公开(公告)号：US20100311811A1

公开(公告)日：2010-12-09

申请号：US12769434

申请日：2010-04-28

Applicant: Frank Sauer

Inventor： Frank Sauer

IPC: A61K31/7115 ,  C12N5/071 ,  A61K31/7088 ,  C12Q1/68 ,  A61P43/00

CPC classification number: C12N15/63

Abstract: The invention provides a method of regulating transcription of a gene that is a target for an epigenetic regulator; a method of characterizing the transcriptional activity of such a gene; a method of screening for a chromosomal element (CE) for an epigenetic regulator of a target gene; an isolated complex including an epigenetic regulator for a target gene, wherein the epigenetic regulator is specifically bound to a non-coding polynucleotide; and a method of screening for a modulator of transcription of a gene that is a target for an epigenetic regulator.

Abstract translation: 本发明提供了调节作为表观遗传调节物靶标的基因的转录的方法。 表征该基因的转录活性的方法; 筛选靶基因的表观遗传调节剂的染色体元件（CE）的方法; 包括靶基因的表观遗传调节剂的分离的复合物，其中所述表观遗传调节子特异性结合于非编码多核苷酸; 以及筛选作为表观遗传调节物的靶基因的转录调节物的方法。

公开(公告)号：US07822291B2

公开(公告)日：2010-10-26

申请号：US11259560

申请日：2005-10-26

Applicant: Christoph Guetter ,  Chenyang Xu ,  Joachim Hornegger ,  Frank Sauer

Inventor： Christoph Guetter ,  Chenyang Xu ,  Joachim Hornegger ,  Frank Sauer

IPC: G06K9/32

CPC classification number: G06K9/6206 ,  G06T7/33 ,  G06T7/35 ,  G06T2200/04 ,  G06T2207/10072 ,  G06T2207/20221

Abstract: A computer-implemented method for non-rigid multi-modal registration, includes providing trained data corresponding to previously registered images captured by different modalities, receiving two or more images captured by the different modalities, and registering the two or more images according to context information determined based on the trained data.

Abstract translation: 一种用于非刚性多模式注册的计算机实现的方法，包括提供对应于由不同模态捕获的先前注册的图像的训练数据，接收由不同模态捕获的两个或多个图像，以及根据上下文信息注册两个或多个图像 根据训练数据确定。

公开(公告)号：US07787683B2

公开(公告)日：2010-08-31

申请号：US11303564

申请日：2005-12-16

Applicant: Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

Inventor： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

IPC: G06K9/00

CPC classification number: G06K9/00208 ,  G06K2009/00932 ,  G06K2209/05

Abstract: A system and method for tree structure based two-dimensional to three-dimensional registration are provided for receiving three-dimensional (3D) data indicative of vessels, segmenting the 3D data with a vessel tree, simulating two-dimensional (2D) data responsive to the segmented 3D data to form a simulated 2D image, receiving 2D data indicative of vessels, segmenting the received 2D data with a vessel tree, finding a distance transform of the segmented 2D data to form a 2D distance map image, considering a set of poses as state vectors with the corresponding probability computed using the similarity measure computation, re-sampling the pose vector to find a set of most probable poses and considering them as hypothesized poses, recomputing the projection and re-evaluating the probability of the hypothesized poses and updating the state vector until the optimal pose is found.

Abstract translation: 提供了一种用于基于树结构的二维至三维配准的系统和方法，用于接收指示血管的三维（3D）数据，用血管树分割3D数据，模拟二维（2D）数据，响应于 分割的3D数据以形成模拟2D图像，接收指示血管的2D数据，用血管树分割接收的2D数据，找到分割的2D数据的距离变换以形成2D距离图图像，考虑一组姿势 作为具有使用相似度测量计算计算的相应概率的状态向量，重新采样姿态向量以找到一组最可能的姿势并将其视为假设姿势，重新计算投影并重新估计假设姿势的概率和更新 状态矢量，直到找到最佳姿势。

公开(公告)号：US07774044B2

公开(公告)日：2010-08-10

申请号：US11056317

申请日：2005-02-11

Applicant: Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

Inventor： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

IPC: A61B5/05 ,  G09G5/00

CPC classification number: G02B7/002 ,  A61B34/10 ,  A61B34/20 ,  A61B90/20 ,  A61B90/36 ,  A61B90/361 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/371 ,  G02B27/017 ,  G02B2027/0138 ,  G02B2027/0187 ,  G06F3/012

Abstract: A method for augmented reality navigation of a medical intervention includes providing a stereoscopic head mounted display, the display including a pair of stereo viewing cameras, at least one tracking camera, and a stereoscopic guidance display. During a medical intervention on a patient, the patient's body pose is determined from a rigid body transformation between the tracking camera and frame markers on the scanning table, and the pose of an intervention instrument with respect to the table is determined. A visual representation of the patient overlaid with an image of the intervention target, the instrument, and a path for guiding the instrument to perform said medical intervention is displayed in the stereoscopic guidance display.

Abstract translation: 用于医疗干预的增强现实导航的方法包括提供立体头戴式显示器，所述显示器包括一对立体观看照相机，至少一个跟踪相机和立体指导显示器。 在患者的医疗干预中，患者的身体姿势由跟踪摄像机和扫描台上的帧标记之间的刚性身体变换确定，并且确定干预仪器相对于桌子的姿势。 在立体指导显示中显示覆盖有介入目标图像，仪器和用于引导仪器执行所述医疗干预的路径的患者的视觉表示。

公开(公告)号：US07740268B2

公开(公告)日：2010-06-22

申请号：US12216922

申请日：2008-07-11

Applicant: Frank Sauer

Inventor： Frank Sauer

IPC: B60R21/20

CPC classification number: B60R21/217 ,  B60R21/203

Abstract: An airbag fastening system in an airbag module has a clamping connection and includes a retaining ring for an injection orifice of the airbag in an airbag receptacle surrounding both the airbag module and the retaining ring. The retaining ring has a reducing width on an outer face in a main pulling direction when the airbag unfolds. At least a portion of the airbag receptacle or a component associated with the airbag receptacle has a smaller width above the retaining ring than a greatest width of the retaining ring. A lower end of the airbag forms the injection orifice, is folded over the retaining ring, and extends between the retaining ring and the airbag receptacle or the component. The retaining ring includes at least one portion having a conically tapered cross-section on the outer face in the main pulling direction when the airbag unfolds.

Abstract translation: 安全气囊模块中的气囊紧固系统具有夹紧连接，并且包括用于安全气囊插入件中的用于安全气囊的注射孔的保持环，围绕安全气囊模块和保持环。 当气囊展开时，保持环在主拉动方向上具有在外表面上的减小宽度。 安全气囊插座的至少一部分或与安全气囊插座相关联的部件在保持环之上具有比保持环的最大宽度更小的宽度。 气囊的下端形成喷射孔，折叠在保持环上，并且在保持环和气囊插座或部件之间延伸。 当气囊展开时，保持环包括在主拉动方向上的外表面上具有锥形锥形横截面的至少一个部分。

公开(公告)号：US07583857B2

公开(公告)日：2009-09-01

申请号：US11380673

申请日：2006-04-28

Applicant: Chenyang Xu ,  Dieter Hahn ,  Yiyong Sun ,  Frank Sauer

Inventor： Chenyang Xu ,  Dieter Hahn ,  Yiyong Sun ,  Frank Sauer

IPC: G06K9/32

CPC classification number: G06T3/0075 ,  G06K9/3216 ,  G06K9/4671 ,  G06K2209/051 ,  G06T7/33 ,  G06T7/35 ,  G06T7/38 ,  G06T2207/30004

Abstract: A method for aligning a pair of images includes providing a pair of images, identifying salient feature regions in both a first image and a second image, wherein each region is associated with a spatial scale, representing feature regions by a center point of each region, registering the feature points of one image with the feature points of the other image based on local intensities, ordering said feature pairs by a similarity measure, and optimizing a joint correspondence set of feature pairs by refining the center points to sub-pixel accuracy.

Abstract translation: 用于对准一对图像的方法包括提供一对图像，识别第一图像和第二图像两者中的突出特征区域，其中每个区域与空间尺度相关联，其中每个区域的中心点表示特征区域， 基于局部强度将一个图像的特征点与另一图像的特征点对准，通过相似性度量对所述特征对进行排序，并通过将中心点精细化为子像素精度来优化特征对的联合对应集合。

公开(公告)号：US20080287787A1

公开(公告)日：2008-11-20

申请号：US11649391

申请日：2007-01-03

Applicant: Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

Inventor： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

IPC: A61B8/13

CPC classification number: A61B8/12 ,  A61B5/062 ,  A61B8/0833 ,  A61B8/4254 ,  A61B8/483 ,  A61B8/587 ,  B33Y80/00

Abstract: Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.

Abstract translation: 用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。

公开(公告)号：US07450743B2

公开(公告)日：2008-11-11

申请号：US11036528

申请日：2005-01-14

Applicant: Hari Sundar ,  Chenyang Xu ,  Frank Sauer

Inventor： Hari Sundar ,  Chenyang Xu ,  Frank Sauer

IPC: G06K9/00

CPC classification number: G06T7/38 ,  G06T7/33 ,  G06T2207/10072 ,  G06T2207/10121 ,  G06T2207/20072 ,  G06T2207/30101

Abstract: A system and method for registering a sequence of inter-operative two dimensional (2D) medical images of a target feature with pre-operative three dimensional (3D) medical images of the target feature is disclosed. The 3D image of the target feature is converted to a first skeletal graph. The 2D image of the target feature is converted to a second skeletal graph. Graph matching of the first and second skeletal graphs is performed to obtain a rough alignment of the graphs, and the first and second skeletal graph registered.

Abstract translation: 公开了一种用于将目标特征的手术间二维（2D）医学图像序列登记到目标特征的手术前三维（3D）医学图像）的系统和方法。 将目标要素的3D图像转换为第一个骨架图。 目标特征的2D图像被转换为​​第二个骨架图。 执行第一和第二骨架图的图形匹配以获得图的粗略对准，并且注册第一和第二骨架图。

公开(公告)号：US20080270095A1

公开(公告)日：2008-10-30

申请号：US11874975

申请日：2007-10-19

Applicant: Herve Jun Alfred Lombaert ,  Frank Sauer ,  Yiyong Sun ,  Chenyang Xu

Inventor： Herve Jun Alfred Lombaert ,  Frank Sauer ,  Yiyong Sun ,  Chenyang Xu

IPC: G06G7/60 ,  A61B5/02

CPC classification number: G06T7/0012 ,  A61B5/7289 ,  A61B6/503 ,  A61B8/0883 ,  A61B8/14 ,  G06T15/08 ,  G06T2207/10076 ,  G06T2207/10136 ,  G06T2207/30048

Abstract: A method of performing 4-dimensional virtual endoscopy includes acquiring a sequence of cardiac images of a patient's heart from an imaging device; acquiring an electrocardiographic signal exhibiting cardiac cycles of the heart; and utilizing the electrocardiographic signal to gate the images for deriving respective 3-dimensional views in succession at corresponding cardiac cycles, from respective cardiac images at a selected phase point common to each of the corresponding cardiac cycles.

Abstract translation: 执行4维虚拟内窥镜检查的方法包括从成像装置获取患者心脏的心脏图像序列; 获取显示心脏心脏周期的心电图信号; 以及利用所述心电图信号对所述图像进行门控，以在相应的心动周期连续地导出相应的三维视图，来自相应心脏周期中每个相关心的所选相位点处的各个心脏图像。

公开(公告)号：US07409108B2

公开(公告)日：2008-08-05

申请号：US10946204

申请日：2004-09-21

Applicant: Chenyang Xu ,  Xiaolei Huang ,  Frank Sauer ,  Christophe Chefd'hotel ,  Jens Gühring ,  Sebastian Vogt ,  Yiyong Sun

Inventor： Chenyang Xu ,  Xiaolei Huang ,  Frank Sauer ,  Christophe Chefd'hotel ,  Jens Gühring ,  Sebastian Vogt ,  Yiyong Sun

IPC: G06K9/32 ,  G06K9/68

CPC classification number: G06K9/00208 ,  G06T7/33 ,  G06T7/35

Abstract: A method of aligning a pair of images with a first image and a second image, wherein said images comprise a plurality of intensities corresponding to a domain of points in a D-dimensional space includes identifying feature points on both images using the same criteria, computing a feature vector for each feature point, measuring a feature dissimilarity for each pair of feature vectors, wherein a first feature vector of each pair is associated with a first feature point on the first image, and a second feature vector of each pair is associated with a second feature point on the second image. A correspondence mapping for each pair of feature points is determined using the feature dissimilarity associated with each feature point pair, and an image transformation is defined to align the second image with the first image using one or more pairs of feature points that are least dissimilar.

Abstract translation: 一种将一对图像与第一图像和第二图像对准的方法，其中所述图像包括对应于D维空间中的点的区域的多个强度，包括使用相同标准在两个图像上识别特征点，计算 每个特征点的特征向量，测量每对特征向量的特征不相似性，其中每对的第一特征向量与第一图像上的第一特征点相关联，并且每对的第二特征向量与 第二个图像上的第二个特征点。 使用与每个特征点对相关联的特征不相似度来确定每对特征点的对应关系，并且定义图像变换以使用至少不相似的一对或多对特征点将第二图像与第一图像对准。