公开(公告)号：US20070015162A1

公开(公告)日：2007-01-18

申请号：US10670185

申请日：2003-09-25

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N5/06

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/24

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060246483A1

公开(公告)日：2006-11-02

申请号：US11366486

申请日：2006-03-03

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060166327A1

公开(公告)日：2006-07-27

申请号：US11389101

申请日：2006-03-27

申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

IPC分类号： C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/7158 ,  A61K38/00 ,  C07K14/723

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

公开(公告)号：US20060062789A1

公开(公告)日：2006-03-23

申请号：US11266444

申请日：2005-11-04

申请人： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

发明人： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

IPC分类号： C07K16/24 ,  A61K39/395 ,  G01N33/53

CPC分类号： C07K14/70575 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/564

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

公开(公告)号：US20060003378A1

公开(公告)日：2006-01-05

申请号：US11214796

申请日：2005-08-31

申请人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

发明人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

公开(公告)号：US20050255532A1

公开(公告)日：2005-11-17

申请号：US11054515

申请日：2005-02-10

申请人： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

发明人： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

IPC分类号： C07H21/04 ,  C07K16/28 ,  C07K16/30 ,  C12N5/06 ,  G01N33/50 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K16/2875 ,  A61K35/12 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5052 ,  G01N33/5091 ,  G01N33/564 ,  G01N33/574 ,  G01N33/68

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated vith aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

摘要翻译： 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体，或免疫特异性结合B淋巴细胞刺激物的相关分子的B淋巴细胞刺激物的不适当功能。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。

公开(公告)号：US20050214209A1

公开(公告)日：2005-09-29

申请号：US10986349

申请日：2004-11-12

申请人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

发明人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  A61K51/00 ,  C07K16/46

CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

公开(公告)号：US20050197285A1

公开(公告)日：2005-09-08

申请号：US10472533

申请日：2002-03-19

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： A61K35/76 ,  A61K38/00 ,  C07K14/47 ,  G01N33/68 ,  A61K38/17

CPC分类号： G01N33/5005 ,  A61K38/00 ,  C07K14/47 ,  G01N33/5091 ,  G01N33/68 ,  A61K35/76 ,  A61K2300/00

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides and also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antogonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与其有关的胃肠道疾病，病症和/或病症。 结合这些多肽并且也包括在本发明中的抗体。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明进一步包括用于鉴定本发明的多核苷酸和多肽的激动剂和亲和体的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20050129614A1

公开(公告)日：2005-06-16

申请号：US10943197

申请日：2004-09-17

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C07K16/28 ,  C12N5/24 ,  A61K51/00 ,  A61K39/395 ,  C07K16/30 ,  C07K16/46

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76

摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding anti-TL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.

摘要翻译： 本发明涉及特异性结合TL5的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括自身免疫疾病，类风湿性关节炎，移植物排斥，移植物抗宿主病和淋巴结病的免疫系统疾病和病症。 本发明还涉及编码抗TL5抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及包括自身免疫性疾病，类风湿性关节炎，移植排斥反应，移植物抗宿主病和免疫系统疾病和病症的方法和组合物。 淋巴腺病，包括向动物，优选人类施用有效量的特异性结合TL5的一种或多种抗体或其片段或变体或相关分子。

公开(公告)号：US20050089984A1

公开(公告)日：2005-04-28

申请号：US10961148

申请日：2004-10-12

申请人： Vishva Dixit ,  Wei-Wu He ,  Kristine Kikly ,  Steven Ruben

发明人： Vishva Dixit ,  Wei-Wu He ,  Kristine Kikly ,  Steven Ruben

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P43/00 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N9/99 ,  C12N15/12 ,  C12Q1/68 ,  C12R1/91 ,  C07H21/04

CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗塞，艾滋病，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。