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公开(公告)号：US07678895B2
公开(公告)日：2010-03-16
申请号：US11449207
申请日：2006-06-07
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。 组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。
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公开(公告)号：US6001651A
公开(公告)日：1999-12-14
申请号：US45106
申请日：1998-03-20
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P1/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , C07H21/04 , C12N15/113 , C12P19/34 , C12Q1/68 , C12N15/85 , C12N15/11 , C12P21/04
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a nucleic acid encoding a lymphocyte function associated antigen 3 (LFA-3; also known as CD58) protein are provided.
摘要翻译： 提供了用于治疗和诊断易于通过调节编码淋巴细胞功能相关抗原3（LFA-3;也称为CD58）蛋白的核酸的表达进行治疗的疾病或病症的组合物和方法。
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公开(公告)号：US5968826A
公开(公告)日：1999-10-19
申请号：US166203
申请日：1998-10-05
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P3/00 , A61P11/06 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P43/00 , C07H21/04 , C12N15/113 , C12Q1/02 , C12Q1/68 , C12N15/00
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods are provided for modulating the expression of integrin .alpha.4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin .alpha.4 are preferred. Methods of using these compounds for modulating integrin .alpha.4 expression and for treatment of diseases associated with expression of integrin .alpha.4 are also provided.
摘要翻译： 提供了用于调节整联蛋白α4表达的组合物和方法。优选靶向编码整联蛋白α4的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节整合素α4表达和治疗与整联蛋白α4表达相关的疾病的方法。
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公开(公告)号：US5955443A
公开(公告)日：1999-09-21
申请号：US44506
申请日：1998-03-19
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P1/04 , A61P9/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12N15/113 , C12P19/34 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a nucleic acid encoding a platelet endothelial cell adhesion molecule-1 (PECAM-1; also known as CD31 antigen or endoCAM) protein are provided.
摘要翻译： 提供了用于治疗和诊断易于通过调节编码血小板内皮细胞粘附分子-1（PECAM-1;也称为CD31抗原或endoCAM）蛋白的核酸的表达进行治疗的疾病或病症的组合物和方法。
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公开(公告)号：US07622455B2
公开(公告)日：2009-11-24
申请号：US11526134
申请日：2006-09-21
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y115/01001 , Y02P20/582 , C12N2310/3525
摘要： Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
摘要翻译： 提供了减轻患有家族性ALS的个体疾病进展的方法。 还提供了增加患有家族性ALS的个体的存活时间的方法。 这些方法使用靶向SOD1的反义寡核苷酸，用于抑制患有家族性ALS的个体的中枢神经系统中SOD1的表达。
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公开(公告)号：US20090048435A1
公开(公告)日：2009-02-19
申请号：US10559401
申请日：2004-04-30
申请人： C. Frank Bennett , Thomas P. Condon
发明人： C. Frank Bennett , Thomas P. Condon
IPC分类号： C07H21/02
CPC分类号： C07H21/02 , C07H21/04 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： Compositions comprising oligonucleotides which are specifically hybridizable with nucleic acids encoding cellular adhesion molecules intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. A series of double stranded RNA molecules targeting human ICAM-1 were designed and inhibition of RNA was measured. Oligonucleotides targeted to ICAM were effective in reducing airway hyperresponsiveness in mouse and monkey asthma models.
摘要翻译： 公开了包含与编码细胞粘附分子的核酸细胞内粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）和内皮细胞粘附分子-1（ELAM-1）特异性杂交的寡核苷酸的组合物 。 设计了靶向人ICAM-1的一系列双链RNA分子，并测定了RNA的抑制。 靶向ICAM的寡核苷酸有效减少小鼠和猴子哮喘模型中的气道高反应性。
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公开(公告)号：US06258790B1
公开(公告)日：2001-07-10
申请号：US09377309
申请日：1999-08-19
IPC分类号： C12N500
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of integrin &agr;4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin &agr;4 are preferred. Methods of using these compounds for modulating integrin &agr;4 expression and for treatment of diseases associated with expression of integrin &agr;4 are also provided.
摘要翻译： 提供组合物和方法用于调节整联蛋白α4的表达。 优选靶向编码整联蛋白α4的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节整联蛋白α4表达和治疗与整联蛋白α4的表达相关的疾病的方法。
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公开(公告)号：US20100081705A1
公开(公告)日：2010-04-01
申请号：US12566549
申请日：2009-09-24
IPC分类号： A61K31/7088 , A61P25/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y115/01001 , Y02P20/582 , C12N2310/3525
摘要： Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
摘要翻译： 提供了减轻患有家族性ALS的个体疾病进展的方法。 还提供了增加患有家族性ALS的个体的存活时间的方法。 这些方法使用靶向SOD1的反义寡核苷酸，用于抑制患有家族性ALS的个体的中枢神经系统中SOD1的表达。
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公开(公告)号：US6111094A
公开(公告)日：2000-08-29
申请号：US62416
申请日：1998-04-17
IPC分类号： C12N15/09 , A01N43/04 , A61K31/70 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/10 , A61P31/12 , A61P31/18 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/341 , C12N2310/346
摘要： The present invention provides compositions and methods for detecting and modulating levels of intercellular adhesion molecule-1 (ICAM-1) proteins, including human ICAM-1.
摘要翻译： 本发明提供了用于检测和调节包括人ICAM-1在内的细胞间粘附分子-1（ICAM-1）蛋白水平的组合物和方法。
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10.发明授权Antisense oligonucleotides directed against connective tissue growth factor and uses thereof 有权针对结缔组织生长因子的反义寡核苷酸及其用途公开(公告)号：US09096851B2
公开(公告)日：2015-08-04
申请号：US13532254
申请日：2012-06-25
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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