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    Human G-protein coupled receptors
    61.
    发明申请
    Human G-protein coupled receptors 审中-公开
    人类G蛋白偶联受体

    公开(公告)号：US20050123961A1

    公开(公告)日：2005-06-09

    申请号：US10968990

    申请日：2004-10-21

    申请人： Yi Li ,  Steven Ruben

    发明人： Yi Li ,  Steven Ruben

    IPC分类号： C12N15/09 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/74

    CPC分类号： C07K14/705

    摘要： Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

    摘要翻译： 公开了两种人G-蛋白偶联受体多肽和编码每种这样的多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽鉴定这种多肽的拮抗剂和激动剂的方法。 还公开了用于检测每个G蛋白偶联受体的核酸序列中的突变的诊断方法。

    Antibodies that bind human prostate specific G-protein receptor HPRAJ70
    63.
    发明授权
    Antibodies that bind human prostate specific G-protein receptor HPRAJ70 失效
    结合人前列腺特异性G蛋白受体HPRAJ70的抗体

    公开(公告)号：US06824993B2

    公开(公告)日：2004-11-30

    申请号：US09968033

    申请日：2001-10-02

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K1618

    CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

    摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

    摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

    Human amine transporter antibodies
    64.
    发明授权
    Human amine transporter antibodies 失效
    人类胺转运蛋白抗体

    公开(公告)号：US06630443B2

    公开(公告)日：2003-10-07

    申请号：US09502018

    申请日：2000-02-11

    申请人： Yi Li ,  Liang Cao ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Craig A. Rosen

    IPC分类号： C07K1618

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.

    摘要翻译： 公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。 还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

    Treatment of fabrics
    65.
    发明授权
    Treatment of fabrics 失效
    面料处理

    公开(公告)号：US06454814B1

    公开(公告)日：2002-09-24

    申请号：US09665061

    申请日：2000-09-19

    申请人： Weilin Xu ,  Yi Li ,  Kwok Wing Yeung ,  Kwok Yi Lin

    发明人： Weilin Xu ,  Yi Li ,  Kwok Wing Yeung ,  Kwok Yi Lin

    IPC分类号： D06M1300

    CPC分类号： D06M14/04 ,  D06M2101/06 ,  D06M2200/00

    摘要： A method of treating a fabric including cellulose fiber to increase water absorption and hydrophilicity by graft polymerisation. The method includes pre-treating the fabric in a solution of an inhibitor for about one hour, and washing the fabric to remove excess inhibitor solution. The fabric is placed in a grafting solution of a hydrophilic monomer for about three hours, washed in methanol, and decrystallized in a solution of zinc chloride for about one hour. The decrystallised fabric is then treated in a solution of sodium hydroxide at 50° C. for about one hour.

    摘要翻译： 一种处理含纤维素纤维的织物以通过接枝聚合增加吸水性和亲水性的方法。 该方法包括将织物在抑制剂溶液中预处理约1小时，并洗涤织物以除去过量的抑制剂溶液。 将织物置于亲水性单体的接枝溶液中约3小时，在甲醇中洗涤，并在氯化锌溶液中结晶约1小时。 然后将去结晶的织物在50℃的氢氧化钠溶液中处理约1小时。

    Human neuropeptide receptor
    66.
    发明授权
    Human neuropeptide receptor 失效
    人神经肽受体

    公开(公告)号：US06410701B1

    公开(公告)日：2002-06-25

    申请号：US08462509

    申请日：1995-06-05

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen

    IPC分类号： C07H2102

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K16/286 ,  C12N2799/026 ,  C12N2799/027 ,  G01N2333/70571 ,  G01N2333/726 ,  G01N2500/10

    摘要： Human neuropeptide receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the neuropeptide receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the neuropeptide receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人类神经肽受体多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与神经肽受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测神经肽受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    G-protein parathyroid hormone receptor HLTDG74
    67.
    发明授权
    G-protein parathyroid hormone receptor HLTDG74 失效

    公开(公告)号：US06338951B1

    公开(公告)日：2002-01-15

    申请号：US09236468

    申请日：1999-01-25

    申请人： Daniel Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K1472

    CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    Transgenic seedless fruit comprising AGL or GH3 promoter operably linked to isopentenyl transferase or tryptophan monooxygenase coding DNA
    68.
    发明授权
    Transgenic seedless fruit comprising AGL or GH3 promoter operably linked to isopentenyl transferase or tryptophan monooxygenase coding DNA 失效
    包含与异戊烯基转移酶或色氨酸单加氧酶编码DNA可操作连接的AGL或GH3启动子的转基因无核果实

    公开(公告)号：US06268552B1

    公开(公告)日：2001-07-31

    申请号：US09073587

    申请日：1998-05-06

    申请人： Yi Li

    发明人： Yi Li

    IPC分类号： A01H500

    CPC分类号： C12N9/1085 ,  C12N9/0069 ,  C12N15/8233 ,  C12N15/8235 ,  C12N15/8287 ,  C12N15/8294 ,  C12N15/8295 ,  C12N15/8297

    摘要： The present invention provides methods and DNA constructs for the genetic engineering of plant cells to produce plants which produce substantially seedless fruit in the absence of exogenous growth factors (auxins or cytokinins) and in the absence of pollination. The substantially seedless fruits produced by the methods described herein are about the size of wildtype seeded fruit (or somewhat larger) and these fruits are equal to or superior to the wildtype seeded fruit with respect to solid content and flavor. The seedless fruits of the present invention are produced in transgenic plants which contain and express auxin or cytokinin biosynthetic genes, e.g., tryptophan oxygenase or isopentenyl transferase coding sequences expressed under the regulatory control of GH3 or AGL promoter sequences directing preferential or tissue specific expression of a downstream gene in the ovaries or developing fruit.

    摘要翻译： 本发明提供用于植物细胞遗传工程的方法和DNA构建体，用于在没有外源性生长因子（生长素或细胞分裂素）的情况下以及不存在授粉的情况下产生基本上无籽果实的植物。 通过本文描述的方法产生的基本无籽的果实是关于野生型种子果实的大小（或稍大），并且这些果实相对于固体含量和风味等于或优于野生型种子果实。 本发明的无核果实在含有并表达生长素或细胞分裂素生物合成基因的转基因植物中产生，例如在GH3或AGL启动子序列的调节控制下表达的色氨酸加氧酶或异戊烯基转移酶编码序列，其指导优先或组织特异性表达 下游基因在卵巢或发育水果。

    Human G-protein receptor HPRAJ70
    69.
    发明授权
    Human G-protein receptor HPRAJ70 失效

    公开(公告)号：US5948890A

    公开(公告)日：1999-09-07

    申请号：US53303

    申请日：1998-04-01

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K14/705 ,  C07K16/28

    CPC分类号： C07K16/28 ,  A61K2039/505

    摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    Polynucleotides encoding human G-protein coupled receptor HIBEF51
    70.
    发明授权
    Polynucleotides encoding human G-protein coupled receptor HIBEF51 失效
    编码人G蛋白偶联受体HIBEF51的多核苷酸

    公开(公告)号：US5942414A

    公开(公告)日：1999-08-24

    申请号：US465971

    申请日：1995-06-06

    申请人： Yi Li ,  Mark D. Adams

    发明人： Yi Li ,  Mark D. Adams

    IPC分类号： C07H21/04 ,  C07K14/705 ,  C12N15/09 ,  C12N15/12

    CPC分类号： C07K14/705

    摘要： Human G-protein Coupled receptor HIBEF51 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the human G-protein Coupled receptor HIBEF51 nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了人G-蛋白偶联受体HIBEF51多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测人G-蛋白偶联受体HIBEF51核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。