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71.发明申请System and Methods for Determination of Analyte Concentration Using Time Resolved Amperometry 有权使用时间分解电流分析法测定分析物浓度的系统和方法公开(公告)号：US20090101523A1
公开(公告)日：2009-04-23
申请号：US12179853
申请日：2008-07-25
Applicant: David Deng
Inventor： David Deng
CPC classification number: G01N27/3273
Abstract: This invention is a method for determining a concentration of an analyte. The steps include applying a potential excitation to a fluid sample containing an analyte, and measuring a current associated with the potential excitation at a plurality of time-points. The method also includes calculating an analyte concentration based on the measured current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments.
Abstract translation: 本发明是用于测定分析物浓度的方法。 这些步骤包括对含有分析物的流体样品施加潜在的激发，并在多个时间点测量与潜在激发相关的电流。 该方法还包括基于测量的电流和校准曲线计算分析物浓度，其中校准曲线选自多个校准曲线，并且每个校准曲线与从多个时间段中选择的时间段相关联。
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公开(公告)号：US20070277812A1
公开(公告)日：2007-12-06
申请号：US11443484
申请日：2006-05-30
Applicant: David Deng
Inventor： David Deng
Abstract: In certain embodiments, a pressure regulating device for selectively coupling with a first source or a second source includes a housing defining at least a portion of a first input channel, a second input channel, and an output channel. In some embodiments, the device further includes a first connector configured to couple with the first source such that the first source is in communication with the first input channel. The device also includes a second connector configured to couple with the second source such that the second source is in communication with the second input channel. The device further includes a first regulator configured to regulate flow from the first input channel to the output channel and a second regulator configured to regulate flow from the second input channel to the output channel.
Abstract translation: 在某些实施例中，用于选择性地与第一源或第二源耦合的压力调节装置包括限定第一输入通道，第二输入通道和输出通道的至少一部分的壳体。 在一些实施例中，设备还包括配置成与第一源耦合的第一连接器，使得第一源与第一输入通道通信。 该设备还包括被配置为与第二源耦合以使得第二源与第二输入通道通信的第二连接器。 该装置还包括配置成调节从第一输入通道到输出通道的流量的第一调节器，以及被配置为调节从第二输入通道到输出通道的流量的第二调节器。
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公开(公告)号：US20060190190A1
公开(公告)日：2006-08-24
申请号：US11048970
申请日：2005-02-02
Applicant: Zohar Yakhini , Amir Ben-Dor , Anya Tsalenko , David Deng
Inventor： Zohar Yakhini , Amir Ben-Dor , Anya Tsalenko , David Deng
IPC: G06F19/00
CPC classification number: G16B25/00
Abstract: In various embodiments of the present invention, initial gene-expression data is initially partitioned into classes by patient, subject, or other identifier of a source of samples, expression-level-differences are computed for each gene with respect to each initial partition, and a rank consistency score or fold-change consistency score is computed for each gene from the expression-level difference metrics computed for each initial partition. In other words, rather than partitioning gene-expression-level data directly into two or more classes relative to an event of interest, the gene-expression-level data is first partitioned according to sample source, and then each sample-source partition is partitioned into two or more classes relative to an event of interest. Levels of significance, or p-values, can be straightforwardly computed for both rank consistency scores and fold-change consistency scores.
Abstract translation: 在本发明的各种实施方案中，初始基因表达数据最初按照样品来源的患者，受试者或其他标识符分类，根据每个初始分区计算每个基因的表达水平差异， 根据为每个初始分区计算的表达级差异度量，为每个基因计算排序一致性分数或倍数变化一致性分数。 换句话说，不是将基因表达级数据直接分为两个或更多相关于感兴趣事件的类别，因此首先根据样本源分割基因表达级数据，然后将每个样本源分区分区 相对于感兴趣的事件进入两个或更多个类。 对于等级一致性分数和折叠一致性分数，可以直接计算重要程度或p值。
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74.发明申请Biosensors comprising semiconducting electrodes or ruthenium containing mediators and method of using the same 审中-公开包含半导体电极或含钌介质的生物传感器及其使用方法公开(公告)号：US20060113187A1
公开(公告)日：2006-06-01
申请号：US11242925
申请日：2005-10-05
Applicant: David Deng , Natasha Popovich , Thomas Hunter , Dennis Slomski , Douglas Bell
Inventor： David Deng , Natasha Popovich , Thomas Hunter , Dennis Slomski , Douglas Bell
IPC: G01N33/487 , G01N27/26
CPC classification number: C12Q1/005
Abstract: Disclosed herein are biosensors for measuring analyte concentration in a bodily fluid comprising at least one electrode comprising semiconducting, conducting, or thin film carbon material, and an electron mediator comprising a ruthenium containing electron mediator, or a ferricyanide material or ferrocene carboxylic acid. Methods of measuring analyte concentration in a bodily fluid using such biosensors are also disclosed.
Abstract translation: 本文公开了用于测量体液中分析物浓度的生物传感器，其包括至少一个包含半导体，导电或薄膜碳材料的电极，以及包含含钌电子介体或铁氰化物材料或二茂铁羧酸的电子介体。 还公开了使用这种生物传感器测量体液中的分析物浓度的方法。
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公开(公告)号：US20050139208A1
公开(公告)日：2005-06-30
申请号：US10746063
申请日：2003-12-26
Applicant: David Deng
Inventor： David Deng
CPC classification number: F24C15/06
Abstract: A simulated fireplace panel comprises of multiple layers of a mixture of yellow sand and high temperature paint applied by spraying the mixture onto the surfaces of a sheet metal. The surface treatment comprises of the steps of forming grooves on sheet metals that simulate stone surfaces, coating the sheet metal with zinc, applying a mixture of 70 micron yellow sand and high temperature paint in one to one proportion to the surface of the sheet metal by spraying, removing excess accumulated mixture in the grooves in the sheet metal, allowing the mixture on the sheet metal to dry, applying another thin layer of the mixture of 70 micron yellow sand and high temperature paint in one to one proportion to the surface of the sheet metal, allowing the mixture on the sheet metal to dry, applying a thin layer of high temperature paint, and applying a thin final layer of the mixture of 70 micron yellow sand and high temperature paint to the surface of the sheet metal.
Abstract translation: 模拟壁炉面板包括通过将混合物喷射到金属板表面上而施加的多层黄砂和高温漆的混合物。 表面处理包括以下步骤：在模拟石材表面的金属板上形成凹槽，用锌涂覆金属板，将70微米的黄砂和高温涂料的混合物与金属板的表面一比一的比例 喷涂，除去金属板中的槽中多余的积聚混合物，允许金属板上的混合物干燥，将70微米黄砂和高温漆的混合物的另一薄层与表面成一比例地 使金属板上的混合物干燥，施加薄层的高温涂料，并将70微米黄砂和高温漆的混合物的薄的最终层施加到金属板的表面。
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Patent Agency Ranking
76.发明申请Systems and methods for determining cell type composition of mixed cell populations using gene expression signatures 审中-公开使用基因表达特征确定混合细胞群体的细胞类型组成的系统和方法公开(公告)号：US20050048463A1
公开(公告)日：2005-03-03
申请号：US10841164
申请日：2004-05-07
Applicant: David Deng , Anya Tsalenko , Zohar Yakhini , Laurakay Bruhn , Amir Ben-Dor
Inventor： David Deng , Anya Tsalenko , Zohar Yakhini , Laurakay Bruhn , Amir Ben-Dor
Abstract: The present invention provides systems and methods for determining the cell type composition of a mixed cell population. The invention provides systems and methods for identifying and defining pure cell type specific signatures. These pure cell type specific signatures may be used to determine the cell type composition of a mixed cell population. The systems and methods of the invention may be used for a variety of research and clinical purposes. For example, they may be used to detect the presence or absence of cells of particular types, and to determine whether variations in gene expression, e.g., between different samples, represent true changes in gene expression or differences in cell type composition of the samples.
Abstract translation: 本发明提供了用于确定混合细胞群体的细胞类型组成的系统和方法。 本发明提供用于识别和定义纯细胞类型特异性特征的系统和方法。 这些纯细胞类型特异性标记可用于确定混合细胞群体的细胞类型组成。 本发明的系统和方法可用于各种研究和临床目的。 例如，它们可以用于检测特定类型的细胞的存在或不存在，并且确定基因表达的变化，例如不同样品之间的变化是否代表基因表达的真实变化或样品的细胞类型组成的差异。
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公开(公告)号：US06245159B1
公开(公告)日：2001-06-12
申请号：US09541741
申请日：2000-04-03
Applicant: David Deng
Inventor： David Deng
IPC: A47L514
Abstract: A vacuum cleaner for removing dirt and debris from a floor covering includes a motor that generates a low pressure input air stream and a high pressure output air stream. An inlet directs the input stream such that dirt and debris are drawn into the inlet. The inlet is fluidly connected to a dustbin and filter that removes the dirt and debris from the input stream. Next, the motor converts the low pressure input stream into the high pressure output stream. An output disposed adjacent to the inlet directs the output stream onto the floor covering. The output stream agitates the dirt and debris in the floor covering such that a conventional rolling agitator is unnecessary. Therefore, the vacuum cleaner constructed in accordance with present invention can use a smaller motor, thereby making such vacuum cleaner lighter and quieter to use.
Abstract translation: 用于从地板覆盖物去除灰尘和碎屑的真空吸尘器包括产生低压输入气流和高压输出气流的马达。 入口引导输入流，使得污物和碎屑被吸入入口。 入口流体连接到垃圾箱和过滤器，以从输入流中除去污垢和碎屑。 接下来，马达将低压输入流转换成高压输出流。 靠近入口设置的输出将输出流引导到地板覆盖物上。 输出流搅动地板覆盖物中的污物和碎屑，使得不需要常规的滚动搅拌器。 因此，根据本发明构造的真空吸尘器可以使用较小的电动机，从而使这种真空吸尘器更轻更安静地使用。
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公开(公告)号：US09822996B2
公开(公告)日：2017-11-21
申请号：US14954723
申请日：2015-11-30
Applicant: David Deng
Inventor： David Deng
CPC classification number: F25B13/00 , F25B47/02 , F25B2313/004 , F25B2313/02521 , F25B2313/0254 , F25B2313/02543 , F25B2313/02742
Abstract: An additive heat transfer unit (AHTU) can be part of or added to an air source heat pump HVAC system. The heat pump system can include a compressor, an expansion valve, first and second air source heat exchangers, and a reversing valve. The system can have a cooling mode and a heating mode, such that in the cooling mode the first air source heat exchanger functions as an evaporator and the second air source heat exchanger functions as a condenser, this being reversed in the heating mode. The AHTU can include a liquid source heat exchanger that can be used to increase the efficiency of the system.
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公开(公告)号：US09752782B2
公开(公告)日：2017-09-05
申请号：US14578088
申请日：2014-12-19
Applicant: David Deng
Inventor： David Deng
CPC classification number: F24C1/02 , F16K11/10 , F23C1/08 , F23N2037/08 , F24C3/00 , G05D16/0661 , Y10T137/87249 , Y10T137/87917 , Y10T137/87981
Abstract: A heater assembly can be used with a gas appliance. The gas appliance can be a dual fuel appliance for use with one of a first fuel type or a second fuel type different than the first. The heater assembly can include at least one pressure regulator, a housing, and an actuation member. The housing has a first fuel hook-up for connecting the first fuel type to the heater assembly, a second fuel hook-up for connecting the second fuel type to the heater assembly, and an internal valve. The actuation member can control the position of the internal valve based on whether the first or the second fuel hook-up is used.
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公开(公告)号：US09752779B2
公开(公告)日：2017-09-05
申请号：US14192822
申请日：2014-02-27
Applicant: David Deng
Inventor： David Deng
Abstract: A heating assembly can include a gas hook-up and a pressure switch. The pressure switch can be in fluid communication with the gas hook-up and be movable at a predetermined threshold pressure from a first position to a second position. The pressure switch can be further configured such that if a fuel is connected to the gas hook-up that has a delivery pressure either above the predetermined threshold pressure in one situation or below the predetermined threshold pressure in another, the fuel will act on the pressure switch to move it from the first position to the second position.
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