公开(公告)号：US09718886B2

公开(公告)日：2017-08-01

申请号：US13808423

申请日：2011-07-04

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Maria Kreuzberg ,  Sylvia Luxen

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Maria Kreuzberg ,  Sylvia Luxen

IPC分类号： C07K1/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.

公开(公告)号：US09487584B2

公开(公告)日：2016-11-08

申请号：US13503461

申请日：2010-11-11

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Stefan Woll ,  Maria Kreuzberg ,  Bernd Hubner ,  Michael Erdeljan

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Stefan Woll ,  Maria Kreuzberg ,  Bernd Hubner ,  Michael Erdeljan

IPC分类号： C07K16/30 ,  A61K39/00 ,  C07K16/28

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

摘要翻译： 本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。

公开(公告)号：US09321842B2

公开(公告)日：2016-04-26

申请号：US14117118

申请日：2012-04-20

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Stefan Woll ,  Maria Kreuzberg ,  Bernd Hubner ,  Michael Erdeljan ,  Michael Weichel

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Stefan Woll ,  Maria Kreuzberg ,  Bernd Hubner ,  Michael Erdeljan ,  Michael Weichel

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。

公开(公告)号：US20140178438A1

公开(公告)日：2014-06-26

申请号：US14119348

申请日：2012-05-23

申请人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

发明人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC分类号： C12Q1/68

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

摘要翻译： 本发明涉及提供对患者肿瘤特异的疫苗，并且可能用于原发性肿瘤的免疫治疗以及肿瘤转移。 一方面，本发明涉及提供个体化癌症疫苗的方法，其包括以下步骤：（a）鉴定癌症患者的肿瘤标本中的癌症特异性体细胞突变，以提供患者的癌症突变特征; 和（b）提供特征在步骤（a）中获得的癌症突变特征的疫苗。 另一方面，本发明涉及可通过所述方法获得的疫苗。

公开(公告)号：US20130156782A1

公开(公告)日：2013-06-20

申请号：US13710828

申请日：2012-12-11

申请人： Ugur Sahin ,  Michael Koslowski ,  Ozlem Tureci

发明人： Ugur Sahin ,  Michael Koslowski ,  Ozlem Tureci

IPC分类号： C07K16/30 ,  A61K47/48

CPC分类号： C07K16/30 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.

公开(公告)号：US20110223182A1

公开(公告)日：2011-09-15

申请号：US13119027

申请日：2009-09-16

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Rita Mitnacht-Kraus

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Rita Mitnacht-Kraus

IPC分类号： A61K39/395 ,  C07K16/30 ,  C12N5/16 ,  C12N5/09 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast Cancer, lung Cancer, gastric Cancer, ovarian Cancer, hepatocellular Cancer, colon Cancer, pancreatic Cancer, esophageal Cancer, head & neck Cancer, kidney Cancer, in particular renal cell Carcinoma, prostate Cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid Cancer, and the metastatic forms thereof. In one embodiment, the rumor disease is metastatic cancer in the lung.

摘要翻译： 本发明提供可用作治疗和/或预防与表达GT468的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，神经母细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，谣言疾病是肺中的转移性癌症。

公开(公告)号：US20090155817A1

公开(公告)日：2009-06-18

申请号：US12326997

申请日：2008-12-03

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： G01N33/53

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。

公开(公告)号：US20090081214A1

公开(公告)日：2009-03-26

申请号：US12197956

申请日：2008-08-25

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： A61K39/395 ,  A61P31/00

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39558 ,  A61K48/00 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。

公开(公告)号：US10738355B2

公开(公告)日：2020-08-11

申请号：US14119348

申请日：2012-05-23

申请人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

发明人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC分类号： C12Q1/6869 ,  A61K39/00 ,  G16B20/00 ,  G16B40/00 ,  C12Q1/6886

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

公开(公告)号：US20150337052A1

公开(公告)日：2015-11-26

申请号：US14821411

申请日：2015-08-07

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： C07K16/30

CPC分类号： C07K16/3076 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.