Polypeptide and DNA thereof
    73.
    发明授权
    Polypeptide and DNA thereof 失效
    多肽及其DNA

    公开(公告)号:US06797483B1

    公开(公告)日:2004-09-28

    申请号:US10019455

    申请日:2001-12-28

    IPC分类号: G01N3353

    CPC分类号: C07K14/4703 A61K38/00

    摘要: The present invention relates to novel secretory polypeptides and precursor proteins thereof, which show a high homology to MIA (melanoma inhibitor activity)/CD-RAP (bovine cartilage-derived retinoic acid-sensitive protein); are specifically expressed in the cartilage tissue; and have an effect on the cartilage differentiation. The polypeptides and the DNAs encoding the same can be used for the diagnosis, treatment, or prevention of bone and joint diseases or pathological angiogenesis. As well, the polypeptides are useful as a reagent for screening a compound that promotes or inhibits the activity of the polypeptides. The antibody to the polypeptides can be used for the detection, quantification, or neutralization of the polypeptide in a test sample fluid. Further by using the promoter of the present invention, a therapeutic protein can be expressed predominantly in the cartilage tissue for a gene therapy.

    摘要翻译: 本发明涉及与MIA(黑素瘤抑制剂活性)/ CD-RAP(牛软骨衍生的视黄酸敏感蛋白)高同源性的新型分泌多肽及其前体蛋白; 在软骨组织中特异性表达; 并对软骨分化有影响。 编码该多肽和DNA的DNA可用于诊断,治疗或预防骨和关节疾病或病理性血管生成。 同样,多肽可用作筛选促进或抑制多肽活性的化合物的试剂。 多肽的抗体可用于在测试样品流体中检测,定量或中和多肽。 此外,通过使用本发明的启动子,治疗性蛋白质主要在软骨组织中表达用于基因治疗。

    Automatic performing apparatus and electronic instrument
    74.
    发明授权
    Automatic performing apparatus and electronic instrument 有权
    自动执行装置和电子仪器

    公开(公告)号:US06750390B2

    公开(公告)日:2004-06-15

    申请号:US10179734

    申请日:2002-06-24

    IPC分类号: G10H700

    摘要: An automatic performing apparatus and an electronic instrument with which a user can carry out an automatic musical performance, even for a complicated arrangement, simply by providing external events at certain intervals or corresponding only to a melody. In such an electronic instrument, at the time of execution of the automatic musical performance, the keyboard events are provided at intervals of one beat. Then, the automatic musical performance is progressed within a certain section corresponding to each of the provided keyboard events. Otherwise, at the time of execution of the automatic musical performance, the keyboard events are provided at the timing of a melody. Then, musical tones for the corresponding melody are generated, while those for accompaniments following the melody are also automatically generated. Furthermore, the tempo of the automatic musical performance is set on the basis of intervals between the keyboard events.

    摘要翻译: 一种自动执行装置和电子乐器,即使是复杂的装置,用户也可以通过这些自动执行装置和电子乐器,以一定的间隔提供外部事件或仅对应于旋律。 在这样的电子乐器中,在执行自动演奏时,以一拍为间隔提供键盘事件。 然后,在对应于所提供的每个键盘事件的某一部分内进行自动演奏。 否则,在执行自动演奏时,在旋律的定时提供键盘事件。 然后,产生对应旋律的乐音,而自动生成伴奏旋律的乐曲。 此外,基于键盘事件之间的间隔来设定自动演奏的速度。

    Writing implement
    75.
    发明授权
    Writing implement 有权
    书写工具

    公开(公告)号:US6010269A

    公开(公告)日:2000-01-04

    申请号:US173166

    申请日:1998-10-15

    CPC分类号: B43K7/08

    摘要: Ink and a follower advancing with consumption of the ink are stored directly in the inside of a barrel having a pen point at its forward end. An outer tail plug constituted by a closed-end cylinder is fitted to a rear outer surface of the barrel. An air course is formed between the rear outer surface of the barrel and an inner surface of the outer tail plug to communicate with the inside of the barrel through a rear end aperture portion of the barrel. At least one air hole is provided ahead of the rear end aperture portion of the barrel to make the air course communicate with the outside air.

    摘要翻译: 墨水和随着墨水消耗而前进的随动物被直接存储在其前端具有笔尖的桶的内部。 由封闭圆筒构成的外尾塞装配在筒的后外表面上。 在筒的后外表面和外尾塞的内表面之间形成有气流,以通过筒的后端开口部与筒的内部连通。 在筒的后端开口部的前方设置至少一个气孔,使空气路与外界空气连通。

    Disc music box
    76.
    发明授权
    Disc music box 失效
    光盘音乐盒

    公开(公告)号:US5962796A

    公开(公告)日:1999-10-05

    申请号:US931290

    申请日:1997-09-16

    IPC分类号: G04B21/08 G10F1/06 G10F5/04

    CPC分类号: G10F5/04 G10F1/06

    摘要: A disc music box for playing a melody comprises a base (21); a music box disc (1) having a plurality of engaging drive parts (3) and a drive hole (4); a plurality of music box petals (27a) provided on the base; a plurality of star wheels (26) each guided and revolved by one of the engaging drive parts, a turn plate (23) provided coaxially with the music box disc and having a detecting member (42) thereon; a motor (M) provided on the base; a transmission mechanism (24) disposed between the turn plate and the motor to transmit the drive force of the motor to the turn plate; a drive projection (23d) provided on the turn plate for engagement with the drive hole of the music box disc for positioning the music box disc; and a switch (43) provided on the base for engagement with the detecting member of the turn plate when the music box disc makes one rotation.

    摘要翻译: 用于播放旋律的盘音乐盒包括基座(21); 具有多个接合驱动部分(3)和驱动孔(4)的音乐盒盘(1); 设置在基座上的多个音乐盒花瓣(27a) 多个星形轮(26),每个星形轮由所述接合驱动部分中的一个引导和旋转;与所述音乐盒盘同轴设置的转板(23),其上具有检测部件(42) 设置在基座上的马达(M) 设置在转板和马达之间的传动机构(24),以将马达的驱动力传递到转板; 设置在所述转板上用于与音乐盒盘的驱动孔接合的驱动突起(23d),用于定位音乐盒盘; 以及当所述音乐盒盘旋转一周时,设置在所述底座上用于与所述转板的检测构件接合的开关(43)。

    Polyester-grafted starch-polymer alloy
    78.
    发明授权
    Polyester-grafted starch-polymer alloy 失效
    聚酯接枝淀粉 - 聚合物合金

    公开(公告)号:US5719214A

    公开(公告)日:1998-02-17

    申请号:US606879

    申请日:1996-02-26

    摘要: A polyester-grafted starch-polymer alloy is capable of imparting practical flexibility and toughness to moldings with no or only a little plasticizer. The polyester-grafted starch-polymer alloy comprises a blend of a polyester-grafted starch (a starch which has polyester graft chains on the starch molecule, with the terminal hydroxyl groups of the polyester graft chains and the hydroxyl groups connected directly to the starch entirely or partly blocked with the ester group) and an independent polyester (a polyester which is constructed of the same unit as said polyester graft chain, with its terminal hydroxyl groups entirely or partly blocked with the ester group) which are uniformly mixed together. A method of preparing the alloy and thermoplastic resin compositions containing the alloy also are disclosed.

    摘要翻译: 聚酯接枝的淀粉 - 聚合物合金能够赋予模制品实用的柔韧性和韧性,而不用或只有一点增塑剂。 聚酯接枝的淀粉 - 聚合物合金包括聚酯接枝淀粉(在淀粉分子上具有聚酯接枝链的淀粉,聚酯接枝链的末端羟基和直接与淀粉直接相连的羟基)的共混物 或部分被酯基封端)和独立的聚酯(由与所述聚酯接枝链相同的单元构成的聚酯,其端羟基全部或部分被酯基封端)并均匀混合。 还公开了制备含有该合金的合金和热塑性树脂组合物的方法。