公开(公告)号：US20210271730A1

公开(公告)日：2021-09-02

申请号：US16800500

申请日：2020-02-25

Applicant: International Business Machines Corporation ,  Trustees of Tufts College ,  Ramot at Tel Aviv University Ltd.

Inventor： Lior Horesh ,  Misha Elena Kilmer ,  Haim Avron ,  Jiani Zhang

IPC: G06F17/13 ,  G06F16/28 ,  G06F17/15 ,  G06F17/16 ,  G06F16/2458

Abstract: An illustrative embodiment includes a method for solving a dynamical system. The method comprises: obtaining multidimensional snapshots representing respective discrete solutions of the dynamical system; storing the multidimensional snapshots within a snapshot tensor having an order of at least three; generating a basis for at least a subspace of a state space of the dynamical system at least in part by performing a decomposition of the snapshot tensor; deriving a reduced order model at least in part by using the basis to project the dynamical system from the state space onto the subspace; and solving the reduced order model of the dynamical system.

公开(公告)号：US11104651B2

公开(公告)日：2021-08-31

申请号：US16920710

申请日：2020-07-05

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Gerardo Zelmar Lederkremer ,  Julia Leitman ,  Hagit Eiger ,  Daniel Offen ,  Javier Ganz ,  Moshe Portnoy

IPC: A61K45/06 ,  A61K31/505 ,  A61P25/00 ,  C07D239/42

Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.

公开(公告)号：US20210244828A1

公开(公告)日：2021-08-12

申请号：US17054938

申请日：2019-05-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Eran PERLSON ,  Roy MAIMON ,  Oded BEHAR

IPC: A61K48/00 ,  C12N15/113 ,  A61K9/00 ,  A61P25/28

Abstract: The present invention relates to methods for treating motor neuron diseases and neuromuscular junction abnormalities. Particularly, the methods comprise increasing miRNA126-5p expression in skeletal muscle cells and/or motor neurons, and/or inhibiting miRNA126-5p expression in glial cells, thereby spatially up-regulating and/or down-regulating miRNA126-5p levels, and thus treating amyotrophic lateral sclerosis.

公开(公告)号：US20210214699A1

公开(公告)日：2021-07-15

申请号：US17142072

申请日：2021-01-05

Applicant: LEMPO THERAPEUTICS LTD ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Anat KAHANA ,  Rotem VOLKMAN ,  Ben Zion GARTY ,  Daniel OFFEN

IPC: C12N9/22 ,  C12N15/113 ,  C12N5/077

Abstract: The present invention relates to methods of modulating the expression and/or activity of Myeloperoxidase (MPO) in a mammalian subject, by modulating ex vivo and/or in vivo MPO levels and/or activity in undifferentiated bone marrow (BM) cells of the subject. The invention further provides therapeutic methods and compositions for treating MPO-related disorders.

公开(公告)号：US20210145783A1

公开(公告)日：2021-05-20

申请号：US17099455

申请日：2020-11-16

Applicant: Augusta University Research Institute, Inc. ,  Bar Ilan University ,  Ramot at Tel-Aviv University Ltd.

Inventor： Betty S. PACE ,  Abraham Nudelman ,  Zvi MALIK ,  Ada REPHAELI

IPC: A61K31/22 ,  A61K31/17 ,  A61K9/00 ,  A61P7/06

Abstract: It has been found that the prodrug 1-(butyryloxy)ethyl-5-amino-4-oxopentanoate (AN-233), an oral active conjugate of BA (histone deacetylase inhibitor) and ALA (heme precursor), is useful for the treatment of hemoglobinopathies including but not limited to sickle cell disease and thalassemias. In one embodiment, AN-233 activates γ-globin transcription, induces HbF expression, produces an anti-sickling effect, or combinations thereof when administered to a subject in need thereof.

公开(公告)号：US20210080631A1

公开(公告)日：2021-03-18

申请号：US17094902

申请日：2020-11-11

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Alon BAHABAD

IPC: G02B5/20 ,  G02B5/18

Abstract: An optical device comprises a first grating and a second grating formed on or attached to a dielectric layer, and configured to simultaneously couple an optical field interacting therewith into two distinct Fano-Feshbach resonances.

公开(公告)号：US20210073959A1

公开(公告)日：2021-03-11

申请号：US16952184

申请日：2020-11-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Shay ELMALEM ,  Raja GIRYES ,  Harel HAIM ,  Alexander BRONSTEIN ,  Emanuel MAROM

IPC: G06T5/30 ,  G06T5/00 ,  G06T7/50 ,  G06T19/00 ,  G06N3/08

Abstract: A method of designing an element for the manipulation of waves, comprises: accessing a computer readable medium storing a machine learning procedure, having a plurality of learnable weight parameters. A first plurality of the weight parameters corresponds to the element, and a second plurality of the weight parameters correspond to an image processing. The method comprises accessing a computer readable medium storing training imaging data, and training the machine learning procedure on the training imaging data, so as to obtain values for at least the first plurality of the weight parameters.

公开(公告)号：US20210071014A1

公开(公告)日：2021-03-11

申请号：US16958189

申请日：2019-01-02

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEVREW UNIVERSITY OF JERUSALEM LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD

Inventor： Shachar Richter ,  Julia Gotta ,  Oded Shoseyov ,  Tal Ben Shalom

IPC: C09D5/22 ,  C09D101/02 ,  C09D7/65 ,  C09K11/06 ,  C09B57/00 ,  C09B23/01 ,  H01L51/50 ,  H01L33/50

Abstract: The invention concerns a stable white light emitting diode (WLED) coating, composed of biological and organic materials and free of rare earth elements.

公开(公告)号：US10915630B2

公开(公告)日：2021-02-09

申请号：US16776535

申请日：2020-01-30

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tsvika Dagan ,  Avishai Wool

IPC: G06F21/00 ,  G06F21/55 ,  H04L29/06

Abstract: A method includes identifying an impersonating message, transmitted over a Controller Area Network (CAN) bus by an attacking node connected to the bus, that appears to originate from a source other than the attacking node. The method further includes, in response to identifying the impersonating message, driving the attacking node into an error-passive state in which an ability of the attacking node to communicate over the bus is limited, relative to before entering the error-passive state. The method further includes, subsequently to driving the attacking node into the error-passive state, driving the attacking node into a bus-off state in which the attacking node cannot communicate over the bus, by transmitting, over the bus, a plurality of passive-error-flag-trumping messages that collide with, and trump, respective instances of a passive-error flag that the attacking node transmits over the bus. Other embodiments are also described.

公开(公告)号：US20200329685A1

公开(公告)日：2020-10-22

申请号：US16959878

申请日：2019-01-03

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ehud QIMRON ,  Ido YOSEF ,  Mordechay GERLIC

IPC: A01K67/027 ,  A01K67/033 ,  C12N15/82 ,  C12N15/11 ,  C12N9/22

Abstract: The present invention provides systems and non-invasive methods for gender selection of eukaryotic organisms More specifically, the invention applies the CRISPR-Cas system as well as any derivatives and fusion proteins thereof for creation of transgenic eukaryotic organisms and for selecting the desired gender of the resulting progeny.