公开(公告)号：US09439591B2

公开(公告)日：2016-09-13

申请号：US12962000

申请日：2010-12-07

申请人： Stephan-Michael Frey ,  Hans List ,  Andrea Rittinghaus ,  Volker Zimmer ,  Guenter Ihle ,  Wolfgang Roedel

发明人： Stephan-Michael Frey ,  Hans List ,  Andrea Rittinghaus ,  Volker Zimmer ,  Guenter Ihle ,  Wolfgang Roedel

IPC分类号： A61B5/157 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/151

CPC分类号： A61B5/157 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15163

摘要： A system for determining an analyte in a body fluid includes a magazine comprising two partial magazines, one including chambers containing analysis elements having a sample contact zone and a reagent system containing a reagent, whose reaction with the body fluid results in a change of a variable, and another including chambers containing puncturing elements having a tip having a capillary channel, which forms a fluid connection between the tip and a sample transfer zone of the puncturing element. The system may also include an analysis instrument having a puncturing drive for driving a puncturing element on a movement path, a mounting for receiving the magazine such that one chamber of the magazine at a time is located in a functional position, in which a puncturing element in the chamber can be moved by the puncturing drive, and a measuring and evaluation apparatus for measuring the change of the variable.

摘要翻译： 用于确定体液中的分析物的系统包括：包含两个部分杂志的盒，一个包括具有样品接触区的分析元件的腔室和含有试剂的试剂系统，其与体液的反应导致变量 ，另一个包括具有具有毛细通道的尖端的穿刺元件的腔室，其形成尖端和穿刺元件的样品转移区域之间的流体连接。 该系统还可以包括具有用于在移动路径上驱动穿刺元件的穿刺驱动器的分析仪器，用于接收盒子的安装件，使得一次一次的仓库位于功能位置，其中穿刺元件 可以通过穿刺驱动器移动腔室，以及用于测量变量的变化的测量和评估装置。

公开(公告)号：US09289162B2

公开(公告)日：2016-03-22

申请号：US13365404

申请日：2012-02-03

申请人： Hans-Juergen Kuhr ,  Herbert Harttig ,  Hans-Peter Haar ,  Hans List

发明人： Hans-Juergen Kuhr ,  Herbert Harttig ,  Hans-Peter Haar ,  Hans List

IPC分类号： A61B5/00 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/151 ,  A61B5/157

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150946 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/15132 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157

摘要： The invention concerns a control device for a medical test system which has a lancing element that can be inserted into body tissue to collect body fluid and a lancing drive for the lancing element. A sensor element for body fluid is arranged on the lancing element and a control unit is coupled to the sensor element for detecting a fault when collecting body fluid. In order to improve the success rate, the control unit actuates the lancing drive for an automatic puncture repetition in less than 1 second when a fault, e.g., inadequate wetting of a detection field, occurs.

摘要翻译： 本发明涉及用于医疗测试系统的控制装置，其具有可以插入身体组织以收集体液的穿刺元件和用于穿刺元件的穿刺驱动器。 用于体液的传感器元件布置在穿刺元件上，并且控制单元联接到传感器元件，用于在收集体液时检测故障。 为了提高成功率，当出现故障（例如，检测场的不充分）时，控制单元在小于1秒钟内启动穿刺驱动以进行自动穿刺重复。

公开(公告)号：US08932313B2

公开(公告)日：2015-01-13

申请号：US11743410

申请日：2007-05-02

申请人： Thomas Weiss ,  Hans List

发明人： Thomas Weiss ,  Hans List

IPC分类号： A61B17/32 ,  A61B5/15

CPC分类号： A61B5/1411 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150236 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194

摘要： A blood collection system for collecting blood from a body part for diagnostic purposes, comprising a housing with a lancet guide, by which a lancet is guided on a predetermined puncture path, and a lancet drive for driving a puncturing movement of the lancet on the predetermined puncture path. The puncturing movement comprises a forward movement phase in the direction of puncturing and, after reaching a reversal point, a subsequent retraction movement phase in the direction opposite the puncture direction. The lancet drive has a driving spring, which is arranged behind the lancet and is connected to the lancet during the forward movement phase of the puncturing movement so that the lancet is driven in the puncturing direction. The system comprises an oscillation control device for controlling oscillation of the lancet and the driving spring in such a manner that repeated puncturing of the body part by the lancet is prevented.

摘要翻译： 一种用于从身体部分收集用于诊断目的的血液的采血系统，包括：具有刺血针引导件的壳体，穿刺针在预定穿刺路径上被引导;以及刺血针驱动器，用于在所述预定的穿刺引导件上驱动刺血针的穿刺运动 穿刺路径 穿刺动作包括在穿刺方向上的向前移动相位，并且在到达反转点之后，沿与穿刺方向相反的方向的后续的缩回移动相位。 刺血针驱动器具有驱动弹簧，该驱动弹簧布置在刺血针后面，并且在穿刺运动的向前运动阶段期间连接到刺血针，使得刺血针沿穿刺方向被驱动。 该系统包括用于控制刺血针和驱动弹簧的振动的振荡控制装置，以防止柳叶刀重复穿刺身体部位。

公开(公告)号：US08888715B2

公开(公告)日：2014-11-18

申请号：US12712236

申请日：2010-02-25

申请人： Hans List ,  Stephan-Michael Frey ,  Kai Fluegge

发明人： Hans List ,  Stephan-Michael Frey ,  Kai Fluegge

IPC分类号： A61B5/00 ,  B65D81/00 ,  A61B5/15 ,  A61B5/151

CPC分类号： A61B5/1405 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15115 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/157

摘要： Analysis system for determining an analyte in a body fluid is presented. The system comprises a reusable analysis instrument and a magazine having a plurality of integrated sample acquisition and analyzing elements. Each element comprises a puncturing element and an analyzing element. A coupling unit couples the integrated sample acquisition and analyzing element to a drive. The magazine comprises a housing having a plurality of elongate neighboring chambers separated by two side walls running in a longitudinal. The chambers contain the integrated sample acquisition and analyzing element. The chambers have an exit opening allowing for the at least partial exiting of the puncturing element. The chambers of the magazine are accessible to a coupling element that can be formfitting coupled to the coupling structure of the puncturing element, when the puncturing element is in the chamber of the magazine and the magazine is located in a holder.

摘要翻译： 提出了用于确定体液中分析物的分析系统。 该系统包括可重复使用的分析仪器和具有多个集成样品采集和分析元件的杂志。 每个元件包括穿刺元件和分析元件。 耦合单元将集成的采样和分析元件耦合到驱动器。 该杂志包括具有由纵向延伸的两个侧壁隔开的多个细长相邻室的壳体。 这些室包含集成的采样和分析元件。 腔室具有允许穿刺元件的至少部分离开的出口。 当穿刺元件位于钉仓的腔室中并且刀库位于保持器中时，可以将联接元件接近联接元件，该联接元件可被联接到穿刺元件的联接结构上。

公开(公告)号：US08414609B2

公开(公告)日：2013-04-09

申请号：US12717359

申请日：2010-03-04

申请人： Hans List

发明人： Hans List

IPC分类号： A61B17/32 ,  A61B5/151

CPC分类号： A61B5/150198 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/1519 ,  A61B5/15194

摘要： A lancet device for generating a puncture wound in a skin surface, comprising a housing, in which a lancet can be moved on a puncturing path, a lancet drive with a drive rotor that can be driven by a drive spring, a lancet coupling mechanism that transforms a rotational motion of the drive rotor into a puncturing and returning motion of the lancet during a working cycle of the lancet drive, a reference element that is mobile relative to the lancet and relative to the housing and is fixed in a defined position relative to the lancet drive during the puncturing and rests against the surface of the skin with a contact surface thereof such that a puncture wound with a reproducible puncturing depth is generated by the puncturing motion, and a reference element coupling mechanism that is coupled to the lancet drive in order to move the reference element. The invention further relates to a suitable lancet drive assembly for a lancet device of this type.

摘要翻译： 一种用于在皮肤表面产生穿刺伤口的刺血针装置，其特征在于，具有可以在穿刺路径上移动刺血针的壳体，能够由驱动弹簧驱动的驱动转子的柳叶刀驱动器， 将所述驱动转子的旋转运动变换成在所述柳叶刀驱动器的工作循环期间所述刺血针的穿刺和返回运动，所述参考元件相对于所述刺血针并且相对于所述壳体是可移动的并且相对于所述壳体被固定在限定位置 在穿刺期间的刺血针驱动器和其接触表面靠在皮肤表面上，使得通过穿刺运动产生以可再现的穿刺深度缠绕的穿刺，以及参考元件联接机构，其连接到刺血针驱动器 命令移动参考元素。 本发明还涉及一种用于这种类型的刺血针装置的合适的柳叶刀驱动组件。

公开(公告)号：US08394117B2

公开(公告)日：2013-03-12

申请号：US12040905

申请日：2008-03-02

申请人： Heinz-Michael Hein ,  Irio Calasso ,  Hans List

发明人： Heinz-Michael Hein ,  Irio Calasso ,  Hans List

IPC分类号： A61B17/14 ,  A61B17/32 ,  A61B17/34 ,  B26F1/24

CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150152 ,  A61B5/150175 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/15123 ,  A61B5/1519 ,  A61B5/15194 ,  Y10T83/0481

摘要： The invention relates to a method for creating a puncture wound for obtaining a sample of a body fluid from a body part in which a skin opening is created at a puncture site in the epidermis in a skin-opening step. Then, in a sample collection step a sample collection puncture is executed by using a puncture element with which the skin opening is deepened with the puncture element, thereby creating a puncture wound for obtaining the sample. The invention also relates to a handheld apparatus for implementing this method.

摘要翻译： 本发明涉及一种创造穿刺伤口的方法，该穿刺伤口从皮肤开放步骤中在表皮的穿刺位置处产生皮肤开口的身体部位获得体液样品。 然后，在取样步骤中，通过使用与穿刺元件加深皮肤开口的穿刺元件进行样本采集穿刺，由此形成用于获取样本的穿刺伤口。 本发明还涉及一种用于实现该方法的手持设备。

公开(公告)号：US20120283528A1

公开(公告)日：2012-11-08

申请号：US13479006

申请日：2012-05-23

申请人： Ahmet Konya ,  Hans List ,  Hans-Jürgen Kuhr

发明人： Ahmet Konya ,  Hans List ,  Hans-Jürgen Kuhr

IPC分类号： A61B5/145

CPC分类号： A61B5/1427 ,  A61B5/02035 ,  A61B5/14 ,  A61B5/1405 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150916 ,  A61B5/15115 ,  A61B5/15153 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176

摘要： A replaceable magazine for use in an analytic test instrument a plurality of analytic aids on a carrier tape. The analytic aids can be made available in an application position of the magazine by means of the carrier tape. The magazine has a supply reel for holding regions of the carrier tape with unused analytic aids and a take-up reel for holding regions of the carrier tape with used-up analytic aids. The carrier tape can be moved in a spooling direction from the supply reel to the take-up reel. The magazine has a rewind lock of the take-up reel. The magazine has a tape release device, which is configured to make available a take-up reel tape reserve of the carrier tape on the side of the application position facing the take-up reel. The take-up reel tape reserve enables a lifting movement of an analytic aid situated in the application position.

摘要翻译： 用于分析测试仪器的可替换的杂志，在载带上的多个分析助剂。 分析助剂可以通过载带在料仓的施加位置中可用。 杂志具有用于保持载带的区域的未使用的分析助剂的供带盘和用于将用过的分析助剂保持载带区域的卷取卷轴。 载带可以沿卷线方向从供带盘移动到卷取卷轴。 该杂志具有卷绕卷轴的倒带锁。 该杂志具有一个磁带释放装置，该磁带释放装置被配置成在面向卷取卷轴的应用位置的一侧提供载带的卷取卷轴磁带保留。 收纸卷轴带保留能够提供位于施加位置的分析助剂的提升运动。

公开(公告)号：US08231547B2

公开(公告)日：2012-07-31

申请号：US11849280

申请日：2007-09-01

申请人： Frank Deck ,  Ortrud Quarder ,  Thomas Weiss ,  Christian Hörauf ,  Michael Keil ,  Ahmet Konya ,  Herbert Harttig ,  Felix Baader ,  Hans List ,  Karl-Peter Ebert

发明人： Frank Deck ,  Ortrud Quarder ,  Thomas Weiss ,  Christian Hörauf ,  Michael Keil ,  Ahmet Konya ,  Herbert Harttig ,  Felix Baader ,  Hans List ,  Karl-Peter Ebert

IPC分类号： A61B5/00

CPC分类号： A61B5/15148 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150198 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150832 ,  A61B5/150916 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/15196

摘要： The present invention provides a puncturing system for withdrawing body fluid. The puncturing system comprises a disposable puncturing unit, which includes a needle element for piercing into skin and a puncturing depth reference element with a skin contact area. The system includes a puncturing instrument which has a puncturing drive, wherein the puncturing drive is coupled by a coupling mechanism to the puncturing unit for driving the needle element to a puncturing depth, the puncturing depth being determined by the distance in the piercing direction between the skin contact area and the position of the tip of the needle at a reversal point of the puncturing movement. The puncturing depth reference element is connected to the needle element such that the puncturing depth reference element moves with the needle element during at least part of the puncturing movement. The puncturing depth reference element has a defined longitudinal position in the piercing direction relative to the needle element at least at the reversal point of the puncturing movement.

摘要翻译： 本发明提供一种用于抽出体液的穿刺系统。 穿刺系统包括一次性穿刺单元，其包括用于刺入皮肤的针元件和具有皮肤接触区域的穿刺深度参考元件。 该系统包括具有穿刺驱动器的穿刺器具，其中穿刺驱动器通过联接机构联接到穿刺单元，用于将针元件驱动到穿刺深度，穿刺深度由穿刺方向上的距离确定 皮肤接触区域和针的尖端在穿刺运动的反转点处的位置。 穿刺深度参考元件连接到针元件，使得穿刺深度参考元件在穿刺运动的至少一部分期间与针元件一起移动。 穿刺深度参考元件至少在穿刺运动的反转点处具有相对于针元件在穿刺方向上的限定的纵向位置。

公开(公告)号：US20120063970A1

公开(公告)日：2012-03-15

申请号：US13212715

申请日：2011-08-18

申请人： Hans LIST ,  Uwe KRÄMER ,  Wilhelm LEICHNER

发明人： Hans LIST ,  Uwe KRÄMER ,  Wilhelm LEICHNER

IPC分类号： G01N33/50 ,  B23P11/00 ,  B23P17/04

CPC分类号： A61B5/15148 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/15186 ,  B01L3/502 ,  B01L2200/12 ,  B01L2300/0609 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0838 ,  B01L2300/0861 ,  B01L2300/12 ,  B01L2300/16 ,  B29C65/16 ,  G01N33/4875 ,  Y10T29/49817 ,  Y10T29/49826

摘要： A method for producing an analytical magazine is proposed. The analytical magazine is designed to receive a plurality of analytical aids in a plurality of chambers. The method comprises the following steps: providing at least one first component of the analytical magazine, wherein the first component comprises a plurality of receptacles; providing a plurality of analytical aids, wherein the analytical aids are connected to one another and preferably oriented with respect to one another by at least one holding element; introducing the analytical aids into the receptacles; and separating the analytical aids from the holding element.

摘要翻译： 提出了一种生产分析盒的方法。 分析盒被设计成在多个室中接收多个分析助剂。 该方法包括以下步骤：提供分析盒的至少一个第一部件，其中第一部件包括多个插座; 提供多个分析助剂，其中分析助剂彼此连接并且优选通过至少一个保持元件相对于彼此定向; 将分析助剂引入容器中; 并将分析助剂与保持元件分离。

公开(公告)号：US20120045825A1

公开(公告)日：2012-02-23

申请号：US13205886

申请日：2011-08-09

申请人： Herbert Harttig ,  Josef Roeper ,  Otto Fuerst ,  Thomas Jaeck ,  Ralf Dagenbach ,  Juergen Braun ,  Ronald Moench ,  Hans List ,  Beate Koschorreck

发明人： Herbert Harttig ,  Josef Roeper ,  Otto Fuerst ,  Thomas Jaeck ,  Ralf Dagenbach ,  Juergen Braun ,  Ronald Moench ,  Hans List ,  Beate Koschorreck

IPC分类号： C12M1/34

CPC分类号： G01N33/48764 ,  B01L3/5023 ,  B01L2200/12 ,  B01L2300/0825 ,  B01L2300/0887 ,  G01N21/898

摘要： A diagnostic test tape for liquid samples is provided comprising a flexible transport tape and a plurality of test fields applied to the transport tape that are distributed in the longitudinal direction of the tape, where said test fields comprise a detection layer and a spreading net spanning the detection layer for a planar uptake of liquid sample, wherein the spreading net is formed from a lattice-like fabric comprising fabric threads that cross at right angles. In order to prevent the fabric from arching up under tape tension it is proposed that the fabric is oriented obliquely to the transport tape such that all fabric threads run obliquely to the longitudinal direction of the tape.

摘要翻译： 提供了用于液体样品的诊断测试带，其包括柔性输送带和应用于输送带的多个测试区域，所述测试区域沿着带的纵向方向分布，其中所述测试区域包括检测层和跨越 用于液体样品的平面摄取的检测层，其中所述铺展网由包括以直角交叉的织物线的格子状织物形成。 为了防止织物在带张力下弯曲，建议织物相对于输送带倾斜地定向，使得所有织物线沿着带的纵向倾斜地延伸。