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公开(公告)号：US20110053924A1
公开(公告)日：2011-03-03
申请号：US12865930
申请日：2009-02-06
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stjepan Jelakovic , Dirk Behnke
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stjepan Jelakovic , Dirk Behnke
IPC分类号： A61K31/538 , C07D413/12 , A61P9/12 , A61P9/04 , A61P9/10 , A61P27/06
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译： 本发明涉及通式（I）的化合物及其盐，优选其药学上可接受的盐; 其中R具有说明书中解释的含义，其制备方法和这些化合物用作药物，特别是作为肾素抑制剂。
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公开(公告)号：US20100256146A1
公开(公告)日：2010-10-07
申请号：US12734197
申请日：2008-10-17
申请人： Peter Herold , Vincenzo Tschinke , Dirk Behnke , Stjepan Jelakovic , Nathalie Jotterand , Robert Mah
发明人： Peter Herold , Vincenzo Tschinke , Dirk Behnke , Stjepan Jelakovic , Nathalie Jotterand , Robert Mah
IPC分类号： A61K31/445 , C07D413/02 , A61P9/00 , A61P13/12
CPC分类号： C07D413/14 , C07D413/12
摘要： The application relates to trisubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R1, R2, R3 and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译： 本申请涉及通式（I）的三取代哌啶及其盐，优选其药学上可接受的盐，其中R 1，R 2，R 3和X具有说明书中所述的含义，其制备方法及其用途 化合物作为药物，特别是作为肾素抑制剂。
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公开(公告)号：US08022068B2
公开(公告)日：2011-09-20
申请号：US12865930
申请日：2009-02-06
申请人： Dirk Behnke , Peter Herold , Stjepan Jelakovic , Robert Mah , Vincenzo Tschinke
发明人： Dirk Behnke , Peter Herold , Stjepan Jelakovic , Robert Mah , Vincenzo Tschinke
IPC分类号： C07D413/12 , C07D413/14 , A61K31/445
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
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公开(公告)号：US20100331322A1
公开(公告)日：2010-12-30
申请号：US12865932
申请日：2009-02-06
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stjepan Jelakovic , Dirk Behnke
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stjepan Jelakovic , Dirk Behnke
IPC分类号： A61K31/538 , C07D413/12 , C07D413/14 , A61P9/00 , A61P9/10 , A61P9/12 , A61P27/06
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译： 本发明涉及通式（I）的化合物及其盐，优选其药学上可接受的盐; 其中R具有说明书中解释的含义，其制备方法和这些化合物用作药物，特别是作为肾素抑制剂。
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公开(公告)号：US20070161622A1
公开(公告)日：2007-07-12
申请号：US10586814
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Martin , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Martin , Michael Quirmbach
IPC分类号： A61K31/55 , A61K31/5415 , A61K31/54 , A61K31/5375 , A61K31/495
CPC分类号： C07D207/27 , C07C233/36 , C07C233/78 , C07C311/05 , C07D205/04 , C07D207/12 , C07D207/273 , C07D209/18 , C07D211/34 , C07D211/76 , C07D213/56 , C07D223/10 , C07D239/10 , C07D277/42 , C07D295/13 , C07D295/15 , C07D303/48 , C07D309/04 , C07D333/34 , C07D413/06 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译： 本申请涉及通式（I）的新型氨基醇，其中R 1，R 1，R 2，R 3，R 3， R 5，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法以及这些的使用 化合物作为药物，特别是作为肾素抑制剂。
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公开(公告)号：US20080076784A1
公开(公告)日：2008-03-27
申请号：US11597585
申请日：2005-05-27
IPC分类号： A61K31/435 , A61K31/437 , A61K31/517 , A61P43/00 , C07D221/04 , C07D239/70 , C07D471/04
CPC分类号： C07D221/04 , C07D217/02 , C07D239/74 , C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) (I*) in which R, R1, R2, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译： 本申请涉及通式（I）（I *）的新型杂环化合物，其中R 1，R 2，R 2，X，Y，Z和n具有 描述中定义的含义，其制备方法和这些化合物作为药物的用途，特别是芳香酶抑制剂。
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公开(公告)号：US07842688B2
公开(公告)日：2010-11-30
申请号：US12068443
申请日：2008-02-06
申请人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
IPC分类号： C07D401/12 , A61K31/4427
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译： 描述通式（I）和（II）的新颖取代的哌啶与具有如在说明书中详细说明的取代基定义。 该化合物特别适合作为肾素抑制剂，并且是非常有效的。
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公开(公告)号：US20090012068A1
公开(公告)日：2009-01-08
申请号：US12223789
申请日：2007-04-12
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Chirstiane Marti , Stefan Stutz , Bibia Bennacer
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Chirstiane Marti , Stefan Stutz , Bibia Bennacer
IPC分类号： A61K31/542 , C07D498/04 , A61K31/5383 , A61P5/00 , C07D513/04
CPC分类号： C07D513/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof, in which R, R1, R2, R3, Q, m and n have the meanings explained in detail in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译： 本申请涉及通式（I）的新型杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，R 3，Q，m和n具有在说明书中详细说明的含义， 其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合酶抑制剂。
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公开(公告)号：US20090012055A1
公开(公告)日：2009-01-08
申请号：US12068443
申请日：2008-02-06
申请人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
IPC分类号： A61K31/397 , C07D211/40 , A61K31/445 , C07D265/36 , A61K31/538 , C07D413/02 , A61K31/454 , A61K31/4525 , A61K31/5415 , A61P13/12 , A61P9/00 , C07D279/16 , C07D401/02 , C07D215/00 , A61K31/4709 , A61K31/5377 , C07D239/24 , A61K31/506
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译： 描述通式（I）和（II）的新颖取代的哌啶与具有如在说明书中详细说明的取代基定义。 该化合物特别适合作为肾素抑制剂，并且是非常有效的。
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公开(公告)号：US20070010511A1
公开(公告)日：2007-01-11
申请号：US10574108
申请日：2004-09-30
申请人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/46 , C07D453/02
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译： 描述通式（I）和（II）的新颖取代的哌啶与具有如在说明书中详细说明的取代基定义。 该化合物特别适合作为肾素抑制剂，并且是非常有效的。
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