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    System for improving cardiac function by sealing a partitioning membrane within a ventricle
    61.
    发明授权
    System for improving cardiac function by sealing a partitioning membrane within a ventricle 有权
    通过密封心室内的分隔膜来改善心脏功能的系统

    公开(公告)号：US08388672B2

    公开(公告)日：2013-03-05

    申请号：US12422144

    申请日：2009-04-10

    申请人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    发明人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    IPC分类号： A61F2/06 ,  A61M29/08

    CPC分类号： A61F2/2487 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12195 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/12095

    摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.

    摘要翻译： 本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。 本文所述的分隔装置可以包括具有向外偏置构件的增强膜。 增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。 这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。 非生产性部分可以填充材料，包括封闭材料。 密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。 本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

    Method of improving cardiac function using a porous membrane
    65.
    发明授权
    Method of improving cardiac function using a porous membrane 有权
    使用多孔膜改善心脏功能的方法

    公开(公告)号：US07887477B2

    公开(公告)日：2011-02-15

    申请号：US10302272

    申请日：2002-11-22

    申请人： Serjan D. Nikolic ,  Hugh R. Sharkey

    发明人： Serjan D. Nikolic ,  Hugh R. Sharkey

    IPC分类号： A61N1/362

    CPC分类号： A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/1205 ,  A61F2/2442 ,  A61N1/05

    摘要： A porous membrane is inserted into a ventricle of a heart. The porous membrane creates a relatively hemostatic volume in which a thrombus can grow. Blood can still pass through fenestrations of the membrane into and out of the hemostatic volume. The fenestrations reduce pressures that act on the membrane, and so reduce stresses within the membrane. The flow characteristics through the hemostatic volume promote growth of the thrombus from a base of the hemostatic volume. The thrombus grows to slightly larger than the original size of the hemostatic volume so as to provide support for the membrane. Any remaining stresses within the membrane are thereby substantially eliminated. The thrombus shrinks over an ensuing period of time, with the membrane merely acting as a barrier to which an outer wall of the myocardium retracts. The function of the membrane is then complete, and may be absorbed.

    摘要翻译： 将多孔膜插入心脏的心室。 多孔膜产生血栓可以生长的相对止血体积。 血液仍然可以通过膜的开窗进入和离开止血体积。 开窗减少作用在膜上的压力，从而减少膜内的应力。 通过止血体积的流动特性促进血栓从止血体积的基底生长。 血栓生长到略大于止血体积的原始尺寸，以便为膜提供支撑。 从而基本上消除了膜内的任何剩余应力。 血栓在随后的一段时间内收缩，膜仅作为心肌外壁缩回的屏障。 然后膜的功能完成，可以被吸收。

    Apparatus and method for accessing and performing a function within an intervertebral disc
    69.
    发明授权
    Apparatus and method for accessing and performing a function within an intervertebral disc 失效
    用于访问和执行椎间盘内功能的装置和方法

    公开(公告)号：US07069087B2

    公开(公告)日：2006-06-27

    申请号：US09792628

    申请日：2001-02-22

    申请人： Hugh R. Sharkey ,  Sepehr Fariabi ,  John Ashley ,  Joel Saal ,  Jeffrey Saal

    发明人： Hugh R. Sharkey ,  Sepehr Fariabi ,  John Ashley ,  Joel Saal ,  Jeffrey Saal

    IPC分类号： A61F7/00 ,  A61F2/00 ,  A61B18/18

    CPC分类号： A61B17/1671 ,  A61B17/3421 ,  A61B2017/00261 ,  A61B2017/003 ,  A61B2017/22044 ,  A61B2017/22049 ,  A61B2017/3488 ,  A61M25/0084 ,  A61M25/09

    摘要： Apparatus and methods are disclosed for accessing the interior of an intervertebral disc to perform a function within the disc. One such apparatus comprises a catheter having a lumen; and a guide wire having a distal portion and a proximal portion, and configured to be positioned within and moved relative to the lumen of the catheter; wherein the guide wire is capable of navigating itself within an intradiscal section of the intervertebral disc to a selected section of the disc and the catheter is capable of being advanced relative to the guide wire such that the catheter follows a path of the guide wire within the intradiscal section of the disc to the selected section. These apparatus and methods may be used for the treatment of intervertebral disc disorders such as sealing fissures of the annulus fibrosus, which may or may not be accompanied with contained or escaped extrusions. These apparatus and methods may also be used, for example, for the removal or addition of material to the intervertebral disc.

    摘要翻译： 公开了用于访问椎间盘内部以执行椎间盘内的功能的装置和方法。 一种这样的装置包括具有内腔的导管; 以及导线，其具有远侧部分和近端部分，并且构造成定位在所述导管的内腔内并相对于所述导管的内腔移动; 其中所述导丝能够在椎间盘的椎间盘内段内自身导航到所述盘的选定部分，并且所述导管能够相对于所述导丝前进，使得所述导管沿着所述导丝的路径 盘片的椎间盘内部分到选定的部分。 这些装置和方法可以用于治疗椎间盘疾病，例如纤维环纤维的密封裂缝，其可能伴随着包含或逃逸的挤出物，也可能不伴随其中。 这些装置和方法也可以用于例如去除或添加到椎间盘的材料。

    Method for treating tissue in arthroscopic environment using precooling and apparatus for same
    70.
    发明授权
    Method for treating tissue in arthroscopic environment using precooling and apparatus for same 有权
    使用预冷处理关节镜环境组织的方法及其装置

    公开(公告)号：US06544260B1

    公开(公告)日：2003-04-08

    申请号：US09476018

    申请日：1999-12-31

    申请人： Mark Markel ,  Hugh R. Sharkey ,  Gary S. Fanton

    发明人： Mark Markel ,  Hugh R. Sharkey ,  Gary S. Fanton

    IPC分类号： A61B1818

    CPC分类号： A61B17/320016 ,  A61B17/1604 ,  A61B17/3203 ,  A61B18/00 ,  A61B18/14 ,  A61B18/1442 ,  A61B18/148 ,  A61B2017/320078 ,  A61B2018/00011 ,  A61B2018/126 ,  A61N1/403 ,  A61N7/02

    摘要： A thermal energy delivery apparatus has a probe including a distal end and a proximal end. A first electrode is positioned at the distal end of the probe. The first electrode is configured to deliver sufficient thermal energy to a fibrillated cartilage surface to reduce a level of fibrillation of the fibrillated cartilage surface. A cabling is coupled to the proximal end of the probe. A method for thermal protection of non-targeted tissues that may be exposed to thermal probes used during arthroscopic procedures includes a pre-procedural cooling Lavage. The pre-cooled tissues provide a convective buffer for tissues not intended for thermal intervention, thereby reducing collateral damage.

    摘要翻译： 热能输送装置具有包括远端和近端的探针。 第一电极位于探头的远端。 第一电极被配置为向原纤维化的软骨表面递送足够的热能，以减少原纤化软骨表面的原纤化水平。 电缆连接到探头的近端。 可能暴露于在关节镜手术期间使用的热探针的非靶组织的热保护方法包括手术前冷却灌洗。 预冷组织为不用于热干预的组织提供对流缓冲液，从而减少附带损伤。