公开(公告)号：US07677078B2

公开(公告)日：2010-03-16

申请号：US11649391

申请日：2007-01-03

申请人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

发明人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

IPC分类号： G01M1/14

CPC分类号： A61B8/12 ,  A61B5/062 ,  A61B8/0833 ,  A61B8/4254 ,  A61B8/483 ,  A61B8/587 ,  B33Y80/00

摘要： Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.

摘要翻译： 用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。

公开(公告)号：US20080287787A1

公开(公告)日：2008-11-20

申请号：US11649391

申请日：2007-01-03

申请人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

发明人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

IPC分类号： A61B8/13

CPC分类号： A61B8/12 ,  A61B5/062 ,  A61B8/0833 ,  A61B8/4254 ,  A61B8/483 ,  A61B8/587 ,  B33Y80/00

摘要： Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.

摘要翻译： 用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。

公开(公告)号：US09681925B2

公开(公告)日：2017-06-20

申请号：US11107640

申请日：2005-04-15

申请人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Sebastian Vogt

发明人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Sebastian Vogt

IPC分类号： A61B5/05 ,  A61B90/00 ,  A61B34/20 ,  A61B90/11 ,  A61B34/10

CPC分类号： A61B90/36 ,  A61B34/10 ,  A61B34/20 ,  A61B90/11 ,  A61B90/361 ,  A61B2034/107 ,  A61B2090/365

摘要： A system and method for instrument placement using an image based navigation system is disclosed. A target of interest is identified in a medical image of a patient. An image plane is displayed that goes through a center of the target. The image plane has a configurable orientation. The image plane is used to select a path for an instrument from a position on the patient's skin to the center of the target. A trajectory plane is viewed from a tip of the instrument to the center of the target. The trajectory plane reflects an orientation of the instrument. A particular trajectory plane is selected that is representative of a desired orientation of the instrument. An image of the particular trajectory plane is frozen. The instrument can then be inserted using a virtual guide and is navigated toward the target.

公开(公告)号：US08244332B2

公开(公告)日：2012-08-14

申请号：US11292338

申请日：2005-12-01

申请人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Bruce Tromberg ,  Albert Cerussi

发明人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Bruce Tromberg ,  Albert Cerussi

IPC分类号： A61B6/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  A61B34/20 ,  A61B2034/105 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/373 ,  G01N21/359 ,  G01N21/474 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4745 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/08

摘要： A diffuse optical spectroscopy system comprises a laser breast scanner, a handheld probe connected to the laser breast scanner for scanning a breast, and a tracking device coupled to the handheld probe, wherein the tracking device determines locations of the handheld probe relative to the breast. The tracking device comprises a magnetic tracking device, an optical tracking device or a laser tracking device.

摘要翻译： 扩散光谱系统包括激光乳房扫描器，连接到用于扫描乳房的激光乳房扫描器的手持式探头以及耦合到手持探针的跟踪装置，其中跟踪装置确定手持式探针相对于乳房的位置。 跟踪装置包括磁跟踪装置，光学跟踪装置或激光跟踪装置。

公开(公告)号：US07711405B2

公开(公告)日：2010-05-04

申请号：US10833742

申请日：2004-04-28

申请人： Ali Khamene ,  Frank Sauer

发明人： Ali Khamene ,  Frank Sauer

IPC分类号： A61B5/05

CPC分类号： G01R33/56 ,  G01R33/5608

摘要： A system and method for registering pre-operative magnetic resonance (MR) images with intra-operative MR images is disclosed. A pre-operative MR image of an object is received. A set of intra-operative MR images of the object is received. The pre-operative MR image is rigidly registered with the initial intra-operative MR image. The subsequent set of intra-operative images is deformably registered. The pre-operative MR image undergoes both rigid and deformation transformation to match specification of each image with in intra-operative MR image set.

摘要翻译： 公开了一种用于将术前磁共振（MR）图像与术中MR图像对准的系统和方法。 接收对象的术前MR图像。 接收对象的一组手术中MR图像。 手术前MR图像与初始手术中MR图像刚性对齐。 随后的一组术中图像可变形地记录。 手术前MR图像经历刚性和变形变换，以在手术中的MR图像组中匹配每个图像的规格。

公开(公告)号：US20050249398A1

公开(公告)日：2005-11-10

申请号：US11109119

申请日：2005-04-19

申请人： Ali Khamene ,  Frank Sauer ,  Chenyang Xu

发明人： Ali Khamene ,  Frank Sauer ,  Chenyang Xu

IPC分类号： A61K31/4439 ,  A61P9/00 ,  C07D401/14 ,  G06K9/00 ,  G06K9/32 ,  G06T7/00

CPC分类号： G06T7/38 ,  G06T2207/30004

摘要： Exemplary methods are provided. In one exemplary method, a lower-dimension signature is generated for each of a plurality of data sets of a given dimension. Registration is performed on the lower-dimension signatures. In another exemplary method, a two-dimensional signature is generated for each of a plurality of three-dimensional volumes. Registration is performed on the two-dimensional signatures.

摘要翻译： 提供了示例性方法。 在一个示例性方法中，为给定维度的多个数据集中的每一个产生较低维度签名。 对较低维的签名执行注册。 在另一示例性方法中，为多个三维体积中的每一个生成二维签名。 对二维签名执行注册。

公开(公告)号：US20050203380A1

公开(公告)日：2005-09-15

申请号：US11056317

申请日：2005-02-11

申请人： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

发明人： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

IPC分类号： A61B5/05

CPC分类号： G02B7/002 ,  A61B34/10 ,  A61B34/20 ,  A61B90/20 ,  A61B90/36 ,  A61B90/361 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/371 ,  G02B27/017 ,  G02B2027/0138 ,  G02B2027/0187 ,  G06F3/012

摘要： A method for augmented reality navigation of a medical intervention includes providing a stereoscopic head mounted display, the display including a pair of stereo viewing cameras, at least one tracking camera, and a stereoscopic guidance display. During a medical intervention on a patient, the patient's body pose is determined from a rigid body transformation between the tracking camera and frame markers on the scanning table, and the pose of an intervention instrument with respect to the table is determined. A visual representation of the patient overlaid with an image of the intervention target, the instrument, and a path for guiding the instrument to perform said medical intervention is displayed in the stereoscopic guidance display.

摘要翻译： 用于医疗干预的增强现实导航的方法包括提供立体头戴式显示器，所述显示器包括一对立体观看照相机，至少一个跟踪相机和立体指导显示器。 在患者的医疗干预中，患者的身体姿势由跟踪摄像机和扫描台上的帧标记之间的刚性身体变换确定，并且确定干预仪器相对于桌子的姿势。 在立体指导显示中显示覆盖有介入目标图像，仪器和用于引导仪器执行所述医疗干预的路径的患者的视觉表示。

公开(公告)号：US07949385B2

公开(公告)日：2011-05-24

申请号：US11405304

申请日：2006-04-17

申请人： Ali Khamene ,  Martin W. Masters ,  Frank Sauer ,  Therese Velde

发明人： Ali Khamene ,  Martin W. Masters ,  Frank Sauer ,  Therese Velde

IPC分类号： A61B5/05

CPC分类号： A61B5/1077 ,  A61B5/0066 ,  H04R25/652 ,  H04R25/658 ,  H04R2225/77

摘要： A method for reconstructing an ear canal from optical coherence tomography (OCT) scan data of an ear comprises extracting frame numbers and line numbers of interference intensities corresponding to one or more markers on an OCT scan guide, receiving reference frame numbers and lines numbers for one or more markers, determining a starting position and direction for the OCT ear scan from the ear scan marker frame and line numbers and the reference marker frame and line numbers, for each scan line, finding a pixel number of a maximum interference intensity value, and determining an offset distance of said pixel from said scan guide, and reconstructing a surface of the ear canal from the distance offset data.

摘要翻译： 用于从耳朵的光学相干断层扫描（OCT）扫描数据重建耳道的方法包括在OCT扫描引导件上提取对应于一个或多个标记的干扰强度的帧号和干扰强度的行号，接收参考帧编号和一个 或更多的标记，为每个扫描线确定来自耳朵扫描标记帧和线号以及参考标记帧和线号的OCT耳朵扫描的起始位置和方向，找到最大干扰强度值的像素数，以及 确定所述像素与所述扫描引导件的偏移距离，以及从所述距离偏移数据重建所述耳道的表面。

公开(公告)号：US07940999B2

公开(公告)日：2011-05-10

申请号：US11686533

申请日：2007-03-15

申请人： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

发明人： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

IPC分类号： G06K9/00 ,  G06K9/32 ,  G06K9/62

CPC分类号： G06K9/00208 ,  G06K9/6212 ,  G06T7/33 ,  G06T7/35 ,  G06T2207/30101

摘要： A method of registering 3-dimensional digitized images to 2-dimensional digitized images during a medical procedure includes providing a pair of correctly-registered training images L={lr, lf} and their joint intensity distribution pl(ir, if), wherein ir and if are reference and floating images, respectively, providing a pair of observed images O={or, of} and their joint intensity distribution po(ir, if), mapping a marginal intensity distribution of the observed pair O={or, of} to a marginal intensity distribution of the training pair L={lr, lf}, and estimating a set of parameters T that registers image of to image or by maximizing a weighted sum of a Jensen-Shannon divergence (JSD) of a joint intensity distribution of the observed pair and a joint intensity distribution of the training pair and a similarity measure between the observed images.

摘要翻译： 在医疗过程中将三维数字化图像注册到二维数字化图像的方法包括提供一对正确注册的训练图像L = {lr，lf}及其联合强度分布pl（ir，if），其中ir 并且如果分别是参考和浮动图像，则提供一对观察图像O = {或，}和它们的联合强度分布po（ir，if），映射观察到的对的边缘强度分布O = {或， }到训练对的边缘强度分布L = {lr，lf}，并且估计登记到图像的图像的一组参数T或者通过最大化联合强度的Jensen-Shannon散度（JSD）的加权和 观察对的分布和训练对的联合强度分布以及观察图像之间的相似性度量。

公开(公告)号：US07853308B2

公开(公告)日：2010-12-14

申请号：US11056318

申请日：2005-02-11

申请人： Frank Sauer ,  Ali Khamene

发明人： Frank Sauer ,  Ali Khamene

IPC分类号： A61B5/05

CPC分类号： A61N5/1049 ,  A61B5/1135 ,  A61B5/7289 ,  A61B6/12 ,  A61N5/1037 ,  A61N2005/1061 ,  A61N2005/1062

摘要： A system and method for positioning a patient for radiotherapy is provided. The method comprises: acquiring a first x-ray image sequence of a target inside the patient at a first angle; acquiring first respiratory signals of the patient while acquiring the first x-ray image sequence; acquiring a second x-ray image sequence of the target at a second angle; acquiring second respiratory signals of the patient while acquiring the second x-ray image sequence; synchronizing the first and second x-ray image sequences with the first and second respiratory signals to form synchronized first and second x-ray image sequences; identifying the target in the synchronized first and second x-ray image sequences; and determining three-dimensional (3D) positions of the target through time in the synchronized first and second x-ray image sequences.

摘要翻译： 提供了一种放射治疗患者定位系统和方法。 该方法包括：以第一角度获取患者内的目标的第一x射线图像序列; 在获取第一x射线图像序列的同时获取患者的第一呼吸信号; 以第二角度获取目标的第二x射线图像序列; 在获取第二X射线图像序列的同时获取患者的第二呼吸信号; 使第一和第二X射线图像序列与第一和第二呼吸信号同步以形成同步的第一和第二X射线图像序列; 识别同步的第一和第二X射线图像序列中的目标; 以及在所述同步的第一和第二X射线图像序列中确定所述目标通过时间的三维（3D）位置。