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71.发明授权7-deazapurine modulators of histone methyltransferase, and methods of use thereof 有权组氨酸甲基转移酶的7-脱氮嘌呤调节剂及其使用方法公开(公告)号：US08722877B2
公开(公告)日：2014-05-13
申请号：US14018171
申请日：2013-09-04
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Kevin Wayne Kuntz , Edward James Olhava , Michael A. Patane
CPC classification number: C07H19/14 , C07D487/04
Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
Abstract translation: 公开了化合物，含有这些化合物的药物组合物，化合物和组合物用作组蛋白甲基转移酶的调节剂，以及治疗受组蛋白甲基转移酶活性调节影响的疾病的方法。
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公开(公告)号：US20140107122A1
公开(公告)日：2014-04-17
申请号：US14054695
申请日：2013-10-15
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki
IPC: C07D405/14 , C07D213/64
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61K31/5375 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US20130317026A1
公开(公告)日：2013-11-28
申请号：US13938067
申请日：2013-07-09
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D401/12
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Abstract translation: 本发明涉及取代的6,5-稠合双环杂芳基化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。
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公开(公告)号：US20130123234A1
公开(公告)日：2013-05-16
申请号：US13722807
申请日：2012-12-20
Applicant: EPIZYME, INC. , EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D401/12 , C07D491/08 , C07D417/12 , C07D491/107 , C07D405/14 , C07D409/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US11642348B2
公开(公告)日：2023-05-09
申请号：US16924962
申请日：2020-07-09
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki , Syuji Shirotori , Wataru Itano , Wanjun Zheng
IPC: C07D405/14 , C07D213/64 , C07D401/12 , C07D405/12 , A61K31/5377 , A61K31/5375 , A61K31/4412 , A61K31/4545
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61K31/5375 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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Patent Agency Ranking
公开(公告)号：US10669243B2
公开(公告)日：2020-06-02
申请号：US16245986
申请日：2019-01-11
Applicant: EPIZYME, INC.
Inventor： Richard Chesworth , Megan Alene Cloonan Foley , Kevin Wayne Kuntz , Lorna Helen Mitchell , Jennifer C. Petter , Carl Eric Schwartz
IPC: C07D261/18 , C07D413/12 , A61P35/02 , A61P35/04 , A61P35/00
Abstract: The present disclosure provides provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
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公开(公告)号：US10577363B2
公开(公告)日：2020-03-03
申请号：US15510588
申请日：2015-09-09
Applicant: EPIZYME, INC.
Inventor： Lorna Helen Mitchell , Andrew Simon Bell , Richard Chesworth , Megan Alene Cloonan Foley , Kevin Wayne Kuntz , James Edward John Mills , Michael John Munchhof
IPC: C07D451/04 , C07D413/14 , C07D413/12 , C07D487/08 , C07D519/00 , A61P35/00
Abstract: The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
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公开(公告)号：US20190322660A1
公开(公告)日：2019-10-24
申请号：US16269338
申请日：2019-02-06
Applicant: EPIZYME, INC.
Inventor： Megan Alene Cloonan Foley , Kevin Wayne Kuntz , James Edward John Mills , Lorna Helen Mitchell , Michael John Munchhof , Darren Martin Harvey
IPC: C07D451/04 , C07D211/34 , C07D213/81 , C07D417/14 , C07C271/18 , C07D205/04 , C07D237/24 , C07D401/14 , C07D403/12 , C07D403/14 , C07D277/56 , C07D209/08 , C07D275/03 , C07D263/34 , C07D261/10 , C07D249/04 , C07D241/26 , C07D401/12 , C07D233/90 , C07D231/14 , C07D213/82 , C07D413/12
Abstract: The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmacentically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
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公开(公告)号：US20190241529A1
公开(公告)日：2019-08-08
申请号：US16245986
申请日：2019-01-11
Applicant: EPIZYME, INC.
Inventor： Richard Chesworth , Megan Alene Cloonan Foley , Kevin Wayne Kuntz , Lorna Helen Mitchell , Jennifer C. Petter , Carl Eric Schwartz
IPC: C07D261/18 , A61P35/00 , C07D413/12 , A61P35/02 , A61P35/04
Abstract: The present disclosure provides provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
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公开(公告)号：US10098888B2
公开(公告)日：2018-10-16
申请号：US15359538
申请日：2016-11-22
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki
IPC: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61K31/5375 , C07D405/14 , C07D213/64
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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