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公开(公告)号:US06589935B1
公开(公告)日:2003-07-08
申请号:US09046572
申请日:1998-03-23
IPC分类号: C12N1500
摘要: The invention provides a human insulin receptor tyrosine kinase substrate (IRS-p53h) and polynucleotides which identify and encode IRS-p53h. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of IRS-p53h.
摘要翻译: 本发明提供了人胰岛素受体酪氨酸激酶底物(IRS-p53h)和鉴定和编码IRS-p53h的多核苷酸。 本发明还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 本发明还提供了治疗或预防与IRS-p53h表达相关的疾病的方法。
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公开(公告)号:US06303297B1
公开(公告)日:2001-10-16
申请号:US08969987
申请日:1997-11-13
申请人: Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人: Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号: C12Q168
CPC分类号: C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译: 本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。 系统的数据存储在与公共数据库接口的关系数据库中,以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。 序列数据在进入系统之前进行编辑,并存储在策略化的功能集群组织中。 与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。
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公开(公告)号:US5919686A
公开(公告)日:1999-07-06
申请号:US907706
申请日:1997-08-08
申请人: Olga Bandman , Jennifer L. Hillman , Karl J. Guegler , Purvi Shah
发明人: Olga Bandman , Jennifer L. Hillman , Karl J. Guegler , Purvi Shah
CPC分类号: C12Y106/05003 , C12N9/0036
摘要: The invention provides two human NADH dehydrogenase subunits (HNDS) and polynucleotides which identify and encode HNDS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HNDS.
摘要翻译: 本发明提供了两种识别和编码HNDS的人NADH脱氢酶亚基(HNDS)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与HNDS表达相关的疾病的方法。
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公开(公告)号:US5854022A
公开(公告)日:1998-12-29
申请号:US855140
申请日:1997-05-13
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C07H21/04
CPC分类号: C07K14/70596 , A61K38/00
摘要: The present invention provides a human transmembrane protein (ONMO) and polynucleotides which identify and encode ONMO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing ONMO and for treating or preventing disorders associated with expression of ONMO.
摘要翻译: 本发明提供了人跨膜蛋白(ONMO)和识别和编码ONMO的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 此外,本发明提供了用于生产ONMO和用于治疗或预防与ONMO表达相关的病症的方法。
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公开(公告)号:US06235477B1
公开(公告)日:2001-05-22
申请号:US09270270
申请日:1999-03-16
申请人: Olga Bandman , Jennifer L. Hillman , Preeti Lal , Neil C. Corley , Purvi Shah
发明人: Olga Bandman , Jennifer L. Hillman , Preeti Lal , Neil C. Corley , Purvi Shah
IPC分类号: C12Q168
CPC分类号: C07K14/4728 , A61K38/00 , Y02A50/387 , Y02A50/465
摘要: The invention provides two human reticulocalbin isoforms designated individually as RCN &ggr; and RCN &dgr; and collectively as RCN, and polynucleotides which identify and encode RCN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of RCN.
摘要翻译: 本发明提供了两种单独指定为RCNγ和RCNδ并统称为RCN的人reticulocalbin同种型,以及识别和编码RCN的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与RCN表达相关的疾病的方法。
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公开(公告)号:US5958746A
公开(公告)日:1999-09-28
申请号:US946528
申请日:1997-10-07
申请人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Neil C. Corley
发明人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Neil C. Corley
CPC分类号: C12N9/0038 , C12N9/0053 , A61K38/00
摘要: The invention provides human electron transport proteins (NHETP) and polynucleotides which identify and encode NHETP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of NHETP.
摘要翻译: 本发明提供了识别和编码NHETP的人电子转运蛋白(NHETP)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗或预防与NHETP表达相关的病症的方法。
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公开(公告)号:US07238506B1
公开(公告)日:2007-07-03
申请号:US09301872
申请日:1999-04-29
申请人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Neil C. Corley
发明人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Neil C. Corley
CPC分类号: C12N9/0038 , A61K38/00 , C12N9/0053
摘要: The invention provides human electron transport proteins (NHETP) and polynucleotides which identify and encode NHETP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of NHETP.
摘要翻译: 本发明提供了识别和编码NHETP的人电子转运蛋白(NHETP)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗或预防与NHETP表达相关的病症的方法。
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公开(公告)号:US5928899A
公开(公告)日:1999-07-27
申请号:US165234
申请日:1998-10-01
申请人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Purvi Shah , Neil C. Corley
发明人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Purvi Shah , Neil C. Corley
IPC分类号: G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , C12N15/63 , C12N15/70
CPC分类号: C07K14/4738 , A61K38/00
摘要: The invention provides three human cell division regulators (HCDR) and polynucleotides which identify and encode HCDR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of HCDR.
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公开(公告)号:US06194186B1
公开(公告)日:2001-02-27
申请号:US08977816
申请日:1997-11-25
申请人: Preeti Lal , Jennifer L. Hillman , Olga Bandman , Neil C. Corley , Purvi Shah
发明人: Preeti Lal , Jennifer L. Hillman , Olga Bandman , Neil C. Corley , Purvi Shah
IPC分类号: C12N912
CPC分类号: C12N9/1205 , A61K38/00 , C07K14/4703 , C12Q1/6883
摘要: The invention provides a human protein kinase (PK) and kinase inhibitors (PKI) and polynucleotides which identify and encode PK and PKI. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PK and PKI.
摘要翻译: 本发明提供了鉴定和编码PK和PKI的人蛋白激酶(PK)和激酶抑制剂(PKI)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供用于诊断,治疗或预防与PK和PKI的表达相关的障碍的方法。
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公开(公告)号:US6121019A
公开(公告)日:2000-09-19
申请号:US274570
申请日:1999-03-23
申请人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Purvi Shah , Neil C. Corley
发明人: Jennifer L. Hillman , Olga Bandman , Preeti Lal , Purvi Shah , Neil C. Corley
IPC分类号: G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , C07K14/435
CPC分类号: C07K14/4738 , A61K38/00
摘要: The invention provides three human cell division regulators (HCDR) and polynucleotides which identify and encode HCDR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of HCDR.
摘要翻译: 本发明提供三种人细胞分裂调节因子(HCDR)和识别和编码HCDR的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了用于预防和治疗与HCDR表达相关的疾病的方法。
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