公开(公告)号：US5424419A

公开(公告)日：1995-06-13

申请号：US971760

申请日：1993-02-11

申请人： Masakatsu Hasegawa ,  Hideo Nagae ,  Yoshio Ito ,  Akihiro Mizutani ,  Kimio Hirose ,  Masahiro Ohgai ,  Yasuji Yamashita ,  Nahoko Tozawa ,  Keiko Yamada ,  Kyoji Kito ,  Shusaburo Hokukoku

发明人： Masakatsu Hasegawa ,  Hideo Nagae ,  Yoshio Ito ,  Akihiro Mizutani ,  Kimio Hirose ,  Masahiro Ohgai ,  Yasuji Yamashita ,  Nahoko Tozawa ,  Keiko Yamada ,  Kyoji Kito ,  Shusaburo Hokukoku

IPC分类号： C07D239/34 ,  A01N43/54 ,  A01N43/66 ,  A61K33/26 ,  A61K41/00 ,  A61K49/18 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60 ,  C07D251/30 ,  C07F9/6512 ,  C07F9/6521 ,  C08B31/18 ,  C08B37/02 ,  C08K3/22 ,  C08L3/10 ,  C08L5/00 ,  A61K31/72 ,  A61K49/00 ,  A61B5/055

CPC分类号： A61K49/1863 ,  A01N43/54 ,  A01N43/66 ,  A61K33/26 ,  A61K41/0052 ,  C07D239/60 ,  C07D251/30 ,  C07F9/65122 ,  C08B37/0021 ,  C08K3/22 ,  C08L3/10 ,  C08L5/00 ,  G01N2400/16 ,  G01N2400/22 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/86 ,  Y10T436/24

摘要： An oxidized complex comprising a water-soluble carboxypolysaccharide and magnetic iron oxide, which is characterized by being obtained by oxidizing a complex comprising a water-soluble carboxypolysaccharide and magnetic iron oxide. Said oxidized complex has very low toxicity, is very stable, exhibits little or no blood pressure-reducing action and has low platelets-aggregating action when administered directly into the blood vessels of animals, and is useful in medical fields such as contrast medium for magnetic resonance imaging, exothermic medium for hyperthermia and the like.

摘要翻译： PCT No.PCT / JP92 / 00735 Sec。 371日期：1993年2月11日 102（e）日期1993年2月11日PCT提交1992年6月8日PCT公布。 公开号WO92 / 22586 日本1992年12月23日。一种包含水溶性羧基多糖和磁性氧化铁的氧化络合物，其特征在于通过氧化包含水溶性羧基多糖和磁性氧化铁的络合物获得。 所述氧化复合物的毒性非常低，非常稳定，显示很少或没有降血压作用，并且当直接施用于动物的血管时具有低的血小板聚集作用，并且可用于医学领域如磁性造影剂 共振成像，热疗用放热介质等。

公开(公告)号：US4080442A

公开(公告)日：1978-03-21

申请号：US623049

申请日：1975-10-16

申请人： Akihiro Mizutani ,  Kyoji Kito ,  Hideki Miyaji ,  Taketoshi Komori ,  Takao Ogawa ,  Hideo Nagae ,  Hiromi Hanai

发明人： Akihiro Mizutani ,  Kyoji Kito ,  Hideki Miyaji ,  Taketoshi Komori ,  Takao Ogawa ,  Hideo Nagae ,  Hiromi Hanai

IPC分类号： A61K31/70 ,  C07H13/12 ,  C07G3/00

CPC分类号： A61K31/70 ,  C07H13/12 ,  Y10S514/838

摘要： A pharmaceutical composition containing as its active ingredient a disaccharide derivative having a derivative group of the following formula (1) bonded to a carbon atom of a disaccharide: ##STR1## wherein Y is a member of the group consisting of NH and O; and when Y is NH, Z is a member of the class consisting of --O-- (disaccharide residue) and --O--, with the proviso that one of the two bonds is attached to the other carbon atom of the same disaccharide to which the formula (1) group is bonded, and when Y is O, Z is a member of the class consisting of --NH.sub.2 and --O--, with the proviso that one of the two bonds is attached to a carbon atom of a disaccharide different from that to which the formula (1) group is bonded. The disaccharide derivative can be prepared by reacting a disaccharide with an activating agent selected from the group consisting of the cyanogen halides, organic cyanic acid esters and halogenocarbonic acid alkyl esters. Said pharmaceutical composition is useful for treating hepatic diseases.

摘要翻译： 含有与二糖的碳原子键合的具有下式（1）的衍生基团的二糖衍生物作为其活性成分的药物组合物：其中Y是由NH和O组成的组的成员 ; 并且当Y是NH时，Z是由-O-（二糖残基）和-O-构成的类别的成员，条件是两个键之一连接到相同二糖的另一个碳原子上， 式（1）基团键合，并且当Y为O时，Z为由-NH 2和-O-构成的类别的成员，条件是两个键中的一个键连接于不同于 式（1）基团所键合的化合物。 二糖衍生物可以通过使二糖与选自氰基卤化物，有机氰酸酯和卤代碳酸烷基酯的活化剂反应来制备。 所述药物组合物可用于治疗肝脏疾病。

公开(公告)号：US4009264A

公开(公告)日：1977-02-22

申请号：US564212

申请日：1975-04-01

申请人： Akihiro Mizutani

发明人： Akihiro Mizutani

IPC分类号： C08B15/00 ,  C08B31/00 ,  C08B33/00 ,  C08B35/00 ,  C08B37/00 ,  C08B37/02 ,  A61K37/00 ,  C07C103/52

CPC分类号： C08B31/00 ,  C08B15/00 ,  C08B33/00 ,  C08B35/00 ,  C08B37/00 ,  C08B37/0021

摘要： A complex of a polysaccharide or its derivative with reduced glutathione having in its infrared absorption spectrum no absorption peak at about 2500 cm.sup.-.sup.1 which appears in the infrared absorption spectrum of the reduced glutathione. The complex is prepared by reacting the polysaccharide or its derivative activated with an activating agent selected from cyanogen halides, organic cyanic acid esters and alkyl esters of halogenocarbonic acids, with the reduced glutathione at a pH of less than 7. The complex is especially useful for stabilizing thiol groups.

公开(公告)号：US20100238281A1

公开(公告)日：2010-09-23

申请号：US12718221

申请日：2010-03-05

申请人： Takayoshi Akao ,  Akihiro Mizutani ,  Kensuke Tanaka

发明人： Takayoshi Akao ,  Akihiro Mizutani ,  Kensuke Tanaka

IPC分类号： H04N7/18

CPC分类号： G01B11/22 ,  G01N21/94 ,  G01N21/95692

摘要： There is disclosed an inspection device of a plugged honeycomb structure in which a plugged honeycomb structure is an inspection target, and the inspection device comprises a light source which illuminates one end face of the plugged honeycomb structure as the inspection target; a camera-side lens which condenses light emitted from the light source to the one end face, transmitted through plugged portions of the plugged honeycomb structure and radiated from the other end face; a camera which receives the light condensed by the camera-side lens; and an image processor which processes an image of the light received by the camera to display the contrast of the light transmitted through the plugged portions of the plugged honeycomb structure.

摘要翻译： 公开了一种堵塞蜂窝结构体的检查装置，其中堵塞的蜂窝结构体是检查对象，检查装置包括照射作为检查对象的封堵蜂窝结构体的一端面的光源; 相机侧透镜，其将从所述光源发射的光会聚到所述一个端面，所述相机侧透镜通过所述堵塞的蜂窝结构体的插入部分透射并从所述另一端面辐射; 接收由相机侧透镜聚光的光的相机; 以及图像处理器，其处理由相机接收的光的图像，以显示透过所述堵塞的蜂窝结构体的所述封堵部分的光的对比度。

公开(公告)号：US07596274B2

公开(公告)日：2009-09-29

申请号：US10577445

申请日：2004-10-28

申请人： Takahiro Kondo ,  Yoichi Aoki ,  Akihiro Mizutani

发明人： Takahiro Kondo ,  Yoichi Aoki ,  Akihiro Mizutani

IPC分类号： G06K9/62

CPC分类号： G06T7/0004 ,  G01N21/95692 ,  G06T2207/30164 ,  Y10T428/24149

摘要： A method of inspecting unevenness of a partition wall surface of a honeycomb structure includes the steps of: allowing a diffusion light to enter from one end face 8 side by a predetermined lighting means 3 and to exit from the other end face 8 side of the honeycomb structure 2 after passing it through the inside of the cells, allowing the exited diffusion light to pass through a translucent screen 4 disposed on the other end face 9 side of the honeycomb structure 2 to act as a transmitted light, projecting a transmitted image 13 by means of the tone of the transmitted light onto the transmitted light side of the screen 4, picking up the transmitted image 13 projected on the screen 4 by an imaging means 5, and analyzing by an analyzing means 6 the gray level of the obtained image to inspect for each cell the degree of the surface unevenness of the partition walls. This method enables easy inspection on the surface unevenness of the partition walls of the honeycomb structure 2.

摘要翻译： 检测蜂窝结构体的隔壁表面的不均匀性的方法包括以下步骤：允许扩散光从预定的照明装置3从一个端面8侧进入并从蜂窝的另一端面8侧退出 结构体2在将其通过电池内部之后，允许出射的扩散光通过布置在蜂窝结构体2的另一端面9侧上的半透明屏幕4以作为透射光，将透射图像13投射到 通过成像装置5拾取投射到屏幕4上的透射图像13，并将所获得图像的灰度级分析为 检查每个电池的分隔壁的表面不均匀度。 该方法能够容易地检查蜂窝结构体2的隔壁的表面凹凸。

公开(公告)号：US20070144024A1

公开(公告)日：2007-06-28

申请号：US10579495

申请日：2004-11-16

申请人： Yoshihiro Sato ,  Tadayoshi Yasui ,  Akihiro Mizutani

发明人： Yoshihiro Sato ,  Tadayoshi Yasui ,  Akihiro Mizutani

IPC分类号： G01B5/20

CPC分类号： G01B7/287 ,  B01D2273/18 ,  G01B5/207

摘要： A shape-measuring device 1 measures the shape of a object to be measured 1 in which segments are arranged and bonded in rows while relatively moving the object 1 in one direction. The shape-measuring device includes rollers 31 provided corresponding to the rows of segments and displaced to follow unevenness of an end face 1a of the object while being rotated on the end face 1a due to the relative movement, detection means 35 provided corresponding to each roller 31 and detecting the amount of displacement of each roller 31, and calculation means 37 for calculating shape data of the object 1 based on the amount of displacement of the roller 31 detected by the detection means 35. The shape-measuring device 1 can accurately and promptly measure the shape of the object such as a DPF in which segments are bonded in rows.

摘要翻译： 形状测量装置1测量在将物体1沿一个方向相对移动的同时以行排列并结合的被测量物体1的形状。 形状测量装置包括对应于这些行段设置的辊31，并且随着相对移动而在端面1a上旋转的同时移动以跟随物体的端面1a的不平坦，检测装置35对应于 每个辊31并检测每个辊31的位移量，以及用于根据由检测装置35检测到的辊31的位移量来计算物体1的形状数据的计算装置37.形状测量装置1可以 准确且及时地测量诸如DPF的物体的形状，其中段被结合成行。

公开(公告)号：US07227757B2

公开(公告)日：2007-06-05

申请号：US10823593

申请日：2004-04-14

申请人： Akihiro Mizutani

发明人： Akihiro Mizutani

IPC分类号： H05K5/00

CPC分类号： H05K5/0069 ,  H01R13/5202 ,  H05K5/061 ,  H05K5/069

摘要： In an electronic control unit, a case has a peripheral side portion formed with a concave groove in which a connector is fitted with a clearance portion between the concave groove and the connector. The connector has first inclined portions connecting its lateral surface (one of its base surfaces) and its longitudinal surface (the other of its base surfaces). Each first inclined portion is inclined with respect to the lateral surface at a first angle. The concave groove comprises a base surface opposite to a lateral surface of the connector and second inclined portions opposite to first inclined portions of the connector, respectively. Each second inclined portion is inclined with respect to the base surface at a second angle. The second angle is larger than the first angle. A seal member is disposed in the clearance portion between the connector and the concave groove of the case so that the seal member seals the clearance portion therebetween.

摘要翻译： 在电子控制单元中，壳体具有形成有凹槽的周边部分，其中连接器在凹槽和连接器之间配有间隙部分。 连接器具有连接其侧表面（其一个基面）和其纵向表面（其另一个基面）的第一倾斜部分。 每个第一倾斜部分以第一角度相对于侧面倾斜。 凹槽包括与连接器的侧表面相对的基底表面和分别与连接器的第一倾斜部分相对的第二倾斜部分。 每个第二倾斜部分以第二角度相对于基部表面倾斜。 第二角度大于第一角度。 密封构件设置在壳体的连接器和凹槽之间的间隙部分中，使得密封构件密封其间的间隙部分。

公开(公告)号：US20050181450A1

公开(公告)日：2005-08-18

申请号：US10683610

申请日：2003-10-10

申请人： Katsuhiko Mikoshiba ,  Hideaki Ando ,  Akihiro Mizutani ,  Toru Matsu-Ura

发明人： Katsuhiko Mikoshiba ,  Hideaki Ando ,  Akihiro Mizutani ,  Toru Matsu-Ura

IPC分类号： G01N33/53 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/02 ,  G01N21/78 ,  G01N33/566 ,  G01N33/58 ,  C07H21/04 ,  C12N9/16

CPC分类号： C07K14/47

摘要： The present invention provides a novel IP3 receptor-binding protein that is used as an indicator effective for detecting and quantifying IP3, and a method for detecting and/or quantifying IP3 using the same. Determined is an IP3 receptor-binding protein, particularly a novel IP3 receptor-binding protein, IRBIT, which interacts with an IP3 receptor, and whose interaction is regulated by IP3. IRBIT has the characteristic that it can be dissociated from the IP3 receptor by IP3 at a physiological concentration. Because of this characteristic, IRBIT can be useful as an indicator for detecting IP3 by the FRET method or the like.

摘要翻译： 本发明提供了一种新的IP 3受体结合蛋白，其被用作用于检测和定量IP 3的有效指标，以及用于检测和/或定量IP的方法 3 使用它们。 确定的是IP 3受体结合蛋白，特别是新的IP 3受体结合蛋白IRBIT，其与IP 3受体相互作用 ，并且其相互作用由IP 3限制。 IRBIT具有其生理浓度可以通过IP 3 N 3从IP 3受体分离的特征。 由于该特性，IRBIT可以用作通过FRET方法等检测IP 3的指示符。

公开(公告)号：US06867968B2

公开(公告)日：2005-03-15

申请号：US10316023

申请日：2002-12-11

申请人： Hajime Katsuro ,  Akihiro Mizutani

发明人： Hajime Katsuro ,  Akihiro Mizutani

IPC分类号： H05K5/00 ,  H05K7/20

CPC分类号： H05K7/20854

摘要： An electronic control unit installed on a high temperature heat source or in its vicinity exhibits an improved heat dissipation ability within its installation environment. The electronic control unit has a chassis incorporating a printed circuit board where electronic devices are mounted. The outer surface of the chassis on the side of the high temperature heat source has a coating for lowering infrared absorption, while the outer surface of the chassis on the side away from the high temperature heat source has a coating for enhancing heat emissivity. Preferably, the inner surfaces of the chassis are subject to a surface treatment for increasing infrared absorption.

摘要翻译： 安装在高温热源或其附近的电子控制单元在其安装环境中表现出改善的散热能力。 电子控制单元具有安装电子装置的印刷电路板的底盘。 在高温热源侧的底盘的外表面具有用于降低红外吸收的涂层，而远离高温热源的一侧的底盘的外表面具有用于增强发热率的涂层。 优选地，底盘的内表面经受表面处理以增加红外吸收。

公开(公告)号：US5403545A

公开(公告)日：1995-04-04

申请号：US990802

申请日：1992-12-14

申请人： Yatsuka Takata ,  Akira Muroga ,  Yoshihiro Wakikado ,  Takao Ooki ,  Masao Goto ,  Hazime Tazumi ,  Teruo Hoshino ,  Masayuki Kitamura ,  Toshihiro Kawaguchi ,  Yoshitaka Natsume ,  Akihiro Mizutani

发明人： Yatsuka Takata ,  Akira Muroga ,  Yoshihiro Wakikado ,  Takao Ooki ,  Masao Goto ,  Hazime Tazumi ,  Teruo Hoshino ,  Masayuki Kitamura ,  Toshihiro Kawaguchi ,  Yoshitaka Natsume ,  Akihiro Mizutani

IPC分类号： C22C38/18 ,  C22C38/22 ,  F16C33/30 ,  F16C33/62 ,  C22C38/46 ,  C22C38/60

CPC分类号： F16C33/30 ,  C22C38/18 ,  C22C38/22 ,  F16C33/62

摘要： A bearing steel having long rolling life comprising, by weight, 0.65 to 0.90% of C, 0.15 to 0.50% of Si, 0.15 to 1.0% of Mn and 2.0 to 5.0% of Cr, and the balance of Fe. Austenite grain size can be prevented from becoming coarser to make hardening in high temperature possible by further adding one or more of 0.0090 to 0.0200% of N, 0.010 to 0.050% of Al and 0.005 to 0.500% of Nb as optional elements to the steel. Further, rolling fatigue life can be improved by further adding one or more of 0.20 to 0.50% of Ni, 0.10 to 2.00% Of Mo and 0.05 to 1.00% of V as optional elements, and machinability can be improved by further adding one or more of 0.02 to 0.05% of S, 0.005 to 0.10% of rare earth elements, 0.02 to 0.30% of Pb, 0.0005 to 0.0100% of Ca, 0.001 to 0.200% of Bi, 0.005 to 0.20% of Se and 0.005 to 0.100% of Te in the steel as optional elements.

摘要翻译： 具有滚动寿命长的轴承钢，其中C：0.65〜0.90％，Si：0.15〜0.50％，Mn：0.15〜1.0％，Cr：2.0〜5.0％ 可以通过进一步添加0.0090〜0.0200％的N，0.010〜0.050％的Al和0.005〜0.500％的Nb作为钢的任意元素，可以防止奥氏体晶粒尺寸变粗，使其在高温下硬化。 此外，通过进一步添加0.20〜0.50％的Ni，0.10〜2.00％的Mo和0.05〜1.00％的V作为任选元素，可以提高轧制疲劳寿命，并且可以进一步添加一个或多个 ，0.02〜0.05％的S，0.005〜0.10％的稀土元素，0.02〜0.30％的Pb，0.0005〜0.0100％的Ca，0.001〜0.200％的Bi，0.005〜0.20％的Se和0.005〜0.100％的 在钢中作为可选元素。