公开(公告)号：US07781421B2

公开(公告)日：2010-08-24

申请号：US10856314

申请日：2004-05-28

Applicant: Douglas F. Covey ,  Xin Jiang

Inventor： Douglas F. Covey ,  Xin Jiang

IPC: A61K31/56 ,  A61K31/58 ,  C07J53/00 ,  C07J71/00

CPC classification number: C07J53/002 ,  C07J53/00 ,  C07J71/001

Abstract: Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent selected from the group consisting of (a) a hydroxyl or carboxyl in the α-configuration and (b) a sulfate or other negatively charged moiety; and (iii) a fused fifth ring, the fused fifth ring comprising a hydrogen bond acceptor, and (a) in the case of the pentacyclic steroid the C(13) and C(17) carbons, or (b) in the case of the pentacyclic D-homosteroid the C(13) and C(17a) carbons, having utility as anesthetics and in the treatment of disorders relating to GABA function and activity.

Abstract translation: 新型五环类固醇和五环D-类固醇激素分别包括：（i）四环类固醇环系统或四环D-类固醇环系统; （ii）选自（a）α-构型的羟基或羧基和（b）硫酸盐或其它带负电荷的部分的C（3）取代基; 和（iii）稠合的第五环，所述稠合的第五环包含氢键受体，和（a）在五环类固醇的情况下，C（13）和C（17）的碳，或（b）在 五环D-类固醇，C（13）和C（17a）碳，可作为麻醉剂用于治疗与GABA功能和活性有关的疾病。

公开(公告)号：US20100174981A1

公开(公告)日：2010-07-08

申请号：US12732113

申请日：2010-03-25

Applicant: Xin Jiang ,  Shinji Yoshida

Inventor： Xin Jiang ,  Shinji Yoshida

IPC: G06F17/00

CPC classification number: G06F8/51 ,  G06F3/1243 ,  G06F3/1257 ,  G06F17/248

Abstract: A template processor converts an initial template document into an XSL template that can be used to automatically generate reports from report data extracted from a database or other application. Users create initial template documents using a word processor or other rich-text editing application. The initial template document employs the word processor's native formatting features to specify the formatting of report data. The initial template document includes placeholder tags inserted by the user to define the locations of report data in the report. The initial template document also includes transformation tags that dynamically define the content of a report based on the value or quantity of report data. The template processor can include a reader adapted to read portions of the initial template file and a parser adapted to create corresponding XSL code from these portions. The XSL template can be combined with XML-formatted data to create a report.

Abstract translation: 模板处理器将初始模板文档转换为可用于根据从数据库或其他应用程序提取的报表数据自动生成报表的XSL模板。 用户使用文字处理器或其他富文本编辑应用程序创建初始模板文档。 初始模板文档采用字处理程序的本机格式化功能来指定报表数据的格式。 初始模板文档包括用户插入的占位符标签，用于定义报表中报表数据的位置。 初始模板文档还包括根据报表数据的值或数量动态定义报表内容的转换标签。 模板处理器可以包括适于读取初始模板文件的部分的读取器和适于从这些部分创建相应的XSL代码的解析器。 XSL模板可与XML格式的数据组合以创建报告。

公开(公告)号：US20100056777A1

公开(公告)日：2010-03-04

申请号：US12426737

申请日：2009-04-20

Applicant: Eric Anderson ,  Xin Jiang ,  Xiaofeng Liu ,  Melean Visnick

Inventor： Eric Anderson ,  Xin Jiang ,  Xiaofeng Liu ,  Melean Visnick

IPC: C07D223/14 ,  C07C61/08 ,  C07C233/57 ,  C07C49/303 ,  C07C69/74 ,  C07C243/12 ,  C07D257/04 ,  C07D285/12 ,  C07D271/10 ,  C07D313/06

CPC classification number: C07D261/20 ,  C07C69/757 ,  C07D207/27 ,  C07D413/08 ,  C07J63/008

Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

Abstract translation: 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。

公开(公告)号：US20090181390A1

公开(公告)日：2009-07-16

申请号：US12263152

申请日：2008-10-31

Applicant: Xianqiang Li ,  Xin Jiang

Inventor： Xianqiang Li ,  Xin Jiang

IPC: C12Q1/68

CPC classification number: C12Q1/6837 ,  C12Q2525/207 ,  C12Q2525/313 ,  C12Q2561/125 ,  C12Q2525/161

Abstract: Methods, compositions and kits are provided for high throughput detection of micro RNAs (miRNA), especially for sensitive and specific detection of miRNA that are in low abundance and closely related to each other. In particular, an assembly of designed oligonucleotide probes with unique tag sequences is used to achieve these purposes via high throughput microarrays, optionally in conjunction with branched-DNA based array detection. The assays can be used for diagnosis, prognosis or monitoring of diseases or disorders such as cancer, for pharmacogenomic studies of patient stratification and drug responses, for discovery of therapeutic targets, or for forensic analysis.

Abstract translation: 提供方法，组合物和试剂盒用于微量RNA（miRNA）的高通量检测，特别是对于低丰度且彼此密切相关的miRNA的敏感和特异性检测。 特别地，使用具有独特标签序列的设计的寡核苷酸探针的组合来通过高通量微阵列实现这些目的，任选地与基于分支DNA的阵列检测结合。 该测定可用于疾病或病症如癌症的诊断，预后或监测，患者分层和药物反应的药物基因组研究，用于发现治疗靶点或进行法医分析。

公开(公告)号：US07378492B2

公开(公告)日：2008-05-27

申请号：US10504973

申请日：2003-02-18

Applicant: Narinder K. Chawla ,  Henry Yue ,  Thomas W. Richardson ,  Joseph P. Marquis ,  Patricia M. Lehr-Mason ,  Ann E. Gorvad ,  Shanya D. Becha ,  Amy E. Kable ,  Anita Swarnakar ,  Pei Jin ,  Phillip R. Hawkins ,  David Chien ,  Jayalaxmi Ramkumar ,  Uyen K. Tran ,  April J. A. Hafalia ,  Mariah R. Baughn ,  Soo Yeun Lee ,  Xin Jiang ,  Alan A. Jackson ,  Reena Khare ,  Sean A. Bulloch

Inventor： Narinder K. Chawla ,  Henry Yue ,  Thomas W. Richardson ,  Joseph P. Marquis ,  Patricia M. Lehr-Mason ,  Ann E. Gorvad ,  Shanya D. Becha ,  Amy E. Kable ,  Anita Swarnakar ,  Pei Jin ,  Phillip R. Hawkins ,  David Chien ,  Jayalaxmi Ramkumar ,  Uyen K. Tran ,  April J. A. Hafalia ,  Mariah R. Baughn ,  Soo Yeun Lee ,  Xin Jiang ,  Alan A. Jackson ,  Reena Khare ,  Sean A. Bulloch

IPC: C07K14/705 ,  C07K19/00

CPC classification number: C07K14/705 ,  C07K16/28

Abstract: Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.

Abstract translation: 本发明的各种实施方案提供鉴定和编码REMAP的人受体和膜相关蛋白（REMAP）和Q多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与REMAP异常表达相关的紊乱的方法。

公开(公告)号：US20070208997A1

公开(公告)日：2007-09-06

申请号：US11383069

申请日：2006-05-12

Applicant: Xin Jiang ,  Shinji Yoshida ,  Itsuo Okamoto

Inventor： Xin Jiang ,  Shinji Yoshida ,  Itsuo Okamoto

IPC: G06F15/00

CPC classification number: C12Q1/6806 ,  C12Q1/6844 ,  G06F17/218 ,  G06F17/2247 ,  G06F17/227 ,  C12Q2537/149 ,  C12Q2521/107

Abstract: This disclosure describes systems, methods and software programs for transforming and/or translating a variety of documents, including without limitation XSL documents. In one aspect, any static information may be removed from XSL/FO files before transforming those files. This can greatly enhance the speed of transformation of such files. In another aspect, an XSL/FO file can be tagged in order to allow for the identification of the translatable data, such that the translatable data can be removed from the XSL/FO file and inserted into an XLIFF file. The translatable data can be then translated (e.g., by an automated process, by a human translator, etc.) and/or inserted back into an XSL file after translation.

Abstract translation: 本公开描述了用于转换和/或翻译各种文档的系统，方法和软件程序，包括但不限于XSL文档。 在一方面，在转换这些文件之前，可以从XSL / FO文件中删除任何静态信息。 这样可以大大提高这些文件的转换速度。 在另一方面，可以标记XSL / FO文件以便允许识别可翻译数据，使得可以从XSL / FO文件移除可翻译的数据并将其插入到XLIFF文件中。 然后可以翻译可翻译的数据（例如，通过自动处理，由人类翻译器等）和/或在翻译后被插入到XSL文件中。

公开(公告)号：US20070065820A1

公开(公告)日：2007-03-22

申请号：US10534579

申请日：2003-11-10

Applicant: Xin Jiang ,  Shanya Becha ,  Sean Bulloch ,  Hsin-Ru Chang ,  Narinder Chawla ,  Vicki Elliott ,  Brooke Emerling ,  Kimberly Gietzen ,  April Hafalia ,  Alan Jackson ,  Amy Kable ,  Reena Khare ,  Soo Lee ,  Joseph Marquis ,  Jagi Murage ,  Anita Swarnakar ,  Yonghong Yang

Inventor： Xin Jiang ,  Shanya Becha ,  Sean Bulloch ,  Hsin-Ru Chang ,  Narinder Chawla ,  Vicki Elliott ,  Brooke Emerling ,  Kimberly Gietzen ,  April Hafalia ,  Alan Jackson ,  Amy Kable ,  Reena Khare ,  Soo Lee ,  Joseph Marquis ,  Jagi Murage ,  Anita Swarnakar ,  Yonghong Yang

IPC: C12Q1/68 ,  C40B30/06 ,  C07K14/775 ,  A61K38/17 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N1/21

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Various embodiments of the invention provide human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM.

Abstract translation: 本发明的各种实施方案提供了识别和编码LIPAM的人类脂质相关分子（LIPAM）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其它实施方案提供用于诊断，治疗或预防与LIPAM异常表达相关的障碍的方法。

公开(公告)号：US07056665B2

公开(公告)日：2006-06-06

申请号：US10053516

申请日：2002-01-16

Applicant: Xianqiang Li ,  Xin Jiang

Inventor： Xianqiang Li ,  Xin Jiang

IPC: G01N33/53 ,  C07H21/04 ,  C12P19/34

CPC classification number: C40B30/04 ,  C12Q1/6897 ,  G01N33/6845

Abstract: A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived from a sample of cells, the sequence from the cDNA library varying within the cell library; contacting the library of cells with a plurality of agents which may affect protein degradation rates; for each agent, selecting cells in the library which express short-lived proteins based on whether the cells have different reporter signal intensities than other cells in the library, the difference being indicative of the selected cells expressing shorter lived fusion proteins than the fusion proteins expressed by the other cells in the library; and characterizing the fusion proteins expressed by the selected cells for each agent.

公开(公告)号：US20050158047A1

公开(公告)日：2005-07-21

申请号：US10893750

申请日：2004-07-16

Applicant: Winston Way ,  Xin Jiang ,  Cedric Lam

Inventor： Winston Way ,  Xin Jiang ,  Cedric Lam

IPC: H04B10/00 ,  H04B10/20 ,  H04B10/213

CPC classification number: H04J14/0283 ,  H04B10/032 ,  H04J14/0204 ,  H04J14/0205 ,  H04J14/0209 ,  H04J14/021 ,  H04J14/0213 ,  H04J14/0217 ,  H04J14/0226 ,  H04J14/0227 ,  H04J14/0232 ,  H04J14/0238 ,  H04J14/0241 ,  H04J14/0294

Abstract: This application describes, among others, fiber ring networks with two fiber rings to provide local fiber failure protection in each node and capability for each node to broadcast to other nodes, and to establish uni-directional and bi-directional communications with one or more selected nodes. Each optical channel may have a single optical break point in the ring networks and this single optical break point is located in a designated node. Various application may advantageously use such ring networks such as ring networks with asymmetric traffic like video-on-demand systems and other information systems.

Abstract translation: 此应用描述了具有两个光纤环的光纤环网络，以在每个节点中提供本地光纤故障保护，并且每个节点能够广播到其他节点，并且建立与一个或多个所选择的单向和双向通信 节点。 每个光信道可以在环网中具有单个光断点，并且该单个光断点位于指定节点中。 各种应用可以有利地使用诸如视频点播系统和其他信息系统之类的诸如具有不对称业务的环网的环网。

公开(公告)号：US20050060313A1

公开(公告)日：2005-03-17

申请号：US10663296

申请日：2003-09-15

Applicant: Aman Naimat ,  Allison Waingold ,  Xin Jiang ,  John Kowtko

Inventor： Aman Naimat ,  Allison Waingold ,  Xin Jiang ,  John Kowtko

IPC: G06F17/30

CPC classification number: G06Q30/02 ,  G06Q10/10

Abstract: A method of and system for evaluating contacts stored in data source. In one embodiment the method allows a user to define a data format; allows a user to define a plurality of rules intended to operate on and assess a quality of data formatted according to the data format; map data identifying a plurality of contacts from the data source to the data format; and execute the plurality of rules on the mapped data to produce a set of analyzed data that allows evaluation of potential contacts according to an assessed quality of the data.

Abstract translation: 用于评估存储在数据源中的联系人的方法和系统。 在一个实施例中，该方法允许用户定义数据格式; 允许用户定义旨在对根据数据格式格式化的数据的质量进行操作和评估的多个规则; 将从数据源识别多个联系人的数据映射到数据格式; 并对映射的数据执行多个规则以产生一组分析数据，其允许根据所评估的数据质量评估潜在的联系人。