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    Method of decomposing gypsum to sulfur dioxide and the apparatus thereof
    61.
    发明申请
    Method of decomposing gypsum to sulfur dioxide and the apparatus thereof 审中-公开
    将石膏分解成二氧化硫的方法及其装置

    公开(公告)号：US20050100503A1

    公开(公告)日：2005-05-12

    申请号：US10363435

    申请日：2001-05-18

    申请人： Yisheng Feng ,  Jiutian Feng ,  Xigang Liu ,  Yurui Wang ,  Tianbao Lu

    发明人： Yisheng Feng ,  Jiutian Feng ,  Xigang Liu ,  Yurui Wang ,  Tianbao Lu

    IPC分类号： C01B17/50 ,  C01F11/08 ,  F27B7/02 ,  F27B7/20 ,  F27D17/00 ,  C01B17/52 ,  F27B7/00

    CPC分类号： C01F11/08 ,  C01B17/506 ,  F27B7/02 ,  F27B7/2025 ,  F27D2017/009 ,  Y02P20/124

    摘要： A method of decomposing gypsum to sulfur dioxide, and the apparatus thereof are disclosed. The apparatus comprises a set of four-stage cyclone preheater and a rotary kiln for decomposing and calcining. In the four-stage cyclone preheater, the off-gas of the kiln conducts heat-exchange with materials. By such processing, the efficiency of heat exchange is high, and gypsum which contains 10-25% of water can be directly used for preparing crude materials. The entrance temperature of the preheated materials can be up to 600-720° C., while the temperature of the off-gas can be decreased to 260-400° C., so that heat utilization ratio is high, and the cost of the apparatus can be cut down. The concentration of SO2 in the off-gas may be up to 11-14%, so that two-conversion two-adsorption process can be employed for preparing sulfuric acid.

    摘要翻译： 公开了将石膏分解成二氧化硫的方法及其装置。 该装置包括一组四级旋风预热器和用于分解和煅烧的回转窑。 在四级旋风预热器中，窑尾废气与材料进行热交换。 通过这种处理，热交换效率高，含10-25％水的石膏可直接用于制备原料。 预热材料的入口温度可达600-720℃，废气温度可降至260-400℃，热利用率高，成本高 设备可以减少。 废气中的SO 2浓度可以达到11-14％，因此可以采用双转化双吸附法来制备硫酸。

    Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
    62.
    发明授权
    Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors 有权
    杂芳基氨基胍和烷氧基胍及其作为蛋白酶抑制剂的用途

    公开(公告)号：US06706021B2

    公开(公告)日：2004-03-16

    申请号：US10400073

    申请日：2003-03-27

    申请人： Tianbao Lu ,  Bruce E. Tomczuk ,  Thomas P. Markotan ,  Colleen Siedem

    发明人： Tianbao Lu ,  Bruce E. Tomczuk ,  Thomas P. Markotan ,  Colleen Siedem

    IPC分类号： A61M514

    CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06139

    摘要： Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12-R15, Ra, Rb, Rc, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

    摘要翻译： 描述了氨基胍和烷氧基胍化合物，包括式VII的化合物：其中X是O或NR 9，Het，R 1，R 7，R 8，R 12 -R 15， R a，R b，R c，Z和n在说明书中列出，以及抑制蛋白水解酶如凝血酶的水合物，溶剂合物或其药学上可接受的盐。 还描述了制备这些化合物的方法。 本发明的化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，如胰凝乳蛋白酶，胰蛋白酶，凝血酶，纤溶酶和因子Xa。 某些化合物通过直接，选择性抑制凝血酶表现出抗血栓形成活性。 本发明包括用于抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制哺乳动物栓塞形成的组合物，其包含本发明化合物在药学上可接受的载体中。 本发明化合物的其它用途是作为凝血剂或者物理上连接于用于血液收集，血液循环和血液储存（例如导管，血液透析机，采血注射器和管）中使用的装置的制造中使用的材料的抗凝剂， 血线和支架。 另外，化合物可以被可检测地标记并用于血栓的体内成像。

    Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
    63.
    发明授权
    Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors 有权

    公开(公告)号：US06566379B1

    公开(公告)日：2003-05-20

    申请号：US10241513

    申请日：2002-09-12

    申请人： Tianbao Lu ,  Bruce E. Tomczuk ,  Thomas P. Markotan ,  Colleen Siedem

    发明人： Tianbao Lu ,  Bruce E. Tomczuk ,  Thomas P. Markotan ,  Colleen Siedem

    IPC分类号： A61K314412

    CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06139

    摘要： Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12-R15, Ra, Rb, Rc, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

    Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
    64.
    发明授权
    Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors 有权

    公开(公告)号：US06472399B2

    公开(公告)日：2002-10-29

    申请号：US10012445

    申请日：2001-12-12

    申请人： Tianbao Lu ,  Bruce E. Tomczuk ,  Thomas P. Markotan ,  Colleen Siedem

    发明人： Tianbao Lu ,  Bruce E. Tomczuk ,  Thomas P. Markotan ,  Colleen Siedem

    IPC分类号： A61K3144

    CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06139

    摘要： Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12-R15, Ra, Rb, Rc, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

    Amidino protease inhibitors
    65.
    发明授权
    Amidino protease inhibitors 有权
    脒基蛋白酶抑制剂

    公开(公告)号：US06414020B2

    公开(公告)日：2002-07-02

    申请号：US09851123

    申请日：2001-05-09

    申请人： Tianbao Lu ,  Bruce E. Tomczuk ,  Carl R. Illig ,  Richard M. Soll

    发明人： Tianbao Lu ,  Bruce E. Tomczuk ,  Carl R. Illig ,  Richard M. Soll

    IPC分类号： A61K31155

    CPC分类号： C07D295/195 ,  C07C309/73 ,  C07C311/21 ,  C07D211/22 ,  C07D211/26

    摘要： Amidino and benzamidino compounds, including compounds of the formula: wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.

    摘要翻译： 脒基和苯甲脒基化合物，包括下式的化合物：其中R1-R4，R6-R9，Y，Z，n和m在本说明书中列出，以及其水合物，溶剂合物或其药学上可接受的盐，其抑制数目 的蛋白水解酶。 还描述了制备式I化合物的方法。

    Aminoguanidines and alkoxyguanidines as protease inhibitors
    66.
    发明授权
    Aminoguanidines and alkoxyguanidines as protease inhibitors 失效
    氨基胍和烷氧基胍作为蛋白酶抑制剂

    公开(公告)号：US06235778B1

    公开(公告)日：2001-05-22

    申请号：US08979234

    申请日：1997-11-26

    申请人： Bruce E. Tomczuk ,  Richard M. Soll ,  Tianbao Lu ,  Cynthia L. Fedde ,  Carl R. Illig ,  Thomas P. Markotan ,  Thomas P. Stagnaro

    发明人： Bruce E. Tomczuk ,  Richard M. Soll ,  Tianbao Lu ,  Cynthia L. Fedde ,  Carl R. Illig ,  Thomas P. Markotan ,  Thomas P. Stagnaro

    IPC分类号： A61K31255

    CPC分类号： C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C309/77 ,  C07C311/16 ,  C07C311/17 ,  C07C311/18 ,  C07C311/19 ,  C07C311/21 ,  C07C317/14 ,  C07C323/66 ,  C07C2601/02 ,  C07C2601/14 ,  C07D211/96 ,  C07D213/42 ,  C07D213/74 ,  C07D215/36 ,  C07D217/02 ,  C07D217/22 ,  C07D239/42 ,  C07D295/13 ,  C07D295/26 ,  C07D307/66

    摘要： Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R114 R4, R6-R9, R11, R12, Ra, Rb, Rc, Y, Z, n and mare set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents.

    摘要翻译： 氨基胍和烷氧基胍化合物，包括下式的化合物：其中X是O或NR9，R114R4，R6-R9，R11，R12，Ra，Rb，Rc，Y，Z，n和母本也在说明书中列出 描述了抑制蛋白水解酶如凝血酶的水合物，溶剂合物或其药学上可接受的盐。 还描述了制备式I化合物的方法。本发明的新化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，例如胰凝乳蛋白酶，胰蛋白酶，凝血酶，纤溶酶和因子Xa。 某些化合物通过直接，选择性抑制凝血酶表现出抗血栓形成活性，或者是用于形成具有抗血栓形成活性的化合物的中间体。 本发明包括用于抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制哺乳动物栓塞形成的组合物，其包含本发明化合物在药学上可接受的载体中。 本发明化合物的其它用途是作为凝血剂或者物理连接于制造用于血液收集，血液循环和血液储存中的装置的材料的抗凝剂，例如导管，血液透析机，采血注射器和管， 血线和支架。