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公开(公告)号:US06494824B1
公开(公告)日:2002-12-17
申请号:US09253310
申请日:1999-02-20
申请人: Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot , James D. Purdy , Joseph P. Lane , Delbert C. Miller , Gregory A. Frankland
发明人: Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot , James D. Purdy , Joseph P. Lane , Delbert C. Miller , Gregory A. Frankland
IPC分类号: A61N0500
CPC分类号: A61N5/1002 , A61M5/1785 , A61M5/31511 , A61M5/31515 , A61M25/10184 , A61M25/104 , A61N2005/1021
摘要: A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. A radiotherapy source vial (700) includes a fluid container (701) of radioactive fluid with a seal (702,731) disposed about the container. Seal (702,731) is moveable with respect to container (701) to change the contained volume therein. A radioactive fluid transport site (703) is in communication with the contained volume and with an exterior (726) of the container (701), and may include a septum (707) or a valve (711). An engagement mechanism (704) is connectable to an external control mechanism (706) whereby the contained volume in the radioactive fluid container can be decreased and increased by actuation of the external control mechanism.
摘要翻译: 导管装置和放射剂量测定单元指示器,用于向患者输送规定的辐射剂量。 放射治疗源小瓶(700)包括具有围绕容器设置的密封件(702,731)的放射性流体的流体容器(701)。 密封件(702,731)能够相对于容器(701)移动以改变其中的容纳体积。 放射性流体输送部位(703)与所容纳的容积和容器(701)的外部(726)连通,并且可以包括隔膜(707)或阀(711)。 接合机构(704)可连接到外部控制机构(706),由此可以通过外部控制机构的致动来减小和增加放射性液体容器中的容纳量。
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公开(公告)号:US6096070A
公开(公告)日:2000-08-01
申请号:US645646
申请日:1996-05-16
申请人: Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人: Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号: A61B17/00 , A61F2/00 , A61K9/00 , A61K51/12 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/02 , A61M37/00 , A61N5/10 , A61F2/06
CPC分类号: A61L31/088 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/022 , A61F2250/0068 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61N5/1002
摘要: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.
摘要翻译: 涂覆的可植入医疗装置10包括适于引入到血管系统,食道,气管,结肠,胆道或尿道中的结构12; 至少一层生物活性材料层18位于结构12的一个表面上; 和位于结构(12)的一个表面上的生物活性材料层18上的至少一个多孔层20和不含生物活性材料的表面。 优选地,结构12是冠状动脉支架。 多孔层20由优选通过蒸气或等离子体沉积施加的聚合物组成,并提供生物活性材料的受控释放。 特别优选的是,聚合物是聚酰胺,聚对二甲苯或聚对二甲苯衍生物,其仅通过单体蒸气的冷凝就不经溶剂,热或催化剂沉积。 还公开了装置10的制造方法,以及在医疗中使用该方法。
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公开(公告)号:US4643711A
公开(公告)日:1987-02-17
申请号:US613805
申请日:1984-05-25
申请人: Brian L. Bates
发明人: Brian L. Bates
CPC分类号: A61M5/1582 , A61M2025/0031 , A61M25/0032
摘要: A dual lumen hemodialysis catheter. The catheter includes a tube having a circular external cross section which is rotatably received within a fitting. The fitting may be attached to the patient by sutures or the like and rotatably mounts the tube of the catheter. Stop means are provided on opposite sides of the fitting preventing the tube of the catheter from moving longitudinally relative to the fitting. The catheter may be rotated relative to the fitting in order to readjust the rotational position of the tube inside the patient's blood vessel without longitudinal movement of the tube. The catheter is cut off at its distal end perpendicularly to the length of the tube in order to define the mouth of one lumen. The tube is tapered from the cut off distal end to a point proximal of the distal end, said point being approximately 3 cm from the distal end. The taper of the tube defines at least a portion of the mouth of the second lumen.
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公开(公告)号:US08945206B2
公开(公告)日:2015-02-03
申请号:US12490162
申请日:2009-06-23
申请人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号: A61F2/06 , A61L33/00 , A61K51/12 , A61F2/82 , A61F2/91 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/02 , A61F2/24 , A61F2/88 , A61N5/10
CPC分类号: A61K51/1282 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2/91 , A61F2210/0076 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译: 涂覆的可植入医疗装置10包括适于引入到血管系统,食道,气管,结肠,胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上,其中涂层16提供生物活性材料从涂层的受控释放。 此外,至少一个多孔层20可以放置在生物活性材料层18上方,其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地,结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物,并提供生物活性材料的受控释放。 特别优选的是,聚合物是聚酰胺,聚对二甲苯或聚对二甲苯衍生物,它们不经溶剂,热或催化剂沉积,并且仅通过单体蒸气的冷凝而沉积。
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公开(公告)号:US08758428B2
公开(公告)日:2014-06-24
申请号:US11931678
申请日:2007-10-31
申请人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
发明人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
IPC分类号: A61F2/06
CPC分类号: A61K51/1282 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2/91 , A61F2210/0076 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译: 涂覆的可植入医疗装置10包括适于引入到血管系统,食道,气管,结肠,胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上,其中涂层16提供生物活性材料从涂层的受控释放。 此外,至少一个多孔层20可以放置在生物活性材料层18上方,其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地,结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物,并提供生物活性材料的受控释放。 特别优选的是,聚合物是聚酰胺,聚对二甲苯或聚对二甲苯衍生物,它们不经溶剂,热或催化剂沉积,并且仅通过单体蒸气的冷凝而沉积。
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公开(公告)号:US08556962B2
公开(公告)日:2013-10-15
申请号:US11137275
申请日:2005-05-25
申请人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号: A61F2/06
CPC分类号: A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
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公开(公告)号:US20110295233A1
公开(公告)日:2011-12-01
申请号:US13206729
申请日:2011-08-10
申请人: Brian L. Bates , Ram H. Paul , Jacob A. Flagle
发明人: Brian L. Bates , Ram H. Paul , Jacob A. Flagle
IPC分类号: A61M31/00
CPC分类号: A61B17/12022 , A61B17/00008 , A61B17/12109 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61L27/3633 , A61L27/3645 , A61L27/50 , A61L27/54 , A61L31/005 , A61L31/04 , A61L31/14 , A61L31/16 , A61L2300/412 , A61L2430/36
摘要: Described are methods, devices, and systems for occluding or ablating vascular vessels. Noninvasive procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous valve insufficiency. Further described is the cooperative use of an angiogenic remodelable material with one or more sclerosing agents to cause closure of a targeted bodily vessel.
摘要翻译: 描述了用于闭塞或消融血管的方法,装置和系统。 非侵入性手术可用于闭塞和闭塞大隐静脉,例如在静脉瓣膜功能不全引起的静脉曲张治疗中。 进一步描述的是具有一种或多种硬化剂的血管生成可重塑材料与靶器官血管闭合的协同使用。
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公开(公告)号:US20110202086A1
公开(公告)日:2011-08-18
申请号:US13060809
申请日:2009-08-28
申请人: Brian L. Bates
发明人: Brian L. Bates
IPC分类号: A61F2/01
CPC分类号: A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要: A removable filter for capturing thrombi in a body vessel is disclosed. The filter comprises a plurality of primary struts comprising proximal and distal portions. Each proximal portion has a first end, wherein the first ends are attached together along a longitudinal axis. Each primary strut extends arcuately along the longitudinal axis and linearly radially. The distal portions of the primary struts are configured to expand in the body vessel, engaging the distal hooks with the body vessel. Each distal portion integrally extends from the proximal portion to a plurality of distal hooks. The distal hooks are substantially equal in size relative to each other.
摘要翻译: 公开了一种用于在身体血管中捕获血栓的可移除过滤器。 过滤器包括多个主支柱,其包括近端部分和远端部分。 每个近端部分具有第一端,其中第一端部沿着纵向轴线附接在一起。 每个主支柱沿着纵向轴线弧线延伸并且线性地径向延伸。 主支柱的远端部分构造成在身体容器中膨胀,将远端钩与身体血管接合。 每个远侧部分从近端部分整体地延伸到多个远端钩。 远端钩相对于彼此大小相等。
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公开(公告)号:US20110196479A1
公开(公告)日:2011-08-11
申请号:US13088862
申请日:2011-04-18
申请人: Brian L. Bates , Anthony O. Ragheb , Neal E. Feamot , Thomas G. Kozma , William D. Voorhees, III
发明人: Brian L. Bates , Anthony O. Ragheb , Neal E. Feamot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号: A61F2/82
CPC分类号: A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要: A coated implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer posited on one surface of the structure; and at least one layer of a bioactive material posited on at least a portion of the coating layer. Preferably the structure is a stent graft.
摘要翻译: 涂覆的可植入医疗装置包括适于引入血管系统,食管,气管,结肠,胆道或尿道的结构; 至少一个涂层位于结构的一个表面上; 并且至少一层生物活性物质定位在涂层的至少一部分上。 优选地,该结构是支架移植物。
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公开(公告)号:US07811622B2
公开(公告)日:2010-10-12
申请号:US11931603
申请日:2007-10-31
申请人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人: Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
CPC分类号: A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译: 涂覆的可植入医疗装置10包括适于引入到血管系统,食道,气管,结肠,胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上,其中涂层16提供生物活性材料从涂层的受控释放。 此外,至少一个多孔层20可以放置在生物活性材料层18上方,其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地,结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物,并提供生物活性材料的受控释放。 特别优选的是,聚合物是聚酰胺,聚对二甲苯或聚对二甲苯衍生物,它们不经溶剂,热或催化剂沉积,并且仅通过单体蒸气的冷凝而沉积。
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