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133 条记录 (耗时 0.037 秒)

    Medical device electrodes having cells disposed on nanostructures
    61.
    发明授权
    Medical device electrodes having cells disposed on nanostructures 失效
    具有设置在纳米结构上的细胞的医疗装置电极

    公开(公告)号：US07991480B2

    公开(公告)日：2011-08-02

    申请号：US11846280

    申请日：2007-08-28

    申请人： Jeffrey E. Stahmann ,  Rodney W. Salo ,  Jihong Qu

    发明人： Jeffrey E. Stahmann ,  Rodney W. Salo ,  Jihong Qu

    IPC分类号： A61N1/05

    CPC分类号： A61N1/05 ,  A61N1/0565

    摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.

    摘要翻译： 用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。 电极对可以彼此靠近放置。 当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。 纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。 此外，电极可以排列成阵列。

    Method and device for treating myocardial ischemia
    62.
    发明授权
    Method and device for treating myocardial ischemia 有权
    治疗心肌缺血的方法和装置

    公开(公告)号：US07941216B2

    公开(公告)日：2011-05-10

    申请号：US11561049

    申请日：2006-11-17

    申请人： Rodney W. Salo ,  Allan C. Shuros ,  Tamara Colette Baynham

    发明人： Rodney W. Salo ,  Allan C. Shuros ,  Tamara Colette Baynham

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.

    摘要翻译： 描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。 在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。 在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

    Method and apparatus for minimizing post-infarct ventricular remodeling
    63.
    发明授权
    Method and apparatus for minimizing post-infarct ventricular remodeling 有权
    用于最小化梗死后心室重塑的方法和装置

    公开(公告)号：US07899532B2

    公开(公告)日：2011-03-01

    申请号：US12396115

    申请日：2009-03-02

    申请人： Rodney W. Salo

    发明人： Rodney W. Salo

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627 ,  A61N1/0587 ,  A61N1/3684

    摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.

    摘要翻译： 一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。 这种起搏服务器可以预防或最小化梗死后重塑。

    Medical device electrodes including nanostructures
    64.
    发明授权
    Medical device electrodes including nanostructures 失效
    包括纳米结构在内的医疗器械电极

    公开(公告)号：US07894914B2

    公开(公告)日：2011-02-22

    申请号：US11846246

    申请日：2007-08-28

    申请人： Jeffrey E. Stahmann ,  Rodney W. Salo ,  Jihong Qu

    发明人： Jeffrey E. Stahmann ,  Rodney W. Salo ,  Jihong Qu

    IPC分类号： A61N1/05

    CPC分类号： A61N1/05 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/375 ,  Y10S977/931

    摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.

    摘要翻译： 用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。 电极对可以彼此靠近放置。 当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。 纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。 此外，电极可以排列成阵列。

    Pacing therapy for diastolic heart failure
    65.
    发明授权
    Pacing therapy for diastolic heart failure 有权
    起搏治疗舒张性心力衰竭

    公开(公告)号：US07869871B2

    公开(公告)日：2011-01-11

    申请号：US11278330

    申请日：2006-03-31

    申请人： Rodney W. Salo ,  Guy Alvarez ,  Eric G. Lovett

    发明人： Rodney W. Salo ,  Guy Alvarez ,  Eric G. Lovett

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

    摘要： Described herein are methods and systems for delivering pacing therapy to HF patients who do not exhibit a reduced EF. Such patients do not have systolic dysfunction and generally do not benefit from established HF therapies that either augment contractile function or counteract conduction abnormalities. In one embodiment, a HF patient with a normal EF is tested for the adequacy of heart rate response during exercise. If the patient is found to be chronotropically incompetent, a rate-adaptive pacing mode is employed in order to improve functional capacity.

    摘要翻译： 本文描述的是用于向没有显示减少的EF的HF患者输送起搏治疗的方法和系统。 这些患者没有收缩功能障碍，一般不会从建立的HF疗法中获益，既可增强收缩功能，又可抵消传导异常。 在一个实施例中，测试具有正常EF的HF患者在运动期间心率反应的适当性。 如果患者被发现是顺应性不足的，则采用速率自适应起搏模式来提高功能能力。

    Method and device for myocardial stress redistribution
    66.
    发明授权
    Method and device for myocardial stress redistribution 有权
    心肌应激再分配的方法和装置

    公开(公告)号：US07778707B2

    公开(公告)日：2010-08-17

    申请号：US11689032

    申请日：2007-03-21

    申请人： Allan C. Shuros ,  Rodney W. Salo ,  Shantha Arcot-Krishnamurthy

    发明人： Allan C. Shuros ,  Rodney W. Salo ,  Shantha Arcot-Krishnamurthy

    IPC分类号： A61N1/368

    CPC分类号： A61N1/3627

    摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such as the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.

    摘要翻译： 描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。 预激发起搏可以用于故意地减压可能预期会发生有害重建的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或者故意强迫远离预激励起搏的区域 为了发挥心脏保护性调理作用，类似于运动的有益效果。 预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

    Cardiac rhythm management system with optimization of cardiac performance using heart rate
    68.
    发明授权
    Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
    心脏节律管理系统使用心率优化心脏性能

    公开(公告)号：US07668595B2

    公开(公告)日：2010-02-23

    申请号：US11619391

    申请日：2007-01-03

    申请人： Rodney W. Salo ,  Kenneth L. Baker ,  Lawrence S. Baumann

    发明人： Rodney W. Salo ,  Kenneth L. Baker ,  Lawrence S. Baumann

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688

    摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.

    摘要翻译： 公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。 微控制器可操作以调节起搏器的起搏模式和站间延迟，以达到最佳的血液动力学性能。 信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。 当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。