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101 条记录 (耗时 0.04 秒)

    Method for producing a multilayer compound on a CIP-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavities
    64.
    发明申请
    Method for producing a multilayer compound on a CIP-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavities 有权
    在具有CIP能力的涂层装置上制备多层化合物的方法以及通过所述透皮施用方法制得的多层化合物或在体腔中的应用

    公开(公告)号：US20110117177A1

    公开(公告)日：2011-05-19

    申请号：US13054153

    申请日：2009-07-20

    申请人： Rudi Brathuhn ,  Peter Schwarz ,  Wolfgang Schaefer

    发明人： Rudi Brathuhn ,  Peter Schwarz ,  Wolfgang Schaefer

    IPC分类号： A61K9/70 ,  B05D3/02 ,  B05D3/12

    CPC分类号： F26B13/00 ,  F26B25/00

    摘要： Methods for producing a mono- or multilayer composite are provided in which one or several layers are applied onto a carrier material by coating, the coated mono- or multilayer composite is dried and rolled up, and the installation is subsequently cleaned. The air circuit in the drying oven is entirely set to fresh air supply, and the drying oven is configured to be cleaned in a controlled manner. All components of the drying oven that come into contact with the product do not have to be removed during cleaning, but can be cleaned-in-place using technology integrated into the drying oven. The drying oven Outer housing is designed so that it can be lifted upwardly. All assembly parts in the drying oven interior are designed to eliminate disassembling for cleaning purposes. Transport rollers within the drying oven are designed as hollow shafts and provided with spraying nozzles.

    摘要翻译： 提供制备单层或多层复合材料的方法，其中通过涂覆将一层或多层施加到载体材料上，将经涂覆的单层或多层复合材料干燥并卷起，随后清洁该装置。 干燥炉中的空气回路完全设置为新鲜空气供应，并且干燥箱被配置为以受控的方式进行清洁。 在清洁过程中，与产品接触的干燥箱的所有部件都不需要移除，但是可以使用集成到干燥箱中的技术将其清洁。 干燥箱外壳设计成可以向上提起。 干燥箱内部的所有装配件均设计为消除拆卸以进行清洁。 干燥箱内的输送辊设计为空心轴，并设有喷嘴。

    Pyrido[2,3-d]pyrimidine dichloro-phenyl derivatives
    69.
    发明授权
    Pyrido[2,3-d]pyrimidine dichloro-phenyl derivatives 失效
    吡啶并[2,3-d]嘧啶二氯 - 苯基衍生物

    公开(公告)号：US07189732B2

    公开(公告)日：2007-03-13

    申请号：US11079623

    申请日：2005-03-14

    申请人： Konrad Honold ,  Wolfgang Schaefer ,  Stefan Scheiblich

    发明人： Konrad Honold ,  Wolfgang Schaefer ,  Stefan Scheiblich

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D471/00

    CPC分类号： C07D471/04

    摘要： The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. These compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

    摘要翻译： 本发明描述了通式I的化合物，其制备方法，含有它们的组合物及其制备方法以及这些化合物作为药物活性剂的用途。 这些化合物显示出作为蛋白激酶抑制剂，特别是src家族酪氨酸激酶抑制剂的活性，因此可用于治疗由所述酪氨酸激酶介导的疾病。

    Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
    70.
    发明授权
    Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders 失效
    用于治疗和预防代谢性骨骼疾病的罗丹明羧酸衍生物

    公开(公告)号：US06673816B1

    公开(公告)日：2004-01-06

    申请号：US09787917

    申请日：2001-06-21

    申请人： Angelika Esswein ,  Wolfgang Schaefer ,  Christos Tsaklakidis ,  Konrad Honold ,  Klaus Kaluza

    发明人： Angelika Esswein ,  Wolfgang Schaefer ,  Christos Tsaklakidis ,  Konrad Honold ,  Klaus Kaluza

    IPC分类号： A61K31426

    CPC分类号： C07D277/20 ,  C07D277/36 ,  C07D417/06 ,  C07D417/12 ,  C07D493/04

    摘要： Compounds of general formula (I), in which m is 0-8, q is a 0-8, a is 0-4, A signifies a single or double bond, R1, R2 signify hydrogen or lower alkyl and, when m signifies 2-8, R1 and R2 in the group CR1═CR2 can have various significances within the following sequence, R3 signifies hydrogen or lower alkyl, X signifies hydrogen or —(CH2)b—COR4 with b=0-4, Y signifies hydrogen, —COR4, phenyl or indolyl residue R4 signifies hydroxyl, lower alkoxy or the NR1R2 residue, W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain hetero atoms, as well physiologically compatible salts, esters, optically active forms, racemates, tautomers, and derivatives which can be metabolized in vivo to compounds of general formula (I).

    摘要翻译： 通式（I）的化合物，其中m为0-8，q为0-8，a为0-4，A表示单键或双键，R1，R2表示氢或低级烷基，当m表示 2-8中，基团CR1 = CR2中的R1和R2可以在以下序列中具有各种含义，R3表示氢或低级烷基，X表示氢或 - （CH2）b-COR4，其中b = 0-4，Y表示氢 ，-COR 4，苯基或吲哚基残基R 4表示羟基，低级烷氧基或NR 1 R 2残基，W表示可以含有杂原子的任选的单取代或多取代的饱和或不饱和单 - ，二 - 或三环，以及生理上相容的盐，酯 ，光学活性形式，外消旋体，互变异构体和衍生物，其可以在体内被代谢为通式（I）的化合物。