tomoyuki Ogawa ,  Masaru Kagoshima

IPC分类号： C08G63/06

CPC分类号： C07D319/12

摘要： Glycolide production through depolymerization of glycolic acid oligomer is stabilized by controlling impurities in the glycolic acid oligomer to allow economical and effective production of glycolide. More specifically, the depolymerization system is controlled to suppress an effective concentration (x+100y wt. %) of depolymerization-obstructing substances calculated as a total of a concentration calculated as diglycolic acid (of x wt. %) of hydroxyl group-free impurity carboxylic acids (A) and 100 times a concentration calculated as ammonia (of y wt. %) of nitrogen-containing substances (B), respectively with respect to the starting glycolic acid oligomer in the depolymerization system, to at most 15 wt. %.

摘要翻译： 通过控制乙醇酸低聚物中的杂质来稳定乙醇酸低聚物解聚的乙交酯生产，从而经济有效地生产乙交酯。 更具体地说，解聚系统被控制以抑制作为无羟基杂质的二甘醇酸（x重量％）计算的浓度的总计计算的解聚阻塞物质的有效浓度（x + 100重量％） 羧酸（A）和相对于解聚体系中的起始乙醇酸低聚物分别计算为含氨物质（B）的氨（y重量％）的浓度的100倍至最多15重量％ ％。

公开(公告)号：US20060197706A1

公开(公告)日：2006-09-07

申请号：US11353250

申请日：2006-02-14

申请人： Ken Takei ,  Tomoyuki Ogawa

发明人： Ken Takei ,  Tomoyuki Ogawa

IPC分类号： H01Q1/38

CPC分类号： H01Q9/16 ,  H01Q1/38 ,  H01Q9/28

摘要： A distributed phase type circular polarized wave antenna is composed of a group of narrow conductor lines 2a, 2b, 2c and 2d, and the group of the narrow conductor lines 2a, 2b, 2c and 2d are laid out in a two-dimensional plane. Complex vectorial sums of respective projections of current induced in each point of the narrow conductor lines 2a, 2b, 2c and 2d in two directions orthogonal to each other in the two-dimensional plane are determined, such that amplitudes of the complex vectorial sums are equal to each other in the two directions and a phase difference between the complex vectorial sums in the two directions is 90°.

摘要翻译： 分布相型圆偏振波天线由一组窄导体线2a，2b，2c和2d构成，并且窄导体线2a，2b，2c和2d的组被布置 在二维平面上。 确定在二维平面中在彼此正交的两个方向上在窄导体线2a，2b，2c和2d的每个点中感应的电流的各个投影的复矢量和，使得复合物的振幅 矢量和在两个方向上彼此相等，两个方向上的复矢量和之间的相位差为90°。

公开(公告)号：US20060116379A1

公开(公告)日：2006-06-01

申请号：US11274308

申请日：2005-11-16

申请人： Tomoyuki Ogawa ,  Kaoru Seno ,  Kohji Hanasaki ,  Minoru Ikeda ,  Takashi Ono

发明人： Tomoyuki Ogawa ,  Kaoru Seno ,  Kohji Hanasaki ,  Minoru Ikeda ,  Takashi Ono

IPC分类号： A61K31/503 ,  A61K31/498 ,  C07D487/04

CPC分类号： C07D403/12 ,  C07D209/12 ,  C07D209/22 ,  C07D209/24 ,  C07D209/42 ,  C07D487/04

摘要： A compound represented by the general formula: wherein R20 is —CH2COOH and the like; R21 is —COCONH2 and the like; R22 is C4-C6 alkyl; and the like; R23 is —CH2—R18 wherein R18 is aryl and the like; R24 is hydrogen or C1-C6 alkyl and the like; an optical active compound, a prodrug thereof, or a pharmaceutically acceptable salt, or a solvate having type X sPLA2 inhibitory effect was found.

摘要翻译： 由以下通式表示的化合物：其中R 20为-CH 2 COOH等; R 21是-COCONH 2 N 2等; R 22是C 4 -C 6烷基; 等等; R 23是-CH 2 - ，其中R 18是芳基等; R 24是氢或C 1 -C 6烷基等; 发现光学活性化合物，其前体药物或药学上可接受的盐，或具有X sPLA 2抑制作用的溶剂化物。