公开(公告)号：US20130045210A1

公开(公告)日：2013-02-21

申请号：US13577212

申请日：2011-02-04

申请人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US20130037534A1

公开(公告)日：2013-02-14

申请号：US13571011

申请日：2012-08-09

申请人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

发明人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

IPC分类号： H05B1/02 ,  F27D11/00

CPC分类号： H01L21/67781 ,  H01L21/67248

摘要： Provided is a method of controlling temperatures of objects to be heated in a heating unit by adjusting a heating rate of each of a plurality of heating elements, based on temperature detection values detected at a plurality of temperature detection elements, wherein the plurality of temperature detection elements are positioned at different positions and the plurality of heating elements are positioned at different positions. The method includes estimating a temperature of each of the plurality of temperature detection elements by using a first estimation algorithm when one of the plurality of temperature detection elements is broken, based on the temperature detection values of the temperature detection elements excluding the broken temperature detection element, and controlling the temperatures of the objects to be heated based on the estimated temperatures.

摘要翻译： 提供了一种通过基于在多个温度检测元件检测到的温度检测值来调节多个加热元件的加热速度来控制加热单元中待加热物体的温度的方法，其中多个温度检测 元件位于不同的位置，并且多个加热元件位于不同的位置。 该方法包括：基于除了断开的温度检测元件之外的温度检测元件的温度检测值，通过使用第一估计算法来估计多个温度检测元件中的每一个的温度， 并且基于估计的温度来控制被加热物体的温度。

公开(公告)号：US20120301476A1

公开(公告)日：2012-11-29

申请号：US13576969

申请日：2011-02-04

申请人： Fumiyoshi Okano ,  Takanori Saito ,  Shinichi Kobayashi ,  Takayoshi Ido ,  Yoshinori Narita

发明人： Fumiyoshi Okano ,  Takanori Saito ,  Shinichi Kobayashi ,  Takayoshi Ido ,  Yoshinori Narita

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/3053 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/34

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。

公开(公告)号：US20120251966A1

公开(公告)日：2012-10-04

申请号：US13429845

申请日：2012-03-26

申请人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

发明人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

IPC分类号： F27D19/00

CPC分类号： H01L21/67109 ,  G05D23/1931 ,  H01L21/324 ,  H01L21/67248

摘要： There is provided a heat treatment control system and method which can accurately estimate the temperatures of wafers upon loading of the wafers, enabling quick heat treatment of the wafers. The heat treatment control system includes: a processing container for processing wafers held in a boat; a lid for hermetically closing the processing container; heaters for heating the processing container; and a controller for controlling the heaters. A profile temperature sensor holding tool is installed on the lid. To the sensor holding tool are mounted profile temperature sensors which are connected to a temperature estimation section. The temperature estimation section estimates the temperature of a wafer by applying a first-order lag filter to a detection signal from a profile temperature sensor. The controller controls the heaters based on the temperatures of wafers thus determined by the temperature estimation section.

摘要翻译： 提供了一种热处理控制系统和方法，其可以在加载晶片时准确地估计晶片的温度，从而能够快速地对晶片进行热处理。 热处理控制系统包括：处理容器，用于处理保存在船上的晶片; 用于气密地关闭处理容器的盖子; 用于加热处理容器的加热器; 以及用于控制加热器的控制器。 外壳温度传感器固定工具安装在盖子上。 传感器保持工具是连接到温度估计部分的安装型材温度传感器。 温度估计部通过对来自轮廓温度传感器的检测信号应用一阶滞后滤波器来估计晶片的温度。 控制器基于由温度估计部确定的晶片的温度来控制加热器。

公开(公告)号：US08253075B2

公开(公告)日：2012-08-28

申请号：US12223162

申请日：2007-02-07

申请人： Makoto Kobayashi ,  Kenichi Yamaga ,  Takanori Saito

发明人： Makoto Kobayashi ,  Kenichi Yamaga ,  Takanori Saito

IPC分类号： F27B5/08 ,  F27B5/16 ,  F27D1/12

CPC分类号： H01L21/67109 ,  H01L21/425 ,  Y10T29/49083

摘要： A heat treatment apparatus with a process chamber, a tubular heater, a heat exhaust system and a cooling section. The heater surrounds an outer circumference of the process chamber. The heat exhaust system exhausts an atmosphere in a space between the heater and the process chamber. The cooling section blows a cooling fluid into the space to cool the atmosphere. The heater includes a tubular heat insulator, a heat generating resistor on an inner circumference of the heat insulator, and an outer shell provided on an outer circumference of the heat insulator. The cooling section includes at least one annular flow path between the heat insulator and the outer shell, and an outlet in the heat insulator. The outlet blows cooling fluid toward a vertical central axis of the heat insulator, or in a direction oblique to the direction toward vertical central axis of the heat insulator.

摘要翻译： 一种具有处理室，管状加热器，散热系统和冷却部分的热处理设备。 加热器围绕处理室的外周。 排热系统排出加热器和处理室之间的空间中的气氛。 冷却部分将冷却液吹入空间以冷却大气。 加热器包括管状隔热件，隔热件的内周上的发热电阻器和设置在隔热件外周上的外壳。 冷却部分包括在绝热器和外壳之间的至少一个环形流动路径以及隔热件中的出口。 出口将冷却流体吹向绝热体的垂直中心轴线，或者朝向与绝热体垂直中心轴方向倾斜的方向。

公开(公告)号：US07528347B2

公开(公告)日：2009-05-05

申请号：US10505900

申请日：2003-02-28

申请人： Takanori Saito ,  Kenichi Yamaga

发明人： Takanori Saito ,  Kenichi Yamaga

IPC分类号： F27B5/14

CPC分类号： H01L21/67109

摘要： A heat treating device (50) has a cooling sleeve that covers a treating vessel (56) and a heater (100). The cooling sleeve has a cylindrical base member (110) and a cooling pipe (112) spirally wound on the outer peripheral surface hereof. The cooling pipe (112) is brazed to the base member (110).

摘要翻译： 热处理装置（50）具有覆盖处理容器（56）和加热器（100）的冷却套筒。 冷却套筒具有圆筒形的基座部件（110）和螺旋地卷绕在其外周面上的冷却管道（112）。 冷却管（112）钎焊到基体（110）上。

公开(公告)号：USRE36138E

公开(公告)日：1999-03-09

申请号：US854136

申请日：1997-05-08

申请人： Eiji Suzuki ,  Hideaki Okabe ,  Takanori Saito

发明人： Eiji Suzuki ,  Hideaki Okabe ,  Takanori Saito

IPC分类号： A61K9/70 ,  A61K47/18 ,  C07C229/56 ,  C07C233/54 ,  A61F13/00

CPC分类号： A61K9/7061 ,  A61K47/18 ,  A61K47/183 ,  A61K9/0014 ,  Y10S514/946 ,  Y10S514/947

摘要： A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

摘要翻译： 经皮吸收促进剂包括其中氨基具有或不具有酰基取代基或烃取代基的氨基酸衍生物，羧基具有烃取代基，氨基和羧基之间的部分具有特定的结构 。 胶带包含上述经皮吸收促进剂。 该方法利用上述经皮吸收促进剂。 本发明的经皮促进剂具有优异的促进药理活性物质的经皮吸收和同时具有优异安全性的能力，能够通过循环系统快速将期望的药理活性物质快速递送至身体的所有部位， 用于治疗各种疾病。 包含它的胶带膏和利用它促进经皮吸收的方法具有相同的优点。

公开(公告)号：US5744162A

公开(公告)日：1998-04-28

申请号：US929044

申请日：1992-08-13

申请人： Hideaki Okabe ,  Ichiro Tsuchida ,  Takanori Saito

发明人： Hideaki Okabe ,  Ichiro Tsuchida ,  Takanori Saito

IPC分类号： A61K9/70 ,  A61K47/32 ,  A61K9/14

CPC分类号： A61K9/7061 ,  A61K47/32

摘要： A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.

摘要翻译： 透皮治疗制剂由包含聚合物和与聚合物混合的成分组成的组合物制成，所述组合物是药理活性物质，醇，根据需要使用的经皮吸收促进剂和根据需要使用的水。 聚合物包含亲脂性单体单元和具有特定比例的亲水性单体单元。 将醇，经皮吸收促进剂和水与特定量的聚合物混合。 透皮治疗剂具有优异的经皮吸收性，具有多种适用的药理活性物质，由于不存在药理活性物质的结晶，显示出良好的经皮吸收稳定性，具有良好的粘合强度，因此有利地用作透皮治疗膏药。

公开(公告)号：US5589192A

公开(公告)日：1996-12-31

申请号：US353322

申请日：1994-12-05

申请人： Hideaki Okabe ,  Eiji Suzuki ,  Masao Kogure ,  Takanori Saito

发明人： Hideaki Okabe ,  Eiji Suzuki ,  Masao Kogure ,  Takanori Saito

IPC分类号： A61K9/70 ,  A61K31/165 ,  A61K31/167 ,  A61K31/245 ,  A61K45/00 ,  A61K47/32 ,  A61P23/02 ,  A61P25/02 ,  A61L15/00

CPC分类号： A61K9/7061 ,  A61K31/245 ,  Y10S514/816 ,  Y10S514/818 ,  Y10S514/944 ,  Y10S514/946

摘要： An article of manufacture in the form of a gel pharmaceutical formulation for local anesthesia is prepared by a process comprising: coating a supporting substrate, which preferably is porous, e.g., a non-woven fabric, and has an impervious backing sheet, with a matrix of a copolymer of alkyl (meth)acrylates and (meth)acrylic acid and a local anesthetic whereby the matrix penetrates the substrate, crosslinking the copolymer in the matrix to form a polymer/drug matrix, and coating the surface of the matrix with an aqueous fluid, thereby converting the matrix into a gel and preferably covering the gel matrix with an impervious protective sheet. The product has excellent percutaneous absorption, provides local anesthesia easily just by attaching the formulation to the skin, enables elimination of various kinds of pain, such as the pain at the time of hypodermic injection, can be removed easily from the skin, and causes no soiling of fingers, hands or cloths.

摘要翻译： 用于局部麻醉的凝胶药物制剂形式的制品是通过以下方法制备的，该方法包括：将优选为多孔的支撑基底（例如无纺织物）涂覆并具有不透水的背衬片， 的（甲基）丙烯酸烷基酯和（甲基）丙烯酸烷基酯和局部麻醉剂的共聚物，由此基质渗透底物，使基质中的共聚物交联以形成聚合物/药物基质，并用水性 从而将基质转化成凝胶，并且优选用不透水的保护片覆盖凝胶基质。 该产品具有优异的经皮吸收，通过将配方附着到皮肤上即可轻松提供局部麻醉，能够消除各种疼痛，如皮下注射时的疼痛，可以容易地从皮肤上清除，不会导致 弄脏手指，手或布。

公开(公告)号：US5284091A

公开(公告)日：1994-02-08

申请号：US884270

申请日：1992-05-08

申请人： Kazuhiro Kon ,  Koichi Hirota ,  Masao Kogure ,  Takanori Saito

发明人： Kazuhiro Kon ,  Koichi Hirota ,  Masao Kogure ,  Takanori Saito

IPC分类号： B41F27/12 ,  B41F13/10 ,  H01L21/68

CPC分类号： B41F27/1275 ,  B41N6/02 ,  Y10S428/913 ,  Y10T428/1462 ,  Y10T428/28 ,  Y10T428/2809 ,  Y10T428/283 ,  Y10T428/2848 ,  Y10T428/2857 ,  Y10T428/2883 ,  Y10T428/2891 ,  Y10T428/31678 ,  Y10T428/31692 ,  Y10T428/31699

摘要： A plate roll attached by an adhesive sheet to a printing plate made of a resin. The attached printing plate is easily detached. The adhesive sheet and remaining adhesive are easily removed after printing is finished and the efficiency of the operation of printing is enhanced. The adhesive sheet includes a photocurable adhesive, which loses adhesive ability by curing by irradiation of electromagnetic waves or an electron beam or a water swelling adhesive, which loses adhesive ability by swelling by water. Adhesive sheets for the plate roll comprise supporting sheets, removable sheets and a photocurable adhesive, which loses adhesive ability by curing by irradiation of electromagnetic waves or an electron beam or a water swelling adhesive, which loses adhesive ability by swelling by water.

摘要翻译： 由粘合片附着到由树脂制成的印版上的平板辊。 附着的印版容易分离。 粘合片和剩余的粘合剂在印刷完成后容易地除去，并且印刷操作的效率提高。 粘合片包括可光固化的粘合剂，其通过电磁波的照射或电子束或水溶性粘合剂的固化而失去粘合性，其通过水膨胀而失去粘合能力。 用于板卷的粘合片包括支撑片，可移除片和可光固化的粘合剂，其通过电磁波的照射或电子束或水溶性粘合剂固化而失去粘合性，其通过水膨胀而失去粘合能力。