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71.发明申请公开(公告)号：US20200371086A1
公开(公告)日：2020-11-26
申请号：US16640590
申请日：2018-08-24
发明人： Kausik Das
IPC分类号： G01N33/493 , G01N33/96
摘要： Provided herein are quality control substances for use with a microscopy-based urine sediment analyzer. The quality control substances comprise a urine matrix and a cancer cell, an algae cell, a yeast cell, egg white, or any combination thereof. Methods of detecting the presence of an analyte in a urine sample from a subject, quality control substances for use in identifying the presence of one or more analytes in a urine sample from a subject, and the use of a cancer cell, an algae cell, a yeast cell, egg white, or any combination thereof in the manufacture of a quality control substance for use with a microscopy-based urine analyzer are also provided.
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公开(公告)号：US10829278B2
公开(公告)日：2020-11-10
申请号：US16308798
申请日：2017-06-22
摘要： Embodiments are directed to a removable cap with a conduction seal closure for sealing an opening of a container. The cap has a side wall and a top wall with an open access hole there-through. A flat upper portion surrounds the open access hole, which is sealed by the conduction seal. The conduction seal comprises a first polymer sealing layer, an aluminum foil layer on top of the first layer to heat seal the first layer to the cap, and a second polymer layer arranged on top of the aluminum foil layer for protection. The aluminum foil provides a formable shaping strength such that upon seal piercing, a permanent memory spread of the first and third layers is achieved. Removal of the cap does not damage the seal. Access to the container contents is achieved without probe contact to the as-pierced seal.
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公开(公告)号：US10824832B2
公开(公告)日：2020-11-03
申请号：US15551565
申请日：2016-02-16
发明人： Stefan Kluckner , Yao-Jen Chang , Wen Wu , Benjamin Pollack , Terrence Chen
摘要： Barcode tag conditions on sample tubes are detected utilizing side view images of sample tubes for streamlining handling in clinical laboratory automation systems. The condition of the tags may be classified into classes, each divided into a list of additional subcategories that cover individual characteristics of the tag quality. According to an embodiment, a tube characterization station (TCS) is utilized to obtain the side view images. The TCS enables the simultaneous or near-simultaneous collection of three images for each tube, resulting in a 360 degree side view for each tube. The method is based on a supervised scene understanding concept, resulting in an explanation of each pixel into its semantic meaning. Two parallel low-level cues for condition recognition, in combination with a tube model extraction cue, may be utilized. The semantic scene information is then integrated into a mid-level representation for final decision making into one of the condition classes.
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74.发明申请公开(公告)号：US20200340939A1
公开(公告)日：2020-10-29
申请号：US16924898
申请日：2020-07-09
发明人： Wei Zhang , Brian Holman , Kevin Horan
IPC分类号： G01N27/333 , G01N33/84 , C12Q1/25 , G01N27/416 , G01N33/50 , G01N33/49 , G01N27/30
摘要： A fluid analyzer for analyzing fluid samples comprising one or more analytes and a method of calibrating such. The fluid analyzer includes a control system to control at least one automated valve to pass at least three calibration reagents through a fluid channel to a secondary ion selective electrode, a primary ion selective electrode, and a reference electrode, and determine calibration information using calibration logic from signals generated by a meter, control the at least one automated valve to selectively pass different subsets of the at least three calibration reagents through the fluid channel to the secondary ion selective electrode, the primary ion selective electrode, and the reference electrode, and determine re-calibration information using the signals generated by the meter and at least one of the calibration information and re-calibration logic.
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公开(公告)号：US20200286621A1
公开(公告)日：2020-09-10
申请号：US16764092
申请日：2018-11-16
发明人： Karen Lim , Prabhu Ramachandran
摘要： A point of care system may comprise a plurality of diagnostic engines and an IDM in electronic communication with each of the plurality of diagnostic engines. Each of the plurality of diagnostic engines may perform testing on a sample inserted into the diagnostic engine. The IDM may be configured to communicate with each of the plurality of diagnostic engines to enable a plurality of tests to be performed on multiple different samples substantially simultaneously by a plurality of users using the plurality of diagnostic engines and to present a single user interface for managing testing by the plurality of diagnostic engines and for receiving the results of tests performed by each of the plurality of diagnostic engines.
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公开(公告)号：US10746724B2
公开(公告)日：2020-08-18
申请号：US15748321
申请日：2016-07-25
发明人： Jennifer A. Samproni , Todd Andrade , Marlene Shi
摘要： In the various illustrative embodiments herein, test devices are described with opposing sensor arrays and same side contacts.
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77.发明申请公开(公告)号：US20200256885A1
公开(公告)日：2020-08-13
申请号：US16635537
申请日：2018-07-25
IPC分类号： G01N35/04 , G01N21/25 , G01N21/31 , G01N33/487 , G01N35/00
摘要： An optical characterization apparatus for imaging a specimen container containing a specimen. The optical characterization apparatus includes a moveable hood configured to move between an open state and a closed state relative to a specimen container imaging location and having an interior, wherein when the moveable hood is in the closed state, a specimen container positioned at the specimen container imaging location is at least partially located within the interior of the moveable hood. One or more optical devices coupled to or within the interior of the moveable hood are positioned, when the moveable hood is in the closed state, to allow imaging of a specimen container positioned at the specimen container imaging location. Automated specimen testing systems, optical characterization apparatus, and methods of measuring characteristics of specimen containers are provided, as are other aspects.
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公开(公告)号：US10690597B2
公开(公告)日：2020-06-23
申请号：US15904823
申请日：2018-02-26
摘要： The timing of the reaction of moisture-sensitive reagents for detecting the presence of analytes, e.g. leukocytes in urine samples, is used to detect when the reagents have been compromised by excess humidity. The ratio of light reflectance at wavelengths characteristic of the products of reaction between the reagents and the analyte and an infra-red reference dye is measured at two preset times after a urine sample has been applied to a test strip and used to determine whether the reagents have been compromised by excessive humidity. The presence of unusually dark samples is determined from the reflected light at 470 and 625 nm in order to confirm that the test strips are humidity-compromised.
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公开(公告)号：US20200173955A1
公开(公告)日：2020-06-04
申请号：US16782511
申请日：2020-02-05
发明人： Wei Zhang , Kevin Horan
IPC分类号： G01N27/333 , G01N33/487 , G01N27/416
摘要： A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.
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公开(公告)号：US10670550B2
公开(公告)日：2020-06-02
申请号：US15946757
申请日：2018-04-06
发明人： Jennifer A. Samproni
IPC分类号： G01N27/327 , G01N27/27
摘要： In one illustrative embodiment, a test strip with a first planar substrate has coplanar electrodes on a first planar surface and a second planar substrate (which opposes the first surface of the first planar substrate) has coplanar electrodes on a second planar surface. The first planar surface of the first planar substrate having a first sensing area electrically connected to a first electrical contact. The second planar surface of the second planar substrate having a second electrical contact electrically connected to the first electrical contact via a conductive element, the conductive element extending between the first surface of the first planar substrate and the second surface of the second planar substrate without passing through the first planar substrate, the second planar substrate, or any intermediate layers.
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