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    FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE
    7.
    发明申请
    FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE 审中-公开
    包含两个FAB片段的FC-FREE抗体及其使用方法

    公开(公告)号：US20130060011A1

    公开(公告)日：2013-03-07

    申请号：US13591010

    申请日：2012-08-21

    申请人： Peter Bruenker ,  Christiane Jaeger ,  Christian Klein ,  Wolfgang Schaefer ,  Pablo Umana

    发明人： Peter Bruenker ,  Christiane Jaeger ,  Christian Klein ,  Wolfgang Schaefer ,  Pablo Umana

    IPC分类号： C07K16/46 ,  C12N1/19 ,  C12N1/00 ,  C12N1/15 ,  C12P21/00 ,  C12N5/10

    CPC分类号： C07K16/468 ,  C07K2317/55 ,  C07K2317/66

    摘要： The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

    摘要翻译： 本发明涉及包含至少两个fab片段的双特异性抗体，其中第一Fab片段包含至少一个对第一抗原特异的抗原结合位点; 并且所述第二Fab片段包含至少一个针对第二抗原特异性的抗原结合位点，其中所述第二Fab重链和轻链的可变区或恒定区被交换; 并且其中所述双特异性抗体缺乏Fc结构域; 其制备方法，含有所述抗体的药物组合物及其用途。