摘要:
4,5-DISUBSTITUTED-3-HYDROXYCYCLOPENTANONES (I) ARE PREPARED BY HYDROGENOLYZING THE CORRESPONDING 4,5-DISUBSTITUTED-2,3-EPOXYCYCLOPENTANONE (IV) WHICH IN TURN IS PROVIDED BY REACTING THE CORRESPONDING 4,5-DISUBSTITUTED2-CYCLOPENTEN-1-ONE (111) WITH ALKINE HYDROGEN PEROXIDE. COMPOUNDS (111) ARE PREPARED BY CYCLIZING THE CORRESPONDING 2,3-DISUBSTITUTED LEVULINALDEHYDE (11) WITH A BASE. THE PRODUCTS OF THE PROCESS ARE BIOLOGICALLY ACTIVE, ESPECIALLY COMPOUND (1) SUBSTITUTED IN THE 4-POSITION WITH 3'', -HYDROXYOCTYL AND IN THE 5-POSITION WITH 6'' -CARBOXYHEXYL. THIS COMPOUND HAS PROSTAGLANDIN-LIKE ACTIVITY, ACTIVITY BLOOD PRESSURE LOWERING AND BRONCHODILATOR E1ESPEACTIVITY, AND IS A TOTALLY-SYNTHETIC DIHYDROPROSTAGLANDIN E1 (DIHYDRO PGE1). THE PROCESSES OF THE INVENTION MAY ALSO BE USED TO OBTAIN COMPOUNDS WITH PROSTAGLANDINLIKE ACTIVITY FROM APPROPRIATELY SUBSTITUTED NATURALLY OCCURRING CYCLOPENTANONES, E.G. THOSE ISOLATED FROM THE CARIBBEAN GORGONIAN, PLEXAURA HOMOMALLA.
摘要:
A HYDROGENATED INDANE DERIVATIVE HAVING THE FORMULA:
DIHYDROINDAN-2-YL OR TETRAHYDROINDAN-2-YL
WHEREIN THE DASHED LINES REPRESENTS SINGLE OR DOUBLE BONDS, NO MORE THAN TWO OF THE DASHED LINES REPRESENT DOUBLE BONDS AND WHEN TWO DOUBLE BONDS ARE PRSENT, SUCH BONDS BEING CONJUGATED OR UNCONJUGATED; PERFUME COMPOSITION CONTAINING SUCH INDANES; AND PROCESSES FOR PRODUCING SAME.
摘要:
THIS INVENTION IS DIRECTED TO A PROCESS FOR PRODUCING 3ETHYL - 10,11 - EPOXY-2,6-DODECADIENOIC ACID DERIVATIVES WHICH ARE USEFUL IN KILLING AND PREVENTNG PROLIFERATION OF INSECTS BY UPSETTING THEIR HORMONE BALANCE FROM 3,7-DILOWER ALKYL-1,6-OCTAFIEN-3-OLS AND INTERMEDIATES THEREIN.