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    SYSTEM AND METHODS OF CHEMISTRY PATTERNING FOR A MULTIPLE WELL BIOSENSOR
    2.
    发明申请
    SYSTEM AND METHODS OF CHEMISTRY PATTERNING FOR A MULTIPLE WELL BIOSENSOR 有权
    用于多种生物传感器的化学方案的系统和方法

    公开(公告)号：US20090038939A1

    公开(公告)日：2009-02-12

    申请号：US12102218

    申请日：2008-04-14

    申请人： Natasha Popovich ,  Gary T. Neel ,  William Milo ,  Zachary Thomas ,  Stephen Davies

    发明人： Natasha Popovich ,  Gary T. Neel ,  William Milo ,  Zachary Thomas ,  Stephen Davies

    IPC分类号： G01N27/27 ,  G01N1/31

    CPC分类号： C12Q1/001 ,  C12Q1/005 ,  G01N27/3272

    摘要： Methods and systems for measuring the concentration of an analyte in a blood sample and, more particularly, to methods of chemistry patterning reagent layers for multiple well biosensors. A first capillary is first configured to receive a dispensed reagent layer such that the reagent layer is distributed in a substantially uniform manner within the first capillary. The first capillary may also configured to isolate the first capillary from other capillaries present in the biosensor. After the reagent layer has been dispensed and dried, the first capillary may then be reconfigured to allow the first capillary to receive a blood sample.

    摘要翻译： 用于测量血液样品中分析物浓度的方法和系统，更具体地，涉及用于多孔生物传感器的化学图案化试剂层的方法。 第一毛细管首先构造成接收分配的试剂层，使得试剂层在第一毛细管内以基本均匀的方式分布。 第一毛细管还可以构造成将第一毛细管与存在于生物传感器中的其它毛细管分离。 在试剂层被分配和干燥之后，然后可以重新配置第一毛细管以允许第一毛细管接收血液样品。

    System and methods for providing corrected analyte concentration measurements
    4.
    发明申请
    System and methods for providing corrected analyte concentration measurements 审中-公开
    用于提供校正分析物浓度测量的系统和方法

    公开(公告)号：US20070235346A1

    公开(公告)日：2007-10-11

    申请号：US11401458

    申请日：2006-04-11

    申请人： Natasha Popovich ,  Stephen Davies ,  Greta Wegner

    发明人： Natasha Popovich ,  Stephen Davies ,  Greta Wegner

    IPC分类号： C12Q1/00 ,  G01N33/487

    CPC分类号： C12Q1/004

    摘要： Methods and devices for determining the concentration of a constituent in a physiological sample are provided. The physiological sample is introduced into an electrochemical cell having a working and counter electrode. At least one electrochemical signal is measured based on a reaction taking place at the cell. The preliminary concentration of the constituent is then calculated from the electrochemical signal. This preliminary concentration is then multiplied by a hematocrit correction factor to obtain the constituent concentration in the sample, where the hematocrit correction factor is a function of the at least one electrochemical signal. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.

    摘要翻译： 提供了用于确定生理样品中成分浓度的方法和装置。 将生理样品引入具有工作电极和对电极的电化学电池中。 基于在细胞发生的反应测量至少一种电化学信号。 然后从电化学信号计算组分的初步浓度。 然后将该初步浓度乘以血细胞比容校正因子以获得样品中的组分浓度，其中血细胞比容校正因子是至少一种电化学信号的函数。 本发明的方法和装置适用于多种样品中多种分析物的测定，特别适用于测定全血或其衍生物中的分析物，其中特别感兴趣的分析物是葡萄糖。

    METHOD OF MANUFACTURING A DIAGNOSTIC TEST STRIP
    5.
    发明申请
    METHOD OF MANUFACTURING A DIAGNOSTIC TEST STRIP 审中-公开
    诊断测试条的方法

    公开(公告)号：US20070117171A1

    公开(公告)日：2007-05-24

    申请号：US11530542

    申请日：2006-09-11

    申请人： Greta Wegner ,  Natasha Popovich ,  Dennis Slomski

    发明人： Greta Wegner ,  Natasha Popovich ,  Dennis Slomski

    IPC分类号： C12Q1/54 ,  B05D3/00

    CPC分类号： C12Q1/006 ,  C12Q1/001 ,  G01N33/521 ,  G01N33/523 ,  G01N33/525 ,  G01N33/526

    摘要： A method for manufacturing a test strip is provided. The method comprises selecting a test strip substrate material and positioning the test strip substrate material a predetermined distance from a matrix material disposed on a second substrate, wherein at least one enzyme to be deposited on the test strip substrate and having glucose as an enzymatic substrate is held within the matrix material. A laser pulse is directed towards the matrix material to release at least a portion of the at least one enzyme having glucose as an enzymatic substrate from the matrix material and deposit the enzyme on the test strip substrate.

    摘要翻译： 提供一种制造测试条的方法。 该方法包括选择测试条基材材料并将测试条基材材料定位在距离设置在第二基底上的基质材料预定距离，其中待沉积在测试条基材上并具有葡萄糖作为酶底物的至少一种酶是 保持在基质材料内。 将激光脉冲引向基质材料以从基质材料释放至少一部分具有作为酶底物的葡萄糖的至少一种酶，并将酶沉积在测试条基材上。

    Method for test strip manufacturing and test card analysis
    6.
    发明申请
    Method for test strip manufacturing and test card analysis 审中-公开
    测试条制造和测试卡分析方法

    公开(公告)号：US20070040567A1

    公开(公告)日：2007-02-22

    申请号：US11504710

    申请日：2006-08-16

    申请人： Natasha Popovich ,  Brent Modzelewski ,  Dennis Slomski

    发明人： Natasha Popovich ,  Brent Modzelewski ,  Dennis Slomski

    IPC分类号： G01R31/26

    CPC分类号： G01N27/3272 ,  G01R3/00

    摘要： A method of manufacturing a plurality of test strips is described where a web is formed containing conductive and base layers. A plurality of test strips are formed on the web by electrically isolating a first group of conductive components. Subsequently, a second group of conductive components are electrically isolated on the web by a different process. A test card for quality control analysis is also described, where the test card includes a plurality of attached test strip traces.

    摘要翻译： 描述了制造多个测试条的方法，其中形成包含导电层和基底层的网。 通过电隔离第一组导电部件而在网状物上形成多个测试条。 随后，第二组导电组件通过不同的工艺在网上电隔离。 还描述了用于质量控制分析的测试卡，其中测试卡包括多个连接的测试条迹线。

    Method of Manufacturing a Diagnostic Test Strip
    8.
    发明申请
    Method of Manufacturing a Diagnostic Test Strip 审中-公开
    制造诊断试纸的方法

    公开(公告)号：US20090057149A1

    公开(公告)日：2009-03-05

    申请号：US12268499

    申请日：2008-11-11

    申请人： Greta Wegner ,  Natasha Popovich

    发明人： Greta Wegner ,  Natasha Popovich

    IPC分类号： G01N27/26 ,  B05D5/12 ,  H05K3/10 ,  C25D5/02 ,  C23C14/34

    CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G03F9/00

    摘要： A method for manufacturing a biosensor is provided. The method may include positioning a shadow mask containing a pattern of a plurality of feature sets over a substantially planar base layer containing a plurality of registration points. The method may also include forming at least one of the plurality of feature sets on the substantially planar base layer by selectively depositing a layer of a conductive material on the substantially planar base layer by passing the conductive material through the pattern of the shadow mask and removing the shadow mask from the substantially planar base layer. Alternatively, the method may include providing a laminate structure including a substantially planar base layer containing a plurality of registration points and a photoresist layer containing a pattern of a plurality of feature sets. The method may further include forming at least one of the plurality of feature sets on the substantially planar base layer by selectively depositing a layer of a conductive material on the substantially planar base layer by passing the conductive material through the pattern of the photoresist layer and removing the photoresist layer from the substantially planar base layer.

    摘要翻译： 提供一种制造生物传感器的方法。 该方法可以包括将包含多个特征集的图案的荫罩定位在包含多个对准点的基本上平面的基底层上。 该方法还可以包括通过使导电材料通过荫罩的图案并去除在基本平坦的基底层上选择性地沉积导电材料层，从而在基本平坦的基底层上形成多个特征组中的至少一个 该荫罩基本平坦的基层。 或者，该方法可以包括提供包括包含多个对准点的基本平坦的基底层和包含多个特征集的图案的光致抗蚀剂层的层压结构。 该方法可以进一步包括通过使导电材料通过光致抗蚀剂层的图案并且去除在基本上平坦的基底层上的多个特征组中的至少一个，通过选择性地将导电材料层沉积在基本平坦的基底层上 来自基本平坦的基底层的光致抗蚀剂层。

    Method of manufacturing a diagnostic test strip
    9.
    发明授权
    Method of manufacturing a diagnostic test strip 有权
    诊断试纸的制造方法

    公开(公告)号：US07465597B2

    公开(公告)日：2008-12-16

    申请号：US11476702

    申请日：2006-06-29

    申请人： Greta Wegner ,  Natasha Popovich

    发明人： Greta Wegner ,  Natasha Popovich

    IPC分类号： H01L21/00

    CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G03F9/00

    摘要： A method for manufacturing a biosensor is provided. The method may include positioning a shadow mask containing a pattern of a plurality of feature sets over a substantially planar base layer containing a plurality of registration points. The method may also include forming at least one of the plurality of feature sets on the substantially planar base layer by selectively depositing a layer of a conductive material on the substantially planar base layer by passing the conductive material through the pattern of the shadow mask and removing the shadow mask from the substantially planar base layer. Alternatively, the method may include providing a laminate structure including a substantially planar base layer containing a plurality of registration points and a photoresist layer containing a pattern of a plurality of feature sets. The method may further include forming at least one of the plurality of feature sets on the substantially planar base layer by selectively depositing a layer of a conductive material on the substantially planar base layer by passing the conductive material through the pattern of the photoresist layer and removing the photoresist layer from the substantially planar base layer.

    摘要翻译： 提供一种制造生物传感器的方法。 该方法可以包括将包含多个特征集的图案的荫罩定位在包含多个对准点的基本平坦的基底层上。 该方法还可以包括通过使导电材料通过荫罩的图案并去除在基本平坦的基底层上选择性地沉积导电材料层，从而在基本平坦的基底层上形成多个特征组中的至少一个 该荫罩基本平坦的基层。 或者，该方法可以包括提供包括包含多个对准点的基本平坦的基底层和包含多个特征集的图案的光致抗蚀剂层的层压结构。 该方法可以进一步包括通过使导电材料通过光致抗蚀剂层的图案并且去除在基本上平坦的基底层上的多个特征组中的至少一个，通过选择性地将导电材料层沉积在基本平坦的基底层上 来自基本平坦的基底层的光致抗蚀剂层。

    DIAGNOSTIC STRIP CODING SYSTEM WITH CONDUCTIVE LAYERS
    10.
    发明申请
    DIAGNOSTIC STRIP CODING SYSTEM WITH CONDUCTIVE LAYERS 审中-公开
    具有导电层的诊断条纹编码系统

    公开(公告)号：US20080020452A1

    公开(公告)日：2008-01-24

    申请号：US11458298

    申请日：2006-07-18

    申请人： Natasha Popovich ,  Gary Neel ,  Dennis Slomski ,  Greta Wegner

    发明人： Natasha Popovich ,  Gary Neel ,  Dennis Slomski ,  Greta Wegner

    IPC分类号： C12M3/00

    CPC分类号： G01N33/48771

    摘要： A diagnostic test strip is provided. The test strip comprises at least one electrically insulating substrate material and a plurality of electrical strip contacts disposed on the least one insulating substrate layer. The at least one electrical strip contact includes a first conductive layer disposed on the substrate, and a second conductive layer disposed on top of the first conductive layer.

    摘要翻译： 提供诊断测试条。 测试条包括至少一个电绝缘基板材料和设置在至少一个绝缘基板层上的多个电条触点。 所述至少一个电条接触包括设置在所述基板上的第一导电层和设置在所述第一导电层顶部上的第二导电层。