公开(公告)号：US07907355B2

公开(公告)日：2011-03-15

申请号：US12467950

申请日：2009-05-18

申请人： Masakazu Kodaira ,  Tsuyoshi Wakazono ,  Masaru Sakamoto ,  Ryuji Nurishi

发明人： Masakazu Kodaira ,  Tsuyoshi Wakazono ,  Masaru Sakamoto ,  Ryuji Nurishi

IPC分类号： G02B9/36

CPC分类号： G02B15/173 ,  G02B27/646

摘要： A zoom lens system includes, in order from the object side to the image side, four lens units having positive, negative, negative and positive refractive powers. A first lens unit includes, in order from the object side to the image side: a front subunit having a negative refractive power; a middle subunit that has a positive refractive power and moves during focusing; and a rear subunit having a positive refractive power. The zoom lens system further includes a variable apex angle prism disposed on the image side of the front subunit. An average Abbe number of materials of a negative lens element and a positive lens element included in the front subunit is set appropriately so as to suppress occurrence of decentering aberration accompanying a variation of a prism apex angle.

摘要翻译： 变焦透镜系统从物体侧到像侧依次包括具有正，负，负和正屈光力的四个透镜单元。 第一透镜单元从物体侧到像侧依次包括具有负折光力的前亚像单元; 具有正折射力并在聚焦期间移动的中间子单元; 以及具有正折光力的后部子单元。 变焦透镜系统还包括设置在前子单元的像侧的可变顶角棱镜。 适当地设置包括在前子单元中的负透镜元件和正透镜元件的材料的平均阿贝数，以便抑制伴随棱镜顶角的变化的偏心像差的发生。

公开(公告)号：US20100194969A1

公开(公告)日：2010-08-05

申请号：US12697564

申请日：2010-02-01

申请人： Masaru Sakamoto

发明人： Masaru Sakamoto

IPC分类号： H04N5/232 ,  G02B15/14 ,  G02B15/10

CPC分类号： G02B15/173 ,  G02B15/177 ,  H04N5/23296

摘要： A zoom lens system having a high zoom ratio and excellently correcting various aberrations over an entire zoom range between a wide angle end and a telephoto end to obtain high optical performance in the entire zoom range, includes, in order from an object side to an image side, a first lens unit having a positive refractive power, a second lens unit having a negative refractive power, a third lens unit, and a fourth lens unit. The fourth lens unit includes a front subunit and a rear subunit, the rear subunit being constituted by two negative lenses and at least three positive lenses. The rear subunit includes a first rear-subunit and a second rear-subunit. Each of the first rear-subunit and the second rear-subunit includes a negative lens and at least one positive lens. Lens materials are suitably set for the first rear-subunit and the rear second-subunit.

摘要翻译： 具有高变焦比并且在广角端和望远端之间的整个变焦范围上的各种像差的变形透镜系统在整个变焦范围内获得高的光学性能包括从物体侧到图像的顺序 具有正折光力的第一透镜单元，具有负屈光力的第二透镜单元，第三透镜​​单元和第四透镜单元。 第四透镜单元包括前子单元和后子单元，后子单元由两个负透镜和至少三个正透镜构成。 后部子单元包括第一后​​部子单元和第二后部子单元。 第一后部子单元和第二后部子单元中的每一个包括负透镜和至少一个正透镜。 镜片材料适用于第一个后部亚基和后部的第二个亚单位。

公开(公告)号：US07675693B2

公开(公告)日：2010-03-09

申请号：US11683715

申请日：2007-03-08

申请人： Masaru Sakamoto

发明人： Masaru Sakamoto

IPC分类号： G02B9/04

CPC分类号： G02B15/10 ,  G02B13/06 ,  G02B15/17 ,  G02B15/177

摘要： An optical accessory having a high optical performance arranged to change an optical characteristic of a shooting lens and to be attached on the object side of a shooting lens is provided. The optical accessory FE is to be detachably attached to the object side of a master lens M and has at least one lens FE having a negative refractive power. The image-side surface r2 of the lens FE is designed to have an aspherical shape having a negative refractive power that decreases toward its periphery.

摘要翻译： 提供具有高光学性能的光学附件，其被设置为改变拍摄镜头的光学特性并附着在拍摄镜头的物体侧。 光学附件FE可拆卸地附接到主镜头M的物体侧，并且具有至少一个具有负屈光力的透镜FE。 透镜FE的图像侧表面r2被设计成具有朝向其周边减小的具有负折光力的非球面形状。

公开(公告)号：US07643221B2

公开(公告)日：2010-01-05

申请号：US12184967

申请日：2008-08-01

申请人： Masaru Sakamoto

发明人： Masaru Sakamoto

IPC分类号： G02B15/14

CPC分类号： G02B15/173 ,  G02B15/08

摘要： A zoom lens comprises a first lens unit that does not move for zooming and that has a positive refractive power, a second lens unit that is configure to move to an image side during zooming from a wide angle end to a telephoto end and that has a negative refractive power, a third lens unit that is configured to reduce image plane variation due to zooming, and a fourth lens unit that does not move for zooming. The fourth lens unit comprises a fourth-F unit, a fourth-B1 unit, and a fourth-B2 unit. The average Abbe number of positive lens and negative lenses in the fourth-B1 unit and the average Abbe number of positive negative lenses in the fourth-B2 unit are set appropriately.

摘要翻译： 变焦透镜包括：第一透镜单元，其不能移动以进行变焦并且具有正的折射光焦度;第二透镜单元，被配置为在从广角端到远摄端的变焦期间移动到像侧，并且具有 负屈光力，被配置为减少由于变焦引起的图像平面变化的第三透镜单元和不能移动用于变焦的第四透镜单元。 第四透镜单元包括第四F单元，第四B1单元和第四B2单元。 适当地设定第四-B1单元中的正透镜和负透镜的平均阿贝数以及第四B2单元中的正负透镜的平均阿贝数。

公开(公告)号：USRE40929E1

公开(公告)日：2009-10-06

申请号：US11396221

申请日：2006-03-31

申请人： Joe W. Gray ,  Daniel Pinkel ,  Olli-Pekka Kallioniemi ,  Anne Kallioniemi ,  Masaru Sakamoto

发明人： Joe W. Gray ,  Daniel Pinkel ,  Olli-Pekka Kallioniemi ,  Anne Kallioniemi ,  Masaru Sakamoto

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： C12Q1/6879 ,  C12Q1/6827 ,  C12Q1/6841 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2563/107 ,  C12Q2563/131 ,  C12Q2525/151

摘要： Methods and compositions for staining based upon nucleic acid sequence that employ nudeic nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

摘要翻译： 基于使用<？delete-start id =“DEL-S-00001”date =“20091006”？> nudeic <？delete-end id =“DEL-S-00001”？>的核酸序列进行染色的方法和组合物 <？insert-start id =“INS-S-00001”date =“20091006”？>核酸<？insert-end id =“INS-S-00001”？>酸性探针。 所述方法产生可针对特定细胞遗传学分析进行定制的染色模式。 所述探针适用于原位杂交并染色具有可靠信号的相间和中期染色体材料。 核酸探针通常具有大于50kb的复杂度，其复杂性取决于细胞遗传学应用。 提供方法和试剂用于检测遗传重排。 探针和测试试剂盒用于检测遗传重排，特别是用于肿瘤细胞遗传学，用于检测疾病相关的基因座，特别是癌症，如慢性骨髓性白血病（CML），视网膜母细胞瘤，卵巢和子宫癌，以及生物学 剂量测定 描述了细胞遗传学研究的方法和试剂，用于细胞遗传学上相似但遗传上不同的疾病的分化，以及许多预后和诊断应用。

公开(公告)号：US20060257895A1

公开(公告)日：2006-11-16

申请号：US11361316

申请日：2006-02-24

申请人： Daniel Pinkel ,  Joe Gray ,  Anne Kallioniemi ,  Ollie-Pekka Kallioniemi ,  Frederic Waldman ,  Masaru Sakamoto

发明人： Daniel Pinkel ,  Joe Gray ,  Anne Kallioniemi ,  Ollie-Pekka Kallioniemi ,  Frederic Waldman ,  Masaru Sakamoto

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6809 ,  C12Q1/6841 ,  C12Q1/6886 ,  C12Q2600/156 ,  G06F15/025 ,  Y10S436/813 ,  C12Q2545/114 ,  C12Q2537/157

摘要： Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and/or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread. Amplifications, duplications and/or deletions in the subject genome(s) can be detected. Also provided is a method of determining the absolute copy numbers of substantially all RNA or DNA sequences in subject cell(s) or cell population(s).

摘要翻译： 公开了包括使用原位杂交来检测一个或多个基因组中的异常核酸序列拷贝数的新方法，其中结合参考染色体扩增的多个基因座的重复序列基本上被去除和/或其杂交信号被抑制。 称为比较基因组杂交（CGH）的发明提供了确定一个或多个受试者基因组或其部分（例如肿瘤细胞）中核酸序列的相对拷贝数的方法，作为这些序列的位置的函数 参考基因组（例如，正常人类基因组）。 比较来自每个标记的对象核酸的信号的强度和/或来自标记的目标核酸序列的不同信号之间的比率差异，以确定一个或多个核酸序列中核酸序列的相对拷贝数 主题基因组作为沿着参考染色体扩散的位置的函数。 可以检测主题基因组中的扩增，重复和/或缺失。 还提供了确定受试细胞或细胞群体中基本上所有RNA或DNA序列的绝对拷贝数的方法。

公开(公告)号：US5965362A

公开(公告)日：1999-10-12

申请号：US562965

申请日：1995-11-27

申请人： Daniel Pinkel ,  Joe W. Gray ,  Anne Kallioniemi ,  Olli-Pekka Kallioniemi ,  Frederic Waldman ,  Masaru Sakamoto

发明人： Daniel Pinkel ,  Joe W. Gray ,  Anne Kallioniemi ,  Olli-Pekka Kallioniemi ,  Frederic Waldman ,  Masaru Sakamoto

IPC分类号： C12Q1/68 ,  G06F15/02 ,  A61K49/00 ,  C07H21/02 ,  C12P19/34

CPC分类号： C12Q1/6809 ,  C12Q1/6841 ,  C12Q1/6886 ,  G06F15/025 ,  C12Q2600/156 ,  Y10S436/813

摘要： Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and/or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread. Amplifications, duplications and/or deletions in the subject genome(s) can be detected. Also provided is a method of determining the absolute copy numbers of substantially all RNA or DNA sequences in subject cell(s) or cell population(s).

公开(公告)号：US5739590A

公开(公告)日：1998-04-14

申请号：US457149

申请日：1995-06-01

申请人： Masaru Sakamoto ,  Masakazu Morishita ,  Shigeru Nishimura

发明人： Masaru Sakamoto ,  Masakazu Morishita ,  Shigeru Nishimura

IPC分类号： H01L21/20 ,  H01L21/225 ,  H01L21/285 ,  H01L21/3215 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40

CPC分类号： H01L21/32155 ,  H01L21/2022 ,  H01L21/2257 ,  H01L21/28525 ,  Y10S148/123 ,  Y10S438/923

摘要： A semiconductor device is constructed to have an insulating layer containing an impurity provided upon a semiconductor substrate. This insulating layer contains a plurality of windows of different sizes. A first layer is provided in the windows. This first layer does not extend over a periphery of the windows to the surface of the insulating layer. Further, this semiconductor device is constructed such that the surface of the insulating layer and the first layer opposite the semiconductor substrate are flat. In addition, the semiconductor substrate in contact with the first layer also contains the impurity. The semiconductor device, having less surface unevenness that a conventional device, provides both improved and greater stability of device properties.

摘要翻译： 半导体器件被构造成具有包含设置在半导体衬底上的杂质的绝缘层。 该绝缘层包含多个不同尺寸的窗口。 在窗口中提供第一层。 该第一层不延伸到窗户的周边至绝缘层的表面。 此外，该半导体器件被构造成使得绝缘层的表面和与半导体衬底相对的第一层的表面是平坦的。 此外，与第一层接触的半导体衬底还含有杂质。 具有较少表面不均匀性的半导体器件，传统器件提供了改进的和更高的器件性能的稳定性。

公开(公告)号：US5663097A

公开(公告)日：1997-09-02

申请号：US313947

申请日：1994-09-28

申请人： Masaru Sakamoto ,  Kei Fujita

发明人： Masaru Sakamoto ,  Kei Fujita

IPC分类号： H01L21/28 ,  H01L21/266 ,  H01L21/285 ,  H01L21/331 ,  H01L21/336 ,  H01L21/768 ,  H01L23/485 ,  H01L21/44

CPC分类号： H01L21/76831 ,  H01L21/266 ,  H01L21/76804 ,  H01L23/485 ,  H01L29/41783 ,  H01L29/66272 ,  H01L29/6659 ,  H01L2924/0002

摘要： A method of fabricating semiconductor devices comprises the following process of: forming an electrode leading out window having its vertical side wall at a given position in the functional element formed on a semiconductor substrate; forming an insulating film on the surface of the side wall; and depositing an electrode metal in the leading out window.

摘要翻译： 制造半导体器件的方法包括以下步骤：在形成在半导体衬底上的功能元件中的给定位置处形成具有其垂直侧壁的电极引出窗口; 在侧壁的表面上形成绝缘膜; 以及在引出窗口中沉积电极金属。

公开(公告)号：US5663094A

公开(公告)日：1997-09-02

申请号：US351957

申请日：1994-12-08

申请人： Masaru Sakamoto

发明人： Masaru Sakamoto

IPC分类号： H01L23/522 ,  H01L21/768 ,  H01L21/443 ,  H01L23/552 ,  H01L31/0224

CPC分类号： H01L21/768 ,  H01L2924/0002

摘要： A semiconductor device having i) a common opening 110 reaching a conductive region 105 through at least one conductive layer 107 and ii) another conductive layer 109 deposited in the opening 101, the conductive layer 107 and the conductive region 105 being electrically connected in the common opening 110. Also disclosed is a process comprising previously forming a plurality of conductive regions 105 and 107, thereafter forming an opening 110 that opens at the conductive regions, and depositing another conductive region 109 in the opening 110 to electrically connect the respective conductive regions in the opening. This can achieve a wiring connection structure that enables prevention of an increase in the number of masks used to form openings for wiring connection, an increase in the number of steps and an increase in the area held by openings, to thereby enhance the degree of integration of semiconductor devices.

摘要翻译： 一种半导体器件，其具有i）通过至少一个导电层107到达导电区域105的公共开口110和ii）沉积在开口101中的另一个导电层109，导电层107和导电区域105在共同的电连接 还公开了一种方法，其包括预先形成多个导电区域105和107，之后形成在导电区域处开口的开口110，并且在开口110中沉积另一个导电区域109以电连接各个导电区域 开幕。 这可以实现能够防止用于形成用于布线连接的开口的掩模的数量增加的布线连接结构，增加台阶数和增加开口所保持的面积，从而提高集成度 的半导体器件。