公开(公告)号：US3526664A

公开(公告)日：1970-09-01

申请号：US3526664D

申请日：1966-05-09

Applicant: STANFORD RESEARCH INST

Inventor： COON CLIFFORD L

IPC: C07C123/00

CPC classification number: C06B43/00

公开(公告)号：US4661522A

公开(公告)日：1987-04-28

申请号：US734049

申请日：1985-05-15

Applicant: Tom Beetz

Inventor： Tom Beetz

IPC: A61K31/155 ,  C07C20060101 ,  C07C123/00

CPC classification number: C07C259/16 ,  C07C2103/10 ,  C07C2103/14 ,  C07C2103/16

Abstract: The present invention is dealing with cycloalkane-indene-carboximidamide derivatives having the general formula: ##STR1## wherein Rx together with either Ry.sub.1 or Ry.sub.2 represent the moiety ##STR2## (the other Ry being hydrogen), n represents the number 1, 2 or 3,R represents hydrogen or a (1-4 C)-alkyl group,R.sub.1 represents hydrogen, (1-4 C)-alkyl, hydroxyl, (1-4 C)-alkoxy or an amino group which is unsubstituted or substituted by (1-4 C)-alkyl andR.sub.2 is hydrogen, hydroxyl or (1-4 C)-alkyl, as well as the pharmaceutically acceptable salts thereof, with powerful blood platelet aggregation-inhibiting activity.

Abstract translation: 本发明涉及具有以下通式的环烷 - 茚 - 肟基亚胺酰胺衍生物：其中Rx与Ry1或Ry2一起代表部分（另一个Ry是氢），n代表数字1,2或 3，R表示氢或（1-4C） - 烷基，R1表示氢，（1-4C） - 烷基，羟基，（1-4C） - 烷氧基或未取代或被 （1-4C） - 烷基和R2是氢，羟基或（1-4C） - 烷基，以及其药学上可接受的盐，具有强大的血小板聚集抑制活性。

公开(公告)号：US4360466A

公开(公告)日：1982-11-23

申请号：US325069

申请日：1981-11-25

Applicant: Walter E. Meyer ,  Andrew S. Tomcufcik ,  Joseph W. Marsico, Jr.

Inventor： Walter E. Meyer ,  Andrew S. Tomcufcik ,  Joseph W. Marsico, Jr.

IPC: C07D317/58 ,  C07D307/77 ,  C07C121/78 ,  C07C123/00

CPC classification number: C07D317/58 ,  Y10S514/869

Abstract: This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylformamidines which possess activity as hypotensive agents and as diuretics.

Abstract translation: 本公开描述了具有作为降压剂和利尿剂的活性的新型N' - [2,6-二氯-4-（取代 - 亚苄基氨基）苯基] -N，N-二甲基甲脒。

公开(公告)号：US4277493A

公开(公告)日：1981-07-07

申请号：US123279

申请日：1980-02-21

Applicant: Akhileswar Sinharay ,  Gerhard Stahler ,  Werner Bonin

Inventor： Akhileswar Sinharay ,  Gerhard Stahler ,  Werner Bonin

IPC: A01N37/52 ,  C07C121/84 ,  C07C123/00

CPC classification number: A01N37/52

Abstract: Compounds of the formula ##STR1## in which R.sup.1 is halogen, alkyl, alkoxy, alkylthio, CF.sub.3, NO.sub.2, CN.sub.2, phenoxy, halophenoxy, phenylthio or halophenylthio, R.sup.2 is CN or COOR.sup.3, R.sup.3 is alkyl, alkoxyalkyl or cycloalkyl and n is 0 to 3 are effective insecticides and acaricides and especially ectoparasiticides.

Abstract translation: 式中，R 1为卤素，烷基，烷氧基，烷硫基，CF 3，NO 2，CN 2，苯氧基，卤代苯氧基，苯硫基或卤代苯硫基，R 2为CN或COOR 3，R 3为烷基，烷氧基烷基或环烷基，n为0 至3种是有效的杀虫剂和杀螨剂，特别是杀螨剂。

公开(公告)号：US4268525A

公开(公告)日：1981-05-19

申请号：US144758

申请日：1980-04-28

Applicant: Jill H. Paul

Inventor： Jill H. Paul

IPC: A01N37/52 ,  A01N41/10 ,  A01N47/02 ,  C07C67/00 ,  C07C239/00 ,  C07C251/58 ,  C07C259/18 ,  C07C313/00 ,  C07C317/44 ,  C07C317/46 ,  C07C317/48 ,  C07C323/47 ,  C07C323/63 ,  C07C323/65 ,  C07C123/00

CPC classification number: C07C259/18 ,  A01N37/52 ,  A01N41/10 ,  A01N47/02

Abstract: This invention is concerned with certain aryl amidoxime ethers of 3-phenoxybenzyl alcohol, which have insecticidal activity.

Abstract translation: 本发明涉及具有杀虫活性的3-苯氧基苄醇的某些芳基偕胺肟醚。

公开(公告)号：US4265911A

公开(公告)日：1981-05-05

申请号：US82656

申请日：1979-10-09

Applicant: Henry Najer ,  Daniel Obitz

Inventor： Henry Najer ,  Daniel Obitz

IPC: A61K31/155 ,  C07C123/00

CPC classification number: A61K31/155 ,  C07C259/14

Abstract: Propionamidoxime derivatives which are compounds of formula (I) ##STR1## in which A is a tetrahydronaphthyl or dihydronaphthyl radical and their pharmaceutically acceptable salts are valuable for treatment of the central nervous system and depression.The above compounds are prepared by reacting the nitrile (II) ##STR2## with hydroxylamine hydrochloride.

Abstract translation: 作为其中A为四氢萘基或二氢萘基的式（I）化合物的丙酰胺肟衍生物及其药学上可接受的盐对于治疗中枢神经系统和抑郁症是有价值的。 上述化合物通过使腈（II）与盐酸羟胺反应来制备。

公开(公告)号：US4262021A

公开(公告)日：1981-04-14

申请号：US85006

申请日：1979-10-15

Applicant: Allen R. Kraska

Inventor： Allen R. Kraska

IPC: C07C41/16 ,  C07C43/15 ,  C07C45/44 ,  C07C47/198 ,  C07C47/575 ,  C07C59/125 ,  C07C217/62 ,  C07D211/26 ,  C07D211/64 ,  C07D303/24 ,  A61K31/155 ,  C07C123/00

CPC classification number: C07C247/00 ,  C07C217/62 ,  C07C41/16 ,  C07C45/44 ,  C07C47/198 ,  C07C47/575 ,  C07C59/125 ,  C07D211/26 ,  C07D211/64 ,  C07D303/24 ,  Y10S514/889

Abstract: Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.

Abstract translation: 二-O-（正 - 高级烷基和烯基） - 甘油和 - 丙二醇的新型胺和脒衍生物及其药学上可接受的酸加成盐可用于对抗哺乳动物中的病毒感染。 特别令人感兴趣的是1,3-二-O-（正十六烷基）-2-O-（3-氨基丙基） - 甘油及其药学上可接受的酸加成盐。

公开(公告)号：US4256636A

公开(公告)日：1981-03-17

申请号：US76235

申请日：1979-09-17

Applicant: Ernst Roos ,  Herbert Bartl ,  Klaus Schuster ,  Adolf Schmidt

Inventor： Ernst Roos ,  Herbert Bartl ,  Klaus Schuster ,  Adolf Schmidt

IPC: C07C257/14 ,  C08F4/04 ,  C07C123/00

CPC classification number: C07C257/14 ,  C08F4/04

Abstract: An azo di-isobutyric acid-(N,N'-hydroxyalkyl)-amidine corresponding to the formula (I): ##STR1## in which R and R', which may be the same or different, represent linear or branched alkylene radicals containing from 2 to 4 carbon atoms, andX represents R'-OH or H.They may be produced by reacting an azo-di-isobutyric acid iminoalkyl ether containing from 1 to 4 carbon atoms in the alkyl group with at least one mono-alkanolamine containing from 2 to 4 carbon atoms or with a mixture of at least one monoalkanolamine and at least one dialkanolamine each containing from 2 to 4 carbon atoms in an alkanol radical, the molar ratio of monoalkanolamines to dialkanolamines in the mixture amounting to substantially 1:1, in substantially equivalent quantitative ratios at a temperature in the range of from 0.degree. to 50.degree. C. The amidines may be used as polymerization initiators, as cross-linking agents and as blowing agents in the production of foams.

Abstract translation: 对应于式（I）的偶氮二异丁酸 - （N，N'-羟基烷基） - 脒：其中R和R'可以相同或不同，表示直链或支链 含有2至4个碳原子的亚烷基，X代表R'-OH或H.

公开(公告)号：US4144271A

公开(公告)日：1979-03-13

申请号：US845096

申请日：1977-10-25

Applicant: Howard Jones ,  Conrad P. Dorn

Inventor： Howard Jones ,  Conrad P. Dorn

IPC: A61K31/155 ,  A61P29/00 ,  C07C67/00 ,  C07C313/00 ,  C07C323/60 ,  C07D295/195 ,  C07C123/00

CPC classification number: C07D295/195

Abstract: N-substituted mercaptomethylacetamidines are prepared, and are useful as immunoregulants for correcting an imbalance of immune homeostasis, particularly, as immunostimulants in the treatment of autoimmune and immune deficient diseases and disorders.

Abstract translation: {PG，1 N-取代的巯基甲基乙酰胺被制备，并且可用作用于校正免疫稳态失衡的免疫调节剂，特别是用作治疗自身免疫和免疫缺陷性疾病和病症的免疫刺激剂。

公开(公告)号：US4071556A

公开(公告)日：1978-01-31

申请号：US449792

申请日：1974-03-11

Applicant: Ferenc M. Pallos

Inventor： Ferenc M. Pallos

IPC: A01N37/52 ,  C07C123/00

CPC classification number: A01N37/52

Abstract: A composition of matter is described herein which has insecticidal and miticidal activity and methods of use. The composition may be defined by the following generic formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently methyl or halogen, preferably methyl or chlorine.