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61.发明申请公开(公告)号：US20090197894A1
公开(公告)日：2009-08-06
申请号：US12423432
申请日：2009-04-14
申请人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael D. Winther , Richard M. Fine , Daniel F. Harvey , Boris Klebansky , Mark P. Gray-Keller , Heinz W. Gschwend , Wenbao Li
发明人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael D. Winther , Richard M. Fine , Daniel F. Harvey , Boris Klebansky , Mark P. Gray-Keller , Heinz W. Gschwend , Wenbao Li
IPC分类号： A61K31/496 , C07D401/04 , A61P3/10
CPC分类号： A61K31/496 , A61K31/551 , Y02A50/387
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中m，n，p，V，R ，R2，R3，R4，R5和R6如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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62.发明申请公开(公告)号：US20120295897A1
公开(公告)日：2012-11-22
申请号：US13557833
申请日：2012-07-25
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC分类号： A61K31/407 , A61K31/429 , C07D491/20 , A61K31/4439 , A61K31/422 , C07D498/20 , A61K31/424 , A61K31/5383 , C07D491/107 , A61K31/475 , C07D495/20 , A61K31/4245 , A61K31/4985 , A61K31/4178 , A61K31/4155 , A61K31/5377 , A61K31/427 , A61K31/433 , A61K31/497 , A61K31/506 , A61K31/454 , A61K31/41 , A61K31/496 , A61P29/00 , A61P25/24 , A61P9/00 , A61P11/00 , A61P25/18 , A61P3/06 , A61P35/00 , A61P17/04 , C07D513/20
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US08415370B2
公开(公告)日：2013-04-09
申请号：US13557833
申请日：2012-07-25
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US08263606B2
公开(公告)日：2012-09-11
申请号：US12578148
申请日：2009-10-13
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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65.发明申请公开(公告)号：US20100137299A1
公开(公告)日：2010-06-03
申请号：US12578148
申请日：2009-10-13
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC分类号： A61K31/5377 , C07D491/10 , C07D498/10 , C07D513/10 , A61K31/407 , A61K31/4439 , A61K31/429 , A61K31/424
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US20060293308A1
公开(公告)日：2006-12-28
申请号：US10566857
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel Harvey , Mikhail Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Rodumuru , Michael Winther , Heinz Gschwend , Nagasres Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel Harvey , Mikhail Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Rodumuru , Michael Winther , Heinz Gschwend , Nagasres Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A01N43/62
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R R 1，R 2，R 3，R 4，R 5，R 5，R 5， R 6，R 7，R 7，R 8，R 8，R 8， R 9，R 9，R 10和R 10 10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20100029718A1
公开(公告)日：2010-02-04
申请号：US12442279
申请日：2007-09-19
申请人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
发明人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
IPC分类号： A61K31/427 , C07D417/04 , C07D417/14 , A61K31/454 , A61K31/4545 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：US08236835B2
公开(公告)日：2012-08-07
申请号：US12442279
申请日：2007-09-19
申请人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
发明人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
IPC分类号： A61K31/426
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。
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69.发明申请公开(公告)号：US20110112162A9
公开(公告)日：2011-05-12
申请号：US12577799
申请日：2009-10-13
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova
IPC分类号： A61K31/407 , C07D491/107 , C07D491/20 , A61P25/00 , A61P9/00 , A61P11/00
CPC分类号： C07D491/107 , C07D491/20
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US08101647B2
公开(公告)日：2012-01-24
申请号：US12577799
申请日：2009-10-13
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova
IPC分类号： C07D491/10 , A61K31/404
CPC分类号： C07D491/107 , C07D491/20
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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