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    Use of CR1-binding molecules in clearance and induction of immune responses
    73.
    发明申请
    Use of CR1-binding molecules in clearance and induction of immune responses 审中-公开
    CR1结合分子在清除和诱导免疫应答中的应用

    公开(公告)号：US20060263792A1

    公开(公告)日：2006-11-23

    申请号：US11263569

    申请日：2005-10-31

    Applicant: Nehal Mohamed ,  George Spitalny ,  Leslie Casey ,  Steven Jones ,  Steven Pincus

    Inventor： Nehal Mohamed ,  George Spitalny ,  Leslie Casey ,  Steven Jones ,  Steven Pincus

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C07K16/2896

    Abstract: The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effecting clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement receptor 1 (CR1) and does not substantially bind to complement receptor 2 (CR2), linked to a second moiety which comprises the antigen or binds to the antigen. Methods of producing such molecules and their therapeutic and/or prophylactic uses are also featured.

    Abstract translation: 本发明提供了与能够既诱导对哺乳动物的抗原的免疫应答的分子的发现相关的方法和组合物，并且还能够实现抗原的清除，其中这些分子包含第一部分，其包含特异性结合于 补体受体1（CR1），并且基本上不与补体受体2（CR2）结合，其与包含抗原或与抗原结合的第二部分连接。 还提出了生产这种分子的方法及其治疗和/或预防用途。

    System and method for suppressing sublimation using opacified aerogel
    75.
    发明申请
    System and method for suppressing sublimation using opacified aerogel 有权
    使用透明气凝胶抑制升华的系统和方法

    公开(公告)号：US20060090475A1

    公开(公告)日：2006-05-04

    申请号：US10977276

    申请日：2004-10-29

    Applicant: Jeff Sakamoto ,  G. Snyder ,  Thierry Calliat ,  Jean-Pierre Fleurial ,  Steven Jones ,  Jong-Ah Palk

    Inventor： Jeff Sakamoto ,  G. Snyder ,  Thierry Calliat ,  Jean-Pierre Fleurial ,  Steven Jones ,  Jong-Ah Palk

    IPC: F25B21/02

    CPC classification number: H01L35/30 ,  F25B21/02 ,  Y10T428/249986

    Abstract: The present invention relates to a castable, aerogel-based, ultra-low thermal conductivity opacified insulation to suppress sublimation. More specifically, the present invention relates to an aerogel opacified with various opacifying or reflecting constituents to suppress sublimation and provide thermal insulation in thermoelectric modules. The opacifying constituent can be graded within the aerogel for increased sublimation suppression, and the density of the aerogel can similarly be graded to achieve optimal thermal insulation and sublimation suppression.

    Abstract translation: 本发明涉及一种可浇铸的，基于气凝胶的超低热导率的不透光绝缘以抑制升华。 更具体地说，本发明涉及一种用各种不透明或反射组分不透明的气凝胶，以抑制升华并提供热电模块中的绝热。 不透明成分可以在气凝胶中分级以增加升华抑制，并且气凝胶的密度可以类似地分级以实现最佳的绝热和升华抑制。

    METHOD AND APPARATUS FOR REDUCING HOT SPOT TEMPERATURES ON STACKED FIELD WINDINGS
    76.
    发明申请
    METHOD AND APPARATUS FOR REDUCING HOT SPOT TEMPERATURES ON STACKED FIELD WINDINGS 审中-公开
    用于减少堆叠场地绕组上的热点温度的方法和装置

    公开(公告)号：US20050275304A1

    公开(公告)日：2005-12-15

    申请号：US11160599

    申请日：2005-06-30

    Applicant: Lamyaa El-Gabry ,  Steven Jones

    Inventor： Lamyaa El-Gabry ,  Steven Jones

    IPC: H02K3/24 ,  H02K3/12 ,  H02K9/00 ,  H02K1/32

    CPC classification number: H02K3/12 ,  H02K9/00 ,  Y10T29/49073

    Abstract: A method and apparatus for a generator coil includes a plurality of stacked windings in a rotor where individual turns are stacked in parallel sided radial slots in the rotor. Each successive turn has the same width substantially corresponding to a constant width of each slot, wherein a first turn has a first thickness and a second turn has a second thickness thicker than said first thickness. The second turn is employed in regions of high temperature thereby reducing the temperature thereof.

    Abstract translation: 用于发电机线圈的方法和装置包括在转子中的多个堆叠的绕组，其中单独的匝在转子中平行的平行的两个侧向的槽中堆叠。 每个连续的匝具有基本上对应于每个槽的恒定宽度的相同的宽度，其中第一匝具有第一厚度，而第二匝具有比所述第一厚度更厚的第二厚度。 第二回合用于高温区域，从而降低其温度。

    Pyrrole and pyrazole DAAO inhibitors
    77.
    发明申请
    Pyrrole and pyrazole DAAO inhibitors 有权
    吡咯和吡唑DAAO抑制剂

    公开(公告)号：US20050143443A1

    公开(公告)日：2005-06-30

    申请号：US11023924

    申请日：2004-12-28

    Applicant: Q. Fang ,  Seth Hopkins ,  Steven Jones

    Inventor： Q. Fang ,  Seth Hopkins ,  Steven Jones

    IPC: A61K31/401 ,  A61K31/405 ,  A61K31/415 ,  A61K31/416 ,  C07D207/34 ,  C07D209/42 ,  C07D209/44 ,  C07D231/14 ,  C07D231/16 ,  C07D231/54 ,  C07D231/56 ,  C07D491/04

    CPC classification number: C07D231/56 ,  C07D207/34 ,  C07D209/42 ,  C07D209/44 ,  C07D231/14 ,  C07D231/16 ,  C07D231/54 ,  C07D491/04

    Abstract: Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein R1 and R2 are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl, and XYR5; or R1 and R2, taken together, form a 5, 6, 7 or 8-membered substituted or unsubstituted carbocyclic or heterocyclic group; X and Y are independently selected from O, S, NH, and (CR6R7)n; R3 is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc ion or a mixture thereof; Z is N or CR4; R4 is from selected from hydrogen, halo, nitro, alkyl, alkylaryl, and XYR5; R5 is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl; R6 and R7 are independently selected from hydrogen and alkyl; n is an integer from 1 to 6; at least one of R1, R2 and R4 is other than hydrogen; and at least one of X and Y is (CR6R7)n. D-serine or cycloserine may be coadministered along with the compound of formula I.

    Abstract translation: 提高D-丝氨酸浓度，降低D-丝氨酸氧化毒性浓度的方法，用于增强学习，记忆和/或认知，或用于治疗精神分裂症，阿尔茨海默病，共济失调或神经性疼痛，或防止神经功能特征丧失 的神经变性疾病涉及向需要治疗的受试者施用治疗有效量的式I化合物或其药学上可接受的盐或溶剂合物：其中R 1和R 2， SUP>独立地选自氢，卤素，硝基，烷基，酰基，烷基芳基和XYR 5。 或R 1和R 2一起形成5,6或7元或8元的取代或未取代的碳环或杂环基; X和Y独立地选自O，S，NH和（CR 6）R 7）。 R 3是氢，烷基或M + H; M是铝，钙，锂，镁，钾，钠，锌离子或它们的混合物; Z是N或CR 4; R 4选自氢，卤素，硝基，烷基，烷基芳基和XYR 5; R 5选自芳基，取代的芳基，杂芳基和取代的杂芳基; R 6和R 7独立地选自氢和烷基; n是1至6的整数; R 1，R 2和R 4中的至少一个不是氢; 并且X和Y中的至少一个是（CR 6）R 7）。 D-丝氨酸或环丝氨酸可以与式I化合物共同给药。

    Blind rivet with steal
    79.
    发明申请
    Blind rivet with steal 失效
    盲铆铆钉

    公开(公告)号：US20050019136A1

    公开(公告)日：2005-01-27

    申请号：US10496705

    申请日：2002-12-07

    Applicant: Steven Jones

    Inventor： Steven Jones

    IPC: F16B19/00 ,  F16B19/10 ,  F16B19/08

    CPC classification number: F16B19/1054 ,  F16B19/008

    Abstract: An open-end blind rivet (210) comprises a headed mandrel (218) with a substantially tubular rivet mounted thereon with a flowable sealant (250) disposed between the mandrel and the rivet whereby setting of the blind rivet compresses the sealant between the head (216) of the mandrel and an inner surface of the rivet to form a seal therebetween.

    Abstract translation: 开口盲铆钉（210）包括头部心轴（218），其上安装有基本上管状的铆钉，其上设置有设置在心轴和铆钉之间的可流动的密封剂（250），由此盲孔铆钉的设置将密封剂压缩在头部 216）和铆钉的内表面之间形成密封。

    Portable signal transfer unit
    80.
    发明授权
    Portable signal transfer unit 失效
    便携式信号传输单元

    公开(公告)号：US06450953B1

    公开(公告)日：2002-09-17

    申请号：US09292158

    申请日：1999-04-15

    Applicant: John D. Place ,  Paul Johnson ,  Steven Jones ,  Harpal S. Kumar ,  William J. Mullarkey ,  William New, Jr. ,  Laurence J. Nicolson ,  Peter M. Relph

    Inventor： John D. Place ,  Paul Johnson ,  Steven Jones ,  Harpal S. Kumar ,  William J. Mullarkey ,  William New, Jr. ,  Laurence J. Nicolson ,  Peter M. Relph

    IPC: A61B500

    CPC classification number: A61B5/0002 ,  Y10S128/903

    Abstract: A portable signal transfer unit for relaying a signal representative of physiological data of a mammalian subject from a remote physiological sensor to a remote receiver unit. The portable transfer unit includes an input device which operably receives the signal, a memory for buffering the signal, and an output device which wirelessly transmits the signal to the remote unit. The signal transfer unit also includes a signal processor for relaying the signal from the signal input to the output device, wherein the signal processor has two or more receivers each receiver adapted to handle a specified signal carrier frequency. An indicator is also provided which indicates to the subject whether the signal transfer unit is within range of the remote unit to enable effective transmission of the signal from the signal transfer unit to the remote unit.

    Abstract translation: 一种便携式信号传送单元，用于将表示哺乳动物受试者的生理数据的信号从远程生理传感器传送到远程接收器单元。 便携式传送单元包括可操作地接收信号的输入设备，用于缓冲信号的存储器以及将信号无线地发送到远程单元的输出设备。 信号传送单元还包括用于将信号从信号输入中继到输出设备的信号处理器，其中信号处理器具有两个或多个接收器，每个接收器适于处理指定的信号载波频率。 还提供了一个指示器，其向主体指示信号传送单元是否在远程单元的范围内，以使信号能够从信号传送单元有效传输到远程单元。

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