公开(公告)号：US20070015161A1

公开(公告)日：2007-01-18

申请号：US10572289

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hynan ,  Pierry Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hynan ,  Pierry Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  A61K48/00 ,  A61K38/17 ,  C07K14/82 ,  C40B30/06

CPC分类号： C12N15/113 ,  A61K38/17 ,  A61K39/00 ,  A61K48/00 ,  C07K14/43545 ,  C07K14/43581 ,  C07K14/4738 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/6893 ,  G01N2500/00

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间细胞周期进程中的重要功能作用，可通过RNA介导的干扰（RNAi）鉴定和鉴定和分离功能 所述基因的直向同源物包括其所有生物功能衍生物。 本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US20070042981A1

公开(公告)日：2007-02-22

申请号：US10572123

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： A61K48/00 ,  A61K39/395 ,  A61K38/55 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12N15/113 ,  A61K38/16 ,  A61K39/00 ,  A61K48/00 ,  C07K14/43545 ,  C07K14/43581 ,  C07K14/47 ,  C12N2799/021 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in chromatin separation during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间染色质分离中的重要功能作用，可以通过RNA介导的干扰（RNAi）和识别和分离功能直系同源物 的所述基因包括其所有生物功能衍生物。 本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US20070093438A1

公开(公告)日：2007-04-26

申请号：US10572004

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： A61K48/00 ,  C40B40/08 ,  C40B30/06

CPC分类号： A01K67/0336 ,  A01K2217/058 ,  A01K2227/703 ,  A01K2267/0331 ,  C07K14/4738 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/12

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间纺锤体形成或微管功能中的重要功能作用，可通过RNA介导的干扰（RNAi）和鉴定和分离鉴定 所述基因的功能直系同源物包括所有生物功能衍生物本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及 它们用于诊断和治疗增殖性和其他疾病。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US20120258104A1

公开(公告)日：2012-10-11

申请号：US13386347

申请日：2010-07-22

申请人： Christophe J. Echeverri ,  Birte Sonnichsen ,  Reinhard Wähler ,  Mike Werner Helms

发明人： Christophe J. Echeverri ,  Birte Sonnichsen ,  Reinhard Wähler ,  Mike Werner Helms

IPC分类号： C07K19/00 ,  A61K38/02 ,  C12N5/071 ,  C12N1/14 ,  C12N1/16 ,  C12N1/18 ,  C12N5/04 ,  A61K39/395 ,  C12N5/07 ,  B82Y5/00

CPC分类号： C12N15/111 ,  A61K47/549 ,  A61K47/64 ,  A61K47/6415 ,  A61K47/65 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/3513 ,  C12N2310/3517 ,  C12N2320/32 ,  C12N2310/3521

摘要： The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell. The present invention further relates to a pharmaceutical composition comprising said conjugate and to its use. The present invention also relates to a method of delivering a compound to a cell or an organism, preferably a patient. The conjugates comprise: (a) at least one module that mediates cell targeting and facilitates cellular uptake, (b) at least one module that facilitates transport to the endoplasmic reticulum (ER), (c) at least one module that mediates translocation from the ER to the cytosol, and (d) at least one compound to be delivered wherein the modules (a) to (c) and the compound (d) are linked to each other in any arrangement.

摘要翻译： 本发明涉及包含有助于将化合物（例如生物活性大分子，特别是核酸或肽）递送到细胞中的缀合物的递送系统。 本发明还涉及用于将化合物例如生物活性大分子，核酸或肽递送到细胞中的所述缀合物。 本发明还涉及包含所述缀合物及其用途的药物组合物。 本发明还涉及将化合物递送至细胞或生物体，优选患者的方法。 缀合物包括：（a）介导细胞靶向和促进细胞摄取的至少一个模块，（b）促进转运到内质网（ER）的至少一个模块，（c）至少一个介导来自 ER至胞质溶胶，和（d）至少一种待递送的化合物，其中模块（a）至（c）和化合物（d）以任何排列彼此连接。