公开(公告)号：US20250059439A1

公开(公告)日：2025-02-20

申请号：US18751011

申请日：2024-06-21

Applicant: The Regents of the University of California

Inventor： Peidong Yang ,  Cheng Zhu ,  Heqing Zhu

IPC: C09K11/08

Abstract: Halide perovskite compounds comprising at least one metal cation, at least one halide anion, and at least one alkali metal-bound crown ether, such as (crown ether@A)2M(IV)X6, (crown ether@A)M(II)X4, or (crown ether@A)M(III)X5 (A=alkali metal cation, M=metal cation, X=halide anion), such as (18C6@K)2HfBr6, (18C6@K)2ZrCl4Br2, (18C6@Ba)MnBr4, and (18C6@Ba)SbCl5 are provided. Methods of generating such halide perovskite compounds are also provided. The halide perovskite compounds provided herein can have improved photoluminescence quantum yield (PLQY), improved tunability, improved purity, and/or improved stability relative to available halide perovskite compounds such as alkali metal cation vacancy-ordered perovskites.

公开(公告)号：US20250059187A1

公开(公告)日：2025-02-20

申请号：US18720571

申请日：2022-12-21

Applicant: The Regents of the University of California

Inventor： Kevan M. Shokat ,  Ziyang Zhang ,  Qinheng Zheng

IPC: C07D471/04 ,  A61K31/519 ,  C07D519/00

Abstract: Described herein, inter alia, are GTPase inhibitors and uses thereof.

公开(公告)号：US12226631B2

公开(公告)日：2025-02-18

申请号：US18141816

申请日：2023-05-01

Applicant: The Regents of The University of California

Inventor： Victor Reggie Edgerton ,  Yuri P. Gerasimenko ,  Nicholas A. Terrafranca ,  Daniel C. Lu

IPC: A61N1/36 ,  A61N1/04

Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

公开(公告)号：US20250055024A1

公开(公告)日：2025-02-13

申请号：US18470746

申请日：2023-09-20

Applicant: LG ENERGY SOLUTION, LTD. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Jeongbeom LEE ,  Min Sang SONG ,  Ying Shirley MENG ,  So-Yeon HAM

IPC: H01M10/0562 ,  H01M4/134 ,  H01M4/62 ,  H01M10/058

Abstract: Disclosed is a negative electrode for an all-solid-state battery and an all-solid-state battery including the negative electrode. More specifically, disclosed is a pre-lithiated silicon negative electrode, and an all-solid-state battery comprising the same.

公开(公告)号：US20250052885A1

公开(公告)日：2025-02-13

申请号：US18722811

申请日：2023-02-07

Applicant: The Regents of the University of California

Inventor： Hao Wang ,  Omeed Momeni ,  Hamidreza Afzal

IPC: G01S13/58 ,  G01S7/35

Abstract: A displacement-sensing Doppler radar with ultra-low noise and high sensing resolution is provided. The radar includes N two frequency synthesizers to respectively generate, at different frequencies, a transmitted signal that is radiated toward a target object, and a local oscillator (LO) signal. The radar further includes a mixer and a rectifier to: (1) receive a returned signal from the target object carrying phase delays corresponding to detected displacements of the target object; (2) mix the returned signal and the LO signal to generate a down-converted sine-wave intermediate frequency (IF) signal; and (3) rectify the sine-wave IF signal to a square-wave IF signal, which also carries the displacement-induced phase delays. The radar also includes a phase demodulation module to convert the displacement-induced phase delays into a pulse-modulated signal. The radar further includes a low-pass filter to convert the modulated pulse signal into an output voltage signal indicative of the detected displacements.

公开(公告)号：US20250052842A1

公开(公告)日：2025-02-13

申请号：US18712624

申请日：2022-11-23

Applicant: The Regents of the University of California

Inventor： Kyung Hyun Sung ,  Jiahao Lin

IPC: G01R33/56 ,  G01R33/483 ,  G01R33/561 ,  G06T3/4046 ,  G06T3/4053 ,  G06T11/00

Abstract: A system for super-resolution of magnetic resonance (MR) images includes an input for receiving a two-dimensional (2D) multi-slice MR dataset of a subject, a pre-processing module coupled to the input and configured to generate a convolved input from the received 2D multi-slice MR dataset by applying slice-profile convolution to the received 2D multi-slice MR dataset, a through plane super resolution neural network coupled to the pre-processing module and configured to generate a through-plane super-resolution imaging volume based on the convolved input, and a post-processing module coupled to the through plane super resolution neural network and configured to generate a three-dimensional (3D) isotropic super resolution imaging volume by applying slice-profile deconvolution. The through plane super resolution neural network can be trained using a training input dataset generated by applying slice-profile downsampling to a 2D multi-slice MR training dataset.

公开(公告)号：US20250049911A1

公开(公告)日：2025-02-13

申请号：US18719643

申请日：2022-12-15

Applicant: The Regents of the University of California

Inventor： Mohammad Mahdi HASANI-SADRABADI ,  Song LI ,  Manish J. BUTTE

IPC: A61K39/215 ,  A61K38/19 ,  A61K38/20 ,  A61K39/00 ,  A61K47/61 ,  A61K47/62 ,  A61K47/69 ,  A61M5/178

Abstract: An implantable or injectable scaffold comprising an antigen, a T memory cell inducer, and other optional components is provided for use in enhancing the immune response to the antigen, in particular for subjects who are elderly, immunosenescent and/or immunocompromised, or undergoing cancer therapy. Coronavirus SARS-CoV-2 has caused millions of confirmed cases and hundreds of thousands of deaths. However, there is no effective drug treatment, and vaccine is in great need to control the spread of such highly infectious virus.

公开(公告)号：US20250049859A1

公开(公告)日：2025-02-13

申请号：US18810813

申请日：2024-08-21

Applicant: The Regents of the University of California

Inventor： Anahid Jewett

IPC: A61K35/32 ,  A61K35/741 ,  A61K39/00 ,  C12N5/078 ,  C12N5/0783

Abstract: The present application relates to methods of activating a NK cells in vitro, ex vivo, and/or in vivo by an osteoclast cell (OC) and/or a dendritic cell, and methods of treating disease using these activated NK cells.

公开(公告)号：US20250049716A1

公开(公告)日：2025-02-13

申请号：US18814247

申请日：2024-08-23

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming (Jack) Hu ,  Ronnie Hongbo Fang ,  Jonathan Copp

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/085 ,  A61K39/39 ,  A61K45/06

Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.

公开(公告)号：US20250043338A1

公开(公告)日：2025-02-06

申请号：US18787091

申请日：2024-07-29

Applicant: CZ Biohub SF, LLC ,  The Regents of the University of California

Inventor： Daniel Austin Foyt ,  Bo Huang

IPC: C12Q1/6841

Abstract: Provided are methods and compositions for in situ detection of RNA in cells that does not require either the use of reverse transcriptase nor use of droplets. The methods can comprise annealing, in fixed and permeabilized cells, a pair of polynucleotide probes to adjacent sequences in a target RNA, which are subsequently ligated. A cell-specific barcode sequence can be subsequently synthesized in the cell using split-pool rounds to add barcode sequences to the ligated probe pair sequences in the cells, wherein an effect of multiple rounds of the split pooling is that ligated probe pair sequences in different cells have unique barcodes that are cell-specific.