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公开(公告)号：US20220351829A1
公开(公告)日：2022-11-03
申请号：US17765880
申请日：2020-10-12
发明人： James Jiong XIA , Jaime GATENO , Peng YUAN , Han DENG
摘要： Methods and systems for establishing dental occlusion are described herein. These systems and methods can be used for 1-, 2-, or 3-piece maxillary orthognathic surgeries. An example computer-implemented method includes receiving a maxillary dental model and a mandibular dental model, identifying a plurality of dental landmarks in each of the maxillary and mandibular dental models, and extracting a plurality of points-of-interest from each of the maxillary and mandibular dental models. The dental landmarks include a plurality of maxillary dental landmarks and a plurality of mandibular dental landmarks. The method further includes aligning the maxillary and mandibular points-of-interest, and fine tuning the alignment of the maxillary and mandibular dental models to achieve maximum contact with a collision constraint.
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72.发明申请公开(公告)号：US20220307087A1
公开(公告)日：2022-09-29
申请号：US17050586
申请日：2019-04-25
发明人： Rongfu WANG , Yicheng WANG , Lili ZHANG , Chen QIAN
IPC分类号： C12Q1/6886 , C12Q1/6872
摘要： Disclosed are compositions and methods for identifying neoantigens and using neoantigens in the use of treating cancer, as well as autoimmune diseases, where antigens causing tissue destruction.
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公开(公告)号：US20220280429A1
公开(公告)日：2022-09-08
申请号：US17803152
申请日：2022-03-03
摘要： Disclosed are liposomal formulations and biomimetic proteolipid nanoparticles that possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types. Leukocyte-based biomimetic nanoparticles are disclosed that incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning the protein integration can affect the in vivo behavior of these nanoparticles and alter their efficacy. Here it is shown that, while increasing the protein:lipid ratio to a maximum of 1:20 (wt./wt.) maintained the nanoparticle's structural properties, increasing protein content resulted in improved targeting of inflamed endothelium in two different animal models. The combined use of a microfluidic, bottom-up approach, and the tuning of key synthesis parameters enabled the synthesis of reproducible, biomimetic nanoparticles for the improved targeted nanodelivery of a variety of inflammatory-based conditions, including particular cancers such as human breast cancer, and TNBC, in particular.
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公开(公告)号：US20220280428A1
公开(公告)日：2022-09-08
申请号：US17686406
申请日：2022-03-04
IPC分类号： A61K9/127 , A61K31/713 , A61K45/06
摘要： Disclosed are liposomal formulations and biomimetic proteolipid nanoparticles that possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types. Leukocyte-based biomimetic nanoparticles are disclosed that incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning the protein integration can affect the in vivo behavior of these nanoparticles and alter their efficacy. Here it is shown that, while increasing the protein:lipid ratio to a maximum of 1:20 (w/w) maintained the nanoparticle's structural properties, increasing protein content resulted in improved targeting of inflamed endothelium in two different animal models. The combined use of a microfluidic, bottom-up approach and tuning of key synthesis parameter enabled the synthesis of reproducible, enhanced biomimetic nanoparticles that have the potential to improve treatment of inflammatory-based conditions through targeted nanodelivery, including particular cancers such as human breast cancer, and TNBC in particular.
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公开(公告)号：US20220215625A1
公开(公告)日：2022-07-07
申请号：US17600909
申请日：2020-04-02
发明人： James Jiong XIA , Jaime GATENO , Dinggang SHEN
摘要： Systems and methods for estimating a patient-specific reference bone shape model for a patient with craniomaxillofacial (CMF) defects are described herein. An example method includes receiving a twodimensional (“2D”) pre-trauma image of a subject, and generating a three-dimensional (“3D”) facial surface model for the subject from the 2D pre-trauma image. The method also includes providing a correlation model between 3D facial and bone surfaces, and estimating a reference bone model for the subject using the 3D facial surface model and the correlation model.
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公开(公告)号：US20220193436A1
公开(公告)日：2022-06-23
申请号：US17567101
申请日：2021-12-31
摘要： The disclosure provides methods of cancer treatment and apparatus and, more particularly, to non-invasive cancer treatments utilizing oscillating magnetic fields to disrupt mitochondrial function or induce apoptosis or another mechanism of cell death in cancer cells. The disclosure also provides a device for providing an OMF treatment to a subject.
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公开(公告)号：US11291853B2
公开(公告)日：2022-04-05
申请号：US16682811
申请日：2019-11-13
IPC分类号： A61N2/00 , A61B5/00 , A61B5/0476 , A61N2/12 , A61B5/05 , A42B1/04 , A42B1/24 , A61B5/04 , A61B5/0478 , A61B5/245 , A61B5/291 , A61B5/369 , A42B1/242 , A61N2/06
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient, the apparatus including a head mount for disposition on the head of a patient; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies includes a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of a patient so as to modify the natural electrical activity of the brain of the patient; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each patient, whereby to provide patient-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.
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公开(公告)号：US20220088221A1
公开(公告)日：2022-03-24
申请号：US17422309
申请日：2020-01-13
发明人： Rongfu WANG , Yicheng WANG , Motao ZHU , Ruifang ZHAO
摘要： Disclosed are self-assembling nanoparticle compositions that comprise a plurality of cationic cell penetrating peptides, each covalently linked to a hydrophobic therapeutic molecule (e.g., an antigenic peptide, mRNA, siRNA, DNA, or the like), and optionally, non-covalently bound to at least one TLR (Toll-like receptor) ligand. Also disclosed are methods for use of the nanoparticle compositions in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of a mammalian disease, including, without limitation, cancer, infection, inflammation, and related diseases and abnormal conditions.
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公开(公告)号：US20210196624A1
公开(公告)日：2021-07-01
申请号：US16879984
申请日：2020-05-21
摘要： An implantable device comprising a nanochanneled membrane is described. The device uses nanofluidics to control the delivery of diagnostic and/or therapeutic agents intratumorally. The devices can be used for chemotherapy, radiosensitization, immunomodulation, and imaging contrast.
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公开(公告)号：US20210187260A1
公开(公告)日：2021-06-24
申请号：US16756938
申请日：2018-10-17
发明人： Marco FARINA , Andrea BALLERINI , Daniel W. FRAGA , Usha Ramachandran THEKKEDATH , Omaima M. SABEK , Ahmed Osama GABER , Alessandro GRATTONI
摘要： Disclosed herein are devices for use in transplanting cells. The devices can include a housing defining a cavity; and a support structure separating the cavity into a cell chamber and a reservoir chamber, wherein the support structure comprises a membrane for fluid communication between the cell chamber and reservoir chamber. The cell chamber can define a first opening comprising a microstructure containing an array of micro-channels, each having a diameter to facilitate growth of vascular tissues; and an array of micro-reservoirs, each having a diameter to facilitate housing of cell aggregates individually. The membrane can define a surface area that is at least 50% of a total surface area of the support structure. Methods of treating a subject for a disease condition, such as diabetes, are also disclosed.
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