公开(公告)号：US4946452A

公开(公告)日：1990-08-07

申请号：US267526

申请日：1988-11-04

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00

CPC classification number: A61F9/0026

Abstract: An ocular treatment apparatus for applying medicament into an eye has an inner housing member with an eyepiece on a free end thereof. The eyepiece defines an opening in one end thereof, and the opening has a peripheral edge shaped for engagement with the facial tissue surrounding an eye. A body portion of the inner housing member is coupled to the eyepiece and is dimensioned to receive a vial of medicament for application to the eye. An outer housing member of the apparatus has an open free end, which is slidably engaged over the inner housing member. The outer housing member has a displacement rod that projects inwardly from a closed end thereof in the axial direction of the apparatus. The displacement rod is engageable with a flexible vial supported within the body portion of the inner housing member. The displacement rod flexes the vial inwardly to dispense medicament therefrom into an eye. A flexible bar is mounted to the outer housing member, and the free end of the flexible bar is adapted to be engaged with the facial tissue below an eye to displace the facial tissue, and thus displace the lower eyelid, to direct the medicament into the exposed ocular cul-de-sac of the eye. The flexible member is engaged with the facial tissue by moving the outer housing member toward the eyepiece, which simultaneously displaces the lower eyelid and allows the medicament dispensed from the vial to fall into the exposed ocular cul-de-sac of the eye.

Abstract translation: 用于将药物施用到眼睛中的眼部治疗装置具有在其自由端上具有目镜的内部壳体构件。 目镜在其一端限定一个开口，并且该开口具有形状成与眼睛周围的面部组织接合的周边边缘。 内部壳体构件的主体部分联接到目镜，并且其尺寸被设计成接收用于施用于眼睛的药物小瓶。 该装置的外部壳体构件具有敞开的自由端，其可滑动地接合在内部壳体构件上。 外壳构件具有从设备的轴向的封闭端向内突出的位移杆。 位移杆可与支撑在内壳体构件的主体部分内的柔性小瓶接合。 位移杆向内弯曲小瓶，以将药物从其中分配到眼睛中。 柔性杆被安装到外部壳体构件上，并且柔性杆的自由端适于与眼睛下方的面部组织接合以移位面部组织，并且因此移位下眼睑，以将药物引导到 暴露眼睛的眼睛死亡。 柔性构件通过将外壳构件朝向目镜移动而与面巾组合，其同时移动下眼睑并允许从小瓶分配的药物落入眼睛的暴露的眼睛凹陷中。

公开(公告)号：US09573741B2

公开(公告)日：2017-02-21

申请号：US12577104

申请日：2009-10-09

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/05 ,  B65D55/08 ,  B29C49/04 ,  B65D1/02 ,  B65D77/06 ,  A61J1/14 ,  B29C47/00 ,  B29C49/22 ,  B29C65/66 ,  B29C65/00 ,  B29K101/12 ,  B29L31/56 ,  B67C3/22

CPC classification number: B65D1/0215 ,  A61J1/05 ,  A61J1/1406 ,  A61J1/1412 ,  B05B11/00412 ,  B05B11/3028 ,  B29C47/003 ,  B29C47/004 ,  B29C49/04 ,  B29C49/22 ,  B29C65/665 ,  B29C66/7371 ,  B29C2791/001 ,  B29C2793/0027 ,  B29K2101/12 ,  B29L2031/565 ,  B65B3/04 ,  B65B7/16 ,  B65B51/22 ,  B65D1/0223 ,  B65D1/0276 ,  B65D1/0284 ,  B65D47/36 ,  B65D55/0818 ,  B65D77/06 ,  B65D2501/0036 ,  B65D2501/0063 ,  B65D2501/0072 ,  B67C2003/227

Abstract: A device comprising a body including a first polymer and a closure including a second polymer that is substantially not bondable to the first polymer and has a relatively higher shrinkage rate than the first polymer, wherein at least a portion of the closure overlaps at least a portion of the body, forming a hermetic seal therebetween and defining a sealed, empty, sterile container.

Abstract translation: 一种包括主体的装置，包括第一聚合物和封闭物，所述封闭物包括基本上不能与第一聚合物结合并且具有比第一聚合物相对较高的收缩率的第二聚合物，其中封闭物的至少一部分与至少一部分 的身体，在其间形成气密密封并限定密封的空的无菌容器。

公开(公告)号：US09090445B2

公开(公告)日：2015-07-28

申请号：US13279141

申请日：2011-10-21

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B67D7/06 ,  B67D3/04 ,  B67B7/00

CPC classification number: B67D3/043 ,  B67B7/24

Abstract: A pouch connector includes a safety cap having a cap base portion and a main connector disposed opposite the safety cap. The main connector and safety cap are configured to receive a portion of a pouch therebetween. The main connector includes a piercing member for piercing the pouch, an actuating portion for actuating the piercing member and a main connector base portion. The piercing member is configured to pierce through a portion of the pouch so as to provide fluid communication between a substance inside the pouch and the interior of the main connector. A polymeric membrane is coupled to at least one of the cap base portion and the main connector base portion.

Abstract translation: 小袋连接器包括具有帽基部的安全帽和与安全帽相对设置的主连接器。 主连接器和安全帽被配置为在其间容纳一部分袋。 主连接器包括用于刺穿小袋的刺穿构件，用于致动刺穿构件的致动部分和主连接器基部。 刺穿构件构造成穿过袋的一部分，以便在袋内的物质和主连接器的内部之间提供流体连通。 聚合物膜联接到帽基部和主连接器基部中的至少一个。

公开(公告)号：US08746278B2

公开(公告)日：2014-06-10

申请号：US13213969

申请日：2011-08-19

Applicant: Daniel Py

Inventor： Daniel Py

IPC: E03B1/00 ,  F16K31/44

CPC classification number: F16L37/36 ,  A61M39/10 ,  A61M2039/1027 ,  F16L2201/44 ,  Y10T29/49826 ,  Y10T137/87925 ,  Y10T137/9029

Abstract: A connector for transferring a fluid includes a first connector and a second connector. Each connector includes a first outer portion including a first obstructive portion and defining a first fluid passageway for receiving a fluid therein. Each connector further includes a first central nozzle coupled to the first outer portion. The central nozzle includes a first engagement member. The first central nozzle is movable between a first position and a second position with rotation of the first outer portion. In the first position, the first obstructive portion and the first engagement portion substantially overlap to impede fluid flow through the first fluid passageway. In the second position, at least one of the first engagement member and the first obstructive member is displaced to allow fluid flow through the first fluid passageway.

Abstract translation: 用于传送流体的连接器包括第一连接器和第二连接器。 每个连接器包括第一外部部分，其包括第一阻塞部分并且限定用于在其中接收流体的第一流体通道。 每个连接器还包括联接到第一外部部分的第一中心喷嘴。 中心喷嘴包括第一接合构件。 第一中心喷嘴可以在第一外部部分旋转的同时在第一位置和第二位置之间移动。 在第一位置，第一阻塞部分和第一接合部分基本上重叠以阻止流体流过第一流体通道。 在第二位置，第一接合构件和第一阻塞构件中的至少一个被移位以允许流体流过第一流体通道。

公开(公告)号：US08690468B2

公开(公告)日：2014-04-08

申请号：US13219597

申请日：2011-08-26

Applicant: Daniel Py ,  Julian Chan ,  David Fellows ,  Eric E. Hartman ,  Bing He

Inventor： Daniel Py ,  Julian Chan ,  David Fellows ,  Eric E. Hartman ,  Bing He

IPC: A46B11/02

CPC classification number: B65D83/0094 ,  A45D34/04 ,  A45D2200/055 ,  A45D2200/056 ,  A61M35/003 ,  B05B11/00416 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3033 ,  B05B11/3094 ,  B65B1/04 ,  B65D83/0033 ,  G01F11/025 ,  G01F11/08

Abstract: A dispenser has a body defining with a variable-volume storage chamber for storing product. A compression chamber is in fluid communication with the storage chamber for receiving substance therefrom A one-way valve of the dispenser includes valve seat and flexible valve cover seated on the valve seat and defining a normally-closed seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat to allow the passage of substance through the seam and out of the dispenser. A manually-engageable actuator connected to the dispensing portion is movable between first and second positions to dispense substance within the compression chamber out of the dispenser.

Abstract translation: 分配器具有限定有用于存储产品的可变容积存储室的主体。 压缩室与存储室流体连通以接收物质。分配器的单向阀包括位于阀座上的阀座和柔性阀盖，并在其间限定一个常闭接缝，形成两者间的流体密封 阀盖和阀座。 柔性阀盖可相对于阀座移动以允许物质通过接缝并从分配器中通过。 连接到分配部分的可手动接合的致动器可在第一和第二位置之间移动，以将分配器内的压缩室内的物质分配。

公开(公告)号：US08627861B2

公开(公告)日：2014-01-14

申请号：US12984482

申请日：2011-01-04

Applicant: Daniel Py ,  Julian V. Chan

Inventor： Daniel Py ,  Julian V. Chan

IPC: B65B1/04

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：US20130292592A1

公开(公告)日：2013-11-07

申请号：US13874839

申请日：2013-05-01

Applicant: Daniel Py

Inventor： Daniel Py

IPC: F16L29/02

CPC classification number: F16L29/02 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/268 ,  B65B3/003 ,  B65B39/001

Abstract: A valve comprises a shell, a flexible valve member sealingly mounted within the shell, and a valve body mounted atop the flexible valve member within the shell. The flexible member is moveable between closed and open positions to allow the flow of fluid therethrough. The valve is engageable with a filling device having flow ports and a surrounding closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). Alternatively, the valve may comprise a portion of a female connector and the filling device may comprise a portion of a male connector to form an aseptic fluid connector for the aseptic transfer of fluid therethrough.

公开(公告)号：US20130190704A1

公开(公告)日：2013-07-25

申请号：US13745721

申请日：2013-01-18

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00 ,  B23P15/00

CPC classification number: A61F9/0008 ,  B05B11/0056 ,  B05B11/0062 ,  B05B11/0067 ,  B05B11/007 ,  B05B11/0097 ,  B23P15/001 ,  B65D83/0022 ,  Y10T29/49412

Abstract: A device has a first part with a valve seat and storage chamber, and a second part with a flexible valve cover and actuator. The storage chamber may be formed from a pre-form blow-molded into a flexible pouch defining a variable-volume storage chamber. The flexible valve cover and valve seat form a normally closed valve seam therebetween. The valve cover is movable in response to fluid at an inlet to the seam exceeding a valve opening pressure of the one-way valve between (i) a normally closed position with valve cover and valve seat in contact with each other and defining the normally closed seam, and (ii) a second position with at least a portion of the valve cover spaced away from the valve seat to allow the fluid to pass through the seam. The one-way valve may have anti-spritz features for using the device to dispense a substance, such as to the eye. The device may contain prostaglandins without the device material absorbing the prostaglandins material and/or without the material being adsorbed into the drug.

Abstract translation: 装置具有带阀座和储存室的第一部分，以及具有柔性阀盖和致动器的第二部分。 存储室可以由吹塑成型的预成型形成为限定可变容积的储存室的柔性袋。 柔性阀盖和阀座在其间形成常闭阀门。 所述阀盖可响应于在所述接缝的入口处的流体在所述单向阀的打开压力之间（i）与阀盖的常闭位置和彼此接触的阀座之间，限定常闭 接缝，和（ii）第二位置，其中阀盖的至少一部分与阀座间隔开，以允许流体穿过接缝。 单向阀可以具有抗喷雾特征，用于使用该装置来分配物质，例如眼睛。 该装置可以含有前列腺素，而没有装置材料吸收前列腺素材料和/或没有材料被吸收到药物中。

公开(公告)号：US08408256B2

公开(公告)日：2013-04-02

申请号：US11901467

申请日：2007-09-17

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

Abstract: Apparatus for filling containers having stoppers that are penetrable for filling the containers with a substance, and thermally resealable for thermally sealing the resulting hole. A container support supports at least one such container in a substantially fixed position during filling and resealing. A manifold drivingly mounted over the container support comprises (1) a cartridge including a filling needle for penetrating the resealable stopper and introducing a substance therethrough into the container, a mount for mounting the cartridge on the manifold, and a removable cover releasably coupled to the mount for covering the filling needle during transportation, installation and/or removal of the cartridge from the manifold. The manifold includes a thermal source for heating a penetrated region of the stopper and, sealing the hole.

Abstract translation: 用于填充容器的装置，所述容器具有用于用物质填充所述容器可穿透的塞子，并且可重新密封以热封所形成的孔。 在填充和再密封期间，容器支撑件支撑至少一个这样的容器处于基本上固定的位置。 驱动地安装在容器支架上的歧管包括（1）一个筒，其包括用于穿透可再密封塞子并将物质引入其中的填充针进入容器，用于将墨盒安装在歧管上的安装座以及可释放地联接到 用于在从歧管运输，安装和/或移除墨盒的过程中覆盖填充针。 歧管包括用于加热塞子的穿透区域并密封孔的热源。

公开(公告)号：US08397950B2

公开(公告)日：2013-03-19

申请号：US12577126

申请日：2009-10-09

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D35/56

CPC classification number: B65D47/24 ,  B05B11/3028 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/065 ,  B29C47/068 ,  B29C49/04 ,  B29L2009/00 ,  B29L2031/7158 ,  B65D23/02 ,  B65D47/205 ,  B65D47/32

Abstract: A device comprises a first portion including a first polymer, and a second portion that is relatively flexible in comparison to the first portion and includes a second polymer that is substantially not bondable to the first polymer. A chamber of the device is hermetically sealable with respect to ambient atmosphere and is defined by (i) an interior of the second portion, and/or (ii) a space formed between the first and second portions. A third portion of the device includes a third polymer that is bondable to the first and second polymers and fixedly secures the first and second portions to each other.

Abstract translation: 一种装置包括包含第一聚合物的第一部分和与第一部分相比具有相对柔性的第二部分，并且包括基本上不能与第一聚合物结合的第二聚合物。 该装置的腔室相对于环境气氛可气密地密封，并且由（i）第二部分的内部和/或（ii）形成在第一和第二部分之间的空间限定。 该装置的第三部分包括可与第一和第二聚合物结合的第三聚合物，并将第一和第二部分彼此固定地固定。