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公开(公告)号：US20100047166A1
公开(公告)日：2010-02-25
申请号：US12544973
申请日：2009-08-20
申请人： Steven B. KANNER , Aya Jakobovits , Jean Gudas , Arthur B. Raitano , Robert Kendall Morrison , Pia M. Challita-Eid , Xiao-chi Jia
发明人： Steven B. KANNER , Aya Jakobovits , Jean Gudas , Arthur B. Raitano , Robert Kendall Morrison , Pia M. Challita-Eid , Xiao-chi Jia
IPC分类号： A61K39/395 , C07K16/00 , A01K67/027 , C12N5/12 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , G01N33/53 , A61K51/10 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57484 , A01K2267/0331 , A61K47/6807 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/2803 , C07K16/30 , C07K2317/21 , C07K2317/34 , C07K2317/54 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to 58P1D12 protein and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症异常表达。因此，58P1D12提供诊断，预后，预防和预后 /或癌症治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20090068098A1
公开(公告)日：2009-03-12
申请号：US12195208
申请日：2008-08-20
申请人： Steven B. KANNER , Aya Jakobovits , Jean Gudas , Arthur B. Raitano , Robert Kendall Morrison , Pia M. Challita-Eid , Xiao-chi Jia
发明人： Steven B. KANNER , Aya Jakobovits , Jean Gudas , Arthur B. Raitano , Robert Kendall Morrison , Pia M. Challita-Eid , Xiao-chi Jia
IPC分类号： A61K51/10 , C07K16/00 , A01K67/033 , C12N1/00 , C12N5/00 , C07H21/00 , C40B20/00 , A61P35/00 , C12Q1/68 , C12N15/63 , G01N33/53 , A61K31/7052 , A61K39/395
CPC分类号： G01N33/5011 , A01K2227/105 , A01K2267/0331 , A61K39/39558 , A61K47/6825 , A61K47/6897 , A61K51/1072 , A61K2039/505 , B82Y5/00 , C07K16/2851 , C07K16/3069 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57484 , G01N2500/00 , A61K2300/00
摘要： Antibodies and molecules derived therefrom that bind to 58P1D12 protein and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症异常表达。因此，58P1D12提供诊断，预后，预防和预后 /或癌症治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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73.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 213P1F11 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白质213P1F11用于治疗和检测癌症公开(公告)号：US20090181891A1
公开(公告)日：2009-07-16
申请号：US12357253
申请日：2009-01-21
申请人： Pia M. CHALLITA-EID , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. CHALLITA-EID , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/82 , A01K2217/05 , A01K2267/0331
摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为213P1F11）及其编码的蛋白及其变体，其中213P1F11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，213P1F11提供诊断，预后， 癌症的预防和/或治疗靶标。 213P1F11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与213P1F11反应的抗体或T细胞可用于主动或被动免疫。
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74.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 161P2F10B USEFUL IN TREATMENT AND DETECTION OF CANCER 有权核酸和相关蛋白161P2F10B可用于治疗和检测癌症公开(公告)号：US20110287016A1
公开(公告)日：2011-11-24
申请号：US13153336
申请日：2011-06-03
申请人： Aya JAKOBOVITS , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jene Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
发明人： Aya JAKOBOVITS , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jene Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07361338B2
公开(公告)日：2008-04-22
申请号：US10147368
申请日：2002-05-15
申请人： Aya Jakobovits , Mary Faris , Arthur B. Raitano , Robert Kendall Morrison , Douglas Saffran , Wangmao Ge , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Arthur B. Raitano , Robert Kendall Morrison , Douglas Saffran , Wangmao Ge , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供 诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08236510B2
公开(公告)日：2012-08-07
申请号：US12842971
申请日：2010-07-23
申请人： Aya Jakobovits , Mary Faris , Arthur B. Raitano , Robert Kendall Morrison , Douglas Saffran , Wangmao Ge , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Arthur B. Raitano , Robert Kendall Morrison , Douglas Saffran , Wangmao Ge , Pia M. Challita-Eid
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供 诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08003100B2
公开(公告)日：2011-08-23
申请号：US12785360
申请日：2010-05-21
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/395 , A61K39/44
CPC分类号： C07K16/30 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K2317/34 , A61K2300/00
摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07553814B2
公开(公告)日：2009-06-30
申请号：US11483302
申请日：2006-07-06
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K16/30 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K2317/34 , A61K2300/00
摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07749746B2
公开(公告)日：2010-07-06
申请号：US12429012
申请日：2009-04-23
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K16/30 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K2317/34 , A61K2300/00
摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。
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80.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 238P1B2 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白实现238P1B2有效治疗和检测癌症公开(公告)号：US20090311274A1
公开(公告)日：2009-12-17
申请号：US12429012
申请日：2009-04-23
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C07K14/435 , C07K16/40 , C12N9/96 , C12N5/00
CPC分类号： C07K16/30 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K2317/34 , A61K2300/00
摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。
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