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98 条记录 (耗时 0.069 秒)

    Substituted pyridoindoles as serotonin agonists and antagonists
    68.
    发明申请
    Substituted pyridoindoles as serotonin agonists and antagonists 有权
    取代的吡啶并吲哚作为血清素激动剂和拮抗剂

    公开(公告)号：US20020173503A1

    公开(公告)日：2002-11-21

    申请号：US10026611

    申请日：2001-12-19

    发明人： Albert Robichaud ,  John M. Fevig ,  Ian S. Mitchell ,  Taekyu Lee ,  Wenting Chen ,  Joseph Cacciola

    IPC分类号： A61K031/553 ,  A61K031/554 ,  A61K031/551 ,  C07D487/22

    CPC分类号： C07D471/16 ,  C07D498/16 ,  C07D513/16

    摘要： The present invention is directed to certain novel compounds represented by structural Formula (I) 1 or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9, X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

    摘要翻译： 本发明涉及由结构式（I）表示的某些新化合物或其药学上可接受的盐形式，其中R1，R5，R6，R7，R8，R9，X，b，k和n以及虚线是 在此描述。 本发明还涉及包含这些新化合物作为活性成分的药物制剂，以及新型化合物及其制剂在治疗某些疾病中的用途。 本发明的化合物是血清素激动剂和拮抗剂，可用于控制或预防中枢神经系统疾病，包括肥胖症，焦虑症，抑郁症，精神病，精神分裂症，睡眠障碍，性障碍，偏头痛，与头痛相关的病症，社交恐怖症 ，以及胃肠道疾病如胃肠道运动功能障碍。

    CRF receptor antagonists and methods relating thereto
    69.
    发明申请
    CRF receptor antagonists and methods relating thereto 失效
    CRF受体拮抗剂及其相关方法

    公开(公告)号：US20020049203A1

    公开(公告)日：2002-04-25

    申请号：US09861195

    申请日：2001-05-18

    发明人： Mustapha Haddach ,  John Patrick Williams ,  Dragan Marinkovic ,  Jane Han Bu

    IPC分类号： A61K031/542 ,  A61K031/5383 ,  A61K031/519 ,  A61K031/4745

    CPC分类号： C07D491/16 ,  C07D498/16 ,  C07D513/16

    摘要： CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: 1 including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein m, R, R1, R2, X, Y, A, B and C are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same

    摘要翻译： 公开了CRF受体拮抗剂，其可用于治疗各种疾病，包括治疗在温血动物（例如中风）中表现出CRF过度分泌的病症。 本发明的CRF受体拮抗剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中m，R，R 1，R 2，X，Y，A，B和C如本文所定义。 还公开了含有CRF受体拮抗剂与药学上可接受的载体的组合物，以及其用途的方法