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71.Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids 失效
标题翻译: 通过用血管抑制类固醇治疗预防和治疗眼新生血管形成公开(公告)号:US5679666A
公开(公告)日:1997-10-21
申请号:US342524
申请日:1994-11-21
申请人: Abbot F. Clark
发明人: Abbot F. Clark
IPC分类号: A61K31/565 , A61K31/57 , C07J3/00 , C07J5/00 , C07J9/00 , C07J11/00 , C07J41/00 , C07J51/00 , A61K31/33
CPC分类号: A61K31/573 , A61K31/565 , A61K31/57 , C07J11/00 , C07J3/00 , C07J41/0005 , C07J41/0027 , C07J5/0053 , C07J51/00 , C07J9/00 , Y10S514/912
摘要: Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.
摘要翻译: 公开了使用血管抑制类固醇治疗眼新生血管形成的方法和制剂。
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72.Use of chemical chaperones to treat glaucoma caused by misfolded or misprocessed proteins 审中-公开
标题翻译: 使用化学伴侣来治疗由错误折叠或错误处理的蛋白质引起的青光眼公开(公告)号:US20120101160A1
公开(公告)日:2012-04-26
申请号:US11302839
申请日:2005-12-14
申请人: Allan Shepard , Nasreen Jacobson , Abbot F. Clark
发明人: Allan Shepard , Nasreen Jacobson , Abbot F. Clark
IPC分类号: A61K31/192 , A61P27/06 , A61K31/131 , A61K31/16 , A61K31/205 , A61K31/10
CPC分类号: A61K31/10 , A61K31/14 , A61K31/16 , A61K31/197 , A61K31/205
摘要: The present invention provides methods for treating glaucoma by administering compounds capable of stabilizing misprocessed or misfolded proteins that are responsible for the condition.
摘要翻译: 本发明提供了通过施用能够稳定负责该病症的错误加工或错误折叠的蛋白质的化合物来治疗青光眼的方法。
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73.AGENTS WHICH REGULATE, INHIBIT, OR MODULATE THE ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AS A UNIQUE MEANS TO BOTH LOWER INTRAOCULAR PRESSURE AND TREAT GLAUCOMATOUS RETINOPATHIES/OPTIC NEUROPATHIES 审中-公开
标题翻译: 代理,禁止或调节连接性组织生长因子(CTGF)的活动和/或表达,作为双重下降的压力和治疗玻璃体积反射/视神经病变的独特手段公开(公告)号:US20110092523A1
公开(公告)日:2011-04-21
申请号:US12970662
申请日:2010-12-16
IPC分类号: A61K31/52 , A61K31/4439 , A61P27/02
CPC分类号: A61K31/4439 , A61K31/202 , A61K31/426 , A61K31/427 , A61K31/519 , A61K31/52
摘要: The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of connective tissue growth factor (CTGF).
摘要翻译: 本发明提供了一种通过施用治疗有效量的至少一种抑制结缔组织生长因子的表达和/或信号转导的非核苷酸或非蛋白质试剂来降低眼内压并向有需要的患者提供神经保护作用的方法 CTGF)。
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74.USE OF INHIBITORS OF JUN N-TERMINAL KINASES FOR THE TREATMENT OF GLAUCOMATOUS RETINOPATHY AND OCULAR DISEASES 审中-公开
标题翻译: 用于治疗乳头状瘤病和卵巢疾病的JUN N末端激酶的抑制剂的使用公开(公告)号:US20100280089A1
公开(公告)日:2010-11-04
申请号:US12831702
申请日:2010-07-07
申请人: Iok-Hou Pang , Abbot F. Clark
发明人: Iok-Hou Pang , Abbot F. Clark
IPC分类号: A61K31/416 , A61P27/06
CPC分类号: A61K31/00 , A61K31/416 , A61K31/47
摘要: Compositions and methods for the treatment of glaucoma and other ocular diseases are disclosed. The compositions and methods are particularly directed to the use inhibitors of Jun N-terminal kinases (JNK), such as SP600125 in the treatment of glaucoma and other ocular diseases.
摘要翻译: 公开了用于治疗青光眼和其它眼部疾病的组合物和方法。 组合物和方法特别涉及Jun N-末端激酶(JNK)如SP600125在治疗青光眼和其它眼部疾病中的用途抑制剂。
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75.Method for treating glaucoma comprising administering to a patient in need thereof a composition comprising an antibody against gremlin 有权
标题翻译: 治疗青光眼的方法,包括向有需要的患者施用包含抗乳腺炎抗体的组合物公开(公告)号:US07744873B2
公开(公告)日:2010-06-29
申请号:US12106653
申请日:2008-04-21
CPC分类号: G01N33/5023 , A61K45/06 , C12Q1/6883 , C12Q2600/158 , G01N33/5041 , G01N2333/51
摘要: The present invention provides methods and kits for diagnosing and treating glaucoma.
摘要翻译: 本发明提供用于诊断和治疗青光眼的方法和试剂盒。
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76.Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma 失效
标题翻译: 糖原合成酶激酶-3(GSK-3)抑制剂用于治疗青光眼公开(公告)号:US07598288B2
公开(公告)日:2009-10-06
申请号:US10488496
申请日:2002-09-23
申请人: Mark R. Hellberg , Abbot F. Clark , Iok-Hou Pang , Peggy Elizabeth Hellberg , Loretta Graves McNatt , Wan-Heng Wang
发明人: Mark R. Hellberg , Abbot F. Clark , Iok-Hou Pang , Peggy Elizabeth Hellberg , Loretta Graves McNatt , Wan-Heng Wang
IPC分类号: A61K31/404 , A61K31/4015 , C12N9/10 , C12N9/12 , A61K38/43 , C12Q1/48
CPC分类号: A61K9/0048 , A61K31/4015 , A61K31/404 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/55
摘要: The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
摘要翻译: 公开了使用可用于治疗青光眼的GSK-3抑制剂。
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公开(公告)号:US20090226425A1
公开(公告)日:2009-09-10
申请号:US12420865
申请日:2009-04-09
申请人: Abbot F. Clark , John Fingert , Loretta McNatt , Edwin M. Stone , Wan-Heng Wang
发明人: Abbot F. Clark , John Fingert , Loretta McNatt , Edwin M. Stone , Wan-Heng Wang
IPC分类号: A61K39/395 , A61K38/16 , A61K48/00 , A61P27/06
CPC分类号: G01N33/5091 , A61K38/00 , C07K14/47 , C12N9/12 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5041 , G01N33/5044 , G01N33/6893 , G01N2800/168
摘要: Methods and compositions for diagnosing and treating glaucoma are disclosed.
摘要翻译: 公开了用于诊断和治疗青光眼的方法和组合物。
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78.AGENTS WHICH REGULATE, INHIBIT, OR MODULATE THE ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AS A UNIQUE MEANS TO BOTH LOWER INTRAOCULAR PRESSURE AND TREAT GLAUCOMATOUS RETINOPATHIES/OPTIC NEUROPATHIES 审中-公开
标题翻译: 代理,禁止或调节连接性组织生长因子(CTGF)的活动和/或表达,作为双重下降的压力和治疗玻璃体积反射/视神经病变的独特手段公开(公告)号:US20080176964A1
公开(公告)日:2008-07-24
申请号:US12024821
申请日:2008-02-01
CPC分类号: A61K31/4439 , A61K31/202 , A61K31/426 , A61K31/427 , A61K31/519 , A61K31/52
摘要: The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of connective tissue growth factor (CTGF).
摘要翻译: 本发明提供了一种通过施用治疗有效量的至少一种抑制结缔组织生长因子的表达和/或信号转导的非核苷酸或非蛋白质试剂来降低眼内压并向有需要的患者提供神经保护作用的方法 CTGF)。
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79.Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents 有权
标题翻译: 血清淀粉样蛋白a基因在青光眼诊断和治疗中的应用及抗青光眼药物鉴定公开(公告)号:US07357931B2
公开(公告)日:2008-04-15
申请号:US11000757
申请日:2004-12-01
申请人: Abbot F. Clark , Wan-Heng Wang , Loretta McNatt
发明人: Abbot F. Clark , Wan-Heng Wang , Loretta McNatt
IPC分类号: A61K39/00
CPC分类号: A61K38/046 , A61K31/385 , G01N33/5023 , G01N2333/4709 , G01N2500/02 , G01N2800/168
摘要: The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
摘要翻译: 本发明提供了用于治疗青光眼的组合物和方法,用于诊断青光眼的方法,以及用于鉴定可用于治疗青光眼的药剂的方法。 更具体地,本发明描述了调节血清淀粉样蛋白A表达的试剂的用途。
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公开(公告)号:US07033755B2
公开(公告)日:2006-04-25
申请号:US09796008
申请日:2001-02-28
申请人: Abbot F. Clark , John Fingert , Loretta McNatt , Edwin M. Stone , Wan-Heng Wang
发明人: Abbot F. Clark , John Fingert , Loretta McNatt , Edwin M. Stone , Wan-Heng Wang
CPC分类号: G01N33/5091 , A61K38/00 , C07K14/47 , C12N9/12 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5041 , G01N33/5044 , G01N33/6893 , G01N2800/168
摘要: Methods and compositions for diagnosing and treating glaucoma are disclosed.
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