公开(公告)号：US3819637A

公开(公告)日：1974-06-25

申请号：US15607071

申请日：1971-06-23

申请人： STERLING DRUG INC

发明人： BELL M

IPC分类号： C07D215/06 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/22 ,  C07D215/227 ,  C07D215/233 ,  C07D215/56 ,  C07D265/26 ,  C07D33/10

CPC分类号： C07D215/227 ,  C07D215/06 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/233 ,  C07D215/56 ,  C07D265/26

摘要： THE INVENTION RELATES TO NOVEL 1-(4-R1O-PHENYL)-2-(4R2-PHENYL)-6-R3-1,2,3,4-TETRAHYDROQUINOLINES HAVING ANTIFERTILITY AND HYPOCHOLESTEROLEMIC ACTIVITES, TO THEIR PREPARATION, AND TO NOVEL INTERMEDIATES THEREFOR.

公开(公告)号：US3790573A

公开(公告)日：1974-02-05

申请号：US3790573D

申请日：1971-11-11

申请人： SMITHKLINE CORP

发明人： BLACKBURN D ,  DEVENNEY R ,  YU WEN JEN T

IPC分类号： C07D209/38 ,  C07D265/26 ,  C07D487/04 ,  C07D51/48

CPC分类号： C07D265/26 ,  C07D209/38 ,  C07D487/04

摘要： THE COMPOUND ARE HEXAHYDRO, OCTAHYDRO AND DECAHYDRO IMIDAZO (2,1-)QUINAZOLINES AND PYRIMIDO (2,1-B) QUINAZOLINES WHICH HAVE HYPOTENSIVE ACTIVITY. FOR EXAMPLE, COMPOUNDS OF THIS INVENTION ARE 1,2,3,5,6,7,8,9-OCTAHYDRO-6H-PYRIMIDO (2,1B) QUINAZOLINE AND 1,2,34,7,8,9,10-OCTAHYDRO-6-H-PYRIMIDO (2,1-B) QUINAZOLINE.

公开(公告)号：US3651061A

公开(公告)日：1972-03-21

申请号：US3651061D

申请日：1970-04-20

申请人： ERNST REIF

发明人： ERICSSON RONALD J ,  REIF ERNST

IPC分类号： C07D209/38 ,  C07D265/26 ,  C07D501/06 ,  C07D51/48

CPC分类号： C07D265/26 ,  C07D209/38 ,  Y10S514/841

摘要： 2,3 - DIHYDRO - 2 - (1-NAPHTHYL) - 4(1H)QUINAZOLINONE AND THE 6 - CHLOROANALOG ARE PROVIDED BY THIS INVENTION. THESE COMPOUNDS ARE USEFUL IN CONTROLLING FERTILITY IN WARM-BLOODED MALE ANIMALS.

公开(公告)号：US3557111A

公开(公告)日：1971-01-19

申请号：US3557111D

申请日：1968-03-29

申请人： BOLA VITHAL SHETTY

发明人： SHETTY BOLA VITHAL

IPC分类号： C07D265/26 ,  C07D51/48

CPC分类号： C07D265/26 ,  Y10S514/869

摘要： A CLASS OF COMPOUND HAVING DIURETIC PROPERTIES HAS THE FOLLOWING FORMULA:

1-R1,2-R2,2-R2'',3-((R3,R3'',R3"-PHENYL)-(CH2)N-),5-R5,6-

(R6-N(-R6'')-SO2-),7-X,8-R8-1,2,3,4-TETRAHYDRO-

QUINAZOLIN-4-ONE

INCLUDING THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, IN WHICH X IS HALOGEN OR TRIFLUOROMETHYL; R6 AND R6'' ARE LOWERALKYL, PHENYL, OR PHENYLLOWERALKYL; OR R6 IS HYDROGEN AND R6'' IS ACYL SUCH AS ACETYL OR C3H7CO, OR PHENYLLOWERALKYL OR PHENYLLOWERALKYL; R2 AND R2'' ARE HYDROGEN, LOWERALKYL, LOWERALKENYL, THIOLOWERALKYL, ALKYLTHIO, HALOGEN SUBSTITUTED LOWERALKYL, PHENYLALKYL, PHENYL, CYCLOALKYL, CYCLOALKYLLOWERALKYL, LOWERALKOXY, LOWERALKOXYLOWERALKYL, OR R2 AND R2'' TOGHETHER ARE LOWER POLYMETHYLENE CHAIN MORPHOLINO, PYRROLIDINO, OR PIPERAZINO; R1 IS HYDROGEN, PHENYLALKYL, HYDROXYALKYL, LOWERALKOXYLOWERALKYL, OR LOWERALKYL; R5 AND R8 ARE HYDROGEN, LOWERALKYL, AMINO, LOWERALKOXY, OR LOWERALKOXYLOWERALKYL; R3, R3'', AND R3" ARE HYDROGEN, LOWERALKYL, HYDROXY, LOWERALKOXY, LOWERALKOXYLOWERALKYL, HALOGEN, TRIFLUOROMETHYL, SULFAMYL, OR AMINO, AND N IS AN INTEGER FROM 0-4.

公开(公告)号：US3528974A

公开(公告)日：1970-09-15

申请号：US3528974D

申请日：1966-01-24

申请人： ROBAPHARM AG

发明人： ENGEL KURT

IPC分类号： C07D265/26 ,  C07D87/08

CPC分类号： C07D265/26

公开(公告)号：US1887820A

公开(公告)日：1932-11-15

申请号：US37015429

申请日：1929-06-11

申请人： IG FARBENINDUSTRIE AG

发明人： ANTON OSSENBECK ,  WINFRID HENTRICH ,  ERNST TIETZE

IPC分类号： C07D265/26

CPC分类号： C07D265/26

公开(公告)号：US11667614B2

公开(公告)日：2023-06-06

申请号：US17720007

申请日：2022-04-13

申请人： Navinta III Inc

发明人： Pankaj Vasudev Parmar ,  Raja Jeyakumar John Muthiah ,  Vikas Kantilal Chauhan ,  Jagdish Kanjibhai Solanki

IPC分类号： C07D265/26

CPC分类号： C07D265/26

摘要： Processes that use novel reagents for the removal of colored impurity during the preparation of Salcaprozic Acid and pharmaceutically acceptable salts thereof. The processes include hydrolysis of 8-(2,4-dioxo-1,3-benzoxazin-3-yl)octanoic acid ethyl ester in the presence of or by contacting it with benzotriazole, hydrazine and/or sodium borohydride.

公开(公告)号：US20220242837A1

公开(公告)日：2022-08-04

申请号：US17721781

申请日：2022-04-15

申请人： FMC Corporation ,  FMC Agro Singapore Pte. Ltd.

发明人： Liang CHEN ,  Yefeng FAN ,  Jianhua MAO ,  Zhijian XU

IPC分类号： C07D265/26 ,  C07D209/38 ,  C07C231/14 ,  C07C237/28

摘要： Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

公开(公告)号：US20180360842A1

公开(公告)日：2018-12-20

申请号：US15868458

申请日：2018-01-11

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Ottavio ARANCIO ,  Shi Xian DENG ,  Donald W. LANDRY ,  Jole FIORITO ,  Rosa PURGATORIO ,  Owen Anthony O'CONNOR ,  Jennifer Effie AMENGUAL

IPC分类号： A61K31/536 ,  C07C235/64 ,  C07C235/42 ,  C07D209/38 ,  C07D265/26 ,  C07D265/22 ,  A61K31/403 ,  A61K31/166 ,  C07D209/34 ,  C07C237/40

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

公开(公告)号：US20180110862A1

公开(公告)日：2018-04-26

申请号：US15848750

申请日：2017-12-20

申请人： The University of North Carolina at Charlotte

发明人： Craig A. Ogle ,  Anthony J. Fowler

IPC分类号： A61K47/54 ,  C07D265/26 ,  A61K47/59 ,  A61K49/00 ,  C12N15/115

CPC分类号： A61K47/545 ,  A61K47/59 ,  A61K47/593 ,  A61K49/0052 ,  C07D265/26 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/351

摘要： Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives of the present disclosure can be advantageously water soluble, easily prepared and purified. Isatoic anhydride derivatives useful in the present disclosure preferably have at least one chemically reactive group or at least one binding group or at least one detectable label. Anthranilate derivatives made from the isatoic anhydrides derivatives or otherwise and kits including the isatoic anhydride derivatives are also disclosed.