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公开(公告)号：US20230132965A1
公开(公告)日：2023-05-04
申请号：US17799804
申请日：2021-02-11
IPC分类号： G01J1/44
摘要： The photomultiplier includes a set of macrocells, each comprising at least two microcells, each being connected to an output node according to an OR diagram, and achieving great energy efficiency upon deactivating each of the microcells when these are activated almost simultaneously, and that otherwise would have been masked by the OR diagram. To this end, each of the microcells comprises an active quenching and recharge circuit; an avalanche diode; a first deactivation transistor with its gate connected to an external processor, and its drain and source associated with the active quenching and recharge circuit; a second deactivation transistor with its gate connected to an external processor, and its source associated with the active quenching and recharge circuit.
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72.发明申请公开(公告)号：US20230055050A1
公开(公告)日：2023-02-23
申请号：US17793818
申请日：2021-01-20
发明人： Jose Maria BENLLOCH BAVIERA , Antonio Javier GONZALEZ MARTINEZ , Victor ILISIE , John BARRIO TOALA , Efthymios LAMPROU
摘要： A device for the detection of gamma rays presents a high resolution in the three-dimensional position of the impact of the gamma ray within one or more scintillation crystal blocks coupled to an array of photosensors, for the determination of the impact energy of said gamma ray, the determination of the instant in time when said impact occurred, the interaction depth and the determination of the time-of-flight. Advantageously, in said device, the scintillation crystal detection blocks are optically isolated, in such a way that the scintillation light can only exit said blocks via the output region; and the scintillation crystal detection blocks and the array of photosensors are disposed in direct optical coupling.
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公开(公告)号：US20230025843A1
公开(公告)日：2023-01-26
申请号：US17780331
申请日：2020-11-25
发明人： Pilar SÁNCHEZ TESTILLANO , Ana MARTINEZ GIL , Carmen GIL AYUSO-GONTAN , Eduardo BERENGUER PEINADO , Elena CARNEROS GARCÍA , Yolanda PÉREZ PÉREZ
摘要： The present invention relates to the use of mammal kinase inhibitors, preferably human kinase inhibitors, to promote the induction of in vitro embryogenesis, a strategy never used in plants systems before. The results obtained indicated that these inhibitors have beneficial effects in both crop and forest plants in in vitro systems of microspore and somatic embryogenesis.
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公开(公告)号：US20220354730A1
公开(公告)日：2022-11-10
申请号：US17733093
申请日：2022-04-29
发明人： Elena Garcia Armada , Alberto Plaza Flores , Mar Hernandez Melero , Manuel Prieto Perez-Borroto
摘要： An exoskeleton (1) having a plurality of autonomously operable modules (2RK, 2LK, 2RH, 2LH) each having a dedicated controller (23RK, 23LK, 23RH, 23LH) connected to an actuated joint. The exoskeleton (1) further having a multimaster electrical communicator (3) between the controllers (23RK, 23LK, 23RH, 23LH) of the modules (2RK, 2LK, 2RH, 2LH). The controller (23RK, 23LK, 23RH, 23LH) of each module (2RK, 2LK, 2RH, 2LH) is configured for: collecting information from sensors; sharing information with the remaining modules through the multimaster electrical communicator (3); determining which other modules (2RK, 2LK, 2RH, 2LH) are present; and autonomously calculating and commanding a desired trajectory of the actuated joint of the module (2RK, 2LK, 2RH, 2LH) for assisting the movement of the corresponding biological joint in coordination with the kinematic condition of other biological joints.
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公开(公告)号：US20220332809A1
公开(公告)日：2022-10-20
申请号：US17738684
申请日：2022-05-06
摘要： The invention relates to monoclonal antibodies, in particular against a peptide of the BAMBI protein, as well as the uses thereof and methods comprising same. Preferably, the antibodies are used for the treatment of autoimmune diseases.
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公开(公告)号：US11446304B2
公开(公告)日：2022-09-20
申请号：US16495613
申请日：2018-03-21
发明人： Ana Martinez Gil , Daniel I. Perez , Carmen Gil Ayuso-Gontán , Angeles Martin-Requero , Elisa Rojas Prats , Loreto Martinez-Gonzalez , Concepción Perez
摘要： The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.
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77.发明申请公开(公告)号：US20210223208A1
公开(公告)日：2021-07-22
申请号：US17058038
申请日：2019-05-27
发明人： Eduardo GIL SANTOS , Jose Jaime RUZ MARTINEZ , Oscar MALVAR VIDAL , Javier TAMAYO DE MIGUEL , Montserrat CALLEJA GOMEZ
IPC分类号： G01N29/02 , G01N29/036 , G01N29/24 , G01N29/34 , G02B6/293
摘要： The invention relates to a method and a system of mechanical resonance transduction for analyte analysis, suitable for its use in the identification of nanoparticles in the range between 1 MHz and 300 GHz, said method being characterized in that it comprises the following steps: a) disposing at least one analyte, possessing at least one mechanical vibration mode, on at least one mechanical resonator sensor that possesses at least one mechanical vibration mode, selectable in a plurality of working frequencies; b) monitoring the mechanical spectra of the of the analyte and the resonator sensor; c) varying the at least one mechanical vibration mode until at least one mechanical vibration mode reaches a strong coupling situation with the at least one mechanical vibration mode; d) collecting the frequency data at which the strong coupling occurs; e) estimating the resonance frequency and quality factor of the at least one mechanical vibration mode from the strong coupling frequency data obtained in step d).
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公开(公告)号：US10858261B2
公开(公告)日：2020-12-08
申请号：US15748323
申请日：2016-07-26
发明人： Felix Antonio Lopez Gomez , Francisco Jose Alguacil Priego , Jose Ramon Gonzalez Gracia , Mario Sergio Ramirez Zablah
IPC分类号： C01F7/16 , C22B7/04 , C21C7/076 , C04B35/622 , C04B35/44 , C04B7/32 , C04B35/626 , C04B35/64 , C04B5/00 , C04B35/22 , C21C7/064 , C22B21/00 , C22B21/04
摘要： The present invention relates to a method for obtaining calcium aluminates for metallurgical use from non-saline aluminum slags by means of reactive grinding and thermal treatment.
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公开(公告)号：US10792617B2
公开(公告)日：2020-10-06
申请号：US16825553
申请日：2020-03-20
IPC分类号： C01B3/04 , B01D53/94 , C07C11/04 , B01J29/72 , B01J29/76 , C01B39/48 , C01B39/02 , B01J35/00 , B01J37/00 , B01J37/04 , B01J37/10 , C07C29/00 , F01N3/20
摘要： The main object of the present invention is to provide a new method for preparing the copper-containing silicoaluminate form of the AEI zeolite structure by means of a direct synthesis methodology. This new process involves combining a organometallic copper-complex with an additional organic molecule capable of directing the crystallisation of the silicoaluminate form of the AEI zeolite structure as organic structure-directing agents (OSDAs).
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公开(公告)号：US20200263151A1
公开(公告)日：2020-08-20
申请号：US16756812
申请日：2018-10-19
IPC分类号： C12N9/12 , C12Q1/6844
摘要： The present invention provides an isolated peptide of SEQ ID NO: 1 needed for primase active as well as new replicative DNA polymerase enzymes, preferably that of SEQ ID NO: 2, comprising said peptide. Thus, these DNA polymerases are endowed with priming activity and do not require externally provided primers for initiating and performing DNA amplification. These polymerases are able to carry out a faithful and processive de novo DNA synthesis of DNA templates in the absence of pre-synthetized primers. Therefore, these enzymes of the invention act both as primases and DNA polymerases. Furthermore, they show translesion synthesis capacity, so that they may be useful not only for whole-genome amplification but also for the amplification of damaged DNAs. The invention further refers to methods for amplifying templates DNAs using these enzymes.
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