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    Deglycosylated and desialidated long pentraxin PTX3
    61.
    发明授权
    Deglycosylated and desialidated long pentraxin PTX3 有权
    去糖基化和去极化的长pentraxin PTX3

    公开(公告)号：US07833981B2

    公开(公告)日：2010-11-16

    申请号：US12710559

    申请日：2010-02-23

    申请人： Rita De Santis ,  Giovanni Salvatori ,  Paolo Carminati ,  Antonio Inforzato

    发明人： Rita De Santis ,  Giovanni Salvatori ,  Paolo Carminati ,  Antonio Inforzato

    IPC分类号： C07K14/00 ,  A61K38/00

    CPC分类号： C07K14/71 ,  A61K38/00

    摘要： Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.

    摘要翻译： 公开了脱糖基化的长五倍体PTX3和去离子的长五聚蛋白PTX3，以及其制备方法，含有它们的药理学组合物及其用于制备用于治疗其中使用长五倍素PTX的疾病的药物的用途 ，特别是感染性和炎性疾病和女性生殖障碍。 这些蛋白质具有优于糖基化五肽的治疗活性。

    Deglycosylated and Desialidated Long Pentraxin Ptx3
    65.
    发明申请
    Deglycosylated and Desialidated Long Pentraxin Ptx3 有权
    脱糖基化和脱离的长Pentraxin Ptx3

    公开(公告)号：US20070249021A1

    公开(公告)日：2007-10-25

    申请号：US11575346

    申请日：2005-09-28

    申请人： Paolo Carminati ,  Rita De Santis ,  Antonio Inforzato ,  Giovanni Salvatori

    发明人： Paolo Carminati ,  Rita De Santis ,  Antonio Inforzato ,  Giovanni Salvatori

    IPC分类号： A61K38/02 ,  A61P31/00 ,  C07K14/00 ,  C12P21/02

    CPC分类号： C07K14/71 ,  A61K38/00

    摘要： Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.

    摘要翻译： 公开了脱糖基化的长五倍体PTX3和去离子的长五聚蛋白PTX3，以及其制备方法，含有它们的药理学组合物及其用于制备用于治疗其中使用长五倍素PTX的疾病的药物的用途 ，特别是感染性和炎性疾病和女性生殖障碍。 这些蛋白质具有优于糖基化五肽的治疗活性。

    Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same
    69.
    发明授权
    Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same 失效
    2-胍基 - 噻唑的某些酰胺衍生物和含有它们的组合物

    公开(公告)号：US4501747A

    公开(公告)日：1985-02-26

    申请号：US489723

    申请日：1983-04-29

    申请人： Dino Nisato ,  Sergio Boveri ,  Romeo Roncucci ,  Paolo Carminati

    发明人： Dino Nisato ,  Sergio Boveri ,  Romeo Roncucci ,  Paolo Carminati

    IPC分类号： C07D277/48 ,  C07D417/12 ,  C07D411/12 ,  C07D263/28

    CPC分类号： C07D417/12 ,  C07D277/48

    摘要： Amides acting as histamine H.sub.2 receptors antagonists, of formula ##STR1## wherein X represents a N.fwdarw.O or C-NH-A-B group in which A is CO or SO.sub.2 and B is alkyl, phenyl, pyridyl, pyridyl 1-oxide, pyrazinyl or thienyl; their salts; process for their preparation by reacting 2-(2-guanidinothiazol-4-ylmethylthio)ethylamine with a derivative of formula ##STR2## and optional salification; and pharmaceutical compositions containing same.

    摘要翻译： 作为组胺H 2受体拮抗剂的酰胺，其中X代表N-或O-C-NH-AB基团，其中A是CO或SO2，B是烷基，苯基，吡啶基，吡啶基1-氧化物，吡嗪基 或噻吩基; 他们的盐 2-（2-胍基噻唑-4-基甲硫基）乙胺与式“IMAGE”的衍生物反应制备方法和任选的成盐方法; 和含有它们的药物组合物。

    Andrexiant aminopiperidines intermediates thereto and drugs containing same
    70.
    发明授权
    Andrexiant aminopiperidines intermediates thereto and drugs containing same 失效
    安非他明氨基哌啶中间体及其含有药物

    公开(公告)号：US4409228A

    公开(公告)日：1983-10-11

    申请号：US327022

    申请日：1981-12-03

    申请人： Dino Nisato ,  Paolo Carminati

    发明人： Dino Nisato ,  Paolo Carminati

    IPC分类号： C07D401/04 ,  A61K31/4427 ,  A61K31/445 ,  A61P3/04

    CPC分类号： A61K31/445

    摘要： The present invention relates to novel 4-amino-1-(2-pyridyl)piperidines with anorexiant action, of formula: ##STR1## in which R represents hydrogen, a halogen, a methyl group, a trifluoromethyl group, a lower alkoxy group, a trifluoromethoxy group, a 2,2,2-trifluoroethoxy group, a lower alkylthio group, a trifluoromethylthio group, a possibly substituted phenoxy group or a possibly substituted phenylthio group; to salts thereof; to a process for preparation thereof; to drugs containing same; and to intermediate products in the synthesis thereof.

    摘要翻译： 本发明涉及具有无意义作用的新型4-氨基-1-（2-吡啶基）哌啶，其结构式如下：其中R表示氢，卤素，甲基，三氟甲基，低级烷氧基， 三氟甲氧基，2,2,2-三氟乙氧基，低级烷硫基，三氟甲硫基，可能取代的苯氧基或可能取代的苯硫基; 其盐; 涉及其制备方法; 含有相同药物; 以及其合成中的中间产物。