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83 条记录 (耗时 0.027 秒)

    Markers for Prosthetic Heart Valves
    62.
    发明申请
    Markers for Prosthetic Heart Valves 有权
    假心瓣膜标记

    公开(公告)号：US20090192591A1

    公开(公告)日：2009-07-30

    申请号：US12358765

    申请日：2009-01-23

    申请人： Timothy R. Ryan ,  Charles Tabor

    发明人： Timothy R. Ryan ,  Charles Tabor

    IPC分类号： A61F2/06 ,  A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2250/0098

    摘要： A replacement prosthetic heart valve for engagement with a structure of an original prosthetic heart valve that includes at least one visually detectable marker. The replacement heart valve includes a stent structure having a generally tubular body portion and at least one visually detectable marker on a portion of the stent structure, and at least two leaflets attached within the interior area of the tubular body portion of the stent structure. At least one visually detectable marker of the stent structure is alignable with at least one visually detectable marker of the original prosthetic heart valve.

    摘要翻译： 一种替换假体心脏瓣膜，用于与包括至少一个视觉上可检测的标记物的原始假体心脏瓣膜的结构接合。 置换心脏瓣膜包括支架结构，该支架结构具有大致管状主体部分和在支架结构的一部分上的至少一个视觉上可检测的标记，以及附接在支架结构的管状主体部分的内部区域内的至少两个小叶。 支架结构的至少一个视觉上可检测的标记可与原始假体心脏瓣膜的至少一个视觉上可检测的标记物对准。

    Method and apparatus for cardiac valve replacement
    63.
    发明申请
    Method and apparatus for cardiac valve replacement 审中-公开
    心脏瓣膜置换的方法和装置

    公开(公告)号：US20070255394A1

    公开(公告)日：2007-11-01

    申请号：US11796681

    申请日：2007-04-27

    申请人： Timothy R. Ryan

    发明人： Timothy R. Ryan

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2250/0003 ,  A61F2250/001 ,  A61F2250/0039 ,  A61F2250/006

    摘要： A method of placing a valve in a tubular organ including the steps of delivering an expandable tubular adapter to a site within the tubular organ, wherein the adapter includes an enclosed volume surrounded by an outer wall that is spaced from an inner wall, and first and second end walls. The method further includes expanding the outer wall relative to the inner wall so that the outer wall contacts the tubular organ, and placing a valve within the inner wall of the adapter. The method may further include inserting material into the enclosed volume of the adapter to expand the outer wall relative to the inner wall, which material may include liquid or gel. Alternatively, the valve may be positioned within the inner wall prior to the adapter being delivered to the desired site.

    摘要翻译： 一种将阀放置在管状器官中的方法，包括将可扩张的管状适配器递送到管状器官内的部位的步骤，其中适配器包括由与内壁隔开的外壁包围的封闭容积，以及第一和 第二端墙。 该方法还包括相对于内壁膨胀外壁，使得外壁接触管状器官，并将阀置于适配器的内壁内。 该方法还可以包括将材料插入适配器的封闭容积以相对于内壁膨胀外壁，该材料可以包括液体或凝胶。 或者，在适配器被递送到期望的位置之前，阀可以定位在内壁内。

    Process for the production of 4'-isobutylacetophenone
    64.
    发明授权
    Process for the production of 4'-isobutylacetophenone 失效
    生产4'-异丁基苯乙酮的方法

    公开(公告)号：US5068448A

    公开(公告)日：1991-11-26

    申请号：US593143

    申请日：1990-10-05

    申请人： Daniel D. Lindley ,  Thomas A. Curtis ,  Timothy R. Ryan ,  Edward M. de la Garza ,  Charles B. Hilton ,  Thomas M. Kenesson

    发明人： Daniel D. Lindley ,  Thomas A. Curtis ,  Timothy R. Ryan ,  Edward M. de la Garza ,  Charles B. Hilton ,  Thomas M. Kenesson

    IPC分类号： B01J27/12 ,  C07B61/00 ,  C07C45/46 ,  C07C45/85 ,  C07C49/76 ,  C07C49/825 ,  C07C51/60

    CPC分类号： C07C51/60 ,  C07C45/46 ,  C07C45/85 ,  C07C2527/1206

    摘要： A continuous process is provided for the production of 4'-isobutylacetophenone (4-IBAP) comprising feeding liquid hydrogen fluoride (HF) and an acetylating agent into an extractor-reactor to form a first, HF-rich phase containing the acetylating agent, feeding isobutylbenzene (IBB) to the extractor-reactor to form a second, IBB-rich phase which is contacted with said first, HF-rich phase in a manner such that the acetylating agent reacts with IBB to form 4-IBAP which is extracted into the first, HF-rich phase, and a light IBB-rich second phase containing the bulk of unreacted IBB, externally recycling said second, IBB-rich phase to the IBB feed point in combination with fresh IBB to make up for IBB consumed in the reaction and that and dissolved in the HF-rich phase, and withdrawing HF-rich phase containing 4-IBAP from the extractor-reactor.

    摘要翻译： 提供了一种连续的方法，用于生产4'-异丁基苯乙酮（4-IBAP），包括将液体氟化氢（HF）和乙酰化剂进料到萃取 - 反应器中以形成含有乙酰化剂的第一富含HF的相， 异丁基苯（IBB），以形成富含IBB的第二相，其与所述第一富HF相接触，使得乙酰化剂与IBB反应形成4-IBAP，其被提取到 首先富含HF的相和富含IBB的第二相含有大部分未反应的IBB，外部将所述第二IBB富集相再循环到IBB进料点并与新鲜IBB组合以补偿在反应中消耗的IBB 并溶解在富HF相中，并从萃取器 - 反应器中取出含有富含HF的4-IBAP相。

    Delivery systems and methods of implantation for prosthetic heart valves
    66.
    发明授权
    Delivery systems and methods of implantation for prosthetic heart valves 有权
    用于假体心脏瓣膜的输送系统和植入方法

    公开(公告)号：US09393115B2

    公开(公告)日：2016-07-19

    申请号：US12358789

    申请日：2009-01-23

    申请人： Charles Tabor ,  Timothy R. Ryan

    发明人： Charles Tabor ,  Timothy R. Ryan

    IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/95

    CPC分类号： A61F2/966 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/844 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9522 ,  A61F2002/9665 ,  A61F2250/0098

    摘要： A delivery system for delivering an implantable stented device to a lumen of a patient, the delivery system including an elongated body having a proximal end and a distal end, a driver mechanism positioned at the proximal end of the elongated body, an elongated threaded rod located axially distal to the driver mechanism, and a sheath including an elongated tubular portion having a hollow interior portion with a first diameter that is sized for compression and retention of the implantable stented device in a compressed configuration for delivery to a body lumen.

    摘要翻译： 一种用于将可植入支架装置输送到患者的内腔的输送系统，所述输送系统包括具有近端和远端的细长主体，位于所述细长体近端的驱动器机构，位于 以及护套，其包括具有中空内部部分的细长管状部分，第一直径的尺寸适于将可植入支架装置压缩和保持在压缩构型中以输送到体腔。

    Delivery systems and methods of implantation for replacement prosthetic heart valves
    67.
    发明授权
    Delivery systems and methods of implantation for replacement prosthetic heart valves 有权
    更换假体心脏瓣膜的输送系统和植入方法

    公开(公告)号：US09060859B2

    公开(公告)日：2015-06-23

    申请号：US13548603

    申请日：2012-07-13

    申请人： Timothy R. Ryan

    发明人： Timothy R. Ryan

    IPC分类号： A61F2/24 ,  A61F2/958

    CPC分类号： A61F2/2418 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2310/00023

    摘要： A method of delivering a replacement prosthetic valve to a previously implanted prosthetic valve including the steps of compressing a replacement prosthetic valve having an expandable stent within a sheath of a delivery system, wherein the delivery system comprises a proximal end, a distal end, and a centering structure positioned between the proximal and distal ends, advancing the delivery system and compressed replacement prosthetic valve into a vessel of a patient until the distal end of the delivery system is positioned adjacent to a second side of a previously implanted prosthetic valve, deploying the centering structure to radially reposition the distal end of the delivery system, further advancing the delivery system toward the previously implanted prosthetic valve, and deploying the replacement prosthetic valve.

    摘要翻译： 将置换的人工瓣膜递送到先前植入的假体瓣膜的方法，包括以下步骤：在输送系统的护套内压缩具有可扩张支架的置换假体瓣膜，其中所述输送系统包括近端，远端和 定心结构定位在近端和远端之间，使输送系统和压缩的替代假体瓣进入患者血管，直到输送系统的远端邻近先前植入的假性瓣膜的第二侧定位，展开定心 结构以径向地重新定位输送系统的远端，进一步使输送系统朝向先前植入的假体瓣膜前进，并展开置换的人造瓣膜。

    Stents for prosthetic heart valves
    69.
    发明授权
    Stents for prosthetic heart valves 有权
    假体心脏瓣膜支架

    公开(公告)号：US08628566B2

    公开(公告)日：2014-01-14

    申请号：US12358980

    申请日：2009-01-23

    申请人： Carol E. Eberhardt ,  Charles Tabor ,  Carolyn Majkrzak ,  Timothy R. Ryan ,  Melissa Denton ,  Maria Botrous ,  Janice L. Shay

    发明人： Carol E. Eberhardt ,  Charles Tabor ,  Carolyn Majkrzak ,  Timothy R. Ryan ,  Melissa Denton ,  Maria Botrous ,  Janice L. Shay

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2220/0075

    摘要： A stented valve including a stent structure including a generally tubular body portion having a first end, a second end, an interior area, a longitudinal axis, and a plurality of vertical wires extending generally parallel to the longitudinal axis around a periphery of the body portion, wherein the plurality of vertical wires includes multiple commissure wires and at least one structural wire positioned between adjacent commissure wires, and a plurality of V-shaped wire structures having a first end, a second end, and a peak between the first and second ends, wherein a first end of each V-shaped structure extends from a first vertical wire and a second end of each V-shaped structure extends from a second vertical wire that is adjacent to the first vertical wire, wherein each V-shaped structure is oriented so that its peak is facing in the same direction relative to the first and second ends of the body portion, and a valve structure including a plurality of leaflets attached to the stent structure within the tubular body portion.

    摘要翻译： 一种支架式阀，包括支架结构，该支架结构包括大体上管状的主体部分，该主体部分具有第一端部，第二端部，内部区域，纵向轴线以及大致平行于纵向轴线围绕主体部分的周边延伸的多个垂直线 ，其中所述多个垂直导线包括多个连合线和位于相邻合金线之间的至少一个结构线，以及多个V形线结构，其具有第一端，第二端和在所述第一和第二端之间的峰 其中，每个V形结构的第一端从第一垂直线延伸，并且每个V形结构的第二端从与所述第一垂直导线相邻的第二垂直导线延伸，其中每个V形结构被定向 使得其峰值相对于主体部分的第一和第二端面向相同的方向，以及阀结构，其包括附接到ste的多个传单 nt结构在管状体部分内。

    Delivery Systems and Methods of Implantation for Replacement Prosthetic Heart Valves
    70.
    发明申请
    Delivery Systems and Methods of Implantation for Replacement Prosthetic Heart Valves 审中-公开
    替代假体心脏瓣膜的植入系统和方法

    公开(公告)号：US20120277854A1

    公开(公告)日：2012-11-01

    申请号：US13548603

    申请日：2012-07-13

    申请人： Timothy R. Ryan

    发明人： Timothy R. Ryan

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2310/00023

    摘要： A method of delivering a replacement prosthetic valve to a previously implanted prosthetic valve including the steps of compressing a replacement prosthetic valve having an expandable stent within a sheath of a delivery system, wherein the delivery system comprises a proximal end, a distal end, and a centering structure positioned between the proximal and distal ends, advancing the delivery system and compressed replacement prosthetic valve into a vessel of a patient until the distal end of the delivery system is positioned adjacent to a second side of a previously implanted prosthetic valve, deploying the centering structure to radially reposition the distal end of the delivery system, further advancing the delivery system toward the previously implanted prosthetic valve, and deploying the replacement prosthetic valve

    摘要翻译： 将置换的人工瓣膜递送到先前植入的假体瓣膜的方法，包括以下步骤：在输送系统的护套内压缩具有可扩张支架的置换假体瓣膜，其中所述输送系统包括近端，远端和 定心结构定位在近端和远端之间，使输送系统和压缩的替代假体瓣进入患者血管，直到输送系统的远端邻近先前植入的假性瓣膜的第二侧定位，展开定心 结构以径向地重新定位输送系统的远端，进一步使输送系统朝向先前植入的假性瓣膜前进，并将替换的人工瓣膜