公开(公告)号：US10741287B2

公开(公告)日：2020-08-11

申请号：US13644344

申请日：2012-10-04

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jay L. Alberts ,  Cameron McIntyre

IPC: G16H50/30 ,  A61B5/16 ,  A61B5/11 ,  G16H50/20 ,  G16H50/70 ,  A61B5/00 ,  G16H15/00

Abstract: In an example embodiment, this disclosure provides a non-transitive computer-readable medium on which are stored instructions executable by a processor, the instructions which, when executed by the processor, cause the processor to perform a method. The method includes computing, based on test performance data of a user, at least one of a performance variable characterizing cognitive functioning and a performance variable characterizing neuromotor functioning. For each of the at least one performance variable, a respective score can be computed based on the respective performance variable and based on a set of performance metrics. The method can also include outputting, via an output device, the at least one computed score.

公开(公告)号：US10730016B2

公开(公告)日：2020-08-04

申请号：US15796162

申请日：2017-10-27

Applicant: The Regents of the University of Michigan ,  The Cleveland Clinic Foundation

Inventor： William H. Fissell ,  Shuvo Roy ,  Aaron Fleischman ,  Kenneth G. Goldman

IPC: B01D61/14 ,  B01D67/00 ,  A61M1/26 ,  A61B5/145 ,  B01D61/18 ,  B01D61/20 ,  G01N1/40 ,  A61M1/16

Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.

公开(公告)号：US20200206477A1

公开(公告)日：2020-07-02

申请号：US16814204

申请日：2020-03-10

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Karl West

IPC: A61M25/09 ,  A61B5/06 ,  A61F2/966 ,  A61B5/00

Abstract: A trackable guidewire apparatus and method for use are described. Longitudinally spaced proximal and distal guidewire ends are separated by a guidewire body. A plurality of longitudinally spaced position sensors are configured to provide signals corresponding to a three-dimensional position of at least one position sensor in a coordinate system of an associated tracking system in response to an electromagnetic field/stimulus. At least one retention mechanism is provided for maintaining the medical device in a predetermined retention position longitudinally along the guidewire body. At least one stop structure is provided in a predetermined stop position longitudinally along the guidewire body.

公开(公告)号：US20200164108A1

公开(公告)日：2020-05-28

申请号：US16666170

申请日：2019-10-28

Applicant: Fortus Medical, Inc. ,  The Cleveland Clinic Foundation

Inventor： Robert Assell ,  Andrew Freeman ,  George Muschler

IPC: A61L27/38 ,  A61L27/46 ,  A61B17/88

Abstract: A method of recovering progenitor cells from bone marrow aspirate. A bone void filler preparation container is provided. The bone void filler preparation container has an inlet port and an outlet port. A bone graft matrix having a particle size of between about 1,000 μm and about 2,000 μm is placed in the bone void filler preparation container. A bone marrow aspirate is passed through the bone void filler preparation container. Progenitor cells in the bone marrow aspirate are retained in the bone void filler preparation container. A selectivity ratio of the progenitor cells retained in the bone void filler preparation container to a total number of nucleated cells retained in the bone void filler preparation container is greater than about 3.

公开(公告)号：US20200163737A1

公开(公告)日：2020-05-28

申请号：US16625163

申请日：2018-06-20

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  LUMITEX, INC.

Inventor： Rishi P. Singh ,  Joe Dombrowski ,  Peter Broer ,  Randolph J. Hagler ,  David G. Felty ,  Andrew W. Browne

IPC: A61B90/35 ,  A61F9/007

Abstract: An ocular lighting assembly (10) including an anchor (16) and a plurality of light guides (14). The anchor is configured to mount to a surface of an eye (30) and to maintain the position of the plurality of discrete light guides. The plurality of light guides are arranged to guide light from a light source into the interior of the eye.

公开(公告)号：US10580139B2

公开(公告)日：2020-03-03

申请号：US16414819

申请日：2019-05-17

Applicant: The Cleveland Clinic Foundation ,  Alicia Fanning

Inventor： Vikash R. Goel ,  Donald P. Greenberg ,  Roy K. Greenberg

IPC: G06K9/00 ,  G06T7/13 ,  G06T7/37 ,  G06T7/155 ,  G06T17/30 ,  G06T7/60

Abstract: A computer implemented method for determining a centerline of a three-dimensional tubular structure is described. The method includes providing an edge-detected data set of voxels that characterize a boundary of the tubular structure according to a three-dimensional voxel data set for the tubular structure. A gradient field of a distance transformation is computed for the edge-detected dataset. A voxel data set corresponding to a centerline of the tubular structure is computed according to derivative of gradient field. A trajectory within the tubular structure is computed based on the centerline.

公开(公告)号：US20200060626A1

公开(公告)日：2020-02-27

申请号：US16578892

申请日：2019-09-23

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  BIOGEN MA INC.

Inventor： Jay L. Alberts ,  David D. Schindler ,  Jane Rhodes ,  Wendy Gabel ,  Jim Best

IPC: A61B5/00 ,  A61B5/11 ,  A61B3/032 ,  A61B5/16 ,  A61B5/22

Abstract: This disclosure relates to a device to mechanically and electrically connect with a touch screen computing device, such as a tablet computer. The device can include a platform that can be moved into and out of physical contact with a surface of a touch screen. During engagement with the surface, the moveable platform electrically interacts with the touch screen (e.g., via capacitive coupling) to enable detection by the touch screen of contact members (e.g., pegs) even in the absence of user contact with the pegs.

公开(公告)号：US20200038117A1

公开(公告)日：2020-02-06

申请号：US16593374

申请日：2019-10-04

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Karl West ,  Jeffrey H. Yanof

IPC: A61B34/20 ,  A61B90/00 ,  G06K9/32 ,  G06K9/00 ,  A61M5/00 ,  A61B5/06 ,  A61B5/00 ,  G06T17/20 ,  G06T3/00 ,  G06T3/20 ,  G06F3/01 ,  G06T7/33 ,  A61B34/00

Abstract: Holographic image-guidance can be used to track an interventional device during an endovascular percutaneous procedure. The holographic image guidance can be provided by a head-mounted device by transforming tracking data and vasculature image data to a common coordinate system and creating a holographic display relative to a patient's vasculature to track the interventional device during the endovascular percutaneous procedure. The holographic display can also include graphics to provide guidance for the physical interventional device as it travels through the patient's anatomy (e.g., the vasculature).

公开(公告)号：US10551372B2

公开(公告)日：2020-02-04

申请号：US15234050

申请日：2016-08-11

Applicant: The Cleveland Clinic Foundation

Inventor： Stanley L. Hazen ,  Zeneng Wang ,  Bruce S. Levison

IPC: G01N24/00 ,  G01N33/49 ,  G01N33/92 ,  G01N33/493 ,  H01J49/00

Abstract: Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds.

公开(公告)号：US20200027209A1

公开(公告)日：2020-01-23

申请号：US16415833

申请日：2019-05-17

Applicant: Case Western Reserve University ,  The Cleveland Clinic Foundation

Inventor： Anant Madabhushi ,  Prateek Prasanna ,  Justis Ehlers

IPC: G06T7/00 ,  G06K9/62 ,  G06T7/32 ,  G06T7/11 ,  G06T5/50 ,  G06T5/20 ,  G06K9/46 ,  A61B3/12 ,  A61B5/00

Abstract: Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a set of graph-network features and a set of morphological features generated based on FA images of tissue demonstrating DME. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a set of graph-network features and a set of morphological features generated based on FA imagery of the patient.