公开(公告)号：US07078421B2

公开(公告)日：2006-07-18

申请号：US10394487

申请日：2003-03-19

Applicant: Zuchun Zhao ,  Xin Chen ,  Jianchao Wang ,  Hongbin Sun ,  Jack Shih-Chieh Liang

Inventor： Zuchun Zhao ,  Xin Chen ,  Jianchao Wang ,  Hongbin Sun ,  Jack Shih-Chieh Liang

IPC: A61K31/4192 ,  C07D249/18 ,  C07D249/20

CPC classification number: C07D207/325 ,  C07D231/12 ,  C07D235/18 ,  C07D239/26 ,  C07D249/08 ,  C07D249/20 ,  C07D261/08 ,  C07D263/57 ,  C07D271/06 ,  C07D277/66 ,  C07D413/04 ,  C07D413/12

Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.

Abstract translation: 提供取代的苯乙酸，苯乙醇和相关化合物，其可用于治疗或控制与葡萄糖代谢，脂质代谢和胰岛素分泌相关的许多疾病。

公开(公告)号：US20060154800A1

公开(公告)日：2006-07-13

申请号：US11031475

申请日：2005-01-07

Applicant: Xin Chen

Inventor： Xin Chen

IPC: C04B35/565

CPC classification number: C04B35/565 ,  C04B35/6263 ,  C04B35/62655 ,  C04B35/6303 ,  C04B35/632 ,  C04B2235/3205 ,  C04B2235/3217 ,  C04B2235/3821 ,  C04B2235/3826 ,  C04B2235/386 ,  C04B2235/421 ,  C04B2235/422 ,  C04B2235/449 ,  C04B2235/48 ,  C04B2235/5436 ,  C04B2235/668 ,  C04B2235/767 ,  C04B2235/77

Abstract: A ceramic composite body comprising sintered silicon carbide as major phase, dispersed boron nitride/carbon granules as minor phase, and the boron nitride/carbon granules comprise hexagonal phase boron nitride powders bonded together by glassy carbon. The composite body contains at least 3 weight percent of boron nitride, the average size of the boron nitride granules is greater than 10 micrometers, and the shape of majority of the granules is irregular. The composite body of high boron nitride loading can be further processed to improve mechanical and thermal properties by filling the porosity with glassy carbon, obtained from carbonizing glassy carbon precursor. The composite material exhibits superior thermal and tribological characteristics than monolithic silicon carbide.

Abstract translation: 包含烧结碳化硅作为主相的陶瓷复合体，分散的氮化硼/碳颗粒作为次相，氮化硼/碳颗粒包含通过玻璃碳粘结在一起的六方相氮化硼粉末。 复合体含有至少3重量％的氮化硼，氮化硼颗粒的平均尺寸大于10微米，大部分颗粒的形状是不规则的。 可以进一步加工高氮化硼负载的复合体，以通过从碳化玻璃碳前体获得的玻璃碳填充孔隙率来改善机械和热性能。 复合材料表现出优于单片碳化硅的热和摩擦特性。

公开(公告)号：US20060133751A1

公开(公告)日：2006-06-22

申请号：US11015509

申请日：2004-12-16

Applicant: Xin Chen ,  Ming-Jun Li ,  Nicol Heron ,  Jeanne Swecker ,  Naiyue Zhou

Inventor： Xin Chen ,  Ming-Jun Li ,  Nicol Heron ,  Jeanne Swecker ,  Naiyue Zhou

IPC: G02B6/02

CPC classification number: C03B37/02745 ,  C03B37/032 ,  C03B37/12 ,  C03B2203/19 ,  C03B2203/36 ,  C03B2205/06 ,  G02B6/02285 ,  G02B6/278

Abstract: A method for producing low-PMD fiber, in which a glass fiber is drawn from an optical fiber perform by a tractor which pulls such optical fiber from said perform; subsequent to said tractor pulling the fiber is twisted about its axis to increase the magnitude of twist which is imparted to said fiber. The fiber is then wound onto a fiber storage spool such that at least a portion of the twist imparted to said optical fiber is retained while said fiber is wound on said spool.

Abstract translation: 一种生产低PMD纤维的方法，其中玻璃纤维从由所述表面拉动这种光纤的拖拉机执行的光纤中拉出; 在所述拖拉机拉动之后，纤维围绕其轴线扭曲以增加赋予所述纤维的捻度的大小。 然后将纤维卷绕到纤维储存卷轴上，使得当所述纤维缠绕在所述卷轴上时，赋予所述光纤的扭曲的至少一部分被保持。

公开(公告)号：US20060116325A1

公开(公告)日：2006-06-01

申请号：US10468182

申请日：2002-02-15

Applicant: Oleg Chertov ,  Joost Oppenheim ,  Xin Chen ,  Connor McGrath ,  Raymond Sowder ,  Jacek Lubkowski ,  Michele Wetzel ,  Thomas Rogers

Inventor： Oleg Chertov ,  Joost Oppenheim ,  Xin Chen ,  Connor McGrath ,  Raymond Sowder ,  Jacek Lubkowski ,  Michele Wetzel ,  Thomas Rogers

IPC: A61K38/10

CPC classification number: A61K38/162 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: Novel methods and compositions are provided for inhibiting interactions between human immunodeficiency viruses (HIVs) and viral coreceptors, including CXCR4 and/or CCR5 coreceptors. The anti-coreceptor binding agent includes a novel peptide portion of the gp120 envelope protein of HIV-1, as well as peptide analogs and mimetics of this peptide, that specifically binds to, or modulates activity of, the coreceptors(s). The anti-coreceptor binding agent is useful as a prophylactic or therapeutic treatment to prevent or inhibit HIV binding to a susceptible cell and thereby reduces infection and/or moderates or treats related diseases. In alternative embodiments, the peptides, analogs and mimetics are effective to inhibit direct co-receptor binding by HIV virus, coreceptor binding by HIV gp120 proteins or peptides, HIV fusion with target host cells, HIV virion entry into host cells, HIV replication, and HIV transmission between cells and hosts. In more detailed embodiments, the anti-coreceptor binding agents of the invention are multi-tropic by exhibiting activity against HIV interactions with multiple, CXCR4 and CCR5, coreceptors.

Abstract translation: 提供新的方法和组合物用于抑制人免疫缺陷病毒（HIV）和病毒共同受体（包括CXCR4和/或CCR5共受体）之间的相互作用。 抗感受器结合剂包括HIV-1的gp120包膜蛋白的新肽部分，以及该肽的肽类似物和模拟物，其特异性结合或调节共受体的活性。 抗感受器结合剂可用作预防或治疗性治疗以预防或抑制HIV与敏感细胞的结合，从而降低感染和/或调节或治疗相关疾病。 在替代实施方案中，肽，类似物和模拟物有效抑制HIV病毒的直接共受体结合，HIV gp120蛋白或肽的共受体结合，与靶宿主细胞的HIV融合，进入宿主细胞的HIV病毒体，HIV复制和 细胞和宿主之间的HIV传播。 在更详细的实施方案中，本发明的抗共感受体结合剂通过展现针对HIV与多种CXCR4和CCR5共受体的相互作用的活性而呈多向性。

公开(公告)号：US20060088261A1

公开(公告)日：2006-04-27

申请号：US11058309

申请日：2005-02-14

Applicant: George Berkey ,  Xin Chen ,  Joohyun Koh ,  Ming-Jun Li ,  Daniel Nolan ,  Donnell Walton ,  Ji Wang ,  Luis Zenteno

Inventor： George Berkey ,  Xin Chen ,  Joohyun Koh ,  Ming-Jun Li ,  Daniel Nolan ,  Donnell Walton ,  Ji Wang ,  Luis Zenteno

IPC: G02B6/02

CPC classification number: G02B6/03666 ,  C03B37/01234 ,  C03B37/01245 ,  C03B37/01413 ,  C03B37/01446 ,  C03B2201/12 ,  C03B2201/14 ,  C03B2201/28 ,  C03B2201/31 ,  C03B2201/36 ,  C03B2203/12 ,  C03B2203/23 ,  C03B2207/90 ,  G02B6/023 ,  G02B6/024 ,  G02B6/03611 ,  G02B6/03661 ,  H01S3/06716 ,  H01S3/0672 ,  H01S3/06729 ,  H01S3/1618 ,  H01S3/1695

Abstract: An optical fiber, comprising: (i) a rare earth doped silica based elongated core with a first refractive index (n1) with an aspect ratio of 1:5 to 1; (ii) a silica based moat abutting and at least substantially surrounding the core, the moat having a refractive index n2, wherein n2 n3; and n3>n2; (iv) a silica based outer cladding surrounding said inner cladding, the outer cladding having a fourth refractive index (n4), such that n4

Abstract translation: 一种光纤，包括：（i）具有长宽比为1:5至1的第一折射率（n <1> 1）的稀土掺杂二氧化硅基细长芯; （ii）邻接并且至少基本上围绕所述芯的基于二氧化硅的护城河，所述护城河具有折射率n 2 N 2，其中n 2 ; （iii）围绕所述护城河的基于二氧化硅的内包层，所述内包层具有第三折射率（n 3/3），其中n 1 <3> n 3 < SUB>; 和n 3 3 n 2; （iv）围绕所述内包层的基于二氧化硅的外包层，所述外包层具有第四折射率（n≥4），使得n 4 光纤在工作波长带表现出单极化。

公开(公告)号：US20060069788A1

公开(公告)日：2006-03-30

申请号：US10875471

申请日：2004-06-24

Applicant: Robert Blackmore ,  Xin Chen ,  Scott Epter ,  Chulho Kim ,  Rajeev Sivaram ,  Hanhong Xue

Inventor： Robert Blackmore ,  Xin Chen ,  Scott Epter ,  Chulho Kim ,  Rajeev Sivaram ,  Hanhong Xue

IPC: G06F15/16

CPC classification number: H04L51/18 ,  H04L69/22

Abstract: A protocol interface is provided for an active message protocol of a computing environment and a client process employing the active message protocol. The protocol interface includes an interface to a header handler function associated with the client process. The interface to the header handler function has parameters to be passed by and a parameter to be returned to the active message protocol when processing a message received through the active message protocol. The parameters to be passed include current message state information and current message type information for the received message. These parameters facilitate message-specific decisions by the header handler function about processing data of the message by the active message protocol. The parameter to be returned to the active message protocol instructs the active message protocol how to process the received message other than just where to store the message.

公开(公告)号：US20050244118A1

公开(公告)日：2005-11-03

申请号：US10837861

申请日：2004-05-03

Applicant: George Berkey ,  Xin Chen

Inventor： George Berkey ,  Xin Chen

IPC: G02B6/024 ,  G02B6/036 ,  G02B6/17

CPC classification number: G02B6/03627 ,  G02B6/024 ,  G02B6/0281 ,  G02B6/03694

Abstract: Disclosed is an optical fiber (20) having a centermost laterally-elongated core (30) having a short dimension (a), a long dimension (b) and a first refractive index (n1), a moat (40) surrounding the central laterally-elongated core, the moat (40) having a second refractive index (n2), an outer dimension (c) and an outer dimension (d), and a cladding (50) surrounding the moat (40), the cladding (50) having a third refractive index (n3), wherein n1>n3>n2, a ratio of b/a is between 1.5 and 5.0, and a ratio of d/a is between 2.0 and 7.0. The fiber supports a single (one and only one) polarization within a Single Polarization Band (SPB). The fiber (20) may be coupled to optical components in apparatus where single polarization properties are desired.

Abstract translation: 公开了一种光纤（20），其具有具有短尺寸（a），长尺寸（b）和第一折射率（n <1> 1）的中心横向细长芯部（30）， 围绕中央横向细长的芯的护城河（40），护城河（40）具有第二折射率（n 2/2），外部尺寸（c）和外部尺寸（d），以及 围绕护城河（40）的包层（50），包层（50）具有第三折射率（n 3/3），其中n 1 n 3 < / SUB >> n 2，b / a的比例在1.5和5.0之间，d / a的比率在2.0和7.0之间。 光纤支持在单极化带（SPB）内的单一（仅一个）极化。 纤维（20）可以耦合到需要单极化性质的设备中的光学部件。

公开(公告)号：US06876804B2

公开(公告)日：2005-04-05

申请号：US10392652

申请日：2003-03-20

Applicant: Xin Chen ,  Ming-Jun Li ,  Jesse C. Meyer ,  Oscar Palmer

Inventor： Xin Chen ,  Ming-Jun Li ,  Jesse C. Meyer ,  Oscar Palmer

IPC: C03B37/027 ,  C03B37/03 ,  C03B37/02 ,  C03B37/022 ,  C03B37/075

CPC classification number: G02B6/02285 ,  C03B37/02745 ,  C03B37/032 ,  C03B2203/19 ,  C03B2203/20 ,  C03B2203/36 ,  C03B2205/06

Abstract: An optical fiber, and a method of making such optical fiber, wherein the optical fiber exhibits a beatlength greater than about 5 meters, and the fiber is spun to provide a polarization mode dispersion in the spun state of said fiber which is less than 0.05 ps/km1/2. The fiber is spun by employing a spin having a spin repeat distance of at least 10 meters. The spin preferably alternates between clockwise and counterclockwise directions.

Abstract translation: 一种光纤，以及制造这种光纤的方法，其中光纤表现出大于约5米的拍子长度，并且纺丝纤维以在所述光纤的纺丝状态下提供小于0.05ps的偏振模色散 / km <1/2>。 通过采用具有至少10米的自旋重复距离的纺丝来纺丝纤维。 旋转优选地在顺时针和逆时针方向之间交替。

公开(公告)号：US06459008B1

公开(公告)日：2002-10-01

申请号：US09599612

申请日：2000-06-23

Applicant: Wei Dai ,  Jing Zhu ,  Helong Li ,  Yanlai Guo ,  Wei Mu ,  Hui Peng ,  Xin Chen

Inventor： Wei Dai ,  Jing Zhu ,  Helong Li ,  Yanlai Guo ,  Wei Mu ,  Hui Peng ,  Xin Chen

IPC: C07C402

CPC classification number: C10G45/40 ,  B01J23/6447

Abstract: A selective hydrogenation catalyst system, and a process for its preparation and its use. The catalyst system of the invention comprises a support material, a Pd-containing catalyst component and a Bi-containing cocatalyst component. The catalyst system of the invention is manufactured by impregnating the support material simultaneously or separately with Pd-containing solution, Bi-containing solution or/and one or more other cocatalyst solutions, and then drying and calcining. The activity and selectivity of the catalyst system of the invention, in selective hydrogenation of acetylenic and diolefmic compounds in hydrocarbon feeds, are significantly improved, while the green oil formation and carbon deposit on the catalyst reduced, and the service life increased and production costs decreased.

Abstract translation: 选择性氢化催化剂体系及其制备方法及其应用。 本发明的催化剂体系包括载体材料，含Pd催化剂组分和含Bi助催化剂组分。 本发明的催化剂体系是通过与含Pd溶液，含Bi的溶液或一种或多种其它助催化剂溶液同时或分开地浸渍载体材料，然后干燥和煅烧来制造的。 本发明的催化剂体系在烃类进料中炔属和二烯化合物的选择性氢化中的活性和选择性得到显着提高，而催化剂上的绿色油形成和碳沉积减少，使用寿命增加，生产成本降低 。

公开(公告)号：US06389478B1

公开(公告)日：2002-05-14

申请号：US09365696

申请日：1999-08-02

Applicant: Robert Sidney Blackmore ,  Xin Chen ,  Rama Krishna Govindaraju ,  Anan Vishwanath Hudli

Inventor： Robert Sidney Blackmore ,  Xin Chen ,  Rama Krishna Govindaraju ,  Anan Vishwanath Hudli

IPC: G06F1500

CPC classification number: H04L29/06 ,  H04L67/10 ,  H04L69/22 ,  H04L69/329

Abstract: A method for grouping I/O vectors to be transferred across a distributed computing environment comprising a plurality of processing nodes coupled together over a network. The method reduces the number of packets transmitted over a network between two or more nodes. The method includes the grouping of two or more I/O vectors into a single message, consisting of one packet with a predetermined maximum size, provided the sizes of the vectors are small enough to be placed into a single packet. The grouping method finds an efficient collection of vectors to form groups that fit inside a single packet. If two or more of the vectors can be combined so that the resulting single packet size does not exceed the predetermined maximum size, the vectors are grouped accordingly. Vectors whose size approach the predetermined maximum packet size are sent as a separate message.

Abstract translation: 一种用于分组要在分布式计算环境中传送的I / O向量的方法，包括通过网络耦合在一起的多个处理节点。 该方法减少了两个或多个节点之间通过网络传输的数据包数量。 该方法包括将两个或更多个I / O向量分组为单个消息，由具有预定最大大小的一个分组组成，只要向量的大小足够小以便放置在单个分组中。 分组方法找到有效的向量集合以形成适合单个数据包内的组。 如果可以组合两个或更多个向量，使得所得到的单个分组大小不超过预定的最大大小，则矢量被相应地分组。 大小接近预定最大数据包大小的向量作为单独消息发送。