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公开(公告)号：US11440963B2
公开(公告)日：2022-09-13
申请号：US16612495
申请日：2018-05-08
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61K45/06 , C07K14/71 , C12N15/62 , C12N15/86 , A61K39/00
摘要： The invention provides a method of inhibiting a malignancy associated with human papilloma virus (HPV) comprising administering to a subject an agent that blocks PD-L1 and TGF-beta pathways, thereby inhibiting a malignancy associated with HPV in the subject.
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公开(公告)号：US11440956B2
公开(公告)日：2022-09-13
申请号：US16586310
申请日：2019-09-27
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00 , A61K38/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US20220276258A1
公开(公告)日：2022-09-01
申请号：US17631414
申请日：2020-07-29
申请人： Larimar Therapeutics, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Servic
IPC分类号： G01N33/68
摘要： The present disclosure provides methods for determining the amount of FXN or FXN fusion protein in a sample, e.g, a tissue sample, by using mass spectrometry.
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公开(公告)号：US20220265689A1
公开(公告)日：2022-08-25
申请号：US17628170
申请日：2020-01-27
申请人： THE UNITED STATES OF AMERICA ,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
IPC分类号： A61K31/675 , A61K31/47 , A61K31/513 , A61K31/5377 , A61P31/18
摘要： Disclosed is the use of a nucleoside reverse transcriptase inhibitor, a nucleotide reverse transcriptase inhibitor, and an integrase inhibitor prior to an exposure to a potential human immunodeficiency virus (HIV) infection, to protect the subject from the HIV infection. In some embodiments, a prophylactically effective amount of emtricitabine (FTC), a prophylactically effective amount of tenofovir or a tenofovir prodrug, such as tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF), a prophylactically effective amount of the integrase inhibitor elvitegravir (EVG), and optionally cobicistat (COBI) are used to inhibit or prevent an HIV infection, wherein these agents are administered only prior to the exposure. In specific non-limiting examples, only one dose of the anti-retroviral viral agents is administered to a subject prior to the exposure.
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公开(公告)号：US11382990B2
公开(公告)日：2022-07-12
申请号：US16349458
申请日：2017-10-31
IPC分类号： A61K49/04
摘要： Described herein are X-ray imageable polymers such as polymeric particles comprising bismuth as a radiopacifying agent, methods of making the polymers, and methods of using the polymers. The imageable particles may comprise a covalently bound compound which chelates the bismuth, for example, through a combination of nitrogen and oxygen atoms.
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公开(公告)号：US11359204B2
公开(公告)日：2022-06-14
申请号：US17117368
申请日：2020-12-10
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C12N15/62 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/18 , A61K48/00 , A61K39/00
摘要： The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
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公开(公告)号：US20220170066A1
公开(公告)日：2022-06-02
申请号：US17534170
申请日：2021-11-23
申请人： Gary P. Wormser , Colorado State University Research Foundation , The United States of America, as represented by the secretary, Department of Health and Human Servic
摘要： The present disclosure provides a biosignature that distinguishes Lyme disease, including early Lyme disease, from STARI. The present disclosure also provides methods for detecting Lyme disease and STARI, as well as methods for treating subjects diagnosed with Lyme disease or STARI.
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公开(公告)号：US11338032B2
公开(公告)日：2022-05-24
申请号：US17373130
申请日：2021-07-12
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
摘要： Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.
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公开(公告)号：US11337971B2
公开(公告)日：2022-05-24
申请号：US17265150
申请日：2019-09-09
发明人： Amy Hauck Newman , Vivek Kumar , Anver Basha Shaik
IPC分类号： A61K31/496 , A61P25/36 , A61K31/485
摘要： Disclosed herein are novel methods of treating pain in a patient in need thereof by providing to the patient a selective dopamine D3 receptor antagonist/partial agonist which when used with an opioid analgesic, can mitigate the development of opioid dependence, by preventing the need for dose escalation while either maintaining the opioid analgesic effect or providing analgesia with a lower dose of the opioid. In addition, the D3 antagonists/partial agonists described herein may be used to augment the effectiveness of current Medication Assisted Treatment regimens (e.g. methadone or buprenorphine) for the treatment of opioid use disorders.
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公开(公告)号：US20220152194A1
公开(公告)日：2022-05-19
申请号：US17587817
申请日：2022-01-28
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , C07K14/16
摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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