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公开(公告)号：US20090317907A1
公开(公告)日：2009-12-24
申请号：US12345725
申请日：2008-12-30
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： C12N5/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
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公开(公告)号：US07622455B2
公开(公告)日：2009-11-24
申请号：US11526134
申请日：2006-09-21
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y115/01001 , Y02P20/582 , C12N2310/3525
摘要： Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
摘要翻译： 提供了减轻患有家族性ALS的个体疾病进展的方法。 还提供了增加患有家族性ALS的个体的存活时间的方法。 这些方法使用靶向SOD1的反义寡核苷酸，用于抑制患有家族性ALS的个体的中枢神经系统中SOD1的表达。
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公开(公告)号：US20090048435A1
公开(公告)日：2009-02-19
申请号：US10559401
申请日：2004-04-30
申请人： C. Frank Bennett , Thomas P. Condon
发明人： C. Frank Bennett , Thomas P. Condon
IPC分类号： C07H21/02
CPC分类号： C07H21/02 , C07H21/04 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： Compositions comprising oligonucleotides which are specifically hybridizable with nucleic acids encoding cellular adhesion molecules intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. A series of double stranded RNA molecules targeting human ICAM-1 were designed and inhibition of RNA was measured. Oligonucleotides targeted to ICAM were effective in reducing airway hyperresponsiveness in mouse and monkey asthma models.
摘要翻译： 公开了包含与编码细胞粘附分子的核酸细胞内粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）和内皮细胞粘附分子-1（ELAM-1）特异性杂交的寡核苷酸的组合物 。 设计了靶向人ICAM-1的一系列双链RNA分子，并测定了RNA的抑制。 靶向ICAM的寡核苷酸有效减少小鼠和猴子哮喘模型中的气道高反应性。
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74.发明授权Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 失效寡核苷酸组合物和调节B7蛋白表达的方法公开(公告)号：US07235653B2
公开(公告)日：2007-06-26
申请号：US10641962
申请日：2003-08-15
CPC分类号： A61K31/711 , A61K38/00 , C07H21/00 , C12N15/1138 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3515 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.
摘要翻译： 用与编码B7蛋白的核酸特异性杂交的寡核苷酸治疗哮喘的组合物和方法。
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公开(公告)号：US06849612B2
公开(公告)日：2005-02-01
申请号：US09982262
申请日：2001-10-18
IPC分类号： A01N1/02 , A01N43/04 , A61K38/00 , A61K48/00 , A61P1/16 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/14 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/02 , C07H21/04 , C12N5/22 , C12N15/113 , C12N15/12 , C12N15/63 , C12P19/34
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise oligonucleotides which are specifically hybridizable with nucleic acids encoding the cellular adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1).
摘要翻译： 用于治疗眼部疾病的组合物和方法，特别是保护角膜外植体和预防角膜同种异体移植排斥。 这些组合物包含与编码细胞粘附分子细胞间粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）和内皮细胞粘附分子-1（ELAM-1）的核酸特异性杂交的寡核苷酸， 。
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76.发明授权Modulation of L-selectin shedding via inhibition of tumor necrosis factor-&agr; converting enzyme (TACE) 有权通过抑制肿瘤坏死因子-α转化酶（TACE）调节L-选择素脱落公开(公告)号：US06632667B1
公开(公告)日：2003-10-14
申请号：US09429096
申请日：1999-10-28
IPC分类号： A61K3170
CPC分类号： C12N15/1137 , A61K31/00 , A61K38/00 , A61K2039/505 , C07K16/40 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/24086 , Y02P20/582 , C12N2310/3525
摘要： The present invention provides methods of modulating the shedding of L-selectin in cells or tissues using an inhibitor of TACE expression or activity. Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred forms of TACE inhibitors. These methods are believed to be useful both therapeutically and diagnostically and as research tools. The present invention further comprises methods of treating conditions associated with altered L-selectin shedding or altered L-selectin levels.
摘要翻译： 本发明提供使用TACE表达或活性抑制剂调节细胞或组织中L-选择素脱落的方法。 靶向编码TACE的核酸的反义寡核苷酸是TACE抑制剂的优选形式。 认为这些方法在治疗和诊断上都是有用的，并且作为研究工具。 本发明还包括治疗与改变的L-选择蛋白脱落或改变的L-选择素水平相关的病症的方法。
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公开(公告)号：US06613567B1
公开(公告)日：2003-09-02
申请号：US09663834
申请日：2000-09-15
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2102
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Her-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-2. Methods of using these compounds for modulation of Her-2 expression and for treatment of diseases associated with expression of Her-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Her-2的表达。 组合物包含靶向编码Her-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Her-2表达和治疗与Her-2表达相关的疾病的方法。
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公开(公告)号：US06440739B1
公开(公告)日：2002-08-27
申请号：US09907843
申请日：2001-07-17
申请人： C. Frank Bennett , Susan M. Freier
发明人： C. Frank Bennett , Susan M. Freier
IPC分类号： C12Q168
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glioma-associated oncogene-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glioma-associated oncogene-2. Methods of using these compounds for modulation of glioma-associated oncogene-2 expression and for treatment of diseases associated with expression of glioma-associated oncogene-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节胶质瘤相关致癌基因-2的表达。 组合物包含靶向编码胶质瘤相关致癌基因-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节神经胶质瘤相关致癌基因-2表达和治疗与神经胶质瘤相关致癌基因-2表达有关的疾病的方法。
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公开(公告)号：US06426220B1
公开(公告)日：2002-07-30
申请号：US09702327
申请日：2000-10-30
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.
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公开(公告)号：US06410324B1
公开(公告)日：2002-06-25
申请号：US09844634
申请日：2001-04-27
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
IPC分类号： C12Q168
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Tumor Necrosis Factor Receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Tumor Necrosis Factor Receptor 2. Methods of using these compounds for modulation of Tumor Necrosis Factor Receptor 2 expression and for treatment of diseases associated with expression of Tumor Necrosis Factor Receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节肿瘤坏死因子受体2的表达。该组合物包含靶向编码肿瘤坏死因子受体2的核酸的反义化合物，特别是反义寡核苷酸2.使用这些化合物调节肿瘤坏死的方法 因子受体2表达和治疗与肿瘤坏死因子受体2表达相关的疾病。
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