公开(公告)号：US5135498A

公开(公告)日：1992-08-04

申请号：US503720

申请日：1990-04-02

申请人： Robert J. Kam ,  Rolf A. Faste ,  Anthony J. Castro

发明人： Robert J. Kam ,  Rolf A. Faste ,  Anthony J. Castro

IPC分类号： A61M5/148

CPC分类号： A61M5/1483 ,  A61M5/148 ,  Y10S128/12

摘要： A means for elimination or compression of trapped air spaces in osmotically powered pumps is disclosed in which the housing of the pump is constructed of movable portions so that movement of the said housing portions will force air out of the device or compress it to such an extent that activation of the pump will result in the minimum lag time between activation of the pump and infusate flow.

摘要翻译： 公开了一种用于消除或压缩渗透动力泵中的被捕获的空气空间的装置，其中泵的壳体由可移动部分构成，使得所述壳体部分的运动将迫使空气流出设备或将其压缩到这样的程度 泵的激活将导致泵的激活和输注流之间的最小滞后时间。

公开(公告)号：US5108367A

公开(公告)日：1992-04-28

申请号：US682871

申请日：1991-04-08

申请人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniva

发明人： Paul Epstein ,  Harry Petschek ,  Eric LaWhite ,  Clair Strohl ,  Henry Coyne ,  Edward Kaleskas ,  George Adaniva

IPC分类号： A61M5/142 ,  A61M5/168 ,  A61M5/172

CPC分类号： A61M5/14224 ,  A61M5/172 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M5/16827 ,  Y10S128/12

摘要： An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact. Air bubbles in the fluid line are automatically detected and disposed of. Fluid pressures are monitored and system operation adjusted as a function of such pressures. Infusates may be administered from syringes as well as from standard bag or bottle containers. Infusate from a selected input port may be controllably pumped into a syringe for unsticking the syringe plunger. The system is selectively operable to adjust total fluid volume and rate to below preselected values for patients whose total intake must be restricted. The system is operable to maintain an accurate record of total infusion history.

摘要翻译： 一种输注系统，用于以多个流体输入端口中的任何一个或多个通过患者输出端口并进入患者的循环系统，以单独可编程的速率，体积和顺序管理多个输注物。 输注物可以是连续的或时间依次施用的，并且输注物可以间歇地以选择性的定期间隔或时间重叠施用以施用稀释。 自动检测各种错误条件，并在发生冲突时产生警报，识别不输注的时间，并识别系统故障。 该系统可以选择性地可操作地在启动模式，维护模式，正常模式和手动超控模式中。 该系统可操作以在正常操作中使实际适应期望的流速。 所有的流体都流经整体的一次性盒式磁带，而不会使任何其他系统接触。 流体管路中的气泡被自动检测并处理。 监测流体压力并根据这种压力调整系统运行。 注射器可以从注射器以及标准袋或瓶容器中进行施用。 从选择的输入端口输注可以可控地泵送到注射器中用于取消对注射器柱塞的取出。 该系统可选择性地可操作地调整总体积体积并且对总入血量必须限制的患者的速率低于预选值。 该系统可操作以保持总输液历史的准确记录。

公开(公告)号：US5090963A

公开(公告)日：1992-02-25

申请号：US599917

申请日：1990-10-19

申请人： Joseph Gross ,  Shlomo Zucker

发明人： Joseph Gross ,  Shlomo Zucker

IPC分类号： A61M5/142 ,  A61M5/155 ,  B05B11/00

CPC分类号： A61M5/155 ,  A61M2005/14204 ,  B05B11/0045 ,  Y10S128/12

摘要： A liquid material dispenser includes a rigid housing having a flexible partition defining first and second compartments on opposite sides of the partition, and an electrolytic cell in the first compartment capable of generating a gas when energized by a source of electric current in order to expand the first compartment and thereby to contract the second compartment. The second compartment contains the liquid material which is dispensed via a discharge opening in accordance with the rate of generation of the gas.

公开(公告)号：US5087245A

公开(公告)日：1992-02-11

申请号：US322291

申请日：1989-03-13

申请人： David Doan

发明人： David Doan

IPC分类号： A61M5/00 ,  A61M5/168

CPC分类号： A61M5/16859 ,  Y10S128/12

摘要： The system and method for detecting abnormalities in infusion of parenteral fluid involves producing perturbation of fluid flow by varying the flow rate of the fluid with respect to an equilibrium flow rate, measuring the pressure level, and measuring the pressure of the fluid over a period of time, to determine equilibrium pressure and a pressure response of the fluid to the perturbation, determining an integral of the difference between the equilibrium pressure and the pressure response, determining resistance to fluid flow, determining a second integral of the difference between the pressure response and equilibrium pressure multiplied by time, and determining compliance by dividing the second integral by the first integral. Resistance and compliance values are displayed, and an alarm is generated when the resistance or compliance parameters fall outside of reference ranges.

公开(公告)号：US5066282A

公开(公告)日：1991-11-19

申请号：US347406

申请日：1989-05-04

申请人： Bandula Wijay ,  Paolo Angelini

发明人： Bandula Wijay ,  Paolo Angelini

IPC分类号： A61F2/958 ,  A61M1/10 ,  A61M25/00 ,  A61M29/02

CPC分类号： A61M25/104 ,  A61M1/1081 ,  A61M25/1002 ,  A61M2025/0006 ,  A61M2025/1059 ,  A61M2025/1079 ,  A61M2025/1093 ,  A61M25/0071 ,  Y10S128/12

摘要： The invention is a disposable, positive-displacement piston pump, having a polycarbonate body, a piston, an inlet valve, and an outlet valve. The outlet valve is connected to an exit chamber, which is separated from the exit valve by an elastomeric membrane. The elastomeric membrane encloses an accumulation chamber which is filled with a fluid such as air under atmospheric pressure. Pulsations in outlet pressure caused by stroking of the piston are dampened by the flexing action of the elastomeric membrane, compressing the fluid within the accumulator chamber. The throw out of the pump is pressure-dampened and is of sufficient pressure to flow through very low-profile angioplasty catheters having perfusion lumens extending therethrough. The combination of the pump with a very low-profile balloon angioplasty catheter allows access of the catheter to a constricted passage with the ability to pump a sufficient volume of blood through such a low-profile catheter during balloon inflations.

摘要翻译： 本发明是具有聚碳酸酯本体，活塞，入口阀和出口阀的一次性，正排量活塞泵。 出口阀连接到出口室，出口室通过弹性膜与出口阀分离。 弹性膜包围积聚室，其在大气压下充满诸如空气的流体。 由活塞触发引起的出口压力的脉冲被弹性体膜的弯曲作用所吸收，压缩蓄液室内的流体。 从泵中排出的压力被抑制并具有足够的压力以流过具有延伸穿过其中的灌注内腔的非常薄型的血管成形术导管。 泵与非常低轮廓的气囊血管成形术导管的组合允许导管进入狭窄的通道，具有在球囊充气期间通过这种低轮廓导管泵送足够体积的血液的能力。

公开(公告)号：US5059174A

公开(公告)日：1991-10-22

申请号：US572696

申请日：1990-08-23

申请人： Vincent L. Vaillancourt

发明人： Vincent L. Vaillancourt

IPC分类号： A61M5/14 ,  A61M5/145

CPC分类号： A61M5/145 ,  A61M2005/1404 ,  Y10S128/12

摘要： The pump of the infusion delivery system delivers fluid at a positive pressure. A restrictor is provided in the line to the IV catheter in order to maintain a flow rate at the catheter outlet in a range of from 0.1 to 5 milliliters per hour. The small amount of fluid infused is sufficient to maintain the vein open without backup of blood.

摘要翻译： 输液系统的泵以正压输送流体。 为了将导管出口处的流速保持在0.1至5毫升/小时的范围内，将限流器设置在IV导管的管线中。 输注的少量液体足以维持静脉开放而无需备用血液。

公开(公告)号：US5057278A

公开(公告)日：1991-10-15

申请号：US514704

申请日：1990-04-26

申请人： Thomas P. Maxwell ,  Thomas G. Hacker

发明人： Thomas P. Maxwell ,  Thomas G. Hacker

IPC分类号： A61B5/145 ,  A61B5/00 ,  B01F5/06 ,  C12M1/34 ,  G01N27/26 ,  G01N27/416

CPC分类号： B01F5/0691 ,  A61B5/1495 ,  G01N27/4163 ,  G01N27/4165 ,  Y10S128/12 ,  Y10S128/13 ,  Y10T436/10 ,  Y10T436/102499

摘要： An endless path calibration system comprising a sensor cassette having a flow-through passage and at least one sensor to be calibrated, a chamber coupled to the sensor cassette to define an endless path and a sterile calibration liquid in the endless path. A gas injection passage for injecting gas into the sterile calibration liquid and a gas vent leading from the endless path to the exterior of the endless path. A check valve allows gas to escape from the endless path and substantially prevents gas and liquid from entering the endless path through the gas vent.

公开(公告)号：US5049141A

公开(公告)日：1991-09-17

申请号：US514442

申请日：1990-04-25

申请人： Peter Olive

发明人： Peter Olive

IPC分类号： A61M5/00 ,  A61M5/142 ,  A61M5/155 ,  A61M5/168 ,  A61M37/00 ,  F04B43/04

CPC分类号： A61M5/14276 ,  A61M5/145 ,  A61M5/16809 ,  F04B43/04 ,  G01F11/08 ,  A61M2206/22 ,  Y10S128/12

摘要： An implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a drug reservoir maintained at constant pressure vapor. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume spike to an outlet catheter. In order to minimize dead volume and insure complete discharge, the accumulator employs a titanium diaphragm seated in one position by a recessed stop and in the discharge position by a spacer plate having a concentric groove pattern. The grooves are in fluid communication with the inlet and outlet. Also, a wide groove extending between inlet and outlet provides fluid communication between the grooves. The unit is externally programmed.

摘要翻译： 公开了用于输送药物的可植入阀蓄能器泵。 可植入泵包括保持在恒定压力蒸汽的药物储存器。 药物计量组件包括位于一对阀之间的固定容积蓄积器。 阀交替地打开和关闭，以将药物从储存器进入蓄能器，并将精确的体积尖峰分配到出口导管。 为了最小化死体积并确保完全放电，蓄能器采用通过凹陷止动件位于一个位置的钛隔膜，并且通过具有同心凹槽图案的间隔板在排出位置。 凹槽与入口和出口流体连通。 此外，在入口和出口之间延伸的宽槽提供槽之间的流体连通。 该单元是外部编程的。

公开(公告)号：US5041094A

公开(公告)日：1991-08-20

申请号：US350588

申请日：1989-05-22

申请人： Jean Perego ,  Francois B. Perego ,  Patrick Guyondet

发明人： Jean Perego ,  Francois B. Perego ,  Patrick Guyondet

IPC分类号： A61M20060101 ,  A61M5/14 ,  A61M5/145

CPC分类号： A61M5/14526 ,  A61M2005/14506 ,  A61M2005/14513 ,  Y10S128/12

摘要： The invention concerns a device and a process for administering a liquid g preparation, in particular by infusion, by implantation or percutaneously, at a given flow rate for relatively long period of time, using a technique involving the retractation of an elastic membrane. More specifically, using this technique, said drug preparation is placed in a tubular reservoir (13) where it is subjected to the action of at least one movable wall (112, 112a). The movable wall is displaced by the pressure of a hydraulic fluid (10), the entry of which is controlled by a capillary tube (4) fed with hydraulic fluid (10) under pressure by a hydraulic accumulator subject to the thrust of a previously dilated retractable elastic membrane (8).

摘要翻译： PCT No.PCT / FR88 / 00386 Sec。 371日期：1989年5月22日 102（e）日期1989年5月22日PCT提交1988年7月25日PCT公布。 出版物WO89 / 00866 日本1989年2月9日。本发明涉及一种装置和方法，特别是通过植入或经皮注射液体药物制剂，以给定流速相对较长的时间，使用涉及缩回的技术 的弹性膜。 更具体地，使用这种技术，所述药物制剂被放置在管状贮存器（13）中，在其中它经受至少一个活动壁（112,112a）的作用。 可移动壁由液压流体（10）的压力移动，液压流体（10）的入口由在液压蓄压器的压力下被供给液压流体（10）的毛细管（4）控制，液压蓄压器受到预先膨胀的推力 伸缩弹性膜（8）。

公开(公告)号：US5006997A

公开(公告)日：1991-04-09

申请号：US484284

申请日：1990-02-26

申请人： Sanford Reich

发明人： Sanford Reich

IPC分类号： A61M5/142 ,  A61M5/168

CPC分类号： A61M5/14276 ,  A61M2209/02 ,  A61M5/16854 ,  Y10S128/12

摘要： A method and apparatus to evaluate the performance of an implanted medication delivery device such as pumps and ports is described. In the case of a pump, the system measures ambient pressure and obtains two pressure measurements from the implanted device. One of these measurements is device reservoir pressure and the other is based on a disturbance pulse injected into the system at a point downstream of the reservoir. Based on those measurements and input calibration data, an expected flow rate is determined. The expected flow rate together with device refill data is in turn used to determine a normalized flow rate for the in-vivo device. Determinations are then made as to the performance of the reservoir, its pump and the condition of the outlet catheter without explant of the device. In the case of a port, the system measures the catheter resistance based on decay time of a disturbance pulse.

摘要翻译： 描述了评价植入药物输送装置如泵和端口的性能的方法和装置。 在泵的情况下，系统测量环境压力并从植入装置获得两个压力测量值。 这些测量中的一个是设备储存器压力，另一个是基于在储存器下游的点处注入到系统中的扰动脉冲。 基于这些测量和输入校准数据，确定预期的流速。 预期的流量与装置补充数据一起用于确定体内装置的归一化流速。 然后确定储存器的性能，其泵和出口导管的状况，而不需要设备外露。 在端口的情况下，系统根据干扰脉冲的衰减时间来测量导管阻力。