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1.发明授权Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 失效寡核苷酸组合物和调节B7蛋白表达的方法公开(公告)号：US07235653B2
公开(公告)日：2007-06-26
申请号：US10641962
申请日：2003-08-15
CPC分类号： A61K31/711 , A61K38/00 , C07H21/00 , C12N15/1138 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3515 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.
摘要翻译： 用与编码B7蛋白的核酸特异性杂交的寡核苷酸治疗哮喘的组合物和方法。
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2.发明授权公开(公告)号：US06210892B1
公开(公告)日：2001-04-03
申请号：US09277020
申请日：1999-03-26
申请人： C. Frank Bennett , Stanley T. Cooke , Muthiah Manoharan , Jacqueline R. Wyatt , Brenda F. Baker , Brett P. Monia , Susan M. Freier , Robert McKay , James G. Karras
发明人： C. Frank Bennett , Stanley T. Cooke , Muthiah Manoharan , Jacqueline R. Wyatt , Brenda F. Baker , Brett P. Monia , Susan M. Freier , Robert McKay , James G. Karras
IPC分类号： C12Q168
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： The present invention provides compositions and methods for controlling the behavior of a cell, tissue or organism through antisense modulation of mRNA processing, using antisense compounds which does not support cleavage of the mRNA target.
摘要翻译： 本发明提供了使用不支持mRNA靶的切割的反义化合物来控制细胞，组织或生物体通过mRNA加工反义调节的行为的组合物和方法。
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公开(公告)号：US07115580B1
公开(公告)日：2006-10-03
申请号：US09980953
申请日：2000-05-25
IPC分类号： A61K31/7105 , A61K31/7115 , A61K31/712 , A61K31/7125 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/1138 , A61K31/711 , A61K38/00 , C07H21/00 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3515 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.
摘要翻译： 提供了用于诊断，预防和治疗适于通过调节T细胞活化治疗的免疫状态和障碍的组合物和方法。 根据优选实施方案，提供了与编码B7蛋白的核酸特异性杂交的寡核苷酸。
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公开(公告)号：US08476421B2
公开(公告)日：2013-07-02
申请号：US12710232
申请日：2010-02-22
申请人： Susan M. Freier , James G. Karras
发明人： Susan M. Freier , James G. Karras
IPC分类号： C07H21/04
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
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公开(公告)号：US07507810B2
公开(公告)日：2009-03-24
申请号：US11548650
申请日：2006-10-11
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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6.发明授权公开(公告)号：US07981868B2
公开(公告)日：2011-07-19
申请号：US10568488
申请日：2004-08-12
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
摘要翻译： 提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。 还提供了降低动物气道高反应性或气道炎症的方法。
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公开(公告)号：US07709628B2
公开(公告)日：2010-05-04
申请号：US11556565
申请日：2006-11-03
申请人： Susan M. Freier , James G. Karras
发明人： Susan M. Freier , James G. Karras
IPC分类号： C07H21/04
CPC分类号： C07K14/4702 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节STAT5的表达。 组合物包含针对编码STAT5的核酸的寡核苷酸。 提供了使用这些化合物调节STAT5表达和用于诊断和治疗与STAT5表达相关的疾病和病症的方法。
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公开(公告)号：US20090281169A1
公开(公告)日：2009-11-12
申请号：US12425190
申请日：2009-04-16
IPC分类号： A61K31/7088 , C07H21/04 , A61P11/00
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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9.发明申请公开(公告)号：US20080194503A1
公开(公告)日：2008-08-14
申请号：US10568488
申请日：2004-08-12
申请人： Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , Wai Shiu Fred Wong , James G. Karras
发明人： Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , Wai Shiu Fred Wong , James G. Karras
IPC分类号： A61K31/7052 , C07H21/04
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
摘要翻译： 提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。 还提供了降低动物气道高反应性或气道炎症的方法。
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公开(公告)号：US08722873B2
公开(公告)日：2014-05-13
申请号：US12710232
申请日：2010-02-22
申请人： Susan M. Freier , James G. Karras
发明人： Susan M. Freier , James G. Karras
IPC分类号： C07H21/04
CPC分类号： C07K14/4702 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节STAT5的表达。 组合物包含针对编码STAT5的核酸的寡核苷酸。 提供了使用这些化合物调节STAT5表达和用于诊断和治疗与STAT5表达相关的疾病和病症的方法。
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