公开(公告)号：US08124814B2

公开(公告)日：2012-02-28

申请号：US12304391

申请日：2007-06-12

申请人： Philippe Krafft ,  Patrick Gilbeau ,  Dominique Balthasart

发明人： Philippe Krafft ,  Patrick Gilbeau ,  Dominique Balthasart

IPC分类号： C07C31/34

CPC分类号： C07C29/62 ,  C07C29/80 ,  C12C11/02 ,  C07C31/36

摘要： The invention relates to a crude glycerol-based product comprising glycerol alkyl ethers, to a purification process comprising a treatment of evaporative concentration, of evaporative crystallization, of distillation, of fractional distillation, of stripping, or of liquid-liquid extraction and to the use of the purified product in the manufacture of dichloropropanol.

摘要翻译： 本发明涉及包含甘油烷基醚的粗甘油基产物，涉及包括蒸发浓缩，蒸发结晶，蒸馏，分馏，汽提或液 - 液萃取的处理和使用的纯化方法 的纯化产物在二氯丙醇的制造中。

公开(公告)号：US08106246B2

公开(公告)日：2012-01-31

申请号：US13051007

申请日：2011-03-18

申请人： Philippe Krafft ,  Christian Franck ,  Ivan de Andolenko ,  Roger Veyrac

发明人： Philippe Krafft ,  Christian Franck ,  Ivan de Andolenko ,  Roger Veyrac

IPC分类号： C07C31/34 ,  C07D301/26

CPC分类号： C07C29/62 ,  C07C31/38

摘要： Process for the manufacture of dichloropropanol in which glycerol is reacted with a chlorinating agent comprising hydrochloric acid in a liquid medium in equilibrium with a vapor phase and in which the condensation of a fraction exhibiting the composition of the vapor phase is prevented.

摘要翻译： 制备二氯丙醇的方法，其中甘油与包含盐酸的氯化剂在与气相平衡的液体介质中反应，并且其中防止表现出气相组成的馏分的冷凝。

公开(公告)号：US08106245B2

公开(公告)日：2012-01-31

申请号：US11914891

申请日：2006-05-19

申请人： Philippe Krafft ,  Patrick Gilbeau

发明人： Philippe Krafft ,  Patrick Gilbeau

IPC分类号： C07C31/34 ,  C07D301/02 ,  C08G59/00

CPC分类号： B01D3/143 ,  C07C29/62 ,  C07C29/82 ,  C07D301/02 ,  C07D301/06 ,  C07D301/26 ,  C07D303/08 ,  C07C31/36

摘要： Process for preparing a chlorohydrin, wherein a polyhydroxylated aliphatic hydrocarbon whose total metal content, expressed in elemental form, is greater than or equal to 0.1 μg/kg and less than or equal to 1000 mg/kg is reacted with a chlorinating agent.

摘要翻译： 制备氯代醇的方法，其中总金属含量（以元素形式表示）大于或等于0.1μg/ kg且小于或等于1000mg / kg的多羟基化脂族烃与氯化剂反应。

公开(公告)号：US20120010420A1

公开(公告)日：2012-01-12

申请号：US13238206

申请日：2011-09-21

申请人： Patrick GILBEAU ,  Ivan DE ANDOLENKO ,  Philippe Krafft ,  Freddy Gielen

发明人： Patrick GILBEAU ,  Ivan DE ANDOLENKO ,  Philippe Krafft ,  Freddy Gielen

IPC分类号： C07D301/26 ,  C07D303/08 ,  C07C29/86 ,  C07C29/80 ,  C07C31/36 ,  C07C29/74

CPC分类号： C07C29/62 ,  C07C29/76 ,  C07C29/82 ,  C07D301/02 ,  C07D301/26 ,  C07D303/08 ,  C07C31/36

摘要： Process for producing a chlorohydrin by reaction between a multihydroxylated-aliphatic hydrocarbon, an ester of a multihydroxylated-aliphatic hydrocarbon, or a mixture thereof, and a chlorinating agent, according to which the multihydroxylated-aliphatic hydrocarbon, the ester of a multihydroxylated-aliphatic hydrocarbon, or the mixture thereof used contains at least one solid or dissolved metal salt, the process comprising a separation operation to remove at least part of the metal salt.

摘要翻译： 多羟基化脂肪族烃，多羟基化脂肪族烃或其混合物的酯与氯化剂反应生成氯代醇的方法，根据该方法，多羟基化脂肪族烃，多羟基化脂肪族烃 ，或其使用的混合物含有至少一种固体或溶解的金属盐，该方法包括去除至少部分金属盐的分离操作。

公开(公告)号：US08088957B2

公开(公告)日：2012-01-03

申请号：US11628269

申请日：2005-07-18

申请人： William J. Kruper, Jr. ,  David J. Schreck ,  Kenneth L. Kearns ,  Richard D. Varjian ,  Mark E. Jones ,  Robert M. Campbell ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

发明人： William J. Kruper, Jr. ,  David J. Schreck ,  Kenneth L. Kearns ,  Richard D. Varjian ,  Mark E. Jones ,  Robert M. Campbell ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

IPC分类号： C07C31/34

CPC分类号： C07D301/24 ,  C07C29/62 ,  C07C29/82 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

摘要翻译： 本发明涉及将多羟基化脂肪族烃或其酯转化为氯代醇的方法，该方法是将多羟基化脂族烃或其起始原料与氯化氢的超大气压分压源接触足够的时间和 足够的温度，并且其中这种收缩步骤在不显着除去水的情况下进行，以产生所需的氯代醇产物; 其中所需的产物或产物可以高产率制备而不显着形成不需要的过氯化副产物。 此外，本发明的某些催化剂可以在超大气压，大气压和低于大气压的条件下用于本方法，并具有改进的结果。

公开(公告)号：US20110152580A1

公开(公告)日：2011-06-23

申请号：US12595488

申请日：2008-04-11

申请人： Bruce D. Hook ,  Anna Forlin ,  Andrei S. Merenov ,  Danil Tirtowidjolo ,  Anil J. Mehta ,  Jan W. Verwijs ,  Aaltje Verwijs-van den Brink ,  Lena Verwijs ,  Hendrika Gerrita Verwijs ,  Wilma Hensen

发明人： Bruce D. Hook ,  Anna Forlin ,  Andrei S. Merenov ,  Danil Tirtowidjolo ,  Anil J. Mehta ,  Jan W. Verwijs ,  Aaltje Verwijs-van den Brink ,  Lena Verwijs ,  Hendrika Gerrita Verwijs ,  Wilma Hensen

IPC分类号： C07C31/34 ,  B01J8/00

CPC分类号： B01D3/38 ,  B01D3/14 ,  B01D3/146 ,  B01D3/36 ,  C07C29/62 ,  Y02P20/127 ,  C07C31/42

摘要： A process for converting multihydroxylated-aliphatic hydrocarbon compound(s) and/or ester(s) thereof to chlorohydrins and/or esters thereof is disclosed in which one or more of multihydroxylated-aliphatic hydrocarbon compound(s) and/or ester(s) thereof and/or monochlorohydrin(s) and/or ester(s) thereof with at least one chlorinating feed stream comprising at least one chlorinating agent and at least one impurity having a boiling point below the boiling point of the chlorohydrin product having the lowest boiling under hydrochlorination conditions, optionally in the presence of water, one or more catalyst(s), and/or one or more heavy byproduct(s) in a reaction vessel under hydrochlorination conditions, wherein the liquid-phase reaction mixture is maintained at a temperature below the boiling point of the chlorohydrin product having the lowest boiling point under hydrochlorination conditions and greater than the boiling point(s) of the at least one impurity and a vapor phase vent stream comprising the at least one impurity is removed from the liquid phase reaction mixture. An apparatus suitable for carrying out the disclosed process is illustrated in FIG. 1 of the drawings. The process and apparatus improve conversion rates and/or provide for recovery of chlorinating agent for lower operating costs.

摘要翻译： 公开了一种将多羟基化脂族烃化合物和/或其酯转化为氯醇和/或其酯的方法，其中一种或多种多羟基化脂族烃化合物和/或酯（一种或多种） 和/或一氯代醇和/或其酯与至少一种氯化进料流一起包含至少一种氯化剂和至少一种沸点低于具有最低沸点的氯代醇产物的沸点的杂质 在氢氯化条件下，任选地在氢氯化条件下在反应容器中存在水，一种或多种催化剂和/或一种或多种重质副产物，其中将液相反应混合物保持在温度 低于氢氯化条件下具有最低沸点的氯代醇产物的沸点并且大于至少一种杂质的沸点和气相排出流c 从液相反应混合物中除去至少一种杂质。 图1中示出了适用于执行所公开的处理的装置。 1图。 该方法和设备提高转化率和/或提供氯化剂的回收以降低运行成本。

公开(公告)号：US20110124892A1

公开(公告)日：2011-05-26

申请号：US13017681

申请日：2011-01-31

申请人： William J. Kruper, JR. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

发明人： William J. Kruper, JR. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

IPC分类号： C07D301/26 ,  C07C29/60 ,  C07C67/00

CPC分类号： C07D301/27 ,  C07C29/62 ,  C07C67/08 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.

公开(公告)号：US20110124890A1

公开(公告)日：2011-05-26

申请号：US13017645

申请日：2011-01-31

申请人： William J. Kruper ,  Tina Arrowood ,  Bruce M. Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

发明人： William J. Kruper ,  Tina Arrowood ,  Bruce M. Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

IPC分类号： C07D301/30 ,  C07C31/42

CPC分类号： C07D301/27 ,  C07C29/62 ,  C07C67/08 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.

摘要翻译： 本发明涉及一种将多羟基化脂肪族烃或其酯转化为氯代醇的方法，其通过使多羟基化的脂族烃或其起始原料与超大气压，大气压和低于大气压的条件下的氯化氢源接触足够的 时间和足够的温度，优选地其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 所述方法没有进行特别去除挥发性氯化烃副产物或氯丙酮的步骤，其中在所述方法的任何阶段，挥发性氯化烃副产物和氯丙酮的组合浓度小于2000ppm。

公开(公告)号：US20100324344A1

公开(公告)日：2010-12-23

申请号：US12525913

申请日：2009-02-14

申请人： Koji Hagiya

发明人： Koji Hagiya

IPC分类号： C07C33/46

CPC分类号： C07C29/62 ,  C07C29/147 ,  C07C29/58 ,  C07C51/363 ,  C07C67/14 ,  C07C33/46 ,  C07C63/68 ,  C07C69/76

摘要： A process for producing 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol including the following steps: (A): a step for fluorinating 2,3,5,6-tetrachloroterephthaloyl dichloride, (B): a step for reducing the product obtained in step (A), (C): a step for chlorinating the product obtained in step (B), and Step (D): a step for hydrogenating the product obtained in step (C).

摘要翻译： 包括以下步骤的制备4-甲基-2,3,5,6-四氟苄醇的方法：（A）：用于氟化2,3,5,6-四氯对苯二甲酰氯的步骤，（B）：还原步骤 在步骤（A），（C）中获得的产物：步骤（B）中获得的产物的氯化步骤和步骤（D）：步骤（C）中获得的产物氢化步骤。

公开(公告)号：US20080281132A1

公开(公告)日：2008-11-13

申请号：US12092178

申请日：2006-11-08

申请人： Philippe Krafft ,  Christian Franck ,  Ivan de Andolenko ,  Roger Veyrac

发明人： Philippe Krafft ,  Christian Franck ,  Ivan de Andolenko ,  Roger Veyrac

IPC分类号： C07C31/34

CPC分类号： C07C29/62 ,  C07C31/38

摘要： Process for the manufacture of dichloropropanol in which glycerol is reacted with a chlorinating agent comprising hydrochloric acid in a liquid medium in equilibrium with a vapour phase and in which the condensation of a fraction exhibiting the composition of the vapour phase is prevented.

摘要翻译： 制备二氯丙醇的方法，其中甘油与包含盐酸的氯化剂在与气相平衡的液体介质中反应，并且其中防止表现出气相组成的馏分的冷凝。