公开(公告)号：US06648823B2

公开(公告)日：2003-11-18

申请号：US09919519

申请日：2001-07-31

申请人： David L. Thompson

发明人： David L. Thompson

IPC分类号： A61B500

CPC分类号： H04W68/00 ,  A61B5/0002 ,  A61B2560/0271 ,  A61N1/37211 ,  A61N1/37264 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3481 ,  G16H15/00 ,  G16H40/40 ,  Y10S128/903

摘要： A method and structure for notifying clinicians with patients with implantable medical devices (IMDs), about recalls and upgrades, therapy improvements, longevity estimates/improvements, and follow-up frequency recommendations is implemented in an interactive preferably wireless communications system involving a preferably web-enabled remote expert station. Either the clinician or the patient may initiate and access the remote expert station. During such communications, the patient's IMDs are evaluated against a first database comprising patient data and a second database comprising statistical, survivability, probability projections. The patient or the clinician may also access a database containing patient-specific information including other device information. If one or more of the patient's IMDs matches with a recalled or an up-gradable unit such message is posted to the clinician and the patient. Remedial action is taken, by replacing the unit, upgrading/reprogramming the unit, adjusting the patient's follow-up timing to thereby ensure effective and safe therapy and clinical care.

公开(公告)号：US06571125B2

公开(公告)日：2003-05-27

申请号：US09781750

申请日：2001-02-12

申请人： David L. Thompson

发明人： David L. Thompson

IPC分类号： A61M500

CPC分类号： A61M5/14276 ,  A61M5/16881 ,  A61N1/056 ,  A61N1/362 ,  A61N1/3962

摘要： An Implantable Medical Device (IMD) for controllably releasing a biologically-active agent such as a drug to a body is disclosed. The IMD includes a catheter having one or more ports, each of which is individually controlled by a respective pair of conductive members located in proximity to the port. According to the invention, a voltage potential difference generated across a respective pair of conductive members is used to control drug delivery via the respective port. In one embodiment of the current invention, each port includes a cap member formed of a conductive material. This cap member is electrically coupled to one of the conductive members associated with the port to form an anode. The second one of the conductive members is located in proximity to the port and serves as a cathode. When the cap member is exposed to a conductive fluid such as blood, a potential difference generated between the conductors causes current to flow from the anode to the catheter, dissolving the cap so that a biologically active agent is released to the body. In another embodiment of the invention, each port is in proximity to a reservoir or other expandable member containing a cross-linked polymer gel of the type that expands when placed within an electrical field. Creation of an electric field between respective conductive members across the cross-linked polymer gel causes the gel to expand. In one embodiment, this expansion causes the expandable member to assume a state that blocks the exit of the drug from the respective port. Alternatively, the expansion may be utilized to assert a force on a bolus of the drug so that it is delivered via the respective port. Drug delivery is controlled by a control circuit that selectively activates one or more of the predetermined ports.

摘要翻译： 公开了一种用于将诸如药物的生物活性剂可控地释放到身体的可植入医疗装置（IMD）。 IMD包括具有一个或多个端口的导管，每个端口由位于端口附近的相应的一对导电构件单独控制。 根据本发明，通过相应的一对导电构件产生的电压电位差用于控制通过相应端口的药物递送。 在本发明的一个实施例中，每个端口包括由导电材料形成的盖构件。 该盖构件电耦合到与端口相关联的导电构件之一以形成阳极。 导电构件中的第二个位于靠近端口并用作阴极。 当帽构件暴露于诸如血液的导电流体时，在导体之间产生的电位差导致电流从阳极流到导管，从而溶解帽，使得生物活性剂释放到身体。 在本发明的另一个实施方案中，每个端口接近储存器或其他可膨胀构件，其包含当放置在电场内时膨胀的类型的交联聚合物凝胶。 通过交联聚合物凝胶在相应导电构件之间形成电场使凝胶膨胀。 在一个实施方案中，该膨胀使可膨胀构件呈现阻止药物从相应端口排出的状态。 或者，扩张可以用于在药物的推注上施加力，使得其经由相应的端口递送。 药物递送由选择性地激活一个或多个预定端口的控制电路来控制。

公开(公告)号：US06562000B2

公开(公告)日：2003-05-13

申请号：US09776471

申请日：2001-02-02

申请人： David L. Thompson ,  Michael F. Mattes ,  Lary R. Larson ,  Kenneth T. Heruth

发明人： David L. Thompson ,  Michael F. Mattes ,  Lary R. Larson ,  Kenneth T. Heruth

IPC分类号： A61B1739

CPC分类号： A61M5/152 ,  A61M5/16813 ,  A61M5/16877 ,  A61M5/16881 ,  A61M2205/3507 ,  A61M2205/50 ,  G06F19/00

摘要： A medical device known as a therapeutic substance delivery device is configured to with an infusion rate control to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and other diseases in humans and other animals. The therapeutic substance delivery device can be configured as a single-use device that is versatile, small, inexpensive, and has many other improvements. The single-use device has a Micro Electro Mechanical System (MEMS) flow restriction with a variable infusion rate. The MEMS flow restriction is fluidly coupled to a reservoir outlet to receive therapeutic substance dispensed from the single-use reservoir at the reservoir rate and restrict the therapeutic substance flow to a desired infusion rate. The single-use reservoir is configured for controlled collapse to dispense therapeutic substance from the reservoir at a reservoir rate through a reservoir outlet. The therapeutic substance delivery device can also be configured as a shrink polymer delivery device that is also versatile, small, inexpensive, and has many other improvements. A flow restriction is fluidly coupled to the shrink polymer reservoir outlet to receive therapeutic substance dispensed from the reservoir at the reservoir rate and restrict the therapeutic substance flow to an infusion rate. Many embodiments of the therapeutic substance delivery device with infusion rate control and its methods of operation are possible.

摘要翻译： 被称为治疗物质递送装置的医疗装置被配置为具有输注速率控制以递送诸如药物组合物，遗传材料和生物制剂之类的治疗物质以治疗各种医学病症如疼痛，口臭，癌症等 人类和其他动物的疾病。 治疗物质输送装置可以被配置为通用性，小型，便宜的一次性装置，并且具有许多其它改进。 一次性装置具有可变输液速率的微机电系统（MEMS）流量限制。 MEMS流量限制流体耦合到储存器出口以接收以储存速率从一次性储存器分配的治疗物质，并将治疗物质流量限制到所需的输注速率。 一次性储存器被配置为可控制的塌陷，以储存器速率通过储存器出口从储存器分配治疗物质。 治疗物质输送装置也可以被配置为也是通用性，小型，便宜的并且具有许多其它改进的收缩聚合物输送装置。 流动限制流体地联接到收缩聚合物储存器出口以接收以储存速率从储存器分配的治疗物质，并将治疗物质流量限制到输注速率。 具有输注速率控制的治疗物质输送装置及其操作方法的许多实施例是可能的。

公开(公告)号：US06477424B1

公开(公告)日：2002-11-05

申请号：US09322560

申请日：1999-05-28

申请人： David L. Thompson ,  Steven D. Goedeke

发明人： David L. Thompson ,  Steven D. Goedeke

IPC分类号： A61N108

CPC分类号： A61N1/37223 ,  A61N1/37217 ,  A61N1/37235 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/40

摘要： An implantable medical device communication system includes an implantable medical device, a medical information management system, and a module interface apparatus for facilitating communication therebetween. The implantable medical device includes transmitter/receiver circuitry coupled to a device antenna. The medical information management system includes at least a computer processing unit and a display unit. The module interface apparatus includes interface receiver/transmitter circuitry coupled to an interface antenna to communicate with the device transmitter/receiver circuitry via the device antenna. Further, the module interface apparatus includes interface circuitry operable to adapt data (e.g., programming commands) received from the medical information management system for transmittal to the implantable medical device and adapt data received from the implantable medical device (e.g., device data including operational data, physiological parameter data, analyzed data, diagnostic data, etc.) such as to communicate such information to:the medical information management system.

摘要翻译： 可植入医疗装置通信系统包括可植入医疗装置，医疗信息管理系统和用于促进其之间的通信的模块接口装置。 可植入医疗设备包括耦合到设备天线的发射器/接收器电路。 医疗信息管理系统至少包括计算机处理单元和显示单元。 模块接口装置包括耦合到接口天线的接口接收机/发射机电路，以经由设备天线与设备发射机/接收机电路进行通信。 此外，模块接口装置包括接口电路，其可操作以适配从医疗信息管理系统接收的数据（例如，编程命令），用于传送到可植入医疗设备并适应从可植入医疗设备接收的数据（例如，包括操作数据的设备数据 ，生理参数数据，分析数据，诊断数据等），以将这些信息传达到：医疗信息管理系统。

公开(公告)号：US06453147B1

公开(公告)日：2002-09-17

申请号：US09730368

申请日：2000-12-05

申请人： Theodore H. Morse ,  David L. Thompson

发明人： Theodore H. Morse ,  David L. Thompson

IPC分类号： G03G2100

CPC分类号： G03G21/0035 ,  G03G21/007

摘要： A method and apparatus of forming a cleaning system for an electrostatographic reproduction system having a photoconductive drum partially within a cleaning system housing and a cleaning brush having conductive core fibers within the cleaning system housing contacting the photoconductive drum with a detoner roller also within the cleaning system housing contacting the cleaning brush. The cleaning system housing is provided with ports that allow for air in enter of leave the cleaning system housing. A curved deflector plate is positioned such that it is spaced about ⅛″ from the cleaning brush. The deflector plate is attached to the enclosure on a side where the brush fibers are moving towards the detoner roller. A skive is made to contact the detoner roller, a baffle is formed contacting the skive and a side of the cleaning housing. The cleaning system is preferably designed such that the ratio of engagements of the detoner roller to the cleaning brush compared to that of the toner bearing surface to the cleaning brush, is essentially three to one.

摘要翻译： 一种形成用于静电复原系统的方法和装置，其具有部分地在清洁系统壳体内的感光鼓和清洁系统壳体内的导电芯纤维的清洁刷，所述清洁系统壳体还在清洁系统内与感光鼓接触， 房屋与清洁刷接触。 清洁系统外壳设有允许空气进入离开清洁系统外壳的端口。 弯曲的偏转板被定位成使得其与清洁刷间隔开“⅛”。 导流板在电刷纤维朝向引爆辊移动的一侧连接到外壳。 制作一个滑板接触引爆辊，形成一个接触滑板和清洁外壳侧面的挡板。 清洁系统优选地被设计成使得与相对于调色剂承载表面到达清洁刷的引导辊相对于清洁刷的接合比例基本上是三比一。

公开(公告)号：US06292698B1

公开(公告)日：2001-09-18

申请号：US09045275

申请日：1998-03-20

申请人： Edwin G. Duffin ,  David L. Thompson ,  Steven D. Goedeke ,  Gregory J. Haubrich

发明人： Edwin G. Duffin ,  David L. Thompson ,  Steven D. Goedeke ,  Gregory J. Haubrich

IPC分类号： A61N137

CPC分类号： A61N1/37282 ,  A61B5/1112 ,  G06F19/00 ,  G06F19/3418

摘要： A system for communicating with a medical device implanted in an ambulatory patient and for locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient. The implanted device includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device that is either worn by or located in proximity to the patient within the implanted device transceiving range. The control device preferably includes a communication link with a remote medical support network, a global positioning satellite receiver for receiving positioning data identifying the global position of the control device, and a patient activated link for permitting patient initiated personal communication with the medical support network. A system controller in the control device controls data and voice communications for selectively transmitting patient initiated personal communications and global positioning data to the medical support network, for initiating telemetry out of data and operating commands from the implanted device and transmission of the same to the medical support network, and for receiving and initiating re-programming of the implanted device operating modes and parameters in response to instructions received from the medical support network. The communications link between the medical support network and the patient communications control device may comprise a world wide satellite network, hard-wired telephone network, a cellular telephone network or other personal communications system.

摘要翻译： 一种用于与植入在步行病人中的医疗设备进行通信并用于定位患者的系统，以便选择性地监测设备功能，改变设备操作参数和模式，并向患者提供紧急援助并与患者通信。 植入装置包括遥测收发器，用于在植入的装置和外部患者通信控制装置之间传送数据和操作指令，所述外部患者通信控制装置在植入装置收发范围内由患者佩戴或位于患者附近。 控制装置优选地包括与远程医疗支持网络的通信链路，用于接收标识控制装置的全局位置的定位数据的全球定位卫星接收机，以及用于允许患者发起与医疗支持网络的个人通信的患者激活的链路。 控制装置中的系统控制器控制数据和语音通信，用于选择性地将患者发起的个人通信和全球定位数据发送到医疗支持网络，用于发起远程数据和从植入设备的操作命令并将其传输到医疗 支持网络，以及响应于从医疗支持网络接收到的指令，接收和启动植入设备操作模式和参数的重新编程。 医疗支持网络和患者通信控制设备之间的通信链路可以包括全球卫星网络，硬连线电话网络，蜂窝电话网络或其他个人通信系统。

公开(公告)号：US06223080B1

公开(公告)日：2001-04-24

申请号：US09181523

申请日：1998-10-28

申请人： David L. Thompson

发明人： David L. Thompson

IPC分类号： A61N1362

CPC分类号： A61N1/37276 ,  A61N1/362 ,  A61N1/3708 ,  A61N1/378 ,  A61N1/3956 ,  G06F1/3203 ,  G06F1/324 ,  G06F1/3296 ,  Y02D10/126 ,  Y02D10/172

摘要： Power consumption in medical and battery powered devices is reduced through the use and operation of multiple digital signal processing systems and through the application of different supply voltages to analog and digital circuits, respectively. Each processor of the multiple systems performs at least one particular function in a predetermined time period. The multiple digital signal processors of such systems can be operated at lower clock frequencies relative to those that would be required by one of such processors to complete the multiple functions within the predetermined time period. With reduced clock frequency, power consumption is reduced. Further, with reduced clock speed, supply voltages applied to such digital signal processors may also be reduced. A source applies a first fixed supply voltage to the digital circuits of the medical or battery powered device and a voltage generation circuit (e.g., a charge pump circuit) having the first fixed supply voltage applied thereto is used for generating a second fixed supply voltage to be applied to analog circuits of the device. Power consumption may also be reduced through the operation of circuits at clock speeds of lower levels to adequately complete desired functions during predetermined time periods (e.g., blanking interval, upper rate interval, etc.) just-in-time prior to subsequent required functional processes; by providing supply voltages tailored for various circuits of an integrated circuit; by operating two or more circuits of an integrated circuit at different clock frequencies; by changing the supply voltage level “on the fly” as required by specific circuit timing functions required for various circuitry based on clock frequencies used to control operation of such circuitry; and/or by tailoring back gate bias or adjusting back gate bias “on the fly” for circuits based on the supply voltage level applied to the circuits.

公开(公告)号：US06167303A

公开(公告)日：2000-12-26

申请号：US289471

申请日：1999-04-09

申请人： David L. Thompson

发明人： David L. Thompson

IPC分类号： A61N1/36 ,  A61N1/362

CPC分类号： A61N1/378 ,  A61N1/36125 ,  A61N1/37276

摘要： Power consumption in medical and battery powered devices is reduced through the use and operation of a data monitor which measures, senses or detects signals, inputs or outputs in a medical device before they are input to a principal or main digital signal processor, controller or microprocessor. In response to detecting or measuring such a signal which meets certain amplitude, frequency and/or phase characteristics, the data monitor directs or controls clock or voltage supply circuits to increase or decrease clock frequency, or to increase or decrease the voltage provided to certain circuits within the medical device. The clock frequencies and/or voltages so employed are tailored to reduce the amount of power consumed by the medical device while preserving computational performance.

摘要翻译： 医疗和电池供电设备的功耗通过使用和操作数据监视器而减少，该数据监视器在输入到主数字信号处理器，控制器或微处理器之前测量，感测或检测医疗设备中的信号，输入或输出 。 响应于检测或测量满足特定幅度，频率和/或相位特性的信号，数据监视器引导或控制时钟或电压供应电路以增加或减少时钟频率，或增加或减少提供给某些电路的电压 在医疗器械内。 所采用的时钟频率和/或电压被定制以减少医疗设备消耗的功率量，同时保持计算性能。

公开(公告)号：US6052623A

公开(公告)日：2000-04-18

申请号：US201059

申请日：1998-11-30

申请人： Andreas A. Fenner ,  Lary R. Larson ,  Daniel R. Greeninger ,  David L. Thompson

发明人： Andreas A. Fenner ,  Lary R. Larson ,  Daniel R. Greeninger ,  David L. Thompson

IPC分类号： A61N1/375

CPC分类号： A61N1/3754

摘要： A feedthrough assembly for an implantable medical device includes one or more electrically conductive pins extending through apertures in a case of the medical device with the electrically conductive pins being insulated from the case. The feedthrough assembly further includes a printed circuit board having a diode protection circuit mounted thereon. The printed circuit board forms at least a part of electrically conductive paths for connection of the electrically conductive pins to a medical device circuit assembly mounted within the case. The printed circuit board further provides for electrical connection of the diode protection circuit mounted thereon between the electrically conductive pins and the case.

摘要翻译： 用于可植入医疗装置的馈通组件包括在医疗装置的壳体中延伸穿过孔的一个或多个导电销，其中导电销与壳体绝缘。 馈通组件还包括其上安装有二极管保护电路的印刷电路板。 印刷电路板形成用于将导电针连接到安装在壳体内的医疗装置电路组件的导电路径的至少一部分。 印刷电路板还提供安装在其上的二极管保护电路在导电引脚和外壳之间的电连接。

公开(公告)号：US6044301A

公开(公告)日：2000-03-28

申请号：US282593

申请日：1999-03-31

申请人： Jerome T. Hartlaub ,  David L. Thompson ,  Daniel R. Greeninger

发明人： Jerome T. Hartlaub ,  David L. Thompson ,  Daniel R. Greeninger

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37258

摘要： Methods and apparatus for confirming programming of implantable medical device (IMD) operating parameter values and operating modes by emission of audible sounds by the IMD are disclosed. The IMD includes an audio transducer that emits audible sounds including voiced statements or musical tones stored in analog memory correlated to a programming or interrogation operating algorithm or to a warning trigger event. The audible sounds can comprise the sole uplink transmission or may augment the contemporaneous uplink RF transmission of stored data, and/or programmed operating modes and parameters and/or device operations and states in an interrogation or during programming. To conserve energy, the audible sounds accompanying interrogation and programming of the IMD are at a low volume that preferably cannot be heard without use of an external audio amplifier or stethoscope. Voiced statements warning of battery energy depletion or imminent delivery of a therapy are emitted at a higher volume that is sufficient to be heard by the patient, so that the patient can take appropriate action. The volume of audible sounds confirming programmed changes made by a patient using a limited function programmer or magnet is also increased so that the patient can hear them.

摘要翻译： 公开了通过IMD发出可听见的声音来确认可植入医疗装置（IMD）操作参数值和操作模式的编程的方法和装置。 IMD包括音频换能器，其发射可听声音，包括存储在与编程或询问操作算法相关的模拟存储器中的语音或音调，或者到警告触发事件。 可听见的声音可以包括唯一的上行链路传输，或者可以在询问中或在编程期间增加存储数据的同时期上行链路RF传输和/或编程的操作模式和参数和/或设备操作和状态。 为了节省能量，伴随着IMD的询问和编程的可听见的声音处于较低的音量，最好在不使用外部音频放大器或听诊器的情况下听不到声音。 电池能量消耗或治疗即将发送的声明声明以足以由患者听到的较高音量发出，以便患者能够采取适当的动作。 使用有限功能的编程器或磁铁确认病人进行的编程改变的可听见声音的音量也增加，以便患者可以听到它们的声音。